Extracting Extra-Telomeric Phenotypes from Telomerase Mouse Models
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초록
Telomerase reverse transcriptase (TERT) is the protein component of telomerase and combined with an RNA molecule, telomerase RNA component, forms the telomerase enzyme responsible for telomere elongation. Telomerase is essential for maintaining telomere length from replicative attrition and thus contributes to the preservation of genome integrity. Although diverse mouse models have been developed and studied to prove the physiological roles of telomerase as a telomere-elongating enzyme, recent studies have revealed non-canonical TERT activities beyond telomeres. To gain insights into the physiological impact of extra-telomeric roles, this review revisits the strategies and phenotypes of telomerase mouse models in terms of the extra-telomeric functions of telomerase.
Abstract
Telomerase reverse transcriptase (TERT) is the protein component of telomerase and combined with an RNA molecule, telomerase RNA component, forms the telomerase enzyme responsible for telomere elongation. Telomerase is essential for maintaining telomere length from replicative attrition and thus contributes to the preservation of genome integrity. Although diverse mouse models have been developed and studied to prove the physiological roles of telomerase as a telomere-elongating enzyme, recent studies have revealed non-canonical TERT activities beyond telomeres. To gain insights into the physiological impact of extra-telomeric roles, this review revisits the strategies and phenotypes of telomerase mouse models in terms of the extra-telomeric functions of telomerase.
참고문헌 (72)
- Bischoff C, "The heritability of telomere length among the elderly and oldest-old", Twin Res Hum Genet, 8, pp.433~439 (2005)
- Kipling D, "Hypervariable ultra-long telomeres in mice", Nature, 347, pp.400~402 (1990)
- Aubert G, "Telomeres and aging", Physiol Rev, 88, pp.557~579 (2008)
- Lansdorp PM, "Telomere length and proliferation potential of hematopoietic stem cells", J Cell Sci, 108(Pt 1), pp.1~6 (1995)
- Heidinger BJ, "Monaghan P. Telomere length in early life predicts lifespan", Proc Natl Acad Sci U S A, 109, pp.1743~1748 (2012)
- Cohen SB, "Protein composition of catalytically active human telomerase from immortal cells", Science, 315, pp.1850~1853 (2007)
- Bianchi A, "Early replication of short telomeres in budding yeast", Cell, 128, pp.1051~1062 (2007)
- Laterreur N, "A new telomerase RNA element that is critical for telomere elongation", Nucleic Acids Res, 41, pp.7713~7724 (2013)
- Wright WE, "Telomerase activity in human germline and embryonic tissues and cells", Dev Genet, 18, pp.173~179 (1996)
- Kim NW, "Specific association of human telomerase activity with immortal cells and cancer", Science, 266, pp.2011~2015 (1994)
- Allshire RC, "Human telomeres contain at least three types of G-rich repeat distributed non-randomly", Nucleic Acids Res, 17, pp.4611~4627 (1989)
- Prowse KR, "Developmental and tissue-specific regulation of mouse telomerase and telomere length", Proc Natl Acad Sci U S A, 92, pp.4818~4822 (1995)
- Sarin KY, "Conditional telomerase induction causes proliferation of hair follicle stem cells", Nature, 436, pp.1048~1052 (2005)
- Starling JA, "Extensive telomere repeat arrays in mouse are hypervariable", Nucleic Acids Res, 18, pp.6881~6888 (1990)
- ez-Suárez E, "Increased epidermal tumors and increased skin wound healing in transgenic mice overexpressing the catalytic subunit of telomerase, mTERT, in basal keratinocytes", EMBO J, 20, pp.2619~2630 (2001)
- Allsopp RC, "Telomerase is required to slow telomere shortening and extend replicative lifespan of HSCs during serial transplantation", Blood, 102, pp.517~520 (2003)
- Nitta E, "Telomerase reverse transcriptase protects ATM-deficient hematopoietic stem cells from ROS-induced apoptosis through a telomere-independent mechanism", Blood, 117, pp.4169~4180 (2011)
- Kang HJ, "Ectopic expression of the catalytic subunit of telomerase protects against brain injury resulting from ischemia and NMDA-induced neurotoxicity", JOURNAL OF NEUROSCIENCE, 24, pp.1280~1287 (2004), SOC NEUROSCIENCE
- Folini M, "Antisense oligonucleotide-mediated inhibition of hTERT, but not hTERC, induces rapid cell growth decline and apoptosis in the absence of telomere shortening in human prostate cancer cells", Eur J Cancer, 41, pp.624~634 (2005)
- Rahman R, "hTERT antagonizes p53-induced apoptosis independently of telomerase activity", Oncogene, 24, pp.1320~1327 (2005)
- Flores I, "Effects of telomerase and telomere length on epidermal stem cell behavior", Science, 309, pp.1253~1256 (2005)
- Heaphy CM, "Prevalence of the alternative lengthening of telomeres telomere maintenance mechanism in human cancer subtypes", Am J Pathol, 179, pp.1608~1615 (2011)
- Sýkorová E, "Structure-function relationships in telomerase genes", Biol Cell, 101, pp.375~392 (2009)
- Ulaner GA, "Telomerase activity in human development is regulated by human telomerase reverse transcriptase (hTERT) transcription and by alternate splicing of hTERT transcripts", Cancer Res, 58, pp.4168~4172 (1998)
- Haendeler J, "Antioxidants inhibit nuclear export of telomerase reverse transcriptase and delay replicative senescence of endothelial cells", Circ Res, 94, pp.768~775 (2004)
- Khoo CM, "Ink4a", Arf tumor suppressor does not modulate the degenerative conditions or tumor spectrum of the telomerase-deficient mouse, 2007, pp.104, 3931~3936
- Siegl-Cachedenier I, "Deficient mismatch repair improves organismal fitness and survival of mice with dysfunctional telomeres", Genes Dev, 21, pp.2234~2247 (2007)
- Liu L, "Irregular telomeres impair meiotic synapsis and recombination in mice", Proc Natl Acad Sci U S A, 101, pp.6496~6501 (2004)
- Herrera E, "Impaired germinal center reaction in mice with short telomeres", EMBO J, 19, pp.472~481 (2000)
- He H, "Pot1b deletion and telomerase haploinsufficiency in mice initiate an ATR-dependent DNA damage response and elicit phenotypes resembling dyskeratosis congenita", Mol Cell Biol, 29, pp.229~240 (2009)
- Herrera E, "Telomere shortening in mTR-", - embryos is associated with failure to close the neural tube, 1999, pp.18, 1172~1181
- Leri A, "Ablation of telomerase and telomere loss leads to cardiac dilatation and heart failure associated with p53 upregulation", EMBO J, 22, pp.131~139 (2003)
- Oh H, "Telomerase reverse transcriptase promotes cardiac muscle cell proliferation, hypertrophy, and survival", Proc Natl Acad Sci U S A, 98, pp.10308~10313 (2001)
- Ding Z, "Telomerase reactivation following telomere dysfunction yields murine prostate tumors with bone metastases", Cell, 148, pp.896~907 (2012)
- Farazi PA, "Cooperative interactions of p53 mutation, telomere dysfunction, and chronic liver damage in hepatocellular carcinoma progression", Cancer Res, 66, pp.4766~4773 (2006)
- Rajaraman S, "Telomere uncapping in progenitor cells with critical telomere shortening is coupled to S-phase progression in vivo", Proc Natl Acad Sci U S A, 104, pp.17747~17752 (2007)
- Jaskelioff M, "Telomerase reactivation reverses tissue degeneration in aged telomerase-deficient mice", Nature, 469, pp.102~106 (2011)
- Cosme-Blanco W, "Telomere dysfunction suppresses spontaneous tumorigenesis in vivo by initiating p53-dependent cellular senescence", EMBO Rep, 8, pp.497~503 (2007)
- Sahin E, "Linking functional decline of telomeres, mitochondria and stem cells during ageing", Nature, 464, pp.520~528 (2010)
- Chin L, "p53 deficiency rescues the adverse effects of telomere loss and cooperates with telomere dysfunction to accelerate carcinogenesis", Cell, 97, pp.527~538 (1999)
- Xu D, "Downregulation of telomerase reverse transcriptase mRNA expression by wild type p53 in human tumor cells", Oncogene, 19, pp.5123~5133 (2000)
- Lee MK, "Ectopic mTERT expression in mouse embryonic stem cells does not affect differentiation but confers resistance to differentiation- and stress-induced p53-dependent apoptosis", J Cell Sci, 118(Pt 4), pp.819~829 (2005)
- Zhu H, "The catalytic subunit of telomerase protects neurons against amyloid beta-peptide-induced apoptosis", J Neurochem, 75, pp.117~124 (2000)
- Lee J, "TERT promotes cellular and organismal survival independently of telomerase activity", ONCOGENE, 27, pp.3754~3760 (2008), NATURE PUBLISHING GROUP
- Blasco MA, "Telomere shortening and tumor formation by mouse cells lacking telomerase RNA", Cell, 91, pp.25~34 (1997)
- Rudolph KL, "Longevity, stress response, and cancer in aging telomerase-deficient mice", Cell, 96, pp.701~712 (1999)
- Artandi SE, "Telomere dysfunction promotes non-reciprocal translocations and epithelial cancers in mice", Nature, 406, pp.641~645 (2000)
- Greenberg RA, "Short dysfunctional telomeres impair tumorigenesis in the INK4a(delta2", 3) cancer-prone mouse, 1999, pp.97, 515~525
- Stewart SA, "Telomerase contributes to tumorigenesis by a telomere length-independent mechanism", Proc Natl Acad Sci U S A, 99, pp.12606~12611 (2002)
- Stampfer MR, "Expression of the telomerase catalytic subunit, hTERT, induces resistance to transforming growth factor beta growth inhibition in p16INK4A(-) human mammary epithelial cells", Proc Natl Acad Sci U S A, 98, pp.4498~4503 (2001)
- Farazi PA, "Differential impact of telomere dysfunction on initiation and progression of hepatocellular carcinoma", Cancer Res, 63, pp.5021~5027 (2003)
- Artandi SE, "Constitutive telomerase expression promotes mammary carcinomas in aging mice", Proc Natl Acad Sci U S A, 99, pp.8191~8196 (2002)
- Lee KH, "Telomere dysfunction alters the chemotherapeutic profile of transformed cells", Proc Natl Acad Sci U S A, 98, pp.3381~3386 (2001)
- Hu X, "Combination of fucoxanthin and conjugated linoleic acid attenuates body weight gain and improves lipid metabolism in high-fat diet-induced obese rats", Arch Biochem Biophys, 519, pp.59~65 (2012)
- Roh JI, "Clinical implications of antitelomeric drugs with respect to the nontelomeric functions of telomerase in cancer", Onco Targets Ther, 6, pp.1161~1166 (2013)
- Samper E, "Long-term repopulating ability of telomerase-deficient murine hematopoietic stem cells", Blood, 99, pp.2767~2775 (2002)
- Allsopp RC, "Effect of TERT over-expression on the long-term transplantation capacity of hematopoietic stem cells", Nat Med, 9, pp.369~371 (2003)
- Siegl-Cachedenier I, "Telomerase reverses epidermal hair follicle stem cell defects and loss of long-term survival associated with critically short telomeres", J Cell Biol, 179, pp.277~290 (2007)
- Flores I, "A p53-dependent response limits epidermal stem cell functionality and organismal size in mice with short telomeres", PLoS One, 4, pp.e4934~ (2009)
- Choi J, "TERT promotes epithelial proliferation through transcriptional control of a Myc- and Wnt-related developmental program", PLoS Genet, 4, pp.e10~ (2008)
- Park JI, "Telomerase modulates Wnt signalling by association with target gene chromatin", NATURE, 460(7251), pp.66~77 (2009), NATURE PUBLISHING GROUP
- Gizard F, "Telomerase activation in atherosclerosis and induction of telomerase reverse transcriptase expression by inflammatory stimuli in macrophages", Arterioscler Thromb Vasc Biol, 31, pp.245~252 (2011)
- Mitchell JR, "A telomerase component is defective in the human disease dyskeratosis congenita", Nature, 402, pp.551~555 (1999)
- Shkreli M, "Reversible cell-cycle entry in adult kidney podocytes through regulated control of telomerase and Wnt signaling", Nat Med, 18, pp.111~119 (2011)
- Ghosh A, "Telomerase directly regulates NF-κB-dependent transcription", Nat Cell Biol, 14, pp.1270~1281 (2012)
- Ahmed S, "Telomerase does not counteract telomere shortening but protects mitochondrial function under oxidative stress", J Cell Sci, 121(Pt 7), pp.1046~1053 (2008)
- Maida Y, "RNA-dependent RNA polymerases in RNA silencing", Biol Chem, 392, pp.299~304 (2011)
- Maida Y, "An RNA-dependent RNA polymerase formed by TERT and the RMRP RNA", Nature, 461, pp.230~235 (2009)
- Haendeler J, "Mitochondrial telomerase reverse transcriptase binds to and protects mitochondrial DNA and function from damage", Arterioscler Thromb Vasc Biol, 29, pp.929~935 (2009)
- Herrera E, "Disease states associated with telomerase deficiency appear earlier in mice with short telomeres", EMBO J, 18, pp.2950~2960 (1999)
- Lee HW, "Essential role of mouse telomerase in highly proliferative organs", Nature, 392, pp.569~574 (1998)
- Canela A, "Constitutive expression of tert in thymocytes leads to increased incidence and dissemination of T-cell lymphoma in Lck-Tert mice", Mol Cell Biol, 24, pp.4275~4293 (2004)
