서울지역 단일 3차병원 천식 및 알레르기비염 소아의 흡입항원 감작률에 대한 10년간의 변화
Changes of aeroallergen sensitization in children with asthma or allergic rhinitis from a tertiary referral hospital in Seoul over 10 years
2
조회
0
다운로드
12
인용
0
참고문헌
키워드
초록
Purpose: Allergic diseases have been increased in Korea. The aim of this study was to investigate the changes of sensitization rate to inhalant allergens over 10 years in children with allergic diseases from a tertiary referral hospital. Methods: Skin prick tests were done in total 2,225 children in 2000, 2005, and 2010. Changes of skin reactivity to 12 major inhalant allergens, including Tree pollen mixture I (Alder, Elm, Hazel, Poplar, Willow), Tree pollen mixture II (Beech, Birch, Oak, Plane tree), Dermatophagoides pteronyssinus, Dermatophagoides farina, Alternaria, cat dander, and dog dander were investigated. Results: The sensitization rates to Tree pollen mixture I and II were increased as 5.0%, 6.8% in 2000, 8.5%, 9.8% in 2005, and 14.8%, 17.3% in 2010, respectively (trend P<0.001, P<0.001, respectively). And the sensitization rates to D. pteronyssinus cat dander and dog dander were changed as 55%, 4.8%, 4.8% in 2000, 62.2%, 11.9%, 28% in 2005, and 63.1%, 12.7%, 16.7% in 2010, respectively. The distribution of sensitized pollens was oak (12.8%), beech (12.4%), pine (10.3%), birch (10%), hazel (9.6%), alder (8%), elder (6.9%), elm (5.4%) in the study of 2010. When allergen/histamine ratio was compared, rates of strong sensitization over 4+ to tree pollen were increased. Conclusion: The sensitization rates to inhalant allergens were increased in children with asthma or allergic rhinitis from a tertiary referral hospital in Seoul over last 10 years. Especially, an increase in the degree of skin reactivity was observed in cat dander, dog dander, and tree pollens. The studies to investigate the etiology of this increase and prevention will be needed.
Abstract
Purpose: Allergic diseases have been increased in Korea. The aim of this study was to investigate the changes of sensitization rate to inhalant allergens over 10 years in children with allergic diseases from a tertiary referral hospital. Methods: Skin prick tests were done in total 2,225 children in 2000, 2005, and 2010. Changes of skin reactivity to 12 major inhalant allergens, including Tree pollen mixture I (Alder, Elm, Hazel, Poplar, Willow), Tree pollen mixture II (Beech, Birch, Oak, Plane tree), Dermatophagoides pteronyssinus, Dermatophagoides farina, Alternaria, cat dander, and dog dander were investigated. Results: The sensitization rates to Tree pollen mixture I and II were increased as 5.0%, 6.8% in 2000, 8.5%, 9.8% in 2005, and 14.8%, 17.3% in 2010, respectively (trend P<0.001, P<0.001, respectively). And the sensitization rates to D. pteronyssinus cat dander and dog dander were changed as 55%, 4.8%, 4.8% in 2000, 62.2%, 11.9%, 28% in 2005, and 63.1%, 12.7%, 16.7% in 2010, respectively. The distribution of sensitized pollens was oak (12.8%), beech (12.4%), pine (10.3%), birch (10%), hazel (9.6%), alder (8%), elder (6.9%), elm (5.4%) in the study of 2010. When allergen/histamine ratio was compared, rates of strong sensitization over 4+ to tree pollen were increased. Conclusion: The sensitization rates to inhalant allergens were increased in children with asthma or allergic rhinitis from a tertiary referral hospital in Seoul over last 10 years. Especially, an increase in the degree of skin reactivity was observed in cat dander, dog dander, and tree pollens. The studies to investigate the etiology of this increase and prevention will be needed.
참고문헌 (28)
- Weinmayr G, "International variation in prevalence of rhinitis and its relationship with sensitisation to perennial and seasonal allergens", Eur Respir J, 32, pp.1250~1261 (2008)
- Pearce N, "Worldwide trends in the prevalence of asthma symptoms: phase III of the International Study of Asthma and Allergies in Childhood (ISAAC)", Thorax, 62, pp.758~766 (2007)
- 오재원, "알레르기 화분의 특성과 최근 소아에서 잡초류 화분의 감작률 증가", Korean Journal of Pediatrics, 51(4), pp.355~361 (2008), 대한소아과학회
- 서미나, "Prevalence of Allergic Diseases among Korean School-age Children: A Nationwide Cross-Sectional Questionnaire Study", Journal of Korean Medical Science, 26(3), pp.332~338 (2011), 대한의학회
- Hong SJ, "Self-reported prevalence and risk factors of asthma among Korean adolescents: 5-year follow-up study, 1995-2000", Clin Exp Allergy, 34, pp.1556~1562 (2004)
- Lee SI, "Prevalences of symptoms of asthma and other allergic diseases in korean children: a nationwide questionnaire survey", J Korean Med Sci, 16, pp.155~164 (2001)
- Lee JY, "Exposure to gene-environment interactions before 1 year of age may favor the development of atopic dermatitis", Int Arch Allergy Immunol, 157, pp.363~371 (2012)
- 권지원, "Changes in the Prevalence of Childhood Asthma in Seoul from 1995 to 2008 and Its Risk Factors", Allergy, Asthma & Immunology Research, 3(1), pp.27~33 (2011), 대한천식알레르기학회
- Yi O, "Effect of environmental tobacco smoke on atopic dermatitis among children in Korea", Environ Res, 113, pp.40~45 (2012)
- Anderson HR, "Ambient particulate pollution and the world-wide prevalence of asthma, rhinoconjunctivitis and eczema in children: Phase One of the International Study of Asthma and Allergies in Childhood (ISAAC)", Occup Environ Med, 67, pp.293~300 (2010)
- Wickens K, "Fast foods - are they a risk factor for asthma?", Allergy, 60, pp.1537~1541 (2005)
- 김주화, "Changes in Sensitization Rate to Weed Allergens in Children with Increased Weeds Pollen Counts in Seoul Metropolitan Area", Journal of Korean Medical Science, 27(4), pp.350~355 (2012), 대한의학회[DOI]
- 오재원, "The Revised Edition of Korean Calendar for Allergenic Pollens", Allergy, Asthma & Immunology Research, 4(1), pp.5~11 (2012), 대한천식알레르기학회
- 정경용, "House Dust Mite Allergy in Korea: The Most Important Inhalant Allergen in Current and Future", Allergy, Asthma & Immunology Research, 4(6), pp.313~325 (2012), 대한천식알레르기학회
- Morris DO, "Human allergy to environmental pet danders: a public health perspective", Vet Dermatol, 21, pp.441~449 (2010)
- Lockey RF, "The myth of hypoallergenic dogs (and cats)", J Allergy Clin Immunol, 130, pp.910~911 (2012)
- 김민희, "고양이할큄병: 증례보고와 사람과 동물을 대상으로 한 국내문헌 고찰", Infection and Chemotherapy, 44(4), pp.299~302 (2012), 대한감염학회
- 2011 Statistics Annual Report for Food, Agriculture, Forestry and Fisheries, "Ministry for Food", Ministry for Food, Agriculture, Forestry and Fisheries, 126~133 (2011)
- Kerkhof M, "Effects of pets on asthma development up to 8 years of age: the PIAMA study", Allergy, 64, pp.1202~1208 (2009)
- Custovic A, "Current mite, cat, and dog allergen exposure, pet ownership, and sensitization to inhalant allergens in adults", J Allergy Clin Immunol, 111, pp.402~407 (2003)
- Carlsten C, "Combined exposure to dog and indoor pollution: incident asthma in a high-risk birth cohort", Eur Respir J, 37, pp.324~330 (2011)
- 최민환, "학동전기 소아에서 흡입항원에의 감작과 알레르기질환과의 연관성", 천식 및 알레르기, 32(3), pp.176~182 (2012), 대한천식알레르기학회
- 이진우, "1999년, 2005년, 2008년 피부반응검사 분석을 통해 본 지난 10년간 경기 남부지역 대학병원에 내원한 알레르기 환자의 화분 알레르겐 감작률의 변화", 천식 및 알레르기, 31(1), pp.33~40 (2011), 대한천식알레르기학회
- So Hyun Park, "Sensitization rates of airborne pollen and mold in children", Korean Journal of Pediatrics, 55(9), pp.372~379 (2012), 대한소아과학회
- 양현종, "기후 변화가 대기 중 알레르겐과 소아알레르기 질환에 미치는 영향", 대한의사협회지, 54(9), pp.971~978 (2011), 대한의사협회
- 오재원, "소아 알레르기 유발 가능성과 화분(꽃가루)농도와의 관련성", Allergy Asthma & Respiratory Diseases, 19(1), pp.4~11 (2009), 대한 소아알레르기 호흡기학회
- 오재원, "소아에서 잡초류 알레르기 감작률의 증가와 알레르기성 잡초류의 연중 화분량과의 상관관계", Allergy Asthma & Respiratory Diseases, 16(2), pp.114~121 (2006), 대한 소아알레르기 호흡기학회
- 김지현, "Sensitization to Aeroallergens in Korean Children: A Populationbased Study in 2010", Journal of Korean Medical Science, 26(9), pp.1165~1172 (2011), 대한의학회