서울지역 의과대학 학생에서 흔한 흡입성 알레르겐에 대한 감작률과 기도과민성의 유병률
Prevalence of Sensitization Rates to Inhalant Allergens and Airway Hyperresponsiveness among Medical Students in Seoul
2
조회
0
다운로드
6
인용
0
참고문헌
키워드
초록
Background: Sensitization to aeroallergens and airway hyperresponsiveness (AHR) are major risk factors for respiratory allergies such as allergic rhinitis and asthma. The frequency of positive skin tests differs depending on countries and environmental exposure. While skin test positivity has been studied in patients with asthma or respiratory symptoms, there have been few reports on sensitization rates to aeroallergens and AHR in the general population in Korea. Objective: In this study, we aimed to assess skin test positivity to common aeroallergens and AHR in medical students living in Seoul with or without respiratory allergy. Method: In medical students aged 21∼36 years respiratory allergy was assessed by the questionnaire regarding the previous diagnosis of allergic rhinitis and asthma. Skin prick testing was performed for 10 common aeroallergens. A positive response was defined as a wheal diameter greater or equal to that of histamine. AHR was determined based on the results of methacholine bronchial provocation tests. Result: The prevalence of allergic rhinitis and asthma in 227 subjects was estimated as 20.7% and 4.4%, respectively. Atopy, which was defined as a positive response to 1 or more allergens on skin test, was present in 48.0% of the population and common aeroallergens were as follows: Dermatophagoides pteronyssinus (37.9%), Dermatophagoides farinae (35.7%), Tyrophagus putrescentiae (8.8%), cat (7.0%), mugwort (6.2%), cockroach (3.5%), ragweed (3.5%), dog (3.5%), Alternaria (3.5%) and Aspergillus (2.2%). Subjects with respiratory allergy showed higher rates of atopy (74.5% vs. 40.3%, P＜0.001) and AHR (31.4% vs. 6.8%, P＜0.001) than those without. AHR was found in 12.2% of the subjects and was significantly associated with atopy and the sensitization to mite allergens. Conclusion: This study shows a significantly high prevalence of atopy and AHR among young medical students in Seoul with or without respiratory allergy. These findings suggest a recent high prevalence of atopy and AHR in young populations in Korea.
Abstract
Background: Sensitization to aeroallergens and airway hyperresponsiveness (AHR) are major risk factors for respiratory allergies such as allergic rhinitis and asthma. The frequency of positive skin tests differs depending on countries and environmental exposure. While skin test positivity has been studied in patients with asthma or respiratory symptoms, there have been few reports on sensitization rates to aeroallergens and AHR in the general population in Korea. Objective: In this study, we aimed to assess skin test positivity to common aeroallergens and AHR in medical students living in Seoul with or without respiratory allergy. Method: In medical students aged 21∼36 years respiratory allergy was assessed by the questionnaire regarding the previous diagnosis of allergic rhinitis and asthma. Skin prick testing was performed for 10 common aeroallergens. A positive response was defined as a wheal diameter greater or equal to that of histamine. AHR was determined based on the results of methacholine bronchial provocation tests. Result: The prevalence of allergic rhinitis and asthma in 227 subjects was estimated as 20.7% and 4.4%, respectively. Atopy, which was defined as a positive response to 1 or more allergens on skin test, was present in 48.0% of the population and common aeroallergens were as follows: Dermatophagoides pteronyssinus (37.9%), Dermatophagoides farinae (35.7%), Tyrophagus putrescentiae (8.8%), cat (7.0%), mugwort (6.2%), cockroach (3.5%), ragweed (3.5%), dog (3.5%), Alternaria (3.5%) and Aspergillus (2.2%). Subjects with respiratory allergy showed higher rates of atopy (74.5% vs. 40.3%, P＜0.001) and AHR (31.4% vs. 6.8%, P＜0.001) than those without. AHR was found in 12.2% of the subjects and was significantly associated with atopy and the sensitization to mite allergens. Conclusion: This study shows a significantly high prevalence of atopy and AHR among young medical students in Seoul with or without respiratory allergy. These findings suggest a recent high prevalence of atopy and AHR in young populations in Korea.
참고문헌 (18)
- Eder W, "The asthma epidemic", N Engl J Med, 355, pp.2226~2235 (2006)
- 김태범, "흡입 알레르겐에 대한 감작율: 다기관 공동연구", 천식 및 알레르기, 23(3), pp.483~493 (2003), 대한천식알레르기학회
- 김영진, "호흡기 알레르기 질환을 가진 소아에서 최근10년간 흡입항원 감작의 변화", 천식 및 알레르기, 24(2), pp.241~246 (2004), 대한천식알레르기학회
- 김경호, "부산지역 호흡기 알레르기 환자에서 흡입 알레르겐에 대한 감작률", 천식 및 알레르기, 25(1), pp.59~63 (2005), 대한천식알레르기학회
- Kim CW, "Changing patterns of skin reactivity to inhalant allergens in asthmatic patients", J Asthma Allergy Clin Immunol, 21, pp.205~215 (2001)
- Kim YY, "Prevalence of childhood asthma based on questionnaires and methacholine bronchial provocation test in Korea", Clin Exp Allergy, 27, pp.761~768 (1997)
- Kim YK, "High prevalence of current asthma and active smoking effect among the elderly", Clin Exp Allergy, 32, pp.1706~1712 (2002)
- Beggs PJ, "Is the global rise of asthma an early impact of anthropogenic climate change?", Environ Health Perspect, 113, pp.915~919 (2005)
- Crapo RO, "Guidelines for methacholine and exercise challenge testing-1999. in: This official statement of the American Thoracic Society was adopted by the ATS Board of Directors, July 1999", Am J Respir Crit Care Med, 161, pp.309~329 (2000)
- Jang AS, "Epidemiologic evidence of a relationship between airway hyperresponsiveness and exposure to polluted air", Allergy, 58, pp.585~588 (2003)
- Yoo Y, "The prevalence of atopy and asthma among university freshmen in Seoul, Korea: association with obesity", J Asthma, 44, pp.45~49 (2007)
- Dottorini ML, "Skin prick-test reactivity to aeroallergens and allergic symptoms in an urban population of central Italy: a longitudinal study", Clin Exp Allergy, 37, pp.188~196 (2007)
- Shea KM, "Climate change and allergic disease", J Allergy Clin Immunol, 122, pp.443~453 (2008)
- 김봉성, "한국 3개 지역 고등학생에서 알레르기질환의 유병률에 대한 조사", 천식 및 알레르기, 27(3), pp.168~175 (2007), 대한천식알레르기학회
- Grootendorst DC, "Mechanisms of bronchial hyperreactivity in asthma and chronic obstructive pulmonary disease", Proc Am Thorac Soc, 통권 : 1, pp.77~87 (2004)
- Laprise C, "Asymptomatic airway hyperresponsiveness: relationships with airway inflammation and remodelling", Eur Respir J, 14, pp.63~73 (1999)
- Choi SH, "Bronchial hyperresponsiveness in young children with allergic rhinitis and its risk factors", Allergy, 62, pp.1051~1056 (2007)
- Mete N, "The determinants of bronchial hyperresponsiveness in patients with allergic rhinitis", Ann Allergy Asthma Immunol, 93, pp.193~199 (2004)