정신분열병환자에서 만발성 운동장애와 5-HT6 수용체 유전자 다형성(267C/T)과의 관계
Association between Tardive Dyskinesia and 267C/T Polymorphism of 5-HT6 Receptor Gene in Schizophrenia
2
조회
0
다운로드
0
인용
0
참고문헌
키워드
초록
Abstract
Tardive dyskinesia(TD) is a serious side effect associated with long-term antipsychotic treatments. Some candidate genetic polymorphisms were reported to be associated with TD and possible involvement of serotonergic receptors in the pathophysiology of TD has been suggested. In the present study, we investigated the association between 5-HT6 receptor gene polymorphism and TD with schizophrenia. Methods：To investigate the relationship between 5-HT6 receptor gene polymorphism and TD, 60 patients with TD were compared with 60 patients without TD. The 267C/T allele of 5-HT6 receptor gene was genotyped by means of polymerase chain reaction method. TD was evaluated using the Abnormal Involuntary Movement Scale(AIMS). Results：The patients with the three 267C/T genotype showed no significant differences in age, gender, and duration of illness. No significant difference in genotype frequencies was observed between schizophrenic patients with and without TD. In addition, there was no difference in allele frequencies. Further analysis with an measure of AIMS scores showed that these scores were not significantly influenced by the 5-HT6 receptor gene polymorphism. Conclusion：These results suggest that 267C/T polymorphism of 5-HT6 receptor gene is not significantly associated with susceptibility to TD in schizophrenia.
참고문헌 (33)
- Kulkarni SK,, "Tardive dyskinesia: An update", 37, pp.97~119 (2001)
- Yassa R,, "Gender differences in tardive dyskinesia a critical review of the literature", pp.701~715
- Shenker D, "Theoretical implicationsof the use of L-dopa in parkinsonism", pp.409~441
- "Duplication of biochemicalchanges of Huntington’s chorea by intrastriatal injectionsof glutamic and kainic acids", pp.517~519
- Schwartz BL,, "Effects of nifedipinea calcium channelantagonist, on cognitive function in schizophrenic patientswith tardive dyskinesia.", 20, pp.364~370 (1997)
- Hori H,, "Manganese superoxide dismutase genepolymorphism and schizophrenia: relation to tardive dyskinesia", 23, pp.170~177 (2000)
- Arch Gen Psychiatry 1972;27, "Implications of amphetamine-induced stereotyped behavior as a model for tardivedyskinesias", pp.502~507
- Meltzer HY, "An overview of the mechanism of actionof clozapine", pp.47~52
- Meltzer HY, "The role of serotonin in antipsychotic drugaction", 21, pp.106~115 (1999)
- Meltzer HY, "Treatment of the neuroleptic-nonresponsiveschizophrenic patient", pp.515~542
- Kane J, "A double-blindcomparison with chlorpromazine", pp.789~796
- Kusumi I,, "Differential effects of subchronic treatments with atypicalantipsychotic drugs on dopamine D2 and serotonin5-HT2A receptors in the rat brain", 107, pp.295~302 (2000)
- Casey DE, "Levodopa and receptorsensitivity modification in tardive dyskinesia", pp.89~92 (1982)
- Glazer WM, "Expected incidence of tardive dyskinesiaassociated with atypical antipsychotics", 61(4), pp.21~26 (2000)
- Kapur S,, "5-HT2 and D2 receptor occupancyof olanzapine in schizophrenia: a PET investigation", 155, pp.921~928 (1998)
- Kapur S,, "The D2 dopamine receptor occupancy of risperidoneand its relationship to extrapyramidal symptoms: aPET study", 57, pp.103~107 (1995)
- Branchek TA,, "5-HT6 receptors as emergingtargets for drug discovery", 40, pp.319~334 (2000)
- Jeste DV,, "Understanding and treating tardivedyskinesia", Cuilford Press;1982
- Guy W, "ECDEU Assessment Manual for Psychopharmacology Department of Health", pp.534~537 (1976)
- Shinkai T,, "Association study of the 5-HT6 receptor gene inschizophrenia", 88, pp.120~122 (1999)
- Segman R,, "Genotypic associationbetween the dopamine D3 receptor and tardive dyskinesiain chronic schizophrenia.", 4, pp.247~253 (1999)
- Armstrong M,, "Antipsychotic drug-induced movement disordersin schizophrenics in relation to CYP2D6 genotype", 170, pp.23~26 (1997)
- Basile VS,, "A functional polymorphism ofthe cytochrome P450 1A2(CYP1A2) gene: associationwith tardive dyskinesia in schizophrenia", 5, pp.410~417 (2000)
- Segman RH,, "Association between theserotonin 2A receptor gene and tardive dyskinesia inchronic schizophrenia", 6, pp.225~229 (2001)
- Segman RH,, "Association between theserotonin 2C receptor gene and tardive dyskinesia inchronic schizophrenia:additive contribution of 5-HT2Cserand DRD3gly alleles to susceptibility", 152, pp.408~413 (2000)
- Tan EC,, "Susceptibility to neuroleptic-induced tardive dyskinesiaand the T102C polymorphism in the serotonin type 2Areceptor", 50, pp.144~147
- 한상우, "지연성 운동장애와 5-HT2A 수용체 유전자T103C his452tyr 다형성과의 관계" (2001), 순천향대학원
- Basile VS,, "Lack of association betweenserotonin-2A receptor gene(HTR2A) polymorphismsand tardive dyskinesia in schizophrenia", 6, pp.230~234 (2001)
- Chong SA,, "Tardive dyskinesia is not associated with theserotonin gene polymorphism(5-HTTLPR)in Chines", 96, pp.712~715 (2000)
- Ohmori O,, "Geneticassociation analysis of 5-HT(6)receptor gene polymorphism(267C", T) with tardive dyskinesia., 2002, pp.110, 97~102
- receptor gene in bipolar affectivedisorder and schizophrenia, , 2000, 217~221
- Masellis M,, "Lack of association between theT→C 267 serotonin 5-HT6 receptor gene(HTR6) polymorphismand prediction of response to clozapine inschizophrenia", 47, pp.49~58 (2001)
- Tsai SJ,, "Associationstudy of serotonin-6 receptor variant(C267T) with schizophreniaand aggressive behavior", 271, pp.135~137 (1999)