Location of Retinal Nerve Fiber Layer Defects in Open-angle Glaucoma and Associated Factors
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Purpose: To investigate the location of retinal nerve fiber layer defects (RNFLDs) in open-angle glaucoma andthe differences in systemic and ocular factors between superotemporal and inferotemporal RNFLDs. Methods: We performed a retrospective review of the 2008 to 2012 data from the Korea National Health andNutrition Examination Survey. Subjects aged ≥19 years with an evaluable fundus photograph of at least oneeye were enrolled, and open-angle glaucoma was diagnosed according to modified International Society ofGeographical and Epidemiological Ophthalmology criteria. In subjects with open-angle glaucoma, locations ofRNFLDs were evaluated, and systemic and ocular factors were compared between the bilateral superotemporalRNFLD group and bilateral inferotemporal RNFLD group. Results: A total of 534 subjects had open-angle glaucoma with RNFLDs. The unilateral inferotemporal region(25.8%) was the most common location for RNFLDs, followed by the unilateral superotemporal region (24.4%). Multivariate analysis revealed that hypertension was more significantly associated (p = 0.048) with the bilateralsuperotemporal RNFLD group than with the bilateral inferotemporal RNFLD group. Conclusions: Superotemporal RNFLDs are more related to hypertension than are inferotemporal RNFLDs.
Abstract
Purpose: To investigate the location of retinal nerve fiber layer defects (RNFLDs) in open-angle glaucoma andthe differences in systemic and ocular factors between superotemporal and inferotemporal RNFLDs. Methods: We performed a retrospective review of the 2008 to 2012 data from the Korea National Health andNutrition Examination Survey. Subjects aged ≥19 years with an evaluable fundus photograph of at least oneeye were enrolled, and open-angle glaucoma was diagnosed according to modified International Society ofGeographical and Epidemiological Ophthalmology criteria. In subjects with open-angle glaucoma, locations ofRNFLDs were evaluated, and systemic and ocular factors were compared between the bilateral superotemporalRNFLD group and bilateral inferotemporal RNFLD group. Results: A total of 534 subjects had open-angle glaucoma with RNFLDs. The unilateral inferotemporal region(25.8%) was the most common location for RNFLDs, followed by the unilateral superotemporal region (24.4%). Multivariate analysis revealed that hypertension was more significantly associated (p = 0.048) with the bilateralsuperotemporal RNFLD group than with the bilateral inferotemporal RNFLD group. Conclusions: Superotemporal RNFLDs are more related to hypertension than are inferotemporal RNFLDs.
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