본문 바로가기
KERD
논문KCI 등재

연옥이 첨가된 콘택트렌즈 보관용기의 항포도알균 효과

Anti-staphylococcal Effect of a Nephrite-containing Contact Lens Storage Case

2

조회

0

다운로드

0

인용

0

참고문헌

키워드

주제분류안과학

초록

목적: 연옥이 첨가된 콘택트렌즈 보관용기의 항포도알균 효과를 일반 콘택트렌즈 보관용기와 비교하였다. 대상과 방법: 5% 연옥이 첨가된 콘택트렌즈 보관용기와 일반 콘택트렌즈 보관용기를 이용하여, 각각의 보관용기에 따른 황색포도알균의 증식 정도와 1-3세대 실리콘하이드로겔 콘택트렌즈에 대한 부착 정도를 비교하였다. 또한 1% 및 5% 연옥수와 상용 다목적 관리용액에서 콘택트렌즈에 대한 황색포도알균의 부착 정도를 비교하였다. 결과: 일반 콘택트렌즈보관용기에 비해 5% 연옥이 첨가된 콘택트렌즈 보관용기에서 황색포도알균의 증식이 유의하게 감소되었으며(p=0.004), 콘택트렌즈에 부착된 황색포도알균의 수도 모든 세대에서 유의하게 감소하였다(각각 p=0.026, p=0.043 및 p=0.001). 1% 및 5% 연옥 수는 다목적관리용액과 비교시 황색포도알균 부착 정도에서 유의한 차이를 보이지 않았다. 결론: 연옥은 콘택트렌즈 보관용기에 첨가시 황색포도알균에 의한 감염각막염을 감소시킬 수 있는 차세대 물질로서 가능성이 있을 것으로 사료된다.

Abstract

Purpose: To compare the anti-staphylococcal effect of nephrite-containing contact lens (CL) storage cases and conventional CL storage cases. Method: The degree of proliferation and adhesion of Staphylococcus aureus (S. aureus) on first- to third-generation silicone hydrogel contact lenses (SHCLs) was analyzed through comparison of 5% nephrite-containing CL storage cases and conventional CL storage cases. The degree of adhesion of S. aureus to the CL was also compared between 1% or 5% nephrite solution and multipurpose solution (MPS). Result: Nephrite-containing CL storage cases showed a significant inhibitory effect on S. aureus proliferation (p = 0.004) and significantly reduced the number of adherent S. aureus on all first- to third generation SHCLs compared with conventional CL storage cases (p = 0.026, p = 0.043, and p = 0.001, respectively). The anti-staphylococcal effect of 1% and 5% nephrite solutions was not significantly better than that of MPS. Conclusions: Nephrite shows potential as a next-generation substance for reducing infectious keratitis caused by S. aureus when added to CL storage cases.

참고문헌 (43)

  1. Buehler PO, "The increased risk of ulcerative keratitis among disposable soft contact lens users", Arch Ophthalmol, 110, pp.1555~1558 (1992)
  2. Poggio EC, "The incidence of ulcerative keratitis among users of daily-wear and extended wear soft contact lenses", N Engl J Med, 321, pp.779~783 (1989)
  3. a multi-center study, "J Korean Ophthalmol Soc", 1998, 1633~1651
  4. 김미래, "그람양성세균각막염에 대한 임상적, 미생물학적 분석: 15년 연구", 대한안과학회지, 55(10), pp.1432~1444 (2014), 대한안과학회
  5. Hawser SP, "Rising incidence of Staphylococcus aureus with reduced susceptibility to vancomycin and susceptibility to antibiotics : a global analysis 2004-2009", Int J Antimicrob Agents, 37, pp.219~224 (2011)
  6. Chang VS, "Antibiotic resistance in the treatment of Staphylococcus aureus keratitis : a 20-year review", Cornea, 34, pp.698~703 (2015)
  7. Weisbarth RE, "Creating antimicrobial surfaces and materials for contact lenses and lens cases", Eye Contact Lens, 33(6 Pt 2), pp.426~429 (2007)
  8. Dantam J, "Biocidal efficacy of silver-impregnated contact lens storage cases in vitro", Invest Ophthalmol Vis Sci, 52, pp.51~57 (2011)
  9. Datta A, "In vitro antimicrobial efficacy of silver lens cases used with a multipurpose disinfecting solution", Transl Vis Sci Technol, 8, pp.52~ (2019)
  10. Tran PL, "Organoselenium polymer inhibits biofilm formation in polypropylene contact lens case material", Eye Contact Lens, 43, pp.110~115 (2017)
  11. 이상민, "연옥이 첨가된 콘택트렌즈 보관용기의 항녹농균 효과", 대한안과학회지, 59(8), pp.724~729 (2018), 대한안과학회
  12. 정재우, "연옥이 첨가된 콘택트렌즈 보관용기의 항아메바 효과", 대한안과학회지, 58(5), pp.509~515 (2017), 대한안과학회
  13. Korean External Eye Disease Society, "Cornea", pp.132~133 (2013), Ilchokak
  14. Hart DE, "Microbial contamination of hydrophilic contact lenses : quantitation and identification of microorganisms associated with contact lenses while on the eye", Optom Vis Sci, 70, pp.185~191 (1993)
  15. Schultz CL, "Bacterial adhesion measurements on soft contact lenses using a Modified Vortex Device and a Modified Robbins Device", J Ind Microbiol, 15, pp.243~247 (1995)
  16. Dutta D, "A laboratory assessment of factors that affect bacterial adhesion to contact lenses", Biology(Basel), 2, pp.1268~1281 (2013)
  17. Liesegang TJ, "Contact lens-related microbial keratitis : Part I : Epidemiology", Cornea, 16, pp.125~131 (1997)
  18. Bennett L, "Contact lens versus non-contact lens-related corneal ulcers at an academic center", Eye Contact Lens, 45, pp.301~305 (2019)
  19. Asbell P, "Ulcerative keratitis. Survey of 30 years' laboratory experience", Arch Ophthalmol, 100, pp.77~80 (1982)
  20. 임수호, "입원치료를 시행한 세균각막염에 대한 12년간의 분석: 원인균주와 항생제내성", 대한안과학회지, 53(3), pp.372~384 (2012), 대한안과학회
  21. Bruce AS, "Corneal pathophysiology with contact lens wear", Surv Ophthalmol, 35, pp.25~58 (1990)
  22. Stern GA, "Contact lens associated bacterial keratitis : past, present, and future", CLAO J, 24, pp.52~56 (1998)
  23. Davies D, "Understanding biofilm resistance to antibacterial agents", Nat Rev Drug Discov, 2, pp.114~122 (2003)
  24. McLaughlin-Borlace L, "Bacterial biofilm on contact lenses and lens storage cases in wearers with microbial keratitis", J Appl Microbiol, 84, pp.827~838 (1998)
  25. Vermeltfoort PBJ, "Bacterial transmission from lens storage cases to contact lenses-effects of lens care solutions and silver impregnation of cases", J Biomed Mater Res B Appl Biomater, 87, pp.237~243 (2008)
  26. Larkin DF, "Contamination of contact lens storage cases by Acanthamoeba and bacteria", Br J Ophthalmol, 74, pp.133~135 (1990)
  27. Szczotka-Flynn LB, "Increased resistance of contact lens related bacterial biofilms to antimicrobial activity of soft contact lens care solutions", Cornea, 28, pp.918~926 (2014)
  28. Balazs DJ, "Inhibition of bacterial adhesion on PVC endotracheal tubes by RF-oxygen glow discharge, sodium hydroxide and silver nitrate treatments", Biomaterials, 25, pp.2139~2151 (2004)
  29. Gurunathan S, "Enhanced antibacterial and anti-biofilm activities of silver nanoparticles against gram-negative and gram-positive bacteria", Nanoscale Res Lett, 9, pp.373~ (2014)
  30. Taheri S, "Substrate independent silver nanoparticle based antibacterial coatings", Biomaterials, 35, pp.4601~4609 (2014)
  31. Stobie N, "Prevention of Staphylococcus epidermidis biofilm formation using a low-temperature processed silver-doped phenyltriethoxysilane sol-gel coating", Biomaterials, 29, pp.963~969 (2008)
  32. Dallas P, "Silver polymeric nanocomposites as advanced antimicrobial agents : classification, synthetic paths, applications, and perspectives", Adv Colloid Interface Sci, 166, pp.119~135 (2011)
  33. "Inorg Chem", 2010, 9788~9797
  34. Dias HVR, "Antimicrobial properties of highly fluorinated silver(I)tris(pyrazolyl)borates", J Inorg Biochem, 100, pp.158~160 (2006)
  35. Cavicchioli M, "Pt(II)and Ag(I)complexes with acesulfame : crystal structure and a study of their antitumoral, antimicrobial and antiviral activities", J Inorg Biochem, 104, pp.533~540 (2010)
  36. Ramstedt M, "Synthesis and characterization of poly(3-sulfopropylmethacrylate)brushes for potential antibacterial applications", Langmuir, 23, pp.3314~3321 (2007)
  37. Sambhy V, "Silver bromide nanoparticle", polymer composites : dual action tunable antimicrobial materials, 2006, pp.128, 9798~9808
  38. Mathews SM, "Prevention of bacterial colonization of contact lenses with covalently attached selenium and effects on the rabbit cornea", Cornea, 25, pp.806~814 (2006)
  39. 염미정, "RAW 264.7 면역세포에서 염증유발인자의 유전자 발현에 대한 軟玉水와 軟玉粉의 억제 효과", 동의생리병리학회지, 18(6), pp.1622~1627 (2004), 한의병리학회
  40. 한동오, "급성염증 동물모델에서 軟玉粉과 軟玉水의 염증억제 효과", 동의생리병리학회지, 19(4), pp.977~981 (2005), 한의병리학회
  41. Santodomingo-Rubido J, "Cytotoxicity and antimicrobial activity of six multipurpose soft contact lens disinfecting solutions", Ophthalmic Physiol Opt, 26, pp.476~482 (2006)
  42. Eun-Kyung Moon, "Efficacy of Korean Multipurpose Contact Lens Disinfecting Solutions against Acanthamoeba castellanii", Parasites, Hosts and Diseases, 54(6), pp.697~702 (2016), 대한기생충학ㆍ열대의학회
  43. Tasse J, "A steam-based method to investigate biofilm", Sci Rep, 8, pp.13040~ (2018)

관련 논문AI추천

이 간행물의 다른 논문 (19건)