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Evaluation of Retinal Nerve Fiber Layer Thickness and Optic Nerve Head Parameters in Obstructive Sleep Apnoea Patients

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Purpose: To study the retinal nerve fiber layer (RNFL) thickness and optic nerve head (ONH) parameters in obstructive sleepapnoea (OSA) patients and their relationship with severity of the disease. Methods: A cross-sectional, hospital-based study. Fifty-four OSA subjects and 54 controls were recruited. Candidate thatfulfil the criteria with normal ocular examinations then proceed with spectrum domain Cirrus optical coherence tomographyexaminations. ONH parameters and RNFL thickness were evaluated. Apnoea-hypopnoea index (AHI) of the OSA group wereobtained from the medical record. Results: In OSA, mean of average RNFL thickness was 93.87 μm, standard deviation (SD) = 9.17, p = 0.008 (p < 0.05) whilesuperior RNFL thickness was 113.59 μm, SD = 16.29, p ≤ 0.001 (p < 0.05). RNFL thickness fairly correlate with severity of thedisease (AHI), superior RNFL with R = 0.293, R2 = 0.087, p = 0.030 (p < 0.05), and nasal RNFL R = 0.292, R2 = 0.085, p = 0.032. Nosignificant difference and correlation observed on ONH parameters. In control group, mean of average RNFL thickness was98.96 μm, SD = 10.50, p = 0.008 (p < 0.05) while superior RNFL thickness was 125.76 μm, SD = 14.93, p ≤ 0.001 (p < 0.05). Conclusions: The mean of the average and superior RNFL thickness were significantly lower in the OSA group compare tocontrol. Regression analysis showed RNFL thickness having significantly linear relationship with the AHI, specifically involvingthe superior and nasal quadrant.

Abstract

Purpose: To study the retinal nerve fiber layer (RNFL) thickness and optic nerve head (ONH) parameters in obstructive sleepapnoea (OSA) patients and their relationship with severity of the disease. Methods: A cross-sectional, hospital-based study. Fifty-four OSA subjects and 54 controls were recruited. Candidate thatfulfil the criteria with normal ocular examinations then proceed with spectrum domain Cirrus optical coherence tomographyexaminations. ONH parameters and RNFL thickness were evaluated. Apnoea-hypopnoea index (AHI) of the OSA group wereobtained from the medical record. Results: In OSA, mean of average RNFL thickness was 93.87 μm, standard deviation (SD) = 9.17, p = 0.008 (p < 0.05) whilesuperior RNFL thickness was 113.59 μm, SD = 16.29, p ≤ 0.001 (p < 0.05). RNFL thickness fairly correlate with severity of thedisease (AHI), superior RNFL with R = 0.293, R2 = 0.087, p = 0.030 (p < 0.05), and nasal RNFL R = 0.292, R2 = 0.085, p = 0.032. Nosignificant difference and correlation observed on ONH parameters. In control group, mean of average RNFL thickness was98.96 μm, SD = 10.50, p = 0.008 (p < 0.05) while superior RNFL thickness was 125.76 μm, SD = 14.93, p ≤ 0.001 (p < 0.05). Conclusions: The mean of the average and superior RNFL thickness were significantly lower in the OSA group compare tocontrol. Regression analysis showed RNFL thickness having significantly linear relationship with the AHI, specifically involvingthe superior and nasal quadrant.

참고문헌 (36)

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