인천과 아산지역 소아청소년의 흡입 알레르겐 감작률 및 다항원 감작과 알레르기질환 발병과의 관계
Sensitization rates to inhalant allergens in children and adolescents of Incheon and Asan area and the relationship between polysensitization and prevalence of allergic diseases
2
조회
0
다운로드
8
인용
0
참고문헌
키워드
초록
Purpose: Sensitization to allergens is considered as major mechanism of allergy and related to the development of allergic diseases. The objective of this study was to evaluate overall sensitization rates of inhalant allergens and the relationship between polysensitization and prevalence of allergic diseases in children and adolescents. Methods: A cross-sectional pilot study of 122 elementary school students, 114 middle school students, and 115 high school students from Incheon and Asan was conducted by using the International Study of Asthma and Allergies in Childhood (ISSAC) questionnaire. The skin prick tests were performed with 14 common inhalant allergens on 339 students. Results: The inhalant allergen that has a significantly different sensitization rate according to age was Dermatophagoides farinae. And the inhalant allergen that has significantly different sensitization rate according to region was Japanese hop. In addition, girls have higher sensitization rate to any mold allergens than boys. In case of having sensitization more than two allergens, the risks of diagnosis of asthma and allergic rhinitis on questionnaire were increased. Asthma is related to sensitization of dog or cat and allergic rhinitis is related to sensitization of house dust mites. However, atopic dermatitis is not related to sensitization of any inhalant allergens. Conclusion: The sensitization rates of inhalant allergens may differ among age, gender, and region in children and adolescents of Incheon and Asan area. The polysensitized children and adolescents with inhalant allergens showed higher prevalences of allergic diseases such as asthma and allergic rhinitis on questionnaire than monosensitized group.
Abstract
Purpose: Sensitization to allergens is considered as major mechanism of allergy and related to the development of allergic diseases. The objective of this study was to evaluate overall sensitization rates of inhalant allergens and the relationship between polysensitization and prevalence of allergic diseases in children and adolescents. Methods: A cross-sectional pilot study of 122 elementary school students, 114 middle school students, and 115 high school students from Incheon and Asan was conducted by using the International Study of Asthma and Allergies in Childhood (ISSAC) questionnaire. The skin prick tests were performed with 14 common inhalant allergens on 339 students. Results: The inhalant allergen that has a significantly different sensitization rate according to age was Dermatophagoides farinae. And the inhalant allergen that has significantly different sensitization rate according to region was Japanese hop. In addition, girls have higher sensitization rate to any mold allergens than boys. In case of having sensitization more than two allergens, the risks of diagnosis of asthma and allergic rhinitis on questionnaire were increased. Asthma is related to sensitization of dog or cat and allergic rhinitis is related to sensitization of house dust mites. However, atopic dermatitis is not related to sensitization of any inhalant allergens. Conclusion: The sensitization rates of inhalant allergens may differ among age, gender, and region in children and adolescents of Incheon and Asan area. The polysensitized children and adolescents with inhalant allergens showed higher prevalences of allergic diseases such as asthma and allergic rhinitis on questionnaire than monosensitized group.
참고문헌 (28)
- Downs SH, "Continued increase in the prevalence of asthma and atopy", Arch Dis Child, 84, pp.20~23 (2001)
- Johnson CC, "Environmental epidemiology of pediatric asthma and allergy", Epidemiol Rev, 24, pp.154~175 (2002)
- 권지원, "Changes in the Prevalence of Childhood Asthma in Seoul from 1995 to 2008 and Its Risk Factors", Allergy, Asthma & Immunology Research, 3(1), pp.27~33 (2011), 대한천식알레르기학회
- 서미나, "Prevalence of Allergic Diseases among Korean School-age Children: A Nationwide Cross-Sectional Questionnaire Study", Journal of Korean Medical Science, 26(3), pp.332~338 (2011), 대한의학회
- Dean T, "Patterns of sensitization to food and aeroallergens in the first 3 years of life", J Allergy Clin Immunol, 120, pp.1166~1171 (2007)
- Arbes SJ Jr, "Asthma cases attributable to atopy: results from the Third National Health and Nutrition Examination Survey", J Allergy Clin Immunol, 120, pp.1139~1145 (2007)
- Chan-Yeung M, "Early environmental determinants of asthma risk in a highrisk birth cohort", Pediatr Allergy Immunol, 19, pp.482~489 (2008)
- 김세훈, "알레르기 증상으로 내원한 한국인에서의 음식물 알레르겐에 대한 감작율 조사: 다기관 공동연구", 천식 및 알레르기, 23(3), pp.502~514 (2003), 대한천식알레르기학회
- 김영진, "호흡기 알레르기 질환을 가진 소아에서 최근10년간 흡입항원 감작의 변화", 천식 및 알레르기, 24(2), pp.241~246 (2004), 대한천식알레르기학회
- 최봉석, "소아 알레르기질환에서의 Tyrophagus putrescentiae 감작률", Allergy Asthma & Respiratory Diseases, 20(2), pp.107~113 (2010), 대한 소아알레르기 호흡기학회
- 이진우, "1999년, 2005년, 2008년 피부반응검사 분석을 통해 본 지난 10년간 경기 남부지역 대학병원에 내원한 알레르기 환자의 화분 알레르겐 감작률의 변화", 천식 및 알레르기, 31(1), pp.33~40 (2011), 대한천식알레르기학회
- 전봉희, "제주 소아 및 청소년의 아토피 및 흡입 알레르기항원에 대한 감작률", 천식 및 알레르기, 30(1), pp.14~20 (2010), 대한천식알레르기학회
- 정현희, "정읍시골, 정읍시, 서울시에서의 실내 항원감작과 인구 통계학적 특징의 관련성", 천식 및 알레르기, 30(4), pp.277~284 (2010), 대한천식알레르기학회
- 김지현, "Sensitization to Aeroallergens in Korean Children: A Populationbased Study in 2010", Journal of Korean Medical Science, 26(9), pp.1165~1172 (2011), 대한의학회
- So Hyun Park, "Sensitization rates of airborne pollen and mold in children", Korean Journal of Pediatrics, 55(9), pp.372~379 (2012), 대한소아과학회
- 김주화, "Changes in Sensitization Rate to Weed Allergens in Children with Increased Weeds Pollen Counts in Seoul Metropolitan Area", Journal of Korean Medical Science, 27(4), pp.350~355 (2012), 대한의학회
- Croner S, "Development of atopic disease in relation to family history and cord blood IgE levels. Eleven-year follow-up in 1654 children", Pediatr Allergy Immunol, 1, pp.14~20 (1990)
- Silvestri M, "Sensitization to airborne allergens in children with respiratory symptoms", Ann Allergy Asthma Immunol, 76, pp.239~244 (1996)
- Kyung Won Kim, "Comparison of Allergic Indices in Monosensitized and Polysensitized Patients with Childhood Asthma", Journal of Korean Medical Science, 21(6), pp.1012~1016 (2006), 대한의학회
- 이종호, "단일항원 감작군과 다항원 감작군의 임상 양상 및 알레르기 지표의 차이: 단일 기관 연구", Allergy Asthma & Respiratory Diseases, 21(4), pp.277~284 (2011), 대한 소아알레르기 호흡기학회
- 김경호, "부산지역 호흡기 알레르기 환자에서 흡입 알레르겐에 대한 감작률", 천식 및 알레르기, 25(1), pp.59~63 (2005), 대한천식알레르기학회
- Park HS, "Clinical and immunologic changes after allergen immunotherapy with Hop Japanese pollen", Ann Allergy Asthma Immunol, 86, pp.444~448 (2001)
- Roberts G, "Relationship between aeroallergen and food allergen sensitization in childhood", Clin Exp Allergy, 35, pp.933~940 (2005)
- Kim BS, "Airway hyperresponsiveness is associated with total serum immunoglobulin E and sensitization to aeroallergens in Korean adolescents", Pediatr Pulmonol, 45, pp.1220~1227 (2010)
- McGrath JA, "The filaggrin story: novel insights into skin-barrier function and disease", Trends Mol Med, 14, pp.20~27 (2008)
- Palmer CN, "Common loss-of-function variants of the epidermal barrier protein filaggrin are a major predisposing factor for atopic dermatitis", Nat Genet, 38, pp.441~446 (2006)
- Baurecht H, "Toward a major risk factor for atopic eczema: meta-analysis of filaggrin polymorphism data", J Allergy Clin Immunol, 120, pp.1406~1412 (2007)
- Elias PM, "Basis for the barrier abnormality in atopic dermatitis: outside-inside-outside pathogenic mechanisms", J Allergy Clin Immunol, 121, pp.1337~1343 (2008)