양극성 기분장애에서 세로토닌 수용체 유전자의 다형성(102T/C)에 관하여
Serotonin Receptor(5-HT2A) Gene Polymorphism(102T/C) in Bipolar Mood Disorder
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연구목적 : 본 연구는 5-HT2A 수용체 유전자의 102T/C 다형성이 양극성 기분장애의 원인으로 작용하는지 알아보기 위하여 시행되었다.방법 : 양극성 기분장애 환자 81명과 정상 대조군 120명을 대상으로 중합효소 연쇄반응을 이용하여 5-HT2A 수용체 유전자의 102T/C 다형성의 유전자형과 대립유전자의 빈도를 비교하였다.결과 : 양극성 기분장애 환자군의 5-HT2A 수용체의 유전자 102T/C 다형성의 유전자형은 102T/T 36(44.4%), 102T/C 31(38.3%), 102C/C 14(17.3%)였고, 정상 대조군의 유전자형은 102T/T 53(44.2%), 102T/C 44(36.7%), 102C/C 23(19.1%)로 양군간에 의미있는 차이는 없었다(x2=0.127, df=2, p=0.938). 대립유전자의 빈도는 양극성 기분장애 환자군에서는 102T가 103(63.6%), 102C는 59(36.4%)이었고, 정상 대조군에서 102T가 150(62.5%), 102C는 90(37.5%)로 양군간에 의미있는 차이는 없었다(x2=0.048, df=1, p=0.826).
Abstract
Object : This study was designed to investigate the association between the 102T/C polymorphism of the 5HT2A receptor gene and bipolar mood disorder in a Korean population. Method : 102T/C polymorphism of the 5-HT2A receptor gene was typed with PCR in 81 patients with bipolar mood disorders and 120 healthy controls. Results : Genotypes of 102T/T, 102T/C, 102C/C were 36(44.4%), 31(38.3%), and 14(17.3%) respectively in the patients with bipolar mood disorder. Genotypes of 102T/T, 102T/C, 102C/C were 53(44.2%), 44(36.7%), and 23(19.1%) respectively in the controls, Allele frequency of 102T in the patients with bipolar mood disorder was 103(63.6%) and that in the controls was 150(62.5%). Allele frequency of 102C in the patients with bipolar mood disorder was 59(36.4%) and that in controls was 90(37.5). There were no differences in genotype and allele frequency of 102T/C between patients with bipolar mood disorder and controls. Conclusion : These results suggest 102T/C polymorphism of the 5-HT2A receptor gene are not causally related to the development of bipolar mood disorder in Korea.