No Association between Dopamine D3 Receptor Gene Ser9Gly Polymorphism and Tardive Dyskinesia in Schizophrenia
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Objective：Tardive dyskinesia (TD) is a long-term adverse effect of antipsychotic drug use. Ser9Gly polymorphism of the dopamine 3 receptor (DRD3) has been shown to affect dopamine binding affinity, and may contribute to the susceptibility of antipsychotic-induced TD. This study investigated the possible association between DRD3 gene variant and TD. Methods：We evaluated whether a DRD3 Ser9Gly polymorphism is associated with antipsychotic-induced TD in 209 Korean schizophrenia patients with (n=83) and without TD (n=126) who were matched for antipsychotic drug exposure and other relevant variables. Results：There was no significant association between genotype and allele frequencies determined by the Ser9Gly polymorphism of DRD3 between TD and non-TD patients. In addition, there was no significant difference in terms of total Abnormal Involuntary Movement Scale scores among the three genotype groups. Conclusion：Within the limitations imposed by the size of the clinical sample, these findings suggest that the Ser9Gly polymorphism of DRD3 does not contribute significantly to the risk of TD.
Abstract
Objective：Tardive dyskinesia (TD) is a long-term adverse effect of antipsychotic drug use. Ser9Gly polymorphism of the dopamine 3 receptor (DRD3) has been shown to affect dopamine binding affinity, and may contribute to the susceptibility of antipsychotic-induced TD. This study investigated the possible association between DRD3 gene variant and TD. Methods：We evaluated whether a DRD3 Ser9Gly polymorphism is associated with antipsychotic-induced TD in 209 Korean schizophrenia patients with (n=83) and without TD (n=126) who were matched for antipsychotic drug exposure and other relevant variables. Results：There was no significant association between genotype and allele frequencies determined by the Ser9Gly polymorphism of DRD3 between TD and non-TD patients. In addition, there was no significant difference in terms of total Abnormal Involuntary Movement Scale scores among the three genotype groups. Conclusion：Within the limitations imposed by the size of the clinical sample, these findings suggest that the Ser9Gly polymorphism of DRD3 does not contribute significantly to the risk of TD.
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