돼지에서 구제역 백신 접종 후 항체가 변화 조사
Development of antibodies after foot and mouth disease vaccination in pigs
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Three serotypes (O＋A＋Asia1 type) of the foot-and-mouth disease (FMD) vaccine were injected into cloven-hoofed animals in Korea after the nationwide spread of FMD at the end of 2010. This study was conducted to investigate FMD antibody development after FMD vaccination, and to determine whether there was a significant correlation between the antibody titer of the sow and the antibody titer of the growing pigs. The antibody titer (percentage inhibition [PI] titer) of the sow (gilt) after FMD vaccination was maintained at a level higher than 50 (P＜0.05) for 5 months. A higher PI titer for the 1-month-old growing pigs corresponded with greater inhibition of the PI titer of the vaccinated growing pigs (P＜0.05). A negative correlation (P＜0.05) between the PI titer of the 1-month-old growing pigs and the PI titer of 3-month-old growing pigs, 4-month-old growing pigs after FMD vaccination at 2 months, 3months was identified, with a coefficient of determination (R2) of 0.274. Thus the PI titer of the growing pigs was inhibited to a greater degree when vaccination was performed at 2 months of age than at 3 months. However, many other factors likely influence growing pigs’ PI titer in addition to the PI titer of the sow and age at vaccination, given that the coefficient of determination was somewhat lower.
Abstract
Three serotypes (O＋A＋Asia1 type) of the foot-and-mouth disease (FMD) vaccine were injected into cloven-hoofed animals in Korea after the nationwide spread of FMD at the end of 2010. This study was conducted to investigate FMD antibody development after FMD vaccination, and to determine whether there was a significant correlation between the antibody titer of the sow and the antibody titer of the growing pigs. The antibody titer (percentage inhibition [PI] titer) of the sow (gilt) after FMD vaccination was maintained at a level higher than 50 (P＜0.05) for 5 months. A higher PI titer for the 1-month-old growing pigs corresponded with greater inhibition of the PI titer of the vaccinated growing pigs (P＜0.05). A negative correlation (P＜0.05) between the PI titer of the 1-month-old growing pigs and the PI titer of 3-month-old growing pigs, 4-month-old growing pigs after FMD vaccination at 2 months, 3months was identified, with a coefficient of determination (R2) of 0.274. Thus the PI titer of the growing pigs was inhibited to a greater degree when vaccination was performed at 2 months of age than at 3 months. However, many other factors likely influence growing pigs’ PI titer in addition to the PI titer of the sow and age at vaccination, given that the coefficient of determination was somewhat lower.
참고문헌 (29)
- Acharya R, "The three dimensional structure of foot-and-mouth disease virus at 2.9 Å resolution", Nature, 337, pp.709~716 (1989)
- Ayebazibwe C, "The role of African buffalos( Suncerus caffer) in the maintenance of foot-and-mouth disease in Uganda", BMC Vet Res, 6, pp.54~ (2010)
- Belsham GJ, "Distinctive features of foot and mouth disease virus, a member of the picornavirus family; aspects of virus protein synthesis, protein processing and structure", Prog Biophys Mol Biol, 60, pp.241~260 (1993)
- Brückner GK, "Foot-and-mouth disease control using vaccination: South African experience", Dev Biol, 119, pp.51~62 (2004)
- Callis JJ, "Foot and mouth disease- a review", J Am Vet Med Assoc, 153, pp.1798~1802 (1968)
- Cox SJ, "Experimental evaluation of foot-andmouth disease vaccines for emergency use in ruminants and pigs: a review", Vet Res, 40, pp.1~30 (2009)
- De Clercq K, "FMD Vaccines: reflections on quality aspects for applicability in European disease control policy", Transbound Emerg Dis, 55, pp.46~56 (2008)
- Doel TR, "FMD Vaccines", Virus Res, 91, pp.81~99 (2003)
- Forman AJ, "Foot and mouth disease:the future of vaccine banks", Rev Sci Tech, 21, pp.601~612 (2002)
- Jones TC, "Disease caused by virus, In Veterinary pathology. 6th ed", pp.271~273 (1996), Williams & Wilkins Co
- Kitching RP, "The interference by maternally-derived antibody with active immunization of farm animals against foot-and-mouth disease", Br Vet J, 151, pp.379~389 (1995)
- Laporte J, "The structure of foot-and-mouth disease virus protein", J Gen Virol, 4, pp.631~634 (1969)
- Leforban Y, "Prevention measures against foot-and-mouth disease in Europe in recent years", Vaccine, 17, pp.1755~1759 (1999)
- Muleme M, "Effectiveness of vaccines and vaccination programs for the control of foot-and-mouth disease in Uganda, 2001-2010", Trop Anim Health Prod, 45, pp.35~43 (2012)
- Mwiine FN, "Serotype specificity of antibodies against foot-and-mouth disease virus in cattle in selected districts in Uganda", Transbound Emerg Dis, 57, pp.365~374 (2010)
- Park JH, "Molecular epidemiological analysis and recent distribution of foot-and-mouth disease in the world", Kor J Vet Publ Hlth, 32, pp.61~68 (2008)
- Paton DJ, "Selection of foot-andmouth disease vaccine strains-a review", Rev Sci Tech, 24, pp.981~993 (2005)
- Pattnaik B, "Foot-and-mouth disease: Global status and future road map for control and prevention in India", Agricultural Research, 1, pp.132~147 (2012)
- Paul S, "Control and eradication of foot-and-mouth disease", Virus Res, 91, pp.101~144 (2003)
- Pay TW, "The use of serum neutralizing antibody assay for the determination of the potency of foot-and-mouth disease(FMD) vaccines in cattle", Dev Biol Stand, 64, pp.153~161 (1986)
- Pfaff E, "Antibodies against a preselected peptide recognise and neutralise foot and mouth disease virus", EMBO J, 1, pp.869~874 (1982)
- Rea LM, "Designing & Conducting Survey Research A Comprehensive Guide. 3rd ed" (2005), Jossey-Bass
- Rodriguez LL, "Foot and mouth disease virus vaccines", Vaccine, 27, pp.D90~D94 (2009)
- Rowlands DJ, "Relationship of the antigenic structure of foot-and-mouth disease virus to the process of infection", J Gen Virol, 13, pp.85~93 (1971)
- Sáiz M, "Foot-and-mouth disease virus: biology and prospects for disease control", Microbes Infect, 4, pp.1183~1192 (2002)
- Sobrino F, "Foot and mouth disease: a long known virus, but a current threat", Vet Res, 32, pp.1~30 (2001)
- Sur JH, "In vivo characterization and transmission of Korean foot-and-mouth disease virus(FMDV)", Korean J Res, 40, pp.719~727 (2000)
- Wong HT, "Plasmids encoding foot-and-mouth disease virus VP1 epitopes elicited immune responses in mice and swine and protected swine against viral infection", Virology, 278, pp.27~35 (2000)
- Zhang L, "Research in advance for FMD novel vaccines", Virol J, 8, pp.268~ (2011)