스펙트럼영역 빛간섭단층촬영으로 측정한 녹내장 환자의 맥락막 두께 분석
Choroidal Thickness in Primary Open-Angle Glaucoma Using Spectral-Domain Optical Coherence Tomography
1
조회
0
다운로드
3
인용
0
참고문헌
키워드
초록
목적: 정상안압녹내장과 원발개방각녹내장 환자의 맥락막 두께를 측정하여 맥락막 두께와 녹내장 시신경병증의 관계를 알아보고자하였다. 대상과 방법: 정상안압녹내장, 원발개방각녹내장, 대조군 세 집단에서 스펙트럼영역 빛간섭단층촬영으로 측정된 망막신경섬유층 두께,황반 두께, 황반 하 및 유두주위 맥락막 두께를 비교하였다. 또한, 녹내장 환자에서 망막신경섬유층 두께와 유두주위 맥락막 두께의연관성을 분석하였다.é결과: 정상안압녹내장 53안, 원발개방각녹내장 21안, 대조군 42안이 포함되었으며, 망막신경섬유층 두께, 황반 두께는 녹내장안에서정상안에 비해 얇게 나타났다. 황반 하 및 유두주위 맥락막 두께는 녹내장안과 정상안 사이에 유의한 차이를 보이지 않았다. 녹내장안에서 망막신경섬유층 두께와 유두주위 맥락막 두께 사이에 유의한 연관성은 없는 것으로 나타났다. 결론: 본 연구 결과, 맥락막 두께는 녹내장안과 정상안 사이에 유의한 차이를 보이지 않았으며, 맥락막 두께와 녹내장 시신경병증 발생의 관련성은 없는 것으로 나타났다. 그러므로 맥락막 두께를 녹내장의 병인 규명 및 진단에 활용하기 위해서는 향후 추가적인 연구가필요할 것으로 생각한다.
Abstract
Purpose: To evaluate the choroidal thickness in patients with primary open-angle glaucoma (POAG) and normal tension glaucoma(NTG) using spectral-domain optical coherence tomography (SD-OCT), and to explore the relationship between the choroidalthickness and glaucoma. Methods: A retrospective analysis was performed on patients who had been diagnosed with POAG or NTG at Ewha WomansUniversity, Mokdong Hospital. SD-OCT scans were obtained to estimate retinal nerve fiber layer (RNFL) thickness, macularthickness, and subfoveal and peripapillary choroidal thickness in groups of POAG patients, NTG patients, and normal controls. Results: A total of 21 patients with POAG, 53 patients with NTG, and 42 normal subjects were enrolled in this study. RNFL thicknessand macular thickness were significantly thinner in the POAG and NTG groups compared to the normal subjects. In contrast,there were no significant differences in subfoveal and peripapillary choroidal thickness among the 3 groups. There was nosignificant correlations between the peripapillary choroidal thickness and retinal nerve fiber layer thickness. Conclusions: Choroidal thickness does not seem to differ between glaucoma patients and normal subjects, and there were nosignificant correlations between the choroidal thickness and glaucomatous optic neuropathy.
참고문헌 (30)
- Kim CS, "Prevalence of primary open-angle glaucoma in central South Korea the Namilstudy", Ophthalmology, 118, pp.1024~1030 (2011)
- Cioffi GA, "Chronic ischemia induces regional axonal damage in experimental primate optic neuropathy", Arch Ophthalmol, 122, pp.1517~1525 (2004)
- Duijm HF, "Choroidal haemodynamics in glaucoma", Br J Ophthalmol, 81, pp.735~742 (1997)
- Fuchsjäger-Mayrl G, "Ocular blood flow and systemic blood pressure in patients with primary open-angle glaucoma and ocular hypertension", Invest Ophthalmol Vis Sci, 45, pp.834~839 (2004)
- Hayreh SS, "Blood supply of the optic nerve head and its role in optic atrophy, glaucoma, and oedema of the optic disc", Br J Ophthalmol, 53, pp.721~748 (1969)
- Spaide RF, "Enhanced depth imaging spectral-domain optical coherence tomography", Am J Ophthalmol, 146, pp.496~500 (2008)
- Ehrlich JR, "Peripapillary choroidal thickness in glaucoma measured with optical coherence tomography", Exp Eye Res, 92, pp.189~194 (2011)
- Flammer J, "The impact of ocular blood flow in glaucoma", Prog Retin Eye Res, 21, pp.359~393 (2002)
- Spraul CW, "Morphometric changes of the chorio capillaris and the choroidal vasculature in eyes with advanced glaucomatous changes", Vision Res, 42, pp.923~932 (2002)
- Yin ZQ, "Widespread choroidal insufficiency in primary open-angle glaucoma", J Glaucoma, 6, pp.23~32 (1997)
- Cristini G, "Choroidal thickness in primary glaucoma", Ophthalmologica, 202, pp.81~85 (1991)
- Drexler W, "Ultrahigh-resolution ophthalmic optical coherence tomography", Nat Med, 7, pp.502~507 (2001)
- Mwanza JC, "Lack of association between glaucoma and macular choroidal thickness measured with enhanced depth-imaging optical coherence tomography", Invest Ophthalmol Vis Sci, 52, pp.3430~3435 (2011)
- Maul EA, "Choroidal thickness measured by spectral domain optical coherence tomography: factors affecting thickness in glaucoma patients", Ophthalmology, 118, pp.1571~1579 (2011)
- Usui S, "Evaluation of the choroidal thickness using high penetration optical coherence tomography with long wavelength in highly myopic normal-tension glaucoma", Am J Ophthalmol, 153, pp.10-6.e1~ (2012)
- Hirooka K, "Evaluation of peripapillary choroidal thickness in patients with normal-tension glaucoma", BMC Ophthalmol, 12, pp.29~ (2012)
- Sogawa K, "Relationship between choroidal thickness and choroidal circulation in healthy young subjects", Am J Ophthalmol, 153, pp.1129-32.e1~ (2012)
- Fujiwara A, "Enhanced depth imaging spectral domain optical coherence tomography of subfoveal choroidal thickness in normal Japanese eyes", Jpn J Ophthalmol, 56, pp.230~235 (2012)
- Ho J, "Analysis of normal peripapillary choroidal thickness via spectral domain optical coherence tomography", Ophthalmology, 118, pp.2001~2007 (2011)
- Manjunath V, "Choroidal thickness in normal eyes measured using Cirrus HD optical coherence tomography", Am J Ophthalmol, 150, pp.325-9.e1~ (2010)
- Suh W, "Evaluation of peripapillary choroidal thickness in unilateral normal-tension glaucoma", Jpn J Ophthalmol, 58, pp.62~67 (2014)
- Kim JM, "Comparison of clinical characteristics between Korean and Western normal-tension glaucoma patients", Am J Ophthalmol, 155, pp.852~857 (2013)
- Mwanza JC, "Choroidal thickness in unilateral advanced glaucoma", Invest Ophthalmol Vis Sci, 53, pp.6695~6701 (2012)
- Rhew JY, "Measurement of subfoveal choroidal thickness in normal-tension glaucoma in Korean patients", J Glaucoma, 23, pp.46~49 (2014)
- Schuman JS, "Spectral domain optical coherence tomography for glaucoma (an AOS thesis)", Trans Am Ophthalmol Soc, 106, pp.426~458 (2008)
- Chung HJ, "Factors determining the peripapillary retinal nerve fiber distribution", J Glaucoma (2013)
- Kim NR, "Comparison of macular ganglion cell complex thickness by Fourier-domain OCT in normal tension glaucoma and primary open-angle glaucoma", J Glaucoma, 22, pp.133~139 (2013)
- Curcio CA, "Topography of ganglion cells in human retina", J Comp Neurol, 300, pp.5~25 (1990)
- Zeimer R, "Quantitative detection of glaucomatous damage at the posterior pole by retinal thickness mapping. A pilot study", Ophthalmology, 105, pp.224~231 (1998)
- Leung CK, "Comparison of macular and peripapillary measurements for the detection of glaucoma: an optical coherence tomography study", Ophthalmology, 112, pp.391~400 (2005)