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논문KCI 등재

Mouse genetics: Catalogue and scissors

김진수|성제경|이한웅|Young Hoon Sung|백인정
생화학분자생물학회 (Korean Society Of Biochemistry And Molecular Biology)|2012.12|BMB Reports|제45권 제12호|pp. 686-692

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참고문헌

키워드

Gene targetingKnockoutTALENZFN
주제분류화학

초록

Phenotypic analysis of gene-specific knockout (KO) mice has revolutionized our understanding of in vivo gene functions. As the use of mouse embryonic stem (ES) cells is inevitable for conventional gene targeting, the generation of knockout mice remains a very time-consuming and expensive process. To accelerate the large-scale production and phenotype analyses of KO mice, international efforts have organized global consortia such as the International Knockout Mouse Consortium (IKMC)and International Mouse Phenotype Consortium (IMPC), and they are persistently expanding the KO mouse catalogue that is publicly available for the researches studying specific genes of interests in vivo. However, new technologies, adopting zinc-finger nucleases (ZFNs) or Transcription Activator-Like Effector (TALE) Nucleases (TALENs) to edit the mouse genome,are now emerging as valuable and effective shortcuts alternative for the conventional gene targeting using ES cells. Here, we introduce the recent achievement of IKMC, and evaluate the significance of ZFN/TALEN technology in mouse genetics. [BMB Reports 2012; 45(12): 686-692]

Abstract

Phenotypic analysis of gene-specific knockout (KO) mice has revolutionized our understanding of in vivo gene functions. As the use of mouse embryonic stem (ES) cells is inevitable for conventional gene targeting, the generation of knockout mice remains a very time-consuming and expensive process. To accelerate the large-scale production and phenotype analyses of KO mice, international efforts have organized global consortia such as the International Knockout Mouse Consortium (IKMC)and International Mouse Phenotype Consortium (IMPC), and they are persistently expanding the KO mouse catalogue that is publicly available for the researches studying specific genes of interests in vivo. However, new technologies, adopting zinc-finger nucleases (ZFNs) or Transcription Activator-Like Effector (TALE) Nucleases (TALENs) to edit the mouse genome,are now emerging as valuable and effective shortcuts alternative for the conventional gene targeting using ES cells. Here, we introduce the recent achievement of IKMC, and evaluate the significance of ZFN/TALEN technology in mouse genetics. [BMB Reports 2012; 45(12): 686-692]

참고문헌 (50)

  1. Paigen, K., "One hundred years of mouse genetics: an intellectual history. II. The molecular revolution (1981-2002)", Genetics, 163, pp.1227~1235 (2003)
  2. Paigen, K., "One hundred years of mouse genetics: an intellectual history. I. The classical period (1902-1980)", Genetics, 163, pp.1~7 (2003)
  3. Sang Kyun Lim, "Glioblastoma multiforme: a perspective on recent findings in human cancer and mouse models", BMB Reports, 44(3), pp.158~164 (2011), 생화학분자생물학회
  4. International Mouse Knockout, C., "A mouse for all reasons", Cell, 128, pp.9~13 (2007)
  5. Pettitt, S. J., "Agouti C57BL", 6N embryonic stem cells for mouse genetic resources, 2009, pp.6, 493~495
  6. Il Yong Kim, "Mouse phenogenomics, toolbox for functional annotation of human genome", BMB Reports, 43(2), pp.79~90 (2010), 생화학분자생물학회
  7. Valenzuela, D. M., "High-throughput engineering of the mouse genome coupled with high-resolution expression analysis", Nat. Biotechnol., 21, pp.652~659 (2003)
  8. Rodriguez, C. I., "High-efficiency deleter mice show that FLPe is an alternative to Cre-loxP", Nat. Genet., 25, pp.139~140 (2000)
  9. Skarnes, W. C., "A conditional knockout resource for the genome- wide study of mouse gene function", Nature, 474, pp.337~342 (2011)
  10. O'Gorman, S., "Protamine-Cre recombinase transgenes efficiently recombine target sequences in the male germ line of mice, but not in embryonic stem cells", Proc. Natl. Acad. Sci. U.S.A., 94, pp.14602~14607 (1997)
  11. Indra, A. K., "Temporally-controlled site-specific mutagenesis in the basal layer of the epidermis: comparison of the recombinase activity of the tamoxifen-inducible Cre-ER(T) and Cre-ER(T2) recombinases", Nucl. Acids Res., 27, pp.4324~4327 (1999)
  12. Smedley, D., "Cre recombinase resources for conditional mouse mutagenesis", Methods, 53, pp.411~416 (2011)
  13. Heffner, C. S., "Supporting conditional mouse mutagenesis with a comprehensive cre characterization resource", Nat. Commun., 3, pp.1218~ (2012)
  14. Jin, X. L., "Emx1-specific expression of foreign genes using "knock-in" approach", Biochem. Biophys. Res. Commun., 270, pp.978~982 (2000)
  15. Chapman, H. A., "Integrin alpha6beta4 identifies an adult distal lung epithelial population with regenerative potential in mice", J. Clin. Invest., 121, pp.2855~2862 (2011)
  16. Bibikova, M., "Enhancing gene targeting with designed zinc fingernucleases", Science, 300, pp.764~ (2003)
  17. Urnov, F. D., "Genome editing with engineered zinc finger nucleases", Nat. Rev. Genet., 11, pp.636~646 (2010)
  18. Carroll, D., "Genome engineering with zinc-finger nucleases", Genetics, 188, pp.773~782 (2011)
  19. Kim, H. J., "Targeted genome editing in human cells with zincfinger nucleases constructed via modular assembly", Genome Res., 19, pp.1279~1288 (2009)
  20. 김석중, "Preassembled zinc-finger arrays for rapid construction of ZFNs", NATURE METHODS, 8(1), pp.7~7, NATURE PUBLISHING GROUP
  21. Pabo, C. O., "Design and selection of novel Cys2His2 zinc finger proteins", Annu. Rev. Biochem., 70, pp.313~340 (2001)
  22. Bae, K. H., "Human zinc fingers as building blocks in the construction of artificial transcription factors", NATURE BIOTECHNOLOGY, 21, pp.275~280 (2003)
  23. Kim, J. S., "Getting a handhold on DNA: design of poly-zinc finger proteins with femtomolar dissociation constants", Proc. Natl. Acad. Sci. U.S.A., 95, pp.2812~2817 (1998)
  24. Kay, S., "A bacterial effector acts as a plant transcription factorand induces a cell size regulator", Science, 318, pp.648~651 (2007)
  25. Boch, J., "Breaking the code of DNA binding specificity of TAL-type III effectors", Science, 326, pp.1509~1512 (2009)
  26. Christian, M., "Targeting DNA double-strand breaks with TAL effector nucleases", Genetics, 186, pp.757~761 (2010)
  27. Li, T., "TAL nucleases (TALNs): hybrid proteins composed of TAL effectors and FokI DNA-cleavage domain", Nucl. Acids Res., 39, pp.359~372 (2011)
  28. Miller, J. C., "A TALE nuclease architecture for efficient genome editing", Nat. Biotechnol., 29, pp.143~148 (2011)
  29. Mussolino, C., "A novel TALE nuclease scaffold enables high genome editing activity in combination with low toxicity", Nucl. Acids Res., 39, pp.9283~9293 (2011)
  30. Bitinaite, J., "FokI dimerization is required for DNA cleavage", Proc. Natl. Acad. Sci. U.S.A., 95, pp.10570~10575 (1998)
  31. Cornu, T. I., "DNAbinding specificity is a major determinant of the activity and toxicity of zinc-finger nucleases", Mol. Ther., 16, pp.352~358 (2008)
  32. Miller, J. C., "An improved zinc-finger nuclease architecture for highly specific genome editing", Nat. Biotechnol., 25, pp.778~785 (2007)
  33. Ramirez, C. L., "Unexpected failure rates for modular assembly of engineered zinc fingers", Nat. Methods, 5, pp.374~375 (2008)
  34. Kim, J. S., "Genome editing with modularly assembled zinc-finger nucleases", Nat. Methods, 7, pp.91~92 (2010)
  35. Joung, J. K., "Reply to “Genome editing with modularly assembled zinc-finger nucleases", Nat. Methods, 7, pp.91~92 (2010)
  36. Lieber, M. R., "The mechanism of double-strand DNA break repair by the nonhomologous DNA end-joining pathway", Annu. Rev. Biochem., 79, pp.181~211 (2010)
  37. Vasquez, K. M., "Manipulating the mammalian genome by homologous recombination", Proc. Natl. Acad. Sci. U.S.A., 98, pp.8403~8410 (2001)
  38. Rouet, P., "Expression of a site-specific endonuclease stimulates homologous recombination in mammalian cells", Proc. Natl. Acad. Sci. U.S.A., 91, pp.6064~6068 (1994)
  39. Porteus, M. H., "Chimeric nucleases stimulate gene targeting in human cells", Science, 300, pp.763~ (2003)
  40. Meyer, M., "Gene targeting by homologous recombination inmouse zygotes mediated by zinc-finger nucleases", Proc.Natl. Acad. Sci. U.S.A., 107, pp.15022~15026 (2010)
  41. Meyer, M., "Modeling disease mutations by gene targeting in one-cell mouse embryos", Proc. Natl. Acad. Sci. U.S.A., 109, pp.9354~9359 (2012)
  42. Mussolino, C., "TALE nucleases: tailored genome engineering made easy", Curr. Opin. Biotechnol., 23, pp.644~650 (2012)
  43. Carlson, D. F., "Efficient TALEN-mediated gene knockout in livestock", Proc. Natl. Acad. Sci. U.S.A., 109, pp.17382~17387 (2012)
  44. Wood, A. J., "Targeted genome editing across species using ZFNs and TALENs", Science, 333, pp.307~ (2011)
  45. Huang, P., "Heritable gene targeting in zebrafish using customized TALENs", Nat. Biotechnol., 29, pp.699~700 (2011)
  46. Sander, J. D., "Targeted gene disruption in somatic zebrafish cells using engineered TALENs", Nat. Biotechnol., 29, pp.697~698 (2011)
  47. Tesson, L., "Knockout rats generated by embryo microinjection of TALENs", Nat. Biotechnol., 29, pp.695~696 (2011)
  48. Geurts, A. M., "Knockout rats via embryo microinjection of zinc-finger nucleases", Science, 325, pp.433~ (2009)
  49. Rao, A., "Epitope-tagged dopamine transporter knock-in mice reveal rapid endocytic trafficking and filopodia targeting of the transporter in dopaminergic axons", FASEB J., 26, pp.1921~1933 (2012)
  50. Cui, X., "Targeted integration in rat and mouse embryos with zinc-finger nucleases", Nat. Biotechnol., 29, pp.64~67 (2011)

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