The Relationship between Neutrophil-to-lymphocyte Ratio and Age-related Macular Degeneration
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Purpose: To investigate the possible associations of neutrophil-to-lymphocyte ratio (NLR) and high sensitivityC-reactive protein (hs-CRP) level with age-related macular degeneration (ARMD). Methods: Patients were divided to three groups of 40 patients with non-neovascular ARMD (group 1), 40patients with neovascular ARMD (group 2), and 40 healthy control subjects (group 3). The neutrophil andlymphocyte counts were evaluated using an ABX Pentra DF120/USA biochemical analyzer, and hs-CRP levelswere measured using a Beckman Coulter Immage 800. The NLR was measured by dividing neutrophil countby lymphocyte count. Results: The patients in group 2 were older and more often diabetic than the patients in groups 1 and 3 (p < 0.001and p < 0.001, respectively). The NLR level was 1.65 ± 0.71 in group 1, 1.98 ± 0.84 in group 2, and 1.46 ± 0.44in group 3. The hs-CRP value was 1.98 ± 0.251 mg/L in group 1, 3.242 ± 0.211 mg/L in group 2, and 1.145 ±0.193 mg/L in group 3. Both NLR and hs-CRP values were significantly higher in group 2 compared to group3 (p = 0.002 and p = 0.002, respectively). In multivariate analysis, NLR remained an independent predictor ofneovascular ARMD (odds ratio, 3.882; 95% confidence interval, 1.574 to 9.576; p = 0.003) together with age (p< 0.001), diabetes mellitus (p = 0.041), and hs-CRP (p = 0.018). Conclusions: Our study suggests that increased NLR value is independently associated with neovascularARMD.
Abstract
Purpose: To investigate the possible associations of neutrophil-to-lymphocyte ratio (NLR) and high sensitivityC-reactive protein (hs-CRP) level with age-related macular degeneration (ARMD). Methods: Patients were divided to three groups of 40 patients with non-neovascular ARMD (group 1), 40patients with neovascular ARMD (group 2), and 40 healthy control subjects (group 3). The neutrophil andlymphocyte counts were evaluated using an ABX Pentra DF120/USA biochemical analyzer, and hs-CRP levelswere measured using a Beckman Coulter Immage 800. The NLR was measured by dividing neutrophil countby lymphocyte count. Results: The patients in group 2 were older and more often diabetic than the patients in groups 1 and 3 (p < 0.001and p < 0.001, respectively). The NLR level was 1.65 ± 0.71 in group 1, 1.98 ± 0.84 in group 2, and 1.46 ± 0.44in group 3. The hs-CRP value was 1.98 ± 0.251 mg/L in group 1, 3.242 ± 0.211 mg/L in group 2, and 1.145 ±0.193 mg/L in group 3. Both NLR and hs-CRP values were significantly higher in group 2 compared to group3 (p = 0.002 and p = 0.002, respectively). In multivariate analysis, NLR remained an independent predictor ofneovascular ARMD (odds ratio, 3.882; 95% confidence interval, 1.574 to 9.576; p = 0.003) together with age (p< 0.001), diabetes mellitus (p = 0.041), and hs-CRP (p = 0.018). Conclusions: Our study suggests that increased NLR value is independently associated with neovascularARMD.
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