기관지천식에서 기계적 자극에 의한 기도재형성
Mechanical Stimuli to Airway Remodeling in Asthma
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Airway remodeling implies structural changes in the airways of patients with asthma. These changes are associated with poor long-term clinical outcomes and are attributed to chronic airway inflammation. However, some recent studies suggest that traditional anti-inflammatory therapies play a limited role in the modulation of airway remodeling. These findings have questioned the concept that persistent inflammation leads to airway remodeling. Growing evidence demonstrates that physical forces elicit a number of biologically relevant signals in the human body. The airway is exposed to a variety of mechanical stimuli, the most prominent of which is acute compressive stress caused by bronchoconstriction. A variety of in vitro studies have demonstrated that airway epithelial cells, as well as lung fibroblasts and smooth muscle cells, are responsive to mechanical stimuli. A recent in vivo study has shown that airway remodeling can be promoted simply by episodic administration of an inhaled bronchoconstrictor, methacholine. This result suggests another possibility of the association between airway remodeling and mechanical stimuli. However, further studies are required using well-designed, 3-dimensional in vitro experimental models as well as more patients with varying severities of asthma. These studies will help understand the interplay between mechanical and inflammatory contributions to airway remodeling.
Abstract
Airway remodeling implies structural changes in the airways of patients with asthma. These changes are associated with poor long-term clinical outcomes and are attributed to chronic airway inflammation. However, some recent studies suggest that traditional anti-inflammatory therapies play a limited role in the modulation of airway remodeling. These findings have questioned the concept that persistent inflammation leads to airway remodeling. Growing evidence demonstrates that physical forces elicit a number of biologically relevant signals in the human body. The airway is exposed to a variety of mechanical stimuli, the most prominent of which is acute compressive stress caused by bronchoconstriction. A variety of in vitro studies have demonstrated that airway epithelial cells, as well as lung fibroblasts and smooth muscle cells, are responsive to mechanical stimuli. A recent in vivo study has shown that airway remodeling can be promoted simply by episodic administration of an inhaled bronchoconstrictor, methacholine. This result suggests another possibility of the association between airway remodeling and mechanical stimuli. However, further studies are required using well-designed, 3-dimensional in vitro experimental models as well as more patients with varying severities of asthma. These studies will help understand the interplay between mechanical and inflammatory contributions to airway remodeling.
참고문헌 (38)
- Durrani SR, "What effect does asthma treatment have on airway remodeling? Current perspectives", J Allergy Clin Immunol, 128, pp.439~448 (2011)
- Al-Muhsen S, "Remodeling in asthma", J Allergy Clin Immunol, 128, pp.451~462 (2011)
- Hoshino M., "Impact of inhaled corticosteroids and leukotriene receptor antagonists on airway remodeling", Clin Rev Allergy Immunol, 27, pp.59~64 (2004)
- Payne DN, "Early thickening of the reticular basement membranein children with difficult asthma", Am J Respir Crit Care Med, 167, pp.78~82 (2003)
- Tschumperlin DJ, "Mechanical stimuli to airway remodeling", Am J Respir Crit Care Med, 164, pp.S90~S94 (2001)
- Tschumperlin DJ, "Mechanical stress triggers selective release of fibrotic mediators from bronchial epithelium", Am J Respir Cell Mol Biol, 28, pp.142~149 (2003)
- Choe MM, "Extracellular matrix remodeling by dynamic strain in a three-dimensional tissue-engineered human airway wall model", Am J Respir Cell Mol Biol, 35, pp.306~313 (2006)
- Park JA, "Chronic intermittent mechanical stress increases MUC5AC protein expression", Am J Respir Cell Mol Biol, 41, pp.459~466 (2009)
- Park JA, "The chitinase-like protein YKL-40 is secreted by airway epithelial cells at base line and in response to compressive mechanical stress", J Biol Chem, 285, pp.29817~29825 (2010)
- Grainge CL, "Effect of bronchoconstriction on airway remodeling in asthma", N Engl J Med, 364, pp.2006~2015 (2011)
- Jeffery PK, "Effects of treatment on airway inflammation and thickening of basement membrane reticular collagen in asthma. A quantitative light and electron microscopic study", Am Rev Respir Dis, 145, pp.890~899 (1992)
- Kamchorn N, "The pathology of bronchial asthma", Am J Med Sci, 30, pp.689~760 (1922)
- Wiggs BR, "On the mechanism of mucosal folding in normal and asthmatic airways", J Appl Physiol, 83, pp.1814~1821 (1997)
- Lambert RK, "Role of bronchial basement membrane in airway collapse", J Appl Physiol, 71, pp.666~673 (1991)
- Ressler B, "Molecular responses of rat tracheal epithelial cells to transmembrane pressure", Am J Physiol Lung Cell Mol Physiol, 278, pp.L1264~L1272 (2000)
- Liu M, "Mechanical force-induced signal transduction in lung cells", Am J Physiol, 277, pp.L667~L683 (1999)
- Sachs F, "Mechanical transduction by membrane ion channels: a mini review", Mol Cell Biochem, 104, pp.57~60 (1991)
- Kim YK, "Stretch-activated channels in airway epithelial cells", Am J Physiol, 265, pp.C1306~C1318 (1993)
- Ingber D, "Integrins as mechanochemical transducers", Curr Opin Cell Biol, 3, pp.841~848 (1991)
- Juliano RL, "Signal transduction from the extracellular matrix", J Cell Biol, 120, pp.577~585 (1993)
- Shibata Y, "Cellular detachment and deformation induce IL-8 gene expression in human bronchial epithelial cells", J Immunol, 156, pp.772~777 (1996)
- Hashimoto S, "Hyperosmolarity-induced interleukin-8 expression in human bronchial epithelial cells through p38 mitogen-activated protein kinase", Am J Respir Crit Care Med, 159, pp.634~640 (1999)
- Yoon JH, "Regulation of the secretory phenotype of human airway epithelium by retinoic acid, triiodothyronine, and extracellular matrix", Am J Respir Cell Mol Biol, 16, pp.724~731 (1997)
- Breen EC, "Calcyclin gene expression is increased by mechanical strain in fibroblasts and lung", Am J Respir Cell Mol Biol, 21, pp.746~752 (1999)
- Kato T, "Up-regulation of COX2 expression by uni-axial cyclic stretch in human lung fibroblast cells", Biochem Biophys Res Commun, 244, pp.615~619 (1998)
- Bishop JE, "Cyclic mechanical deformation stimulates human lung fibroblast proliferation and autocrine growth factor activity", Am J Respir Cell Mol Biol, 9, pp.126~133 (1993)
- Nam YH, "Cellular characteristics of primary bronchial fibroblasts in patients with asthma-expression of α-smooth muscle actin, fibronectin containing extra type III domain A and smothelin; a preliminary study", J Invest Allergol Clin Immunol (2012)
- Le Bellego F, "Mechanical strain increases cytokine and chemokine production in bronchial fibroblasts from asthmatic patients", Allergy, 64, pp.32~39 (2009)
- Smith PG, "Strain increases airway smooth muscle cell proliferation", Am J Respir Cell Mol Biol, 10, pp.85~90 (1994)
- Smith PG, "Strain increases airway smooth muscle contractile and cytoskeletal proteins in vitro", Am J Physiol, 272, pp.L20~L27 (1997)
- Smith PG, "Mechanical strain increases contractile enzyme activity in cultured airway smooth muscle cells", Am J Physiol, 268, pp.L999~L1005 (1995)
- Deng L, "Stress and strain in the contractile and cytoskeletal filaments of airway smooth muscle", Pulm Pharmacol Ther, 22, pp.407~416 (2009)
- Maksym GN, "Beneficial and harmful effects of oscillatory mechanical strain on airway smooth muscle", Can J Physiol Pharmacol, 83, pp.913~922 (2005)
- Maksym GN, "Mechanical properties of cultured human airway smooth muscle cells from 0.05 to 0.4 Hz", J Appl Physiol, 89, pp.1619~1632 (2000)
- Salome CM, "Airway re-narrowing following deep inspiration in asthmatic and nonasthmatic subjects", Eur Respir J, 22, pp.62~68 (2003)
- Zhang S, "Growth factors secreted by bronchial epithelial cells control myofibroblast proliferation: an in vitro co-culture model of airway remodeling in asthma", Lab Invest, 79, pp.395~405 (1999)
- Swartz MA, "Mechanical stress is communicated between different cell types to elicit matrix remodeling", Proc Natl Acad Sci U S A, 98, pp.6180~6185 (2001)
- Tschumperlin DJ, "Physical forces and airway remodeling in asthma", N Engl J Med, 364, pp.2058~2059 (2011)