우울 장애의 세로토닌 전달체 유전자 다형성
Serotonin Transporter Gene Polymorphisms of Depressive Disorder
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초록
본 연구에서는 주요 우울장애 환자 77명과 기분 부전장애 환자 71명을 대상으로 세로토닌 전달체 유전자의 프로모터 부위의 다형성을 조사하였다. 연구 결과로서 세로토닌 전달 단백질 유전자의 다형성 5-HTTLPR과 기분 장애와의 상관성은 발견되지 않았으며, “s" 대립 유전자가 ”l" 대립 유전자에 비해 높은 빈도를 보였다. 또한, 5-HTTLPR의 l/s 유전자형은 주요 우울장애와 기분 부전장애 사이에 유의한 빈도의 차이를 보이지 않았다. 이 결과는 5-HTTLPR이 두 가지 기분 장애의 발병과 상관이 없음을 암시한다고 하겠으나, 향후 더 많은 환자를 대상으로 한 연구를 필요로 한다.
Abstract
Objects: The promoter gene has been regarded as a candidate for genetic involvement in mood disorders owing to its role in serotonergic neurotransmission and the mechanisms of action of antidepressants. The aim of the present study was to investigate whether the polymorphism of the promoter region of serotonin transporter gene (5-HTTLPR) would be associated with major depressive disorder and dysthymic disorder in the context of a genetic association study. Methods: A 44 base pair deletion/insertion polymorphism in 5-HTTLPR was examined in 77 major depressive patients, 71dysthymic patients and 140 healthy controls. Results: There was no significant difference in allele or genotype frequency between major depressive patients and control subjects. And there was also no difference between dysthymic patients and control subjects. In addition, we did not find significant difference of genotype and allele frequency between major depressive disorder and dysthymic disorders. Conclusion: These results suggest that the 5-HTTLPR polymorphisms seem not to play a role in the genetic susceptibility to major depressive disorder and dysthymic disorder.