Bilateral Serous Retinal Detachment as a Presenting Sign of Acute Lymphoblastic Leukemia
1
조회
0
다운로드
0
인용
0
참고문헌
키워드
초록
We present a case of bilateral serous retinal detachment (SRD) as a presenting sign of Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph+ ALL). A 45-year-old woman presented with decreased vision and was found to have bilateral serous retinal detachment. Peripheral blood smears revealed leukocytosis of 53.9x103/µL with 64.6% lymphoblasts. A bone marrow aspirate revealed the presence of lymphoblasts. Cytogenetic and molecular genetic analysis detected a reciprocal translocation between chromosome 9 and 22, t(9;22) (q34;q11). A diagnosis of Ph+ ALL was made. Following systemic chemotherapy, the bilateral SRD resolved completely with full recovery of vision. The sudden appearance of SRD should raise suspicion for leukemia. Prompt recognition of this disease is important for early systemic treatment and restoration of visual function.
Abstract
We present a case of bilateral serous retinal detachment (SRD) as a presenting sign of Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph+ ALL). A 45-year-old woman presented with decreased vision and was found to have bilateral serous retinal detachment. Peripheral blood smears revealed leukocytosis of 53.9x103/µL with 64.6% lymphoblasts. A bone marrow aspirate revealed the presence of lymphoblasts. Cytogenetic and molecular genetic analysis detected a reciprocal translocation between chromosome 9 and 22, t(9;22) (q34;q11). A diagnosis of Ph+ ALL was made. Following systemic chemotherapy, the bilateral SRD resolved completely with full recovery of vision. The sudden appearance of SRD should raise suspicion for leukemia. Prompt recognition of this disease is important for early systemic treatment and restoration of visual function.
참고문헌 (13)
- Kincaid MC, "Ocular and orbital involvement in leukemia", Surv Ophthalmol, 27, pp.211~232 (1983)
- Tang RA, "Acute leukemia presenting as a retinal pigment epithelium detachment", Arch Ophthalmol, 106, pp.21~22 (1988)
- Stewart MW, "Acute leukemia presenting as a unilateral exudative retinal detachment", Retina, 9, pp.110~114 (1989)
- Burns CA, "Acute lymphocytic leukemia and central serous retinopathy", Trans Am Acad Ophthalmol Otolaryngol, 69, pp.307~309 (1965)
- Murphy JA, "Retinal detachments due to chronic lymphocytic leukaemia", Clin Lab Haematol, 13, pp.217~220 (1991)
- Reddy SC, "A prospective study of ocular manifestations in childhood acute leukaemia", Acta Ophthalmol Scand, 76, pp.700~703 (1998)
- Rosenthal AR, "Ocular manifestations of leukemia: a review", Ophthalmology, 90, pp.899~905 (1983)
- Wu L, "Bilateral exudative retinal detachment as the first sign of relapsing acute myelogenous leukaemia", Clin Experiment Ophthalmol, 34, pp.623~625 (2006)
- Park YK, "A case of optic nerve infiltration of acute lymphocytic leukemia", J Korean Ophthalmol Soc, 41, pp.2008~2012 (2000)
- Miyamoto K, "Serous retinal detachment caused by leukemic choroidal infiltration during complete remission", Br J Ophthalmol, 84, pp.1318~1319 (2000)
- Malik R, "Bilateral serous macular detachment as a presenting feature of acute lymphoblastic leukemia", Eur J Ophthalmol, 15, pp.284~286 (2005)
- Hine JE, "Myelogenous leukemia and bilateral exudative retinal detachment", Ann Ophthalmol, 11, pp.1867~1872 (1979)
- Faderl S, "The biology and therapy of adult acute lymphoblastic leukemia", Cancer, 98, pp.1337~1354 (2003)