아토피피부염 환아에서 혈청 TARC(Thymus andActivation-Regulated Chemokine)의 증가
Increased Serum Thymus and Activation-regulated Chemokine(TARC) Levels in Children with Atopic
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초록
목 적 : TARC(thymus and activation-regulated chemokine)는 Th2 세포를 알레르기 염증이 발생한 장소로 이동시키는 역할을 하는 케모카인의 일종이다. 본 연구의 목적은 TARC가 소아의 아토피피부염을 진단하고 중증도를 선별하는 지표로 유용한지를 알아보고, 연령에 따른 TARC의 농도변화를 알아보고자 한다.방 법 : IgE 매개성 아토피피부염 환아 157명, 비 IgE 매개성 아토피피부염 환아 107명, 정상 대조군 137명을 대상으로 혈청 TARC의 농도와 총 IgE 농도, 호산구수, 특이 IgE를 측정하였다.결 과 : 아토피피부염 환아에서 혈청 TARC의 농도는 정상대조군의 환아들에 비해 유의하게 높았다.(152.9±11.6 vs 56.7±5.2 pg/mL, P< 0.05) 혈청 TARC의 농도는 IgE 매개성 아토피피부염 환아(r=0.670, P<0.05)와 비 IgE 매개성 아토피피부염 환아(r=0.605, P<0.05) 모두에서 질병의 중증도와 유의한 상관관계를 보였다. 정상 대조군에서 혈청TARC의 농도는 연령의 증가에 따라 감소하는 경향을 보였다.(r=-0.201, P<0.05)결 론:본 연구에서 소아의 IgE 매개성 아토피피부염과 비 IgE 매개성 아토피피부염 모두에서 혈청 TARC의 농도가 질병의 진단 및 중증도 평가에 객관적인 지표로 사용될 수 있음을 알 수 있었다. 또한 정상 대조군에서 혈청 TARC의 농도가 연령의 증가에 따라 감소하는 경향을 보였다.
Abstract
Purpose : Thymus and activation-regulated chemokine(TARC) is responsible for the trafficking of Th2 lymphocytes into sites of allergic inflammation. We tested whether TARC is a useful marker for childhood atopic dermatitis(AD) and we evaluated age-related differences in the level of TARC. Methods : Serum TARC level, serum total IgE level, total eosinophil count and specific IgE level were measured in 401 children. They were characterized as having IgE-mediated atopic dermatitis(n=157), non-IgE mediated atopic dermatitis(n=107), or as healthy control subjects(n=137). Results : TARC levels in AD significantly were higher than those in healthy control subjects.(152.9±11.6 vs 56.7±5.2 pg/mL, P<0.05) Serum TARC levels significantly correlated with disease severity(SCORAD index) both in children with IgE mediated AD(r=0.670, P< 0.05) and children with non-IgE mediated AD.(r=0.605, P<0.05) Serum TARC levels in control subjects decreased in accordance with age.(r=-0.201, P<0.05) Conclusion : Serum TARC might be a useful marker for disease severity both in children with IgE mediated AD and children with non-IgE mediated AD. Serum TARC levels in control subjects decreased in accordance with ages.
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