Clinicopathological Features and Prognosis of Lobular Carcinoma In Situ
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Purpose: According to the American Joint Committee on Cancer’s 8th Edition Manual, lobular carcinoma in situ (LCIS) is no longer considered a malignant disease, although it may be a precursor to the development of breast cancer. The present study aimed to evaluate the clinicopathological features and prognosis of LCIS. Methods: This study retrospectively analyzed clinicopathological features and prognosis data of LCIS among patients who underwent breast surgery at Severance Hospital, Seoul, South Korea from 1991 to 2016. Results: Of the 47 patients, 49 cases of LCIS were confirmed by postoperative pathology. The mean patient age was 48.15±8.34 years. Most patients (81.6%) did not have palpable tumors at diagnosis, and 51.0% showed no microcalcification on mammography. Breast-conserving surgery was performed more frequently than total mastectomy (77.6% vs. 22.4%). The mean tumor size was 1.63±2.11 cm. There were only 3 cases of pleomorphic LCIS. Hormone receptor-positive tumors were noted in 47 cases, however, the hormone receptor status was unknown in the other 2 cases. There were no LCIS recurrences or deaths during the follow-up period (mean 56 months). Conclusion: LCIS is often incidentally diagnosed without clinical symptoms, especially in women aged <50 years. The prognosis of LCIS is excellent in cases that are surgically treated.
Abstract
Purpose: According to the American Joint Committee on Cancer’s 8th Edition Manual, lobular carcinoma in situ (LCIS) is no longer considered a malignant disease, although it may be a precursor to the development of breast cancer. The present study aimed to evaluate the clinicopathological features and prognosis of LCIS. Methods: This study retrospectively analyzed clinicopathological features and prognosis data of LCIS among patients who underwent breast surgery at Severance Hospital, Seoul, South Korea from 1991 to 2016. Results: Of the 47 patients, 49 cases of LCIS were confirmed by postoperative pathology. The mean patient age was 48.15±8.34 years. Most patients (81.6%) did not have palpable tumors at diagnosis, and 51.0% showed no microcalcification on mammography. Breast-conserving surgery was performed more frequently than total mastectomy (77.6% vs. 22.4%). The mean tumor size was 1.63±2.11 cm. There were only 3 cases of pleomorphic LCIS. Hormone receptor-positive tumors were noted in 47 cases, however, the hormone receptor status was unknown in the other 2 cases. There were no LCIS recurrences or deaths during the follow-up period (mean 56 months). Conclusion: LCIS is often incidentally diagnosed without clinical symptoms, especially in women aged <50 years. The prognosis of LCIS is excellent in cases that are surgically treated.
참고문헌 (21)
- Wen HY, "Lobular carcinoma in situ", Surg Pathol Clin, 11, pp.123~145 (2018)
- Ginter PS, "Current concepts in diagnosis, molecu-lar features, and management of lobular carcinoma in situ of the breast with a discussion of morphologic variants", Arch Pathol Lab Med, 141, pp.1668~1678 (2017)
- Muller KE, "Isolated atypical lobular hyperplasia diagnosed on breast biopsy : low upgrade rate on subse-quent excision with long-term follow-up", Arch Pathol Lab Med, 142, pp.391~395 (2018)
- Afonso N, "Lobular carcinoma in situ", Eur J Cancer Prev, 17, pp.312~316 (2008)
- Logan GJ, "Molecular drivers of lobular carcinoma in situ", Breast Can-cer Res, 17, pp.76~ (2015)
- O’Malley FP, "Lobular neoplasia : morphology, biological potential and management in core biopsies", Mod Pathol, 23, pp.S14~25 (2010)
- Racz JM, "Lobular neoplasia and atypical ductal hyperplasia on core biopsy : current surgical management recommendations", Ann Surg Oncol, 24, pp.2848~2854 (2017)
- Giuliano AE, "Breast cancer-major changes in the American Joint Com-mittee on Cancer eighth edition cancer staging manual", CA Cancer J Clin, 67, pp.291~303 (2017)
- "National comprehensive cancer network guidelines. Breast cancer version 1" (2018)[URL]
- Park S, "Lack of either estrogen or progesterone receptor expression is associated with poor survival outcome among luminal A breast cancer sub-type", Ann Surg Oncol, 20, pp.1505~1513 (2013)
- McDivitt RW, "In situ lobular carcinoma. A prospective follow-up study indicating cumulative patient risks", JAMA, 201, pp.82~86 (1967)
- Chuba PJ, "Bilateral risk for subsequent breast cancer after lobular carcino-ma-in-situ : analysis of surveillance, epidemiology, and end results data", J Clin Oncol, 23, pp.5534~5541 (2005)
- Coopey SB, "The role of chemoprevention in modifying the risk of breast can-cer in women with atypical breast lesions", Breast Cancer Res Treat, 136, pp.627~633 (2012)
- Cuzick J, "Selective oestrogen receptor modulators in prevention of breast cancer : an updated meta-analysis of individual participant data", Lancet, 381, pp.1827~1834 (2013)
- Beute BJ, "Lobular carcinoma in situ of the breast : clinical, pathologic, and mammographic features", AJR Am J Roentgenol, 157, pp.257~265 (1991)
- 강상율, "Basic Findings Regarding Breast Cancer in Korea in 2015: Data from a Breast Cancer Registry", Journal of Breast Cancer, 21(1), pp.1~10 (2018), 한국유방암학회[DOI]
- King TA, "Lobular carcinoma in situ : a 29-year longitudinal experience evalu-ating clinicopathologic features and breast cancer risk", J Clin Oncol, 33, pp.3945~3952 (2015)
- Hanjong Shin, "The Roles of Modern Breast Imaging Techniques for Evaluation of Lobular Carcinoma In Situ of the Breast", Journal of Breast Disease, 3(2), pp.71~76 (2015), 한국유방암학회[DOI]
- Cheng P, "Treatment and survival outcomes of lobular carcinoma in situ of the breast : a SEER population based study", Oncotarget, 8, pp.103047~103054 (2017)
- Schmidt H, "Observation versus excision of lobular neoplasia on core nee-dle biopsy of the breast", Breast Cancer Res Treat, 168, pp.649~654 (2018)
- Niell B, "Is excisional biopsy re-quired after a breast core biopsy yields lobular neoplasia?", AJR Am J Roentgenol, 199, pp.929~935 (2012)