연옥이 첨가된 콘택트렌즈 보관용기의 항녹농균 효과
Anti-pseudomonal Effect of a Nephrite-containing Contact Lens Storage Case
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목적: 연옥이 첨가된 콘택트렌즈 보관용기의 항녹농균 효과를 일반 콘택트렌즈 보관용기와 비교하였다. 대상과 방법: 5% 연옥이 첨가된 콘택트렌즈 보관용기와 일반 콘택트렌즈 보관용기를 이용하여, 각각의 보관용기에 따른 녹농균의 증식 정도와 1-3세대 실리콘하이드로겔 콘택트렌즈에 대한 부착 정도를 비교하였다. 또한 1% 및 5% 연옥수와 상용 다목적관리용액에서 콘택트렌즈에 대한 녹농균의 부착 정도를 비교하였다. 결과: 일반 콘택트렌즈 보관용기에 비해 5% 연옥이 첨가된 콘택트렌즈 보관용기에서 녹농균의 증식이 유의하게 감소되었으며(p=0.03), 콘택트렌즈에 부착된 녹농균의 수도 모든 세대에서 유의하게 감소하였다(각각 p=0.02, p=0.03 및 p<0.01). 1% 및 5% 연옥수는 다목적관리용액과 비교 시 녹농균 부착 정도에서 유의한 차이를 보이지 않았다. 결론: 연옥은 콘택트렌즈 보관용기에 첨가 시 녹농균에 의한 감염 각막염을 감소시킬 수 있는 차세대 물질로서 가능성이 있을 것으로 사료된다.
Abstract
Purpose: To compare the anti-pseudomonal effect of nephrite-containing contact lens (CL) storage cases with conventional CL storage cases. Methods: The degree of proliferation and adhesion of Pseudomonas aeruginosa (P. aeruginosa) on 1st–3rd generation silicone hydrogel contact lenses (SHCLs) was compared by using both 5% nephrite-containing CL storage cases and conventional CL storage cases. The degree of adhesion of P. aeruginosa to the CL was also compared in 1% or 5% nephrite solution and multipurpose solution (MPS). Results: Nephrite-containing CL storage cases showed a significant inhibitory effect on P. aeruginosa proliferation (p = 0.03) and significantly reduced the number of adherent P. aeruginosa on all 1st–3rd generation SHCLs compared with conventional CL storage cases (p = 0.02, p = 0.03, and p < 0.01, respectively). There was no significant anti-pseudomonal effect of 1% and 5% nephrite solutions compared with MPS. Conclusions: Nephrite may be the next generation substance that reduces infectious keratitis caused by P. aeruginosa when added to CL storage cases.
참고문헌 (30)
- Buehler PO, "The increased risk of ulcerative keratitis among disposable soft contact lens users", Arch Ophthalmol, 110, pp.1555~1558 (1992)[DOI]
- Poggio EC, "The incidence of ulcerative keratitis among users of daily-wear and extended wear soft contact lenses", N Engl J Med, 321, pp.779~783 (1989)[DOI]
- A multi-center study, "J Korean Ophthalmol Soc", 1998, 1633~1651
- Duran JA, "Pseudomonas attachment to new hydrogel contact lenses", Arch Ophthalmol, 105, pp.106~109 (1987)[DOI]
- Sy A, "Pseudomonas aeruginosa keratitis: outcomes and response to corticosteroid treatment", Invest Ophthalmol Vis Sci, 53, pp.267~272 (2012)[DOI]
- Vazirani J, "Multidrug-resistant pseudomonas aeruginosa keratitis: risk factors, clinical characteristics, and outcomes", Ophthalmology, 122, pp.2110~2114 (2015)[DOI]
- Kang JS, "Three cases of pseudomonas corneal ulcer in wearer soft contact lens", J Korean Ophthalmol Soc, 26, pp.761~767 (1985)
- Jeon SK, "Pseudomonas keratitis due to mishandling of soft contact lenses", J Korean Ophthalmol Soc, 37, pp.901~907 (1996)
- Donzis PB, "Microbial contamination of contact lens care systems", Am J Ophthalmol, 104, pp.325~333 (1987)[DOI]
- Bailey CS, "A review of relative risks associated with four types of contact lenses", Cornea, 9(Suppl 1), pp.S559~S561 (1990)
- Wilson LA, "Microbial contamination of contact lens storage cases and solutions", Am J Ophthalmol, 110, pp.193~198 (1990)[DOI]
- Amos CF, "Clinical and laboratory testing of a silver-impregnated lens case", Cont Lens Anterior Eye, 29, pp.247~255 (2006)[DOI]
- Vermeltfoort PB, "Bacterial transmission from lens storage cases to contact lenses-Effects of lens care solutions and silver impregnation of cases", J Biomed Mater Res B Appl Biomater, 87, pp.237~243 (2008)
- Scheuer C, "Multipurpose solutions and rates of biocidal efficacy", Eye Contact Lens, 35, pp.88~91 (2009)[DOI]
- 정재우, "연옥이 첨가된 콘택트렌즈 보관용기의 항아메바 효과", 대한안과학회지, 58(5), pp.509~515 (2017), 대한안과학회
- Schein OD, "Ulcerative keratitis in contact lens wearers. Incidence and risk factors", Cornea, 9(Suppl 1), pp.555~558 (1990)
- Asbell P, "Ulcerative keratitis. Survey of 30 years' laboratory experience", Arch Ophthalmol, 100, pp.77~80 (1982)[DOI]
- Bruce AS, "Corneal pathophysiology with contact lens wear", Surv Ophthalmol, 35, pp.25~58 (1990)[DOI]
- Teichroeb JH, "Imaging protein deposits on contact lens materials", Optom Vis Sci, 85, pp.1151~1164 (2008)[DOI]
- Giraldez MJ, "Soft contact lens surface profile by atomic force microscopy", Optom Vis Sci, 87, pp.E475~E481 (2010)
- Shayani Rad M, "Antibacterial activity of silver nanoparticle-loaded soft contact lens materials: the effect of monomer composition", Curr Eye Res, 41, pp.1286~1293 (2016)[DOI]
- Stapleton F, "Epidemiology of Pseudomonas aeruginosa keratitis in contact lens wearers", Epidemiol Infect, 114, pp.395~402 (1995)[DOI]
- Donzis PB, "Microbial contamination of contact lens care systems", Am J Ophthalmol, 104, pp.325~333 (1987)[DOI]
- Bowden FW 3rd, "Pattern of lens care practices and lens product contamination in contact lens associated microbial keratitis", CLAO J, 15, pp.49~54 (1989)
- Lee GH, "Adhesion of Acanthamoeba on silicone hydrogel contact lenses", Cornea, 35, pp.663~668 (2016)[DOI]
- Imayasu M, "Effects of multipurpose contact-lens care solutions on adhesion of Pseudomonas aeruginosa to corneal epithelial cells", Eye Contact Lens, 35, pp.98~104 (2009)[DOI]
- Dantam J, "Biocidal efficacy of silver-impregnated contact lens storage cases in vitro", Invest Ophthalmol Vis Sci, 52, pp.51~57 (2011)[DOI]
- Lee JY, "A mineralogical geochemical and oriental medical study on nephrite well waters", J Science Education Kyungpook National University, 25, pp.43~52 (2001)
- 염미정, "RAW 264.7 면역세포에서 염증유발인자의 유전자 발현에 대한 軟玉水와 軟玉粉의 억제 효과", 동의생리병리학회지, 18(6), pp.1622~1627 (2004), 한의병리학회
- 한동오, "급성염증 동물모델에서 軟玉粉과 軟玉水의 염증억제 효과", 동의생리병리학회지, 19(4), pp.977~981 (2005), 한의병리학회