한국 성인의 정상안에서 빛간섭단층혈관조영술 측정치의 양안 대칭성
Interocular Symmetry of Optical Coherence Tomography Angiography Parameters in Normal Eyes of Korean Adults
1
조회
0
다운로드
2
인용
0
참고문헌
키워드
초록
목적: 한국 성인의 정상안에서 빛간섭단층혈관조영술을 이용한 측정값의 양안 대칭성을 알아보고자 하였다. 대상과 방법: 충남대학교병원 안과에 내원한 한국 성인 91명의 정상안 182안을 대상으로 의무기록을 후향적으로 분석하였다. 스펙트럼 영역 빛간섭단층혈관조영술로 얻어진 황반부의 vessel density (VD), perfusion density (PD), foveal avascular zone (FAZ)과 관련된 수치의 양안 대칭성을 확인하였다. 또한 양안 측정값의 일치도 및 연관성을 알아보기 위해 급내상관계수와 변동계수, 그리고 상관계수를 이용하여 분석하였다. 결과: FAZ area (우안: 0.30 ± 0.11 mm2, 좌안: 0.30 ± 0.10 mm2, p=0.99), FAZ perimeter (우안: 2.35 ± 0.45 mm, 좌안: 2.36 ± 0.39 mm, p=0.86), VD는 1 mm center (우안: 9.42 ± 2.75, 좌안: 9.14 ± 2.96, p=0.163), full area (우안: 19.94 ± 1.65, 좌안: 19.72 ± 1.76, p=0.285), PD는 1 mm center (우안: 0.16 ± 0.05 mm-1, 좌안: 0.16 ± 0.05 mm-1, p=0.151), full area (우안: 0.36 ± 0.03, 좌안: 0.36 ± 0.04, p=0.716)으로 양안에 유의한 차이가 없었다. 양안 측정값은 모두 급내상관계수 0.8 이상, 변동계수 10% 로 높은 일치도를 보였다. 결론: 한국 성인의 정상안에서 빛간섭단층혈관조영술로 측정한 FAZ의 크기, 황반부의 VD, PD의 수치는 양안 대칭적이었다.
Abstract
Purpose: To evaluate the interocular symmetry of microvascular parameters measured by optical coherence tomography angiography (OCTA) in normal eyes of Korean adults. Methods: We retrospectively reviewed the retinal microvascular structure of 91 healthy Korean subjects (182 eyes). We used OCTA to measure the area of the foveal avascular zone (FAZ), vessel density (VD), and perfusion density (PD) in both eyes. Intraclass correlation coefficients (ICCs), coefficients of variation (CVs), and Pearson correlation coefficients were calculated to evaluate the extent of agreement and correlations between binocular OCTA measurements. Results: Both eyes had similar microvascular characteristics: FAZ area (right eye: 0.31 ± 0.11 mm2, left eye: 0.30 ± 0.10 mm2, p = 0.98), FAZ perimeter (right eye: 2.35 ± 0.45 mm, left eye: 2.36 ± 0.39 mm, p = 0.86). VD 1-mm center (right eye: 9.42 ± 2.75, left eye: 9.14 ± 2.96, p = 0.163), full area (right eye: 19.94 ± 1.65, left eye: 19.72 ± 1.76, p = 0.285), and PD 1-mm center (right eye: 0.16 ± 0.05, left eye: 0.16 ± 0.05, p = 0.151), full area (right eye: 0.36 ± 0.03, left eye: 0.36 ± 0.04, p = 0.716). All ICC values were above 0.8 and all CVs below 10%. Conclusions: The microvascular structure, as represented by the VD, PD, and FAZ area measured via OCTA, was bilaterally symmetric in normal eyes of Korean adults.
참고문헌 (23)
- Buttery RG, "How thick should a retina be? A comparative study of mammalian species with and without intraretinal vasculature", Vision Res, 31, pp.169~187 (1991)
- Tan PE, "Quantitative confocal imaging of the retinal microvasculature in the human retina", Invest Ophthalmol Vis Sci, 53, pp.5728~5736 (2012)
- Yannuzzi LA, "Fluorescein angiography complication survey", Ophthalmology, 93, pp.611~617 (1986)
- Wang Q, "Vascular density in retina and choriocapillaris as measured by optical coherence tomography angiography", Am J Ophthalmol, 168, pp.95~109 (2016)
- Spaide RF, "Retinal vascular layers imaged by fluorescein angiography and optical coherence tomography angiography", JAMA Ophthalmol, 133, pp.45~50 (2015)
- Uzun S, "Vascular density in retina and choriocapillaris as measured by optical coherence tomography angiography", Am J Ophthalmol, 169, pp.290~ (2016)
- Parodi MB, "Foveal avascular zone in macular branch retinal vein occlusion", Int Ophthalmol, 19, pp.25~28 (1995)
- Kim AY, "Quantifying microvascular density and morphology in diabetic retinopathy using spectral-domain optical coherence tomography angiography", Invest Ophthalmol Vis Sci, 57, pp.OCT362~370 (2016)
- Rosenfeld PJ, "ZEISS Angioplex™spectral domain optical coherence tomography angiography : technical aspects", Dev Ophthalmol, 56, pp.18~29 (2016)
- Durr GM, "Corneal shape, volume, and interocular symmetry : parameters to optimize the design of biosynthetic corneal substitutes", Invest Ophthalmol Vis Sci, 56, pp.4275~4282 (2015)
- Quigley HA, "Risk factors for the development of glaucomatous visual field loss in ocular hypertension", Arch Ophthalmol, 112, pp.644~649 (1994)
- Cartwright MJ, "Correlation of asymmetric damage with asymmetric intraocular pressure in normal-tension glaucoma(low-tension glaucoma)", Arch Ophthalmol, 106, pp.898~900 (1988)
- Mwanza JC, "Interocular symmetry in peripapillary retinal nerve fiber layer thickness measured with the Cirrus HD-OCT in healthy eyes", Am J Ophthalmol, 151, pp.514~521 (2011)
- Lee SY, "Macular ganglion cell imaging study : interocular symmetry of ganglion cell-inner plexiform layer thickness in normal healthy eyes", Am J Ophthalmol, 159, pp.315~323 (2015)
- Lim HB, "Interocular asymmetry of the ganglion cell-inner plexiform layer in diabetic retinopathy", Optom Vis Sci, 95, pp.594~601 (2018)
- Zhang A, "Methods and algorithms for optical coherence tomography-based angiography : a review and comparison", J Biomed Opt, 20, pp.100901~ (2015)
- Bland JM, "Measurement error", BMJ, 313, pp.744~ (1996)
- Cicchetti DV, "Guidelines, criteria, and rules of thumb for evaluating normed and standardized assessment instruments in psychology", Psychological Assessment, 6, pp.284~ (1994)
- Chen FK, "Intrasession repeatability and interocular symmetry of foveal avascular zone and retinal vessel density in OCT angiography", Transl Vis Sci Technol, 7, pp.6~ (2018)
- Fang D, "Repeatability, interocular correlation and agreement of quantitative swept-source optical coherence tomography angiography macular metrics in healthy subjects", Br J Ophthalmol, 103, pp.415~420 (2019)
- Liu G, "Interocular symmetry of vascular density and association with central macular thickness of healthy adults by optical coherence tomography angiography", Sci Rep, 7, pp.16297~ (2017)
- Shahlaee A, "In vivo assessment of macular vascular density in healthy human eyes using optical coherence tomography angiography", Am J Ophthalmol, 165, pp.39~46 (2016)
- 노동현, "정상 한국인의 연령에 따른 빛간섭단층촬영혈관조영술을 이용한 망막중심오목무혈관부위 혈관 분석", 대한안과학회지, 58(9), pp.1058~1065 (2017), 대한안과학회