The Roles of Modern Breast Imaging Techniques for Evaluation of Lobular Carcinoma In Situ of the Breast
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Purpose: We aimed to evaluate the incidence of multifocal and bilateral lobular carcinoma in situ (LCIS) of the breast in Korean women. Add-itionally, we explored the characteristics of current breast imaging studies and evaluated their roles in detecting multifocal and bilateral lesions in LCIS patients. Methods: Between January 2000 and December 2013, we identified 48 patients with pure LCIS who underwent curative surgery at our institution. The pathological findings and the results of various imaging studies were reviewed. Results: All patients underwent mammography and ultrasonography prior to surgery, and 35 patients (72.9%) also received breast magnetic resonance imaging (MRI). The most common radiologic features of LCIS were the presence of microcalcifications (66.7%) and irregularly shaped masses (64.6%) on mammography and ultrasonography, respectively. MRI often showed the presence of irregularly enhanced mass-like lesions (91.4%). Add-itional suspicious lesions in the ipsilateral breast were identified in 19 (39.6%) and 16 (45.7%) patients on ultrasonography and MRI, respectively. Among them, nine (47.4%) were malignant lesions. In the contralateral breast, there were 14 (29.2%) and 11 (31.4%) lesions requiring biopsy on ultrasonography and MRI, respectively, and eight of these were found to be malignant lesions. All suspicious lesions detected by MRI were also seen on ultrasonography. In total, 20.8% (10/48) of the patients had ipsilateral LCIS, and 16.7% (8/48) had contralateral malignancies. Conclusion: Our study demonstrates that in Korean women, LCIS is associated with a high incidence of ipsilateral and contralateral malignancies. However, breast MRI had a limited role in detecting additional malignant tumors in LCIS patients.
Abstract
Purpose: We aimed to evaluate the incidence of multifocal and bilateral lobular carcinoma in situ (LCIS) of the breast in Korean women. Add-itionally, we explored the characteristics of current breast imaging studies and evaluated their roles in detecting multifocal and bilateral lesions in LCIS patients. Methods: Between January 2000 and December 2013, we identified 48 patients with pure LCIS who underwent curative surgery at our institution. The pathological findings and the results of various imaging studies were reviewed. Results: All patients underwent mammography and ultrasonography prior to surgery, and 35 patients (72.9%) also received breast magnetic resonance imaging (MRI). The most common radiologic features of LCIS were the presence of microcalcifications (66.7%) and irregularly shaped masses (64.6%) on mammography and ultrasonography, respectively. MRI often showed the presence of irregularly enhanced mass-like lesions (91.4%). Add-itional suspicious lesions in the ipsilateral breast were identified in 19 (39.6%) and 16 (45.7%) patients on ultrasonography and MRI, respectively. Among them, nine (47.4%) were malignant lesions. In the contralateral breast, there were 14 (29.2%) and 11 (31.4%) lesions requiring biopsy on ultrasonography and MRI, respectively, and eight of these were found to be malignant lesions. All suspicious lesions detected by MRI were also seen on ultrasonography. In total, 20.8% (10/48) of the patients had ipsilateral LCIS, and 16.7% (8/48) had contralateral malignancies. Conclusion: Our study demonstrates that in Korean women, LCIS is associated with a high incidence of ipsilateral and contralateral malignancies. However, breast MRI had a limited role in detecting additional malignant tumors in LCIS patients.
참고문헌 (19)
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