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지연성 운동장애와 BDNF(Brain-derived Neurotrophic Factor) Val66Met 유전자 다형성과의 연관성 연구

Association Study of the Brain-derivedNeurotrophic Factor(BDNF) Val66Met Polymorphism with Tardive Dyskinesia

박성우|김영훈|김선희|이선정|공보금|주명진
대한생물치료정신의학회 (Korean Society Of Biological Therapies In Psychiatry)|2006.06|생물치료정신의학 (Journal of the Korean Society of Biological Therapies in Psychiatry)|제12권 제1호|pp. 50-56

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참고문헌

키워드

Polymorphism지연성 운동장애brain-derived neurotrophic factor (BDNF)유전자 다형성Tardive dyskinesiaBrain-derived neurotrophic factor (BDNF)
주제분류정신과학

초록

목적 : 신경계의 발달, 분화, 성장에 중요한 역할을 담당하는 brain-derived neurotrophic factor (BDNF)는 지연성 운동장애와 연관된 중추신경계의 여러 질환들의 발생에 관여한다. 본 연구는 항정신병 약물로 인해 초래되는 심각한 부작용인 지연성 운동장애 (tardive dyskinesia : TD)의 발생에 BDNF Val66Met 유전자 다형성이 연관성이 있는지 없는지의 여부를 알아보기 위하여 시행하였다. 방법 : 161명의 정신분열병 환자군 (TD 83명, non-TD 78명)과 95명의 정상대조군을 대상으로 하였고 지연성 운동장애 (TD) 평가는 AIMS(Abnormal Involuntary Movement Scale)를 사용하였다. BDNF Val66Met 유전자 다형성은 정신분열병 환자군 (TD군, non-TD군)과 정상대조군을 비교하였고, 정신분열병 환자에서 지연성운동장애가 있는 군과 없는 군을 비교분석하였다. 결과 : 정신분열병 환자군과 정상대조군, 정신분열병환자에서 TD군과 non-TD군을 비교한 결과, 세가지 유전형 (Val/Val, Val/Met, Met/Met)과 Val, Met 두 대립유전자빈도, 두 경우 모두 통계적으로 의미 있는 결과는 나오지 않았다. 결론 : 이번 한국인 정신분열병 환자를 대상으로 시행한 저자들의 연구에서 지연성 운동장애와 BDNF Val66Met 유전자 다형성 사이에는 연관성이 보이지 않았다.

Abstract

Objectives : Brain-derived neurotrophic factor (BDNF) belongs to a family of neurotrophic factors and has been demonstrated to promote the survival, differentiation, and maintenance of a broad variety of central nervous system neurons. Several reports have suggested that the BDNF gene is associated with variable psychatric disorders and neurologic disesases. We investigated the association of BDNF Val66Met polymorphism with schizophrenia and tardive dyskinesia (TD) to evaluate candidate BDNF gene for association with drug-induced TD. Methods : 161 schizophrenic patients (TD=83, non-TD=78) and 95 normal controls were included in the study. Tardive dyskinesia was assessed by the Abnormal Involuntary Movement Scale (AMIS). We examined the BDNF Val66Met genotype distribution and allele frequency. Statistical analysis was used to test the association between this polymorphism and TD development in the schizophrenic patients. Results : There were no significant differences in the genotype distribution and allele frequency of the BDNF Val66Met polymorphism between schizophrenic patients with and without tardive dyskinesia, normal controls. Conclusion : Our findings suggest that it is unlikely that the BDNF Val66Met polymorphism play a major role in the pathogenesis of TD in the Korean sample.

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