Clinical and Anterior Segment Anatomical Features in Primary Angle Closure Subgroups Based on Configurations of Iris Root Insertion
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Purpose: To compare the clinical and anterior segment anatomical features in primary angle closure sub-groupsbased on configurations of iris root insertion. Methods: Primary angle closure patients were imaged using anterior segment optical coherence tomography. Anterior chamber depth, iris curvature, iris thickness (IT) at the scleral spur and 500, 750, and 1,500 μm fromthe scleral spur (IT0, IT500, IT750, and IT1500), lens vault, iris area, angle opening distance (AOD500), angle recessarea (ARA750), and trabecular iris space area (TISA750) were measured. Iris root insertion was categorized intoa non-basal insertion group (NBG) and basal insertion group (BG). Results: In total, 43 eyes of 39 participants belonged to the NBG and 89 eyes of 53 participants to the BG. Themean age of participants was greater in the NBG than the BG (62.7 ± 5.7 vs. 59.8 ± 7.3 years, p = 0.043), andthe baseline intraocular pressure was higher in the BG than the NBG (16.4 ± 4.4 vs. 14.9 ± 3.3 mmHg, p = 0.037). The BG showed a greater IT0 (0.265 ± 0.04 vs. 0.214 ± 0.03 mm, p < 0.001) and iris area (1.59 ± 0.24 vs. 1.52± 0.27 mm2, p = 0.045), lower ARA750 (0.112 ± 0.08 vs. 0.154 ± 0.08 mm2, p = 0.017) and AOD500 (0.165 ± 0.07vs. 0.202 ± 0.08 mm, p = 0.014) compared to the NBG. Conclusions: The BG had a narrower anterior chamber angle, thicker peripheral iris, and higher pretreatmentintraocular pressure.
Abstract
Purpose: To compare the clinical and anterior segment anatomical features in primary angle closure sub-groupsbased on configurations of iris root insertion. Methods: Primary angle closure patients were imaged using anterior segment optical coherence tomography. Anterior chamber depth, iris curvature, iris thickness (IT) at the scleral spur and 500, 750, and 1,500 μm fromthe scleral spur (IT0, IT500, IT750, and IT1500), lens vault, iris area, angle opening distance (AOD500), angle recessarea (ARA750), and trabecular iris space area (TISA750) were measured. Iris root insertion was categorized intoa non-basal insertion group (NBG) and basal insertion group (BG). Results: In total, 43 eyes of 39 participants belonged to the NBG and 89 eyes of 53 participants to the BG. Themean age of participants was greater in the NBG than the BG (62.7 ± 5.7 vs. 59.8 ± 7.3 years, p = 0.043), andthe baseline intraocular pressure was higher in the BG than the NBG (16.4 ± 4.4 vs. 14.9 ± 3.3 mmHg, p = 0.037). The BG showed a greater IT0 (0.265 ± 0.04 vs. 0.214 ± 0.03 mm, p < 0.001) and iris area (1.59 ± 0.24 vs. 1.52± 0.27 mm2, p = 0.045), lower ARA750 (0.112 ± 0.08 vs. 0.154 ± 0.08 mm2, p = 0.017) and AOD500 (0.165 ± 0.07vs. 0.202 ± 0.08 mm, p = 0.014) compared to the NBG. Conclusions: The BG had a narrower anterior chamber angle, thicker peripheral iris, and higher pretreatmentintraocular pressure.
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