Mouse phenogenomics, toolbox for functional annotation of human genome
2
조회
0
다운로드
2
인용
0
참고문헌
키워드
초록
Mouse models are crucial for the functional annotation of human genome. Gene modification techniques including gene targeting and gene trap in mouse have provided powerful tools in the form of genetically engineered mice (GEM) for understanding the molecular pathogenesis of human diseases. Several international consortium and programs are under way to deliver mutations in every gene in mouse genome. The information from studying these GEM can be shared through international collaboration. However, there are many limitations in utility because not all human genes are knocked out in mouse and they are not yet phenotypically characterized by standardized ways which is required for sharing and evaluating data from GEM. The recent improvement in mouse genetics has now moved the bottleneck in mouse functional genomics from the production of GEM to the systematic mouse phenotype analysis of GEM. Enhanced, reproducible and comprehensive mouse phenotype analysis has thus emerged as a prerequisite for effectively engaging the phenotyping bottleneck. In this review, current information on systematic mouse phenotype analysis and an issue-oriented perspective will be provided.
Abstract
Mouse models are crucial for the functional annotation of human genome. Gene modification techniques including gene targeting and gene trap in mouse have provided powerful tools in the form of genetically engineered mice (GEM) for understanding the molecular pathogenesis of human diseases. Several international consortium and programs are under way to deliver mutations in every gene in mouse genome. The information from studying these GEM can be shared through international collaboration. However, there are many limitations in utility because not all human genes are knocked out in mouse and they are not yet phenotypically characterized by standardized ways which is required for sharing and evaluating data from GEM. The recent improvement in mouse genetics has now moved the bottleneck in mouse functional genomics from the production of GEM to the systematic mouse phenotype analysis of GEM. Enhanced, reproducible and comprehensive mouse phenotype analysis has thus emerged as a prerequisite for effectively engaging the phenotyping bottleneck. In this review, current information on systematic mouse phenotype analysis and an issue-oriented perspective will be provided.
참고문헌 (76)
- Oliver, P. L., "Comparative genetic analysis: the utility of mouse genetic systems for studying human monogenic disease", Mamm. Genome, 18, pp.412~424 (2007)
- Cutler, G., "Significant gene content variation characterizes the genomes of inbred mouse strains", Genome Res., 17, pp.1743~1754 (2007)
- Collins, F. S., "A mouse for all reasons", Cell, 128, pp.9~13 (2007)
- Moore, K. J., "Utilization of mouse models in the discovery of human disease genes", Drug. Discov. Today, 4, pp.123~128 (1999)
- Capecchi, M. R., "Gene targeting in mice: functional analysis of the mammalian genome for the twenty-first century", Nat. Rev. Genet., 6, pp.507~512 (2005)
- Crow, J. F., "Anecdotal, historical and critical commentaries on genetics. R. A. Fisher, a centennial view", Genetics, 124, pp.207~211 (1990)
- Paigen, K., "One hundred years of mouse genetics: an intellectual history. I. The classical period (1902-1980)", Genetics, 163, pp.1~7 (2003)
- Rader, K., "Making mice: Standardizing animals for American biomedical research, 1900-1955, 1st ed" (2004), Princeton University Press
- Cutler, G., "Significant gene content variation characterizes the genomes of inbred mouse strains", Genome Res., 17, pp.1743~1754 (2007)
- Goios, A., "mtDNA phylogeny and evolution of laboratory mouse strains", Genome Res., 17, pp.293~298 (2007)
- Yoshiki, A., "Mouse phenome research: implications of genetic background", ILAR. J., 47, pp.94~102 (2006)
- Little, C. C., "Further experimental studies on the inheritance of susceptibility to a transplantable carcinoma (JA) of the Japanese waltzing mouse", J. Med. Res., 33, pp.393~427 (1916)
- Snell., G. D., "Methods for the study of histocompatibility genes", J. Genet., 49, pp.87~108 (1948)
- Grubb, S. C., "A collaborative database of inbred mouse strain characteristics", Bioinformatics, 20, pp.2857~2859 (2004)
- Coleman, D., "Obese and diabetes: two mutant genes causing diabetes-obesity syndromes in mice", Diabetologia, 14, pp.141~148 (1978)
- Zhang, Y., "Positional cloning of the mouse obese gene and its human homologue", Nature, 372, pp.425~432 (1994)
- Tartaglia, L. A., "Identification and expression cloning of a leptin receptor, OB-R", Cell, 83, pp.1263~1271 (1995)
- Cuénot, L., "Notes et revues", Arch. Zool. Exp. Gen., 27 (1902)
- Soewarto, D., "Features and strategies of ENU mouse mutagenesis", Curr. Pharm. Biotechnol., 10, pp.198~213 (2009)
- Waterson, R. H., "Mouse genome sequencing consortium", Nature, 420, pp.520~562 (2002)
- Hummel, K. P., "The influence of genetic background on expression of mutations at the diabetes locus in the mouse. I. C57BL-KsJ and C57BL-6J strains", Biochem. Genet., 7, pp.1~13 (1972)
- Manis, J. P., "Knock out, knock in, knock down-genetically manipulated mice and the Nobel Prize", N. Engl. J. Med., 357, pp.2426~2429 (2007)
- Ray, M. K., "The cre-loxP system: a versatiletool for targeting genes in a cell- and stage-specific manner", Cell Transplant, 9, pp.805~815 (2000)
- Furth, P. A., "Temporal control of gene expression in transgenic mice by a tetracycline-responsive promoter", Proc. Natl. Acad. Sci. U.S.A., 91, pp.9302~9306 (1994)
- Kistner, A., "Doxycyclinemediated quantitative and tissue-specific control of gene expression in transgenic mice", Proc. Natl. Acad. Sci. U.S.A., 93, pp.10933~10938 (1996)
- No, D., "Ecdysone-inducible gene expression in mammalian-cells and transgenic mice", Proc. Natl. Acad. Sci. U.S.A., 93, pp.3346~3351 (1996)
- Rosenthal, N., "The mouse ascending: perspectives for human-disease models", Nat. Cell. Biol., 9, pp.993~999 (2007)
- 이한웅, "Functional Genomics Approach Using Mice", BMB reports, 37(1), pp.122~132 (2004), 한국생화학분자생물학회
- Rossant, J., "Mouse-based phenogenomics for modelling human disease", Trends. Mol. Med., 7, pp.502~507 (2001)
- Michaud, E. J., "Efficient gene-driven germ-line point mutagenesis of C57BL", 6J mice, 2005, pp.6, 164~
- Abuin, A., "Gene trap mutagenesis", Handb. Exp. Pharmacol., 178, pp.129~147 (2007)
- Gondo, Y., "Trends in large-scale mouse mutagenesis: from genetics to functional genomics", Nat. Rev. Genet., 9, pp.803~810 (2008)
- Perkins, A. S., "Functional genomics in the mouse", Funct. Integr. Genomics., 2, pp.81~91 (2002)
- Acevedo-Arozena, A., "ENU mutagenesis, a way forward to understand gene function", Annu. Rev. Genomics Hum. Genet., 9, pp.49~69 (2008)
- Nolan, P. M., "A systematic, genome-wide, phenotypedriven mutagenesis programme for gene function studies in the mouse", Nat. Genet., 25, pp.440~443 (2000)
- Hacking, D. F., "'Knock, and it shall be opened': knocking out and knocking in to reveal mechanisms of disease and novel therapies", Early Hum. Dev., 84, pp.821~827 (2008)
- Sieberts, S. K., "Moving toward a system genetics view of disease", Mamm. Genome, 18, pp.389~401 (2007)
- Argmann, C. A., "Mouse phenogenomics: the fast track to "systems metabolism"", Cell Metab., 2, pp.349~360 (2005)
- Brown, S. D., "Understanding mammalian genetic systems: the challenge of phenotyping in the mouse", PLoS. Genet., 2, pp.1131~1137 (2006)
- Peters, L. L., "The mouse as a model for human biology: a resource guide for complex trait analysis", Nat. Rev. Genet., 8, pp.58~69 (2007)
- Justice, M. J., "Removing the cloak of invisibility: phenotyping the mouse", Dis. Model. Mech., 1, pp.109~112 (2008)
- Mason, K. D., "Programmed anuclear cell death delimits platelet life span", Cell, 128, pp.1173~1186 (2007)
- Barbaric, I., "Appearances can be deceiving: phenotypes of knockout mice", Brief. Funct. Genomic. Proteomic., 6, pp.91~103 (2007)
- Yu, Q., "ENU induced mutations causing congenital cardiovascular anomalies", Development, 131, pp.6211~6223 (2004)
- Brayton, C., "Evaluating mutant mice: anatomic pathology", Vet. Pathol., 38, pp.1~19 (2001)
- Gailus-Durner, V., "Introducing the German Mouse Clinic: open access platform for standardized phenotyping", Nat. Methods., 2, pp.403~404 (2005)
- Green, E. C., "EMPReSS: European mouse phenotyping resource for standardized screens", Bioinformatics, 21, pp.2930~2931 (2005)
- Brown, S. D., "EMPReSS: standardized phenotype screens for functional annotation of the mouse genome", Nat. Genet., 37, pp.1155~ (2005)
- Mallon, A. M., "EuroPhenome and EMPReSS: online mouse phenotyping resource", Nucleic Acids Res., 36, pp.D715~D718 (2008)
- Strivens, M., "Visualizing the laboratory mouse: capturing phenotype information", Genetica, 122, pp.89~97 (2004)
- Willmann, J. K., "Molecular imaging in drug development", Nat. Rev. Drug. Discov., 7, pp.591~607 (2008)
- Pearson, H., "Surviving a knockout blow", Nature, 415, pp.8~9 (2002)
- Champy, M. F., "Mouse functional genomics requires standardization of mouse handling and housing conditions", Mamm. Genome, 15, pp.768~783 (2004)
- Austin, C. P., "The knockout mouse project", Nat. Genet., 36, pp.921~924 (2004)
- Auwerx, J., "The European dimension for the mouse genome mutagenesis program", Nat. Genet., 36, pp.925~927 (2004)
- Friedel, R. H., "EUCOMM--the European conditional mouse mutagenesis program", Brief. Funct. Genomic. Proteomic., 6, pp.180~185 (2007)
- Collins, F. S., "A new partner for the international knockout mouse consortium", Cell, 129, pp.235~ (2007)
- FIMRe Board of Directors, "FIMRe: Federation of International Mouse Resources: Global networking of resource centers", Mamm. Genome, 17, pp.363~364 (2006)
- Hagn, M., "EMMA--the European mouse mutant archive", Brief. Funct. Genomic. Proteomic., 6, pp.186~192 (2007)
- Yoshiki, A., "The mouse resources at the RIKEN BioResource center", Exp. Anim., 58, pp.85~96 (2009)
- Wakana, S., "Introduction to the Japan Mouse Clinic at the RIKEN BioResource Center", Exp. Anim., 58, pp.443~450 (2009)
- of mouse phenome data resources, "Mamm. Genome", 2007, 157~163
- Adams, D. J., "Mutagenic insertion and chromosome engineering resource (MICER)", Nat. Genet., 36, pp.867~871 (2004)
- Dennis, M. B., "Welfare issues of genetically modified animals", ILAR. Journal, 43, pp.100~109 (2002)
- Zambrowicz, B. P., "Knockouts model the 100 best-selling drugs--will they model the next 100?", Nat. Rev. Drug. Discov., 2, pp.38~51 (2003)
- Heck, S., "Genetically engineered mouse models for drug discovery: new chemical genetic approaches", Curr. Drug. Discov. Technol., 1, pp.13~26 (2004)
- Sharpless, N. E., "The mighty mouse: genetically engineered mouse models in cancer drug development", Nat. Rev. Drug. Discov., 5, pp.741~754 (2006)
- Kelly-Spratt, K. S., "A mouse model repository for cancer biomarker discovery", J. Proteome. Res., 7, pp.3613~3618 (2008)
- Gulezian, D., "Use of transgenic animals for carcinogenicity testing: considerations and implications for risk assessment", Toxicol. Pathol., 28, pp.482~499 (2000)
- Bos, J. L., "Ras oncogenes in human cancer: a review", Cancer. Res., 49, pp.4682~4689 (1989)
- You, M., "Activation of the K-ras protooncogenes in spontaneously occurring and chemically induced lung tumors of the strain A mouse", Proc. Natl. Acad. Sci. U.S.A., 86, pp.3070~3074 (1989)
- Leder, A., "v-Ha-ras transgene abrogates the initiation step in mouse skin tumorigenesis: Effects of phorbol esters and retinoic acid", Proc. Natl. Acad. Sci. U.S.A., 87, pp.9178~9182 (1990)
- Janssen, K. P., "Mouse models of K-ras-initiated carcinogenesis", Biochim. Biophys. Acta., 1756, pp.145~154 (2005)
- Attardi, L. D., "Probing p53 biological functions through the use of genetically engineered mouse models", Mutat. Res., 576, pp.4~21 (2005)
- Tennant, R. W., "Identifying chemical carcinogens and assessing potential risk in short-term bioassays using transgenic mouse models", Environ Health Perspect, 103, pp.942~950 (1995)
- de Vries, A., "Increased susceptibility to ultraviolet-B and carcinogens of mice lacking the DNA excision repair gene XPA", Nature, 377, pp.169~173 (1995)
