살인을 범한 남자 정신분열병 환자와 5-HT2A 수용체 유전자 다형성(T102C)과의 관련 연구
T102C Polymorphism of the 5-HT2A Receptor Gene is not Associated with Homicide in Male Schizophrenics
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목 적：세로토닌체계의 변화가 정신분열병이나 폭력행동과 관련이 있다고 알려져 있다. 저자 등은 5-HT2A 수용체 유전자 다형성(T102C)이 살인을 범한 남성 정신분열병과 관련이 있는지 알아보기 위하여 본 연구를 시행하였다. 방 법：살인을 범한 정신분열병 환자 105명, 비폭력 정신분열병 환자 102명, 정상 대조군 104명을 대상으로 중합효소 연쇄반응을 이용하여 5-HT2A 수용체 유전자 다형성(T102C)의 유전자형과 대립유전자의 빈도를 비교하였다. 모든 대상은 한국인 남자였다. 결 과：살인을 범한 정신분열병군, 비폭력 정신분열병군, 정상대조군을 비교한 결과 세군간에 유전자형(χ2=8.090, df=4, p=0.088)이나 대립유전자(χ2=2.880, df=2, p=0.237)에서 통계적인 차이가 없었다. 또한 살인을 범한 정신분열병군과 비폭력 정신분열병군, 살인을 범한 정신분열병군과 정상 대조군, 그리고 비폭력 정신분열병군과 정상 대조군을 각각 비교하였을 때도 유전자형과 대립유전자에서 통계적인 차이가 없었다. 결 론：이러한 결과는 5-HT2A 수용체 유전자 다형성(T102C)이 남성 정신분열병환자의 살인행동과는 관련이 없음을 제시한다. 향후 살인을 범한 여성정신분열병환자와 살인을 범한 일반 범죄인을 포함한 연구가 필요할 것으로 사료된다.
Abstract
Objective : Alterations in the serotonergic system are related to schizophrenia and violent behavior. This study investigated whether T102C polymorphism of the 5-HT2A receptor gene is related to homicide in male schizophrenics. Methods : T102C polymorphism of the 5-HT2A gene was typed with PCR in 105 homicidal schizophrenics, 102 nonviolent schizophrenics, and 104 normal controls. All of the subjects were Korean males. Results : There were no differences in the genotypic distributions(χ2=8.090, df=4, p=0.088) or allele frequencies(χ2=2.880, df=2, p=0.237) of the T102C polymorphism of the 5-HT2A receptor in the three groups. In pairwise comparisons, no differences in the genotype distributions or allele frequencies were observed when homicidal schizophrenics and non-violent schizophrenics were compared, in the genotype distributions or allele frequencies of homicidal schizophrenics and normal controls, or in the genotype distributions and allele frequencies of nonviolent schizophrenics and normal controls. Conclusion : These results suggest that T102C polymorphism of the 5-HT2A receptor gene is not causally related to homicide in male schizophrenics. Further studies are required and should include homicidal female schizophrenics and non-psychotic subjects who have committed homicide.
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