본문 바로가기
KERD
논문KCI 등재

소아 알레르기 환자에서 혈청 흉선과 활동화 조절 케모카인, 대식세포 유래 케모카인의 상승과 호산구 염증지표와의 연관성

Elevated Serum Levels of Thymus and Activation-Regulated Chemokine and Macrophage-Derived Chemokine and Their Relationships with Eosinophilic Inflammatory Markers in Children with Allergic Diseases

2

조회

0

다운로드

1

인용

0

참고문헌

키워드

주제분류임상병리학

초록

Background: Thymus and activation-regulated chemokine (CCL17) and macrophage-derived chemokine (CCL22) are known as important mediators in allergic inflammation. Recently many researchers have focused on these mediators,but the role of the serum CCL17 and CCL22 in allergic diseases in children are still controversial. The aims of this study were to compare serum levels of CCL17 and CCL22between children with different manifestation of allergic diseases,such as bronchial asthma, allergic rhinitis and atopic dermatitis, to analyze relationship with blood eosinophil makers and to find clinical significance of these markers. Methods: A total of 49 children (14 bronchial asthma, 13allergic rhinitis and 13 atopic dermatitis) and the 9 healthy control subjects were enrolled in this study. Clinical characteristics and serum chemokine (CCL17, CCL22) levels were analyzed. We examined whether serum levels of CCL17 and CCL22 would be related to serum immunoglobulin E levels,blood eosinophils and serum eosinophil cationic protein concentrations. Results: Serum levels of CCL17 and CCL22 were significantly higher in children with bronchial asthma and atopic dermatitis than that in controls. Serum levels of CCL17and CCL22 were significantly related to serum immunoglobulin E levels, blood eosinophil counts and serum eosinophil cationic protein concentrations with different strength in children with allergic diseases. Conclusion: Serum CCL17 and CCL22 may play a crucial role in the chronic allergic inflammatory process and can be used as inflammatory markers. These suggest that serum CCL17 and CCL22 might be involved in the pathophysiology of allergic diseases in children.

Abstract

Background: Thymus and activation-regulated chemokine (CCL17) and macrophage-derived chemokine (CCL22) are known as important mediators in allergic inflammation. Recently many researchers have focused on these mediators,but the role of the serum CCL17 and CCL22 in allergic diseases in children are still controversial. The aims of this study were to compare serum levels of CCL17 and CCL22between children with different manifestation of allergic diseases,such as bronchial asthma, allergic rhinitis and atopic dermatitis, to analyze relationship with blood eosinophil makers and to find clinical significance of these markers. Methods: A total of 49 children (14 bronchial asthma, 13allergic rhinitis and 13 atopic dermatitis) and the 9 healthy control subjects were enrolled in this study. Clinical characteristics and serum chemokine (CCL17, CCL22) levels were analyzed. We examined whether serum levels of CCL17 and CCL22 would be related to serum immunoglobulin E levels,blood eosinophils and serum eosinophil cationic protein concentrations. Results: Serum levels of CCL17 and CCL22 were significantly higher in children with bronchial asthma and atopic dermatitis than that in controls. Serum levels of CCL17and CCL22 were significantly related to serum immunoglobulin E levels, blood eosinophil counts and serum eosinophil cationic protein concentrations with different strength in children with allergic diseases. Conclusion: Serum CCL17 and CCL22 may play a crucial role in the chronic allergic inflammatory process and can be used as inflammatory markers. These suggest that serum CCL17 and CCL22 might be involved in the pathophysiology of allergic diseases in children.

참고문헌 (35)

  1. Lam KP, "Inhibitory effects of albuterol and fenoterol on RANTES and IP-10 expression in bronchial epithelial cells", Pediatr Allergy Immunol, 22, pp.431~439 (2011)
  2. Shimada Y, "Both Th2 and Th1 chemokines (TARC", CCL17, MDC, CXCL9) are elevated in sera from patients with atopic dermatitis, pp.J Dermatol Sci, 2004[DOI]
  3. Romagnani S, "The role of lymphocytes in allergic disease", J Allergy Clin Immunol, 105, pp.399~408 (2000)
  4. Commins SP, "Immunologic messenger molecules: cytokines, interferons, and chemokines", J Allergy Clin Immunol, 125, pp.S53~S72 (2010)
  5. Huang CH, "Effect of procaterol on Th2-related chemokines production in human monocyte and bronchial epithelial cells", Pediatr Pulmonol, 45, pp.977~984 (2010)
  6. Leung TF, "Plasma concentration of thymus and activation-regulated chemokine is elevated in childhood asthma", J Allergy Clin Immunol, 110, pp.404~409 (2002)
  7. Sugawara N, "TARC in allergic disease", Allergy, 57, pp.180~181 (2002)
  8. Leung TF, "Plasma TARC concentration may be a useful marker for asthmatic exacerbation in children", Eur Respir J, 21, pp.616~620 (2003)
  9. Vestergaard C, "A Th2 chemokine, TARC, produced by keratinocytes may recruit CLA+CCR4+ lymphocytes into lesional atopic dermatitis skin", J Invest Dermatol, 115, pp.640~646 (2000)
  10. Terada N, "Expression of C-C chemokine TARC in human nasal mucosa and its regulation by cytokines", Clin Exp Allergy, 31, pp.1923~1931 (2001)
  11. Kakinuma T, "Thymus and activation-regulated chemokine in atopic dermatitis: Serum thymus and activation-regulated chemokine level is closely related with disease activity", J Allergy Clin Immunol, 107, pp.535~541 (2001)
  12. Fujisawa T, "Presence of high contents of thymus and activation-regulated chemokine in platelets and elevated plasma levels of thymus and activation-regulated chemokine and macrophage- derived chemokine in patients with atopic dermatitis", J Allergy Clin Immunol, 110, pp.139~146 (2002)
  13. Hijnen D, "Serum thymus and activation-regulated chemokine (TARC) and cutaneous T cell- attracting chemokine (CTACK) levels in allergic diseases: TARC and CTACK are disease-specific markers for atopic dermatitis", J Allergy Clin Immunol, 113, pp.334~340 (2004)
  14. Fujisawa T, "Serum measurement of thymus and activation- regulated chemokine", CCL17 in children with atopic dermatitis: elevated normal levels in infancy and age-specific analysis in atopic dermatitis, 2009, pp.20, 633~641
  15. Kakinuma T, "Serum macrophage-derived chemokine (MDC) levels are closely related with the disease activity of atopic dermatitis", Clin Exp Immunol, 127, pp.270~273 (2002)
  16. Lloyd CM, "CC chemokine receptor (CCR)3", eotaxin is followed by CCR4, J Exp Med, pp.2000, 191[DOI]
  17. Brozek JL, "Global Allergy and Asthma European Network; Grading of Recommendations Assessment, Development and Evaluation Working Group. Allergic Rhinitis and its Impact on Asthma (ARIA) guidelines: 2010 revision", J Allergy Clin Immunol, 126, pp.466~476 (2010)
  18. Hanifin JM, "Diagnostic features of atopic dermatitis", Acta Derm Venereol (Stockh), 92, pp.44~47 (1980)
  19. "Severity scoring of atopic dermatitis: the SCORAD index. Consensus Report of the European Task Force on Atopic Dermatitis", Dermatology, 186, pp.23~31 (1993)
  20. 장여순, "아토피피부염에서 특이 알레르겐에 따른 Chemokines의 상관성의 차이", Allergy Asthma & Respiratory Diseases, 17(4), pp.404~411 (2007), 대한 소아알레르기 호흡기학회
  21. Brown WG, "The relationship of respiratory allergy, skin test reactivity, and serum IgE in a community population sample", J Allergy Clin Immunol, 63, pp.328~335 (1979)
  22. Backman A, "Skin tests for epidemiologic studies", Allergy, 49, pp.493~494 (1994)
  23. "Standardization of Spirometry, 1994 Update. American Thoracic Society", Am J Respir Crit Care Med, 152, pp.1107~1136 (1995)
  24. Chai H, "Standardization of bronchial inhalation challenge procedures", J Allergy Clin Immunol, 56, pp.323~327 (1975)
  25. Song TW, "Increased serum thymus and activation-regulated chemokine and cutaneous T cell-attracting chemokine levels in children with atopic dermatitis", Clin Exp Allergy, 36, pp.346~351 (2006)
  26. Hamid Q, "Immunobiology of asthma", Annu Rev Physiol, 71, pp.489~507 (2009)
  27. Sallusto F, "Flexible programs of chemokine receptor expression on human polarized T helper 1 and 2 lymphocytes", J Exp Med, 187, pp.875~883 (1998)
  28. Hartl D, "Pulmonary chemokines and their receptors differentiate children with asthma and chronic cough", J Allergy Clin Immunol, 115, pp.728~736 (2005)
  29. Berin MC, "Regulated production of the T helper 2-type T-cell chemoattractant TARC by human bronchial epithelial cells in vitro and in human lung xenografts", Am J Respir Cell Mol Biol, 24, pp.382~389 (2001)
  30. Sekiya T, "Inducible expression of a Th2-type CC chemokine thymus- and activation-regulated chemokine by human bronchial epithelial cells", J Immunol, 165, pp.2205~2213 (2000)
  31. Yanai M, "The role of CCL22", macrophage-derived chemokine in allergic rhinitis, 2007, pp.125, 291~298
  32. Takeuchi H, "Changes in thymus- and activation-regulated chemokine (TARC) associated with allergen immunotherapy in patients with perennial allergic rhinitis", J Investig Allergol Clin Immunol, 15, pp.172~176 (2005)
  33. Furukawa H, "Enhanced TARC production by dust-mite allergens and its modulation by immunosuppressive drugs in PBMCs from patients with atopic dermatitis", J Dermatol Sci, 35, pp.35~42 (2004)
  34. Leung TF, "Serum concentration of macrophage-derived chemokine may be a useful inflammatory marker for assessing severity of atopic dermatitis in infants and young children", Pediatr Allergy Immunol, 14, pp.296~301 (2003)
  35. Machura E, "Serum TARC and CTACK concentrations in children with atopic dermatitis, allergic asthma, and urticaria", Pediatr Allergy Immunol, 23, pp.278~284 (2012)

관련 논문AI추천

아토피피부염 환아에서 혈청 TARC(Thymus andActivation-Regulated Chemokine)의 증가권병철, 김경원, 김규언, 김은수, 손명현, 송태원, 신윤호, 양혜선, 이경은, 최성연대한 소아알레르기 호흡기학회 · Allergy Asthma & Respiratory Disease2005 · 제15권 제3호아토피피부염 환자에서 혈중 케모카인 농도와 SCORAD 점수의 상관관계우성일, 최종성, 한윤수대한 소아알레르기 호흡기학회 · Allergy Asthma & Respiratory Disease2007 · 제17권 제4호소아 천식에서 유도 객담 내 CXCL13의 의의김경원, 김규언, 박여훈, 백지영, 손명현, 이용주, 최봉석대한 소아알레르기 호흡기학회 · Allergy Asthma & Respiratory Disease2009 · 제19권 제4호학동기 전 소아 아토피피부염에서 Thymus and Activation-Regulated Chemokine /CCL17과 삶의 질, 주의력결핍-과잉행동장애와의 관계김덕수, 박동혁, 박문수, 심재원, 심정연, 정선희, 정혜림대한 소아알레르기 호흡기학회 · Allergy Asthma & Respiratory Disease2011 · 제21권 제3호소아 천식군과 영유아 천명군에서 혈청 내 가용성 ST2 상승의 의의박혜진, 이계향, 이은주, 이형직, 정혜리, 추미애, 홍석진대한 소아알레르기 호흡기학회 · Allergy Asthma & Respiratory Disease2013 · 제1권 제4호아토피피부염에서 특이 알레르겐에 따른 Chemokines의 상관성의 차이김창렬, 염명걸, 오재원, 이하백, 장여순, 정은영대한 소아알레르기 호흡기학회 · Allergy Asthma & Respiratory Disease2007 · 제17권 제4호

이 간행물의 다른 논문 (12건)