Glaucoma Progression Detection by Retinal Nerve Fiber Layer Measurement Using Scanning Laser Polarimetry: Event and Trend Analysis
2
조회
0
다운로드
1
인용
0
참고문헌
키워드
초록
Purpose: To evaluate the use of scanning laser polarimetry (SLP, GDx VCC) to measure the retinal nerve fiber layer (RNFL) thickness in order to evaluate the progression of glaucoma. Methods: Test-retest measurement variability was determined in 47 glaucomatous eyes. One eye each from 152 glaucomatous patients with at least 4 years of follow-up was enrolled. Visual field (VF) loss progression was determined by both event analysis (EA, Humphrey guided progression analysis) and trend analysis (TA,linear regression analysis of the visual field index). SLP progression was defined as a reduction of RNFL exceeding the predetermined repeatability coefficient in three consecutive exams, as compared to the baseline measure (EA). The slope of RNFL thickness change over time was determined by linear regression analysis (TA). Results: Twenty-two eyes (14.5%) progressed according to the VF EA, 16 (10.5%) by VF TA, 37 (24.3%) by SLP EA and 19 (12.5%) by SLP TA. Agreement between VF and SLP progression was poor in both EA and TA (VF EA vs. SLP EA, k = 0.110; VF TA vs. SLP TA, k = 0.129). The mean (±standard deviation) progression rate of RNFL thickness as measured by SLP TA did not significantly differ between VF EA progressors and nonprogressors (-0.224 ± 0.148 μm/yr vs. -0.218 ± 0.151 μm/yr, p = 0.874). SLP TA and EA showed similar levels of sensitivity when VF progression was considered as the reference standard. Conclusions: RNFL thickness as measurement by SLP was shown to be capable of detecting glaucoma progression. Both EA and TA of SLP showed poor agreement with VF outcomes in detecting glaucoma progression.
Abstract
Purpose: To evaluate the use of scanning laser polarimetry (SLP, GDx VCC) to measure the retinal nerve fiber layer (RNFL) thickness in order to evaluate the progression of glaucoma. Methods: Test-retest measurement variability was determined in 47 glaucomatous eyes. One eye each from 152 glaucomatous patients with at least 4 years of follow-up was enrolled. Visual field (VF) loss progression was determined by both event analysis (EA, Humphrey guided progression analysis) and trend analysis (TA,linear regression analysis of the visual field index). SLP progression was defined as a reduction of RNFL exceeding the predetermined repeatability coefficient in three consecutive exams, as compared to the baseline measure (EA). The slope of RNFL thickness change over time was determined by linear regression analysis (TA). Results: Twenty-two eyes (14.5%) progressed according to the VF EA, 16 (10.5%) by VF TA, 37 (24.3%) by SLP EA and 19 (12.5%) by SLP TA. Agreement between VF and SLP progression was poor in both EA and TA (VF EA vs. SLP EA, k = 0.110; VF TA vs. SLP TA, k = 0.129). The mean (±standard deviation) progression rate of RNFL thickness as measured by SLP TA did not significantly differ between VF EA progressors and nonprogressors (-0.224 ± 0.148 μm/yr vs. -0.218 ± 0.151 μm/yr, p = 0.874). SLP TA and EA showed similar levels of sensitivity when VF progression was considered as the reference standard. Conclusions: RNFL thickness as measurement by SLP was shown to be capable of detecting glaucoma progression. Both EA and TA of SLP showed poor agreement with VF outcomes in detecting glaucoma progression.
참고문헌 (23)
- Quigley HA, "An evaluation ofoptic disc and nerve fiber layer examinations in monitoringprogression of early glaucoma damage", Ophthalmology, 99, pp.19~28 (1992)
- Sommer A, "Clinically detectablenerve fiber atrophy precedes the onset of glaucomatousfield loss", Arch Ophthalmol, 109, pp.77~83 (1991)
- Zeyen TG, "Progression of disc and field damagein early glaucoma", Arch Ophthalmol, 111, pp.62~65 (1993)
- Chauhan BC, "Optic disc and visual field changes in a prospective longitudinalstudy of patients with glaucoma: comparison of scanninglaser tomography with conventional perimetry andoptic disc photography", Arch Ophthalmol, 119, pp.1492~1499 (2001)
- Fayers T, "Monitoringglaucomatous progression using a novel Heidelberg retinatomograph event analysis", Ophthalmology, 114, pp.1973~1980 (2007)
- Medeiros FA, "Detectionof glaucoma progression with stratus OCT retinal nervefiber layer, optic nerve head, and macular thickness measurements", Invest Ophthalmol Vis Sci, 50, pp.5741~5748 (2009)
- Leung CK, "Evaluation ofretinal nerve fiber layer progression in glaucoma: a studyon optical coherence tomography guided progression analysis", Invest Ophthalmol Vis Sci, 51, pp.217~222 (2010)
- Lee EJ, "Ability of Stratus OCT todetect progressive retinal nerve fiber layer atrophy in glaucoma", Invest Ophthalmol Vis Sci, 50, pp.662~668 (2009)
- Sehi M, "Assessment of retinal nerve fiberlayer using optical coherence tomography and scanninglaser polarimetry in progressive glaucomatous optic neuropathy", Am J Ophthalmol, 142, pp.1056~1059 (2006)
- Wollstein G, "Optical coherencetomography longitudinal evaluation of retinal nervefiber layer thickness in glaucoma", Arch Ophthalmol, 123, pp.464~470 (2005)
- Medeiros FA, "The Relationshipbetween intraocular pressure and progressiveretinal nerve fiber layer loss in glaucoma", Ophthalmology, 116, pp.1125~1133 (2009)
- Medeiros FA, "Detectionof progressive retinal nerve fiber layer loss in glaucoma usingscanning laser polarimetry with variable corneal compensation", Invest Ophthalmol Vis Sci, 50, pp.1675~1681 (2009)
- Alencar LM, "Agreementfor detecting glaucoma progression with the GDx guidedprogression analysis, automated perimetry, and optic discphotography", Ophthalmology, 117, pp.462~470 (2010)
- Grewal DS, "Detecting glaucomatousprogression using GDx with variable and enhancedcorneal compensation using guided progression analysis", Br J Ophthalmol, 95, pp.502~508 (2011)
- Lleo-Perez A, "Intraobserverreproducibility of retinal nerve fiber layer measurementsusing scanning laser polarimetry and opticalcoherence tomography in normal and ocular hypertensivesubjects", Eur J Ophthalmol, 14, pp.523~530 (2004)
- Iacono P, "Intersession reproducibilityof retinal nerve fiber layer thickness measurementsby GDx-VCC in healthy and glaucomatous eyes", Ophthalmologica, 220, pp.266~271 (2006)
- Medeiros FA, "Long-termvariability of GDx VCC retinal nerve fiber layer thicknessmeasurements", J Glaucoma, 16, pp.277~281 (2007)
- Leung CK, "Longitudinal variabilityof optic disc and retinal nerve fiber layer measurements", Invest Ophthalmol Vis Sci, 49, pp.4886~4892 (2008)
- Mai TA, "Longitudinal measurement variabilityof corneal birefringence and retinal nerve fiber layer thicknessin scanning laser polarimetry with variable cornealcompensation", Arch Ophthalmol, 126, pp.1359~1364 (2008)
- Kook MS, "Scanning laserpolarimetry using variable corneal compensation in thedetection of glaucoma with localized visual field defects", Ophthalmology, 112, pp.1970~1978 (2005)
- Choi J, "Scanning laser polarimetrywith variable corneal compensation in the area ofapparently normal hemifield in eyes with normal-tensionglaucoma", Ophthalmology, 113, pp.1954~1960 (2006)
- Asaoka R, "HRT-3Moorfields reference plane: effect on rim area repeatabilityand identification of progression", Br J Ophthalmol, 93, pp.1510~1513 (2009)
- Leske MC, "Factors for glaucomaprogression and the effect of treatment: the early manifestglaucoma trial", Arch Ophthalmol, 121, pp.48~56 (2003)