정상안압녹내장에서 당뇨 유무에 따라 분석한 안토시아노사이드, 은행잎추출물의 치료 효과
The Effect of Anthocyanoside and Ginkgo Biloba Extract on Normal-Tension Glaucoma According to Presence of Diabetes
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목적: 당뇨 유무에 따라 정상안압녹내장 환자에서 Anthocyanoside 제제 및 Ginkgo Biloba Extract (GBE) 제제를 복용하는 환자들의치료 효과를 분석해 보고자 하였다. 대상과 방법: 2005년 1월부터 2013년 12월까지 강북삼성병원 안과 외래에 내원한 정상안압녹내장 환자를 대상으로 후향적 의무기록분석을 시행하였다. 모든 환자들은 6개월 간격으로 교정시력과 시야 검사를 시행하였으며, 당뇨 유무에 따라 나누어 Anthocyanoside를 복용한 환자군과 GBE를 복용한 환자군 그리고 둘 다 복용하지 않은 대조군의 교정시력과 시야 검사 지표를 비교 분석하였다. 결과: 총 406명 중 당뇨를 진단받지 않은 환자는 255명(대조군 80명, Anthocyanoside군 76명, GBE군 99명), 당뇨를 진단받은 환자는151명(대조군 36명, Anthocyanoside군 83명, GBE군 32명)이었다. 치료 후 시야검사상 MD 값은 Anothocyanoside군과 GBE군에서호전되었다. PSD 값은 세 군에서 모두 유의한 변화를 보여주지 않았다. 교정시력은 대조군에서 악화되었으나, Anthocyanoside군에서는 향상되었다. 이런 결과는 당뇨가 없는 환자와 있는 환자 모두 동일하였으며, 일반화선형모형 분석에서 전신약제 복용이 시기능에 유의한 영향을 미치는 것으로 나타났다. 결론: 정상안압녹내장 환자에서 Anthocyanoside와 GBE는 당뇨의 유무에 상관없이 시기능의 호전에 도움을 줄 수 있는 것으로 나타났다.
Abstract
Purpose: This study was performed to evaluate the effect of anthocyanoside and ginkgo biloba extract (GBE) in patients withnormal tension glaucoma (NTG), according to the presence of diabetes mellitus (DM). Methods: A chart review of patients with normal tension glaucoma was retrospectively analyzed. All patients underwent aHumphrey visual field (HVF) test and logarithm of the minimal angle of resolution best-corrected visual acuity (log MAR BCVA)was measured over a 6 months period. Changes in mean deviation (MD), pattern standard deviation (PSD) of visual field and logMAR BCVA were compared among anthocyanoside, GBE and no medication (control) groups. Patients were divided accordingto the presence of DM. Results: A total of 406 NTG patients, including 151 DM patients, were included in the present study. MD was improved in the anthocyanosideand GBE groups, but not in the control group. PSD was not significantly different in all groups. BCVA was improvedin the anthocyanoside group, but deteriorated in the control group. The results were similar in patients with or without DM. Thegeneralized linear model demonstrated that systemic medication affected changes in visual indices. Conclusions: The results from the present study suggest that anthocyanoside and GBE may be helpful for improving visual functionin some patients with NTG regardless of their DM status.
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