Expression of Vimentin Intermediate Filament for Vascular Development in Olive Flounder (Paralichthys olivaceus)
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Cardiovascular system is the primary organ to develop and reach a functional state, which underscores theessential role of the vasculature in the developing embryo. The vasculature is a highly specialized organ that functions in anumber of key physiological works including the carrying of oxygen and nutrients to tissues. It is closely involved in theformation of heart, and hence it is essential for survival during the hatching period. The expression of genes involved duringvascular development in the olive flounder (Paralichthys olivaceus) in the days after hatching is not fully understood. Therefore, we examined the expression patterns of genes activated during the development of flounder. Microscopicobservations showed that formation of blood vessels is related to the expression of the vimentin gene. Also, the temporalexpression patterns of this vimentin-like gene in the developmental stages and in the normal tissues of olive flounder. Thepurpose of this study was to examine the expression patterns of vimentin in normal tissues of the olive flounder and during thedevelopment of the vascular system in newly hatched olive flounders and HIF-1 plays a vital role in the formation of bloodvessels during development. Vimentin expression was strong at the beginning of the development of blood vessels, and waspresent throughout all developmental stages. Our findings have important implications with respect to the roles of vimentinand HIF-1 in the development and evolution of the first blood vessels in olive flounder. Further studies are required toelucidate the vimentin-mediated hypoxic response signal transduction and to decipher the functional role of vimentin indevelopmental stages.
Abstract
Cardiovascular system is the primary organ to develop and reach a functional state, which underscores theessential role of the vasculature in the developing embryo. The vasculature is a highly specialized organ that functions in anumber of key physiological works including the carrying of oxygen and nutrients to tissues. It is closely involved in theformation of heart, and hence it is essential for survival during the hatching period. The expression of genes involved duringvascular development in the olive flounder (Paralichthys olivaceus) in the days after hatching is not fully understood. Therefore, we examined the expression patterns of genes activated during the development of flounder. Microscopicobservations showed that formation of blood vessels is related to the expression of the vimentin gene. Also, the temporalexpression patterns of this vimentin-like gene in the developmental stages and in the normal tissues of olive flounder. Thepurpose of this study was to examine the expression patterns of vimentin in normal tissues of the olive flounder and during thedevelopment of the vascular system in newly hatched olive flounders and HIF-1 plays a vital role in the formation of bloodvessels during development. Vimentin expression was strong at the beginning of the development of blood vessels, and waspresent throughout all developmental stages. Our findings have important implications with respect to the roles of vimentinand HIF-1 in the development and evolution of the first blood vessels in olive flounder. Further studies are required toelucidate the vimentin-mediated hypoxic response signal transduction and to decipher the functional role of vimentin indevelopmental stages.
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