소아 근시 환자에서 각막굴절교정렌즈와 싸이클로펜톨레이트의 근시억제 효과에 대한 비교 연구
Comparison of the Effects of Orthokeratology Lens and Cyclopentolate on Myopia Progression in Children
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목적: 소아 근시 환자에서 각막굴절교정렌즈(orthokeratology lens, Ortho‐K 렌즈)와 싸이클로펜톨레이트(cyclopentolate)의 근시억제효과를 비교해보고자 하였다. 대상과 방법: 본 연구는 양안에 Ortho‐K 렌즈를 적용한 36명, 싸이클로펜톨레이트를 점안한 28명의 소아 근시 환자의 우안을 대상으로 총 64안의 의무기록을 후향적으로 분석하여 임상 결과를 비교하였다. 성별, 나이, 첫 개입을 시작한 나이, 관찰 기간을 조사하였다. 시력 및 첫 개입 당시, 6개월, 12개월, 24개월째의 안축장을 측정하여 비교하였다. 결과: 2년 추적 관찰 후 Ortho‐K 렌즈군에서 기저 안축장(baseline axial length [AL])에 대한 시간에 따른 안축장 변화(AL change, △AL)는 12개월째 0.3 ± 0.25 mm, 24개월째 0.52 ± 0.34 mm로 통계적으로 유의하게 감소하였으며(p for trend ＜0.001), 싸이클로펜톨레이트군에서도 12개월째 0.36 ± 0.17 mm, 24개월째 0.62 ± 0.29 mm로 시간에 따라 안축장의 변화가 유의하게 감소하였다(p for trend=0.022). 두 군 간의 근시 조절 효과를 비교해보았을 때 Ortho‐K 렌즈군이 싸이클로펜톨레이트군에 비해 시간에 따른안축장 변화가 통계적으로 유의하게 더 적었다(p=0.038). 결론: Ortho‐K 렌즈는 근시 진행을 효과적으로 억제할 수 있으며, 싸이클로펜톨레이트는 Ortho‐K 렌즈에 비해 소아 근시억제 효과가유의하게 적었다.
Abstract
Purpose: To compare the effects of orthokeratology lens (Ortho‐K lens) and topical cyclopentolate on myopia progression in children. Methods: This retrospective study analyzed the medical records of 36 children who received Ortho‐K lens and 28 who received cyclopentolate (i.e., total of 64 eyes). The following data were recorded: sex, age, age at first intervention, follow‐up duration, and visual acuity and axial length (AL) at the time of first treatment and after 6, 12, and 24 months of treatment. Results: In the Ortho‐K group, the changes of AL significantly decreased by 0.3 ± 0.25 mm at 12 months and 0.52 ± 0.34 mm at 24 months (p for trend < 0.001). In the cyclopentolate group, the changes of AL significantly decreased by 0.36 ± 0.17 mm at 12 months and 0.62 ± 0.29 mm at 24 months (p for trend = 0.022). Compared to the use of cyclopentolate, the use of Ortho‐K lens resulted in smaller changes in AL during follow‐up (p = 0.038). Conclusions: In myopic children, Ortho‐K reduced myopia progression, whereas cyclopentolate significantly less affect myopia progression than Ortho‐K lens.
참고문헌 (27)
- Holden BA, "Global prevalence of myopia and high myopia and temporal trends from 2000 through 2050", Ophthalmology, 123, pp.1036~1042 (2016)
- Moriyama M, "Correlation between visual prognosis and fundus autofluorescence and optical coherence tomographic findings in highly myopic eyes with submacular hemorrhage and without choroidal neovascularization", Retina, 31, pp.74~80 (2011)
- Walline JJ, "Interventions to slow progression of myopia in children", Cochrane Database Syst Rev, 1, pp.CD004916~ (2020)
- Queirós A, "Peripheral re fraction in myopic patients after orthokeratology", Optom Vis Sci, 87, pp.323~329 (2010)
- Kang P, "Peripheral refraction in myopic children wearing orthokeratology and gas-permeable lenses", Optom Vis Sci, 88, pp.476~482 (2011)
- Cho P, "Myopia and orthokeratology for myopia control", Clin Exp Optom, 102, pp.364~377 (2019)
- Syniuta LA, "Atropine and bifocals can slow the progression of myopia in children", Binocul Vis Strabismus Q, 16, pp.203~208 (2001)
- Shih YF, "An intervention trial on efficacy of atropine and multi-focal glasses in controlling myopic progression", Acta Ophthalmol Scand, 79, pp.233~236 (2001)
- Brodstein RS, "The treatment of myopia with atropine and bifocals. A long‐term prospective study", Ophthalmology, 91, pp.1373~1379 (1984)
- Qu J, "The presence of m1 to m5 receptors in human sclera : evidence of the sclera as a potential site of action for muscarinic receptor antagonists", Curr Eye Res, 31, pp.587~597 (2006)
- Lind GJ, "Muscarinic acetylcholine receptor antagonists inhibit chick scleral chondrocytes", Invest Ophthalmol Vis Sci, 39, pp.2217~2231 (1998)
- Prepas SB, "Light, literacy and the absence of ultraviolet radiation in the development of myopia", Med Hypotheses, 70, pp.635~637 (2008)
- Yen MY, "Comparison of the effect of atropine and cyclopentolate on myopia", Ann Ophthalmol, 21, pp.180~187 (1989)
- Lin HJ, "Overnight orthokeratology is comparable with atropine in controlling myopia", BMC Ophthalmol, 14, pp.40~ (2014)
- Lyu Y, "Comparison of administration of 0.02%atropine and orthokeratology for myopia control", Eye Contact Lens, 47, pp.81~85 (2021)
- Tsai WS, "A comparative study of orthokeratology and low-dose atropine for the treatment of anisomyopia in children", Sci Rep, 10, pp.14176~ (2020)
- Zhao Q, "Comparison of the clinical efficacies of 0.01%atropine and orthokeratology in controlling the progression of myopia in children", Ophthalmic Epidemiol, 28, pp.376~382 (2021)
- Cheung SW, "Subjective and objective assessments of the effect of orthokeratology--a cross-sectional study", Curr Eye Res, 28, pp.121~127 (2004)
- Dave T, "Current trends in modern orthokeratology", Ophthalmic Physiol Opt, 18, pp.224~233 (1998)
- Reinstein DZ, "Epithelial, stromal, and corneal pachymetry changes during orthokeratology", Optom Vis Sci, 86, pp.E1006~14 (2009)
- Zhong X, "Differences between overnight and long-term wear of orthokeratology contact lenses in corneal contour, thickness, and cell density", Cornea, 28, pp.271~279 (2009)
- Kakita T, "Influence of overnight orthokeratology on axial elongation in childhood myopia", Invest Ophthalmol Vis Sci, 52, pp.2170~2174 (2011)
- Chen C, "Myopia control using toric orthokeratology(TO-SEE study)", Invest Ophthalmol Vis Sci, 54, pp.6510~6517 (2013)
- Cho P, "Retardation of myopia in orthokeratology(ROMIO)study : a 2-year randomized clinical trial", Invest Ophthalmol Vis Sci, 53, pp.7077~7085 (2012)
- Hiraoka T, "Long-term effect of overnight orthokeratology on axial length elongation in childhood myopia : a 5-year follow-up study", Invest Ophthalmol Vis Sci, 53, pp.3913~3919 (2012)
- Huang F, "The effect of topical administration of cyclopentolate on ocular biometry : an analysis for mouse and human models", Sci Rep, 7, pp.9952~ (2017)
- Kennedy RH, "Reducing the progression of myopia with atropine : a long term cohort study of Olmsted County students", Binocul Vis Strabismus Q, 15(Suppl 3), pp.281~304 (2000)