Changes in Fundus Autofluorescence after Anti-vascular Endothelial Growth Factor According to the Type of Choroidal Neovascularization in Age-related Macular Degeneration
2
조회
0
다운로드
0
인용
0
참고문헌
키워드
초록
Purpose: To describe the changes of fundus autofluorescence (FAF) in patients with age-related macular degenerationbefore and after intravitreal injection of anti-vascular endothelial growth factor according to the typeof choroidal neovascularization (CNV) and to evaluate the correlation of FAF with spectral domain optical coherencetomography (SD-OCT) parameters and vision. Methods: This was a retrospective study. Twenty-one treatment-naïve patients with neovascular age-relatedmacular degeneration were included. Study eyes were divided into two groups according to the type of CNV. Fourteen eyes were type 1 CNV and seven eyes were type 2 CNV. All eyes underwent a complete ophthalmologicexamination, including an assessment of best-corrected visual acuity, SD-OCT, fluorescein angiography,and FAF imaging, before and 3 months after intravitreal anti-vascular endothelial growth factor injection. Gray scales of FAF image for CNV areas, delineated as in fluorescein angiography, were analyzed using theImageJ program, which were adjusted by comparison with normal background areas. Correlation of changesin FAF with changes in SD-OCT parameters, including CNV thickness, photoreceptor inner and outer segmentjunction disruption length, external limiting membrane disruption length, central macular thickness, subretinalfluid, and intraretinal fluid were analyzed. Results: Eyes with both type 1 and type 2 CNV showed reduced FAF before treatment. The mean gray scales (%)of type 1 and type 2 CNV were 52.20% and 42.55%, respectively. The background values were 106.72 and96.86. After treatment, the mean gray scales (%) of type 1 CNV and type 2 CNV were changed to 57.61% (p= 0.005) and 57.93% (p = 0.008), respectively. After treatment, CNV thickness, central macular thickness, andinner and outer segment junction disruption length were decreased while FAF increased. Conclusions: FAF was noted to be reduced in eyes with newly diagnosed wet age-related macular degeneration,but increased after anti-vascular endothelial growth factor therapy regardless of CNV lesion type.
Abstract
Purpose: To describe the changes of fundus autofluorescence (FAF) in patients with age-related macular degenerationbefore and after intravitreal injection of anti-vascular endothelial growth factor according to the typeof choroidal neovascularization (CNV) and to evaluate the correlation of FAF with spectral domain optical coherencetomography (SD-OCT) parameters and vision. Methods: This was a retrospective study. Twenty-one treatment-naïve patients with neovascular age-relatedmacular degeneration were included. Study eyes were divided into two groups according to the type of CNV. Fourteen eyes were type 1 CNV and seven eyes were type 2 CNV. All eyes underwent a complete ophthalmologicexamination, including an assessment of best-corrected visual acuity, SD-OCT, fluorescein angiography,and FAF imaging, before and 3 months after intravitreal anti-vascular endothelial growth factor injection. Gray scales of FAF image for CNV areas, delineated as in fluorescein angiography, were analyzed using theImageJ program, which were adjusted by comparison with normal background areas. Correlation of changesin FAF with changes in SD-OCT parameters, including CNV thickness, photoreceptor inner and outer segmentjunction disruption length, external limiting membrane disruption length, central macular thickness, subretinalfluid, and intraretinal fluid were analyzed. Results: Eyes with both type 1 and type 2 CNV showed reduced FAF before treatment. The mean gray scales (%)of type 1 and type 2 CNV were 52.20% and 42.55%, respectively. The background values were 106.72 and96.86. After treatment, the mean gray scales (%) of type 1 CNV and type 2 CNV were changed to 57.61% (p= 0.005) and 57.93% (p = 0.008), respectively. After treatment, CNV thickness, central macular thickness, andinner and outer segment junction disruption length were decreased while FAF increased. Conclusions: FAF was noted to be reduced in eyes with newly diagnosed wet age-related macular degeneration,but increased after anti-vascular endothelial growth factor therapy regardless of CNV lesion type.
참고문헌 (20)
- Klaver CC, "Age-specific prevalence and causes of blindness and visual impairment in an older population: the Rotterdam Study", Arch Ophthalmol, 116, pp.653~658 (1998)
- Attebo K, "Visual acuity and the causes of visual loss in Australia: the Blue Mountains Eye Study", Ophthalmology, 103, pp.357~364 (1996)
- Veritti D, "Neovascular age-related macular degeneration", Ophthalmologica, 227(Suppl 1), pp.11~20 (2012)
- Grossniklaus HE, "Choroidal neovascularization", Am J Ophthalmol, 137, pp.496~503 (2004)
- Lim JI, "Age-related macular degeneration", pp.87~96 (2007), CC Press
- Rosenfeld PJ, "Ranibizumab for neovascular age-related macular degeneration", N Engl J Med, 355, pp.1419~1431 (2006)
- Abraham P, "Randomized, double-masked, sham-controlled trial of ranibizumab for neovascular age-related macular degeneration: PIER study year 2", Am J Ophthalmol, 150, pp.315~324 (2010)
- Brown DM, "R anibizumab versus verteporfin photodynamic therapy for neovascular age-related macular degeneration: two-year results of the ANCHOR study", Ophthalmology, 116, pp.57~65 (2009)
- Comparison of Age-related Macular Degeneration Treatments Trials (CATT) Research Group, "Ranibizumab and bevacizumab for treatment of neovascular age-related macular degeneration: two-year results", Ophthalmology, 119, pp.1388~1398 (2012)
- Schmitz-Valckenberg S, "Fundus autofluorescence and progression of age-related macular degeneration", Surv Ophthalmol, 54, pp.96~117 (2009)
- Delori FC, "In vivo fluorescence of the ocular fundus exhibits retinal pigment epithelium lipofuscin characteristics", Invest Ophthalmol Vis Sci, 36, pp.718~729 (1995)
- Boulton M, "The formation of autofluorescent granules in cultured human RPE", Invest Ophthalmol Vis Sci, 30, pp.82~89 (1989)
- von Ruckmann A, "In vivo fundus autofluorescence in macular dystrophies", Arch Ophthalmol, 115, pp.609~615 (1997)
- Feeney-Burns L, "Lipofuscin of human retinal pigment epithelium", Am J Ophthalmol, 90, pp.783~791 (1980)
- Framme C, "Fundus autofluorescence before and after photodynamic therapy for choroidal neovascularization secondary to age-related macular degeneration", Ophthalmic Surg Lasers Imaging, 37, pp.406~414 (2006)
- Vaclavik V, "Autofluorescence imaging in age-related macular degeneration complicated by choroidal neovascularization: a prospective study", Ophthalmology, 115, pp.342~346 (2008)
- Dandekar SS, "Autofluorescence imaging of choroidal neovascularization due to age-related macular degeneration", Arch Ophthalmol, 123, pp.1507~1513 (2005)
- Shin HJ, "Association between foveal microstructure and visual outcome in age-related macular degeneration", Retina, 31, pp.1627~1636 (2011)
- Hayashi H, "Association between foveal photoreceptor integrity and visual outcome in neovascular age-related macular degeneration", Am J Ophthalmol, 148, pp.83~89 (2009)
- McBain VA, "Fundus autofluorescence in the diagnosis of cystoid macular oedema", Br J Ophthalmol, 92, pp.946~949 (2008)