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한국인 및 중국 한족 정신분열병 환자의 5-HT2A 수용체 유전자 -1438A/G 다형성

-1438A/G Polymorphism of the 5-HT2A Receptor Gene in Korean and Han Chinese Patients with Schizophrenia

최영근|이광철|조아랑|정주호|장환일|이장호|이승부|오용인
대한신경정신의학회 (Korean Neuropsychiatric Association)|2005.01|신경정신의학 (JOURNAL OF THE KOREAN NEUROPSYCHIATRIC ASSOCIATION)|제44권 제1호|pp. 25-31

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참고문헌

주제분류정신과학

초록

Abstract

Objectives：The purpose of the present study was to investigate the association between -1438A/G polymorphism of 5- HT2A receptor gene and schizophrenia in Korean and Han Chinese population. Methods：A sample of 184 Korean patients with schizophrenia and 96 Korean healthy normal controls and 96 Han Chinese patients with schizophrenia and 96 Han-Chinese healthy normal controls were genotyped for a single nucleotide polymorphism with in 5-HT2A receptor gene (promoter region, A-1438G) by Msp I Restriction Fragment Length Polymorphism (RFLP). Results：There was no difference in allelic frequencies and genotype frequencies of -1438A/G polymorphism between Korean schizophrenics and controls (p=0.13) and Han Chinese schizophrenics and controls (p=0.40). Also, -1438A/G polymorphism did not show ethnical difference between Korean and Han Chinese controls. The Scale for the Assessment of Negative Symptoms (SANS) scores showed no significant differences between genotypes of -1438A/G polymorphism in both of Korean and Han Chinese schizophrenics. Conclusion：These results suggest that -1438A/G polymorphism of the 5-HT2A receptor gene is not causally related to the development of schizophrenia in Korean and Han Chinese population, and there no ethnic difference between Korean and Han Chinese population.

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관련 논문AI추천

한국인 정신분열병과 5-HT2A Receptor Gene Promoter 다형성(-1438A/G)과의 관련 연구Gene Promoter조현, 손정우, 이영호, 지익성대한신경정신의학회 · 신경정신의학2001 · 제40권 제2호한국인 양극성 장애와 5-HT2A Receptor Gene Promoter-1438A/G Polymorphism과의 연관성 연구오승용, 이영호, 지익성대한신경정신의학회 · 신경정신의학2001 · 제40권 제1호한국인 정신분열병 환자 및 정상인에서 기능적 세로토닌 운반체 유전자 다형성 분석이철, 권오주, 김석범, 김정진, 백인호, 이수정, 이창욱대한신경정신의학회 · 신경정신의학2002 · 제41권 제2호정신분열병 환자의 비정형 항정신병약물 반응과 세로토닌 2A 및 도파민 D3 수용체 유전자 다형성의 관련연구김병수, 김창윤, 박지홍, 송규영, 주연호, 한오수대한신경정신의학회 · 신경정신의학2002 · 제41권 제3호정신분열병환자에서 Taq I A 도파민 D2 수용체 다형성과 항정신병약물의 치료반응과의 연관강철중대한생물정신의학회 · 생물정신의학2005 · 제12권 제2호한국인 정신분열병 환자에서 CYP2D6*10B 유전자에 관한 연구고재광, 김철응, 노형근, 문혜원, 박창신대한신경정신의학회 · 신경정신의학2001 · 제40권 제6호

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