본문 바로가기
KERD
논문KCI 등재

Microbial linguistics: perspectives and applications of microbial cell-to-cell communication

이성국|김철민|김태성|Robert James Mitchell
생화학분자생물학회 (Korean Society Of Biochemistry And Molecular Biology)|2011.01|BMB Reports|제44권 제1호|pp. 1-10

1

조회

0

다운로드

1

인용

0

참고문헌

키워드

Microbial communitySynthetic biologyMicrochemostatQuorum sensing
주제분류화학

초록

Inter-cellular communication via diffusible small molecules is a defining character not only of multicellular forms of life but also of single-celled organisms. A large number of bacterial genes are regulated by the change of chemical milieu mediated by the local population density of its own species or others. The cell density-dependent “autoinducer” molecules regulate the expression of those genes involved in genetic competence, biofilm formation and persistence, virulence,sporulation, bioluminescence, antibiotic production, and many others. Recent innovations in recombinant DNA technology and micro-/nano-fluidics systems render the genetic circuitry responsible for cell-to-cell communication feasible to and malleable via synthetic biological approaches. Here we review the current understanding of the molecular biology of bacterial intercellular communication and the novel experimental protocols and platforms used to investigate this phenomenon. A particular emphasis is given to the genetic regulatory circuits that provide the standard building blocks which constitute the syntax of the biochemical communication network. Thus, this review gives focus to the engineering principles necessary for rewiring bacterial chemo-communication for various applications, ranging from population-level gene expression control to the study of host-pathogen interactions. (BMB reports 2011; 44(1): 1-10)

Abstract

Inter-cellular communication via diffusible small molecules is a defining character not only of multicellular forms of life but also of single-celled organisms. A large number of bacterial genes are regulated by the change of chemical milieu mediated by the local population density of its own species or others. The cell density-dependent “autoinducer” molecules regulate the expression of those genes involved in genetic competence, biofilm formation and persistence, virulence,sporulation, bioluminescence, antibiotic production, and many others. Recent innovations in recombinant DNA technology and micro-/nano-fluidics systems render the genetic circuitry responsible for cell-to-cell communication feasible to and malleable via synthetic biological approaches. Here we review the current understanding of the molecular biology of bacterial intercellular communication and the novel experimental protocols and platforms used to investigate this phenomenon. A particular emphasis is given to the genetic regulatory circuits that provide the standard building blocks which constitute the syntax of the biochemical communication network. Thus, this review gives focus to the engineering principles necessary for rewiring bacterial chemo-communication for various applications, ranging from population-level gene expression control to the study of host-pathogen interactions. (BMB reports 2011; 44(1): 1-10)

참고문헌 (93)

  1. Bhattacharyya, R. P, "Domains, motifs, and scaffolds: the role of modular interactions in the evolution and wiring of cell signaling circuits", Ann. Rev. Biochem, 75, pp.655~680 (2006)
  2. Bassler, B. L, "Bacterially speaking", Cell, 125, pp.237~246 (2006)
  3. Wagner, V. E, "Microarray analysis of Pseudomonas aeruginosa quorum-sensing regulons: effects of growth phase and environment", J. Bacteriol, 185, pp.2080~2095 (2003)
  4. You, L, "Programmed population control by cell-cell communication and regulated killing", Nature, 428, pp.868~871 (2004)
  5. Choudhary, S, "Applications of quorum sensing in biotechnology", Appl. Microbiol. Biotechnol, 86, pp.1267~1279 (2010)
  6. Rasmussen, T. B, "Quorum-sensing inhibitors as anti-pathogenic drugs", Int. J. Med. Microbiol, 296, pp.149~161 (2006)
  7. Lerat, E, "Evolutionary history of quorum-sensing systems in bacteria", Mol. Biol. Evol, 21, pp.903~913 (2004)
  8. Fuqua, W. C, "Quorum sensing in bacteria: the LuxR", LuxI family of cell density-responsive transcriptional regulators, 1994, pp.176, 269~275
  9. Hense, B. A, "Does efficiency sensing unify diffusion and quorum sensing", Nat. Rev. Microbiol, 5, pp.230~239 (2007)
  10. Nealson, K. H, "Cellular control of the synthesis and activity of the bacterial luminescent system", J. Bacteriol, 104, pp.313~322 (1970)
  11. Eberhard, A, "Inhibition and activation of bacterial luciferase synthesis", J. Bacteriol, 109, pp.1101~1105 (1972)
  12. Eberhard, A, "Structural identification of autoinducer of Photobacterium fischeri luciferase", Biochemistry, 20, pp.2444~2449 (1981)
  13. Shaw, P. D, "Detecting and characterizing N-acyl-homoserine lactone signal molecules by thin-layer chromatography", Proc. Natl. Acad. Sci. U.S.A, 94, pp.6036~6041 (1997)
  14. McClean, K. H, "Quorum sensing and Chromobacterium violaceum: exploitation of violacein production and inhibition for the detection of N-acylhomoserine lactones", Microbiology, 143, pp.3703~3711 (1997)
  15. Blosser, R. S, "Extraction of violacein from Chromobacterium violaceum provides a new quantitative bioassay for N-acyl homoserine lactone autoinducers", J. Microbiol. Methods, 40, pp.47~55 (2000)
  16. Charlton, T. S, "A novel and sensitive method for the quantification of N-3-oxoacyl homoserine lactones using gas chromatographymass spectrometry: application to a model bacterial biofilm. Environ", Microbiol, 2, pp.530~541 (2000)
  17. Winson, M. K, "Construction and analysis of luxCDABE-based plasmid sensors for investigating N-acyl homoserine lactone-mediated quorum sensing", FEMS Microbiol. Lett, 163, pp.185~192 (1998)
  18. Andersen, J. B, "gfp-based N-acyl homoserine-lactone sensor systems for detection of bacterial communication", Appl. Environ. Microbiol, 67, pp.575~585 (2001)
  19. Ji, G, "Bacterial interference caused by autoinducing peptide variants", Science, 276, pp.2027~2030 (1997)
  20. Mayville, P, "Structure-activity analysis of synthetic autoinducing thiolactone peptides from Staphylococcus aureus responsible for virulence", Proc. Natl. Acad. Sci. U.S.A, 96, pp.1218~1223 (1999)
  21. Xavier, K. B, "LuxS quorum sensing: more than just a numbers game", Curr. Opin. Microbiol, 6, pp.191~197 (2003)
  22. Vendeville, A, "Making 'sense' of metabolism: autoinducer- 2, LuxS and pathogenic bacteria", Nat. Rev. Microbiol, 3, pp.383~396 (2005)
  23. Schauder, S, "The LuxS family of bacterial autoinducers: biosynthesis of a novel quorum-sensing signal molecule", Mol. Microbiol, 41, pp.463~476 (2001)
  24. Sun, J, "Is autoinducer-2 a universal signal for interspecies communication: a comparative genomic and phylogenetic analysis of the synthesis and signal transduction pathways", BMC Evol. Biol, 4, pp.36~ (2004)
  25. Pottathil, M, "The extracellular Phr peptide-Rap phosphatase signaling circuit of Bacillus subtilis", Front. Biosci, 8, pp.d32~d45 (2003)
  26. Aceves-Diez, A. E, "SKPDT is a signaling peptide that stimulates sporulation and cry1Aa expression in Bacillus thuringiensis but not in Bacillus subtilis", Appl. Microbiol. Biotechnol, 76, pp.203~209 (2007)
  27. Pierson, L. S, "Homoserine lactone-mediated gene regulation in plant-associated bacteria", Ann. Rev. Phytopathol, 36, pp.207~225 (1998)
  28. d'Angelo-Picard, C, "Diversity of N-acyl homoserine lactone-producing and degrading bacteria in soil and tobacco rhizosphere", Environ. Microbiol, 7, pp.1796~1808 (2005)
  29. Wang, Y. J, "Rapid acyl-homoserine lactone quorum signal biodegradation in diverse soils", Appl. Environ. Microbiol, 71, pp.1291~1299 (2005)
  30. Schaefer, A. L, "Detection, purification, and structural elucidation of the acylhomoserine lactone inducer of Vibrio fischeri luminescence and other related molecules", ethods Enzymol, 305, pp.288~301 (2000)
  31. Dong, Y. H, "AiiA, an enzyme that inactivates the acylhomoserine lactone quorum-sensing signal and attenuates the virulence of Erwinia carotovora", Proc. Natl. Acad. Sci. U.S.A, 97, pp.3526~3531 (2000)
  32. Dong, Y. H, "Quenching quorum-sensing- dependent bacterial infection by an N-acyl homoserine lactonase", Nature, 411, pp.813~817 (2001)
  33. Dong, Y. H, "Identification of quorum-quenching N-acyl homoserine lactonases from Bacillus species", Appl. Environ. Microbiol, 68, pp.1754~1759 (2002)
  34. Zhang, H. B, "Genetic control of quorum-sensing signal turnover in Agrobacterium tumefaciens", Proc. Natl. Acad. Sci. U.S.A, 99, pp.4638~4643 (2002)
  35. Park, S. Y, "AhlD, an N-acylhomoserine lactonase in Arthrobacter sp., and predicted homologues in other bacteria", MICROBIOLOGY-SGM, 149, pp.1541~1550 (2003), SOC GENERAL MICROBIOLOGY
  36. Leadbetter, J. R, "Metabolism of acyl-homoserine lactone quorum-sensing signals by Variovorax paradoxus", J. Bacteriol, 182, pp.6921~6926 (2000)
  37. 한종인, "Utilization of acyl-homoserine lactone quorum signals for growth by a soil pseudomonad and Pseudomonas aeruginosa PAO1", APPLIED AND ENVIRONMENTAL MICROBIOLOGY, 69(10), pp.5941~5949, AMER SOC MICROBIOLOGY
  38. Lin, Y. H, "Acyl-homoserine lactone acylase from Ralstonia strain XJ12B represents a novel and potent class of quorum-quenching enzymes", Mol. Microbiol, 47, pp.849~860 (2003)
  39. Surette, M. G, "Quorum sensing in Escherichia coli and Salmonella typhimurium", Proc. Natl. Acad. Sci. U.S.A, 95, pp.7046~7050 (1998)
  40. Surette, M. G, "Regulation of autoinducer production in Salmonella typhimurium", Mol. Microbiol, 31, pp.585~595 (1999)
  41. Xavier, K. B, "Regulation of uptake and processing of the quorum-sensing autoinducer AI-2 in Escherichia coli", J. Bacteriol, 187, pp.238~248 (2005)
  42. Xavier, K. B, "Interference with AI-2-mediated bacterial cell-cell communication", Nature, 437, pp.750~753 (2005)
  43. Redfield, R. J, "Is quorum sensing a side effect of diffusion sensing", Trends Microbiol, 10, pp.365~370 (2002)
  44. Keller, L, "Communication in", Nat. Rev. Microbiol, 4, pp.249~258 (2006)
  45. Klausen, M, "Dynamics of development and dispersal in sessile microbial communities: examples from Pseudomonas aeruginosa and Pseudomonas putida model biofilms", FEMS Microbiol. Lett, 261, pp.1~11 (2006)
  46. Weibel, D. B, "Microfabrication meets microbiology", Nat. Rev. Microbiol, 5, pp.209~218 (2007)
  47. Cheol-Min Ghim, "Synthetic Biology for Biofuels: Building Designer Microbes from the Scratch", Biotechnology and Bioprocess Engineering, 15(1), pp.11~21 (2010), 한국생물공학회
  48. Gulati, S, "Opportunities for microfluidic technologies in synthetic biology", J. Roy. Soc. Interface, 6, pp.S493~S506 (2009)
  49. Ingham, C. J, "The micro-petri dish, a million-well growth chip for the culture and high-throughput screening of microorganisms", Proc. Natl. Acad. Sci. U.S.A, 104, pp.18217~182222 (2007)
  50. Velve-Casquillas, G, "Microfluidic tools for cell biological research", Nano Today, 5, pp.28~47 (2010)
  51. Calvert, P, "Printing cells", Science, 318, pp.208~209 (2007)
  52. Cohen, D. J, "A modified consumer inkjet for spatiotemporal control of gene expression", PLoS One, 4, pp.e7086~ (2009)
  53. Merrin, J, "Printing multistrain bacterial patterns with a piezoelectric inkjet printer", PLoS One, 2, pp.e663~ (2007)
  54. Xu, T, "Construction of high-density bacterial colony arrays and patterns by the ink-jet method", Biotech. Bioeng, 85, pp.29~33 (2004)
  55. Kim, H. J, "Defined spatial structure stabilizes a synthetic multispecies bacterial community", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 105(47), pp.18188~18193 (2008), NATL ACAD SCIENCES
  56. Lee, S. H, "Capillary Based Patterning of Cellular Communities in Laterally Open Channels", ANALYTICAL CHEMISTRY, 82, pp.2900~2906 (2010), AMER CHEMICAL SOC
  57. Yaguchi, T, "Micropatterning bacterial suspensions using aqueous two phase systems", ANALYST, 135, pp.2848~2852 (2010), ROYAL SOC CHEMISTRY
  58. Boedicker, J. Q, "Microfluidic confinement of single cells of bacteria in small volumes initiates high-density behavior of quorum sensing and growth and reveals its variability", Angewandte Chemie - Int. Ed, 48, pp.5908~5911 (2009)
  59. Chen, M. T, "Artificial cell-cell communication in yeast Saccharomyces cerevisiae using signaling elements from Arabidopsis thaliana", Nat. Biotechnol, 23, pp.1551~1555 (2005)
  60. Choi, W. S, "Synthetic multicellular cell-to-cell communication in inkjet printed bacterial cell systems", Biomaterials (2011)[DOI]
  61. Basu, S, "A synthetic multicellular system for programmed pattern formation", Nature, 434, pp.1130~1134 (2005)
  62. Brenner, K, "Engineered bidirectional communication mediates a consensus in a microbial biofilm consortium", Proc. Natl. Acad. Sci. U.S.A, 104, pp.17300~17304 (2007)
  63. Ingham, C, "High-resolution microcontact printing and transfer of massive arrays of microorganisms on planar and compartmentalized nanoporous aluminium oxide", Lab on a Chip, 10, pp.1410~1416 (2010)
  64. Xu, L. P, "Microcontact printing of living bacteria arrays with cellular resolution", Nano Lett, 7, pp.2068~2072 (2007)
  65. Holz, C, "Bacterial motility and clustering guided by microcontact printing", Nano Lett, 9, pp.4553~4557 (2009)
  66. Eun, Y. J, "Fabrication of microbial biofilm arrays by geometric control of cell adhesion", Langmuir, 25, pp.4643~4654 (2009)
  67. Shou, W, "Synthetic cooperation in engineered yeast populations", Proc. Natl. Acad. Sci. U.S.A, 104, pp.1877~1882 (2007)
  68. Balagaddé, F. K, "A synthetic Escherichia coli predator-prey ecosystem", Mol. Sys. Biol, 4, pp.e187~ (2008)
  69. Nealson, K. H, "Bacterial bioluminescence: its control and ecological significance", Microbiol. Rev, 43, pp.496~518 (1979)
  70. Basu, S, "Spatiotemporal control of gene expression with pulse-generating networks", Proc. Natl. Acad. Sci. U.S.A, 101, pp.6355~6360 (2004)
  71. Pai, A, "Engineering multicellular systems by cell-cell communication", Curr. Opin. Biotechnol, 20, pp.461~470 (2009)
  72. Levskaya, A, "Engineering E. coli to see light", Nature, 438, pp.441~442 (2005)
  73. Tabor, J. J, "Multichromatic control of gene expression in Escherichia coli", J. Mol. Biol (2010)[DOI]
  74. Lu, T. K, "Next-generation synthetic gene networks", Nat. Biotechnol, 27, pp.1139~1150 (2009)
  75. Levskaya, A, "Spatiotemporal control of cell signalling using a light-switchable protein interaction", Nature, 461, pp.997~1001 (2009)
  76. Eiteman, M. A, "A co-fermentation strategy to consume sugar mixtures effectively", J. Biol. Engin, 2, pp.3~ (2008)
  77. Brenner, K, "Engineering microbial consortia: a new frontier in synthetic biology", Trends Biotechnol, 26, pp.483~489 (2008)
  78. 김주성, "Microbial production of plant benzylisoquinoline alkaloids", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 105(21), pp.7393~7398, NATL ACAD SCIENCES
  79. Hoang, T. T, "Characterization of Pseudomonas aeruginosa enoyl-acyl carrier protein reductase (FabI): a target for the antimicrobial triclosan and its role in acylated homoserine lactone synthesis", J. Bacteriol, 181, pp.5489~5497 (1999)
  80. Manefield, M, "Halogenated furanones inhibit quorum sensing through accelerated LuxR turnover", Microbiology, 148, pp.1119~1127 (2002)
  81. Raina, S, "Microbial quorum sensing: a tool or a target for antimicrobial therapy", Biotechnol. Appl. Bioc, 54, pp.65~84 (2009)
  82. Uroz, S, "Quorum sensing and quorum quenching: the Yin and Yang of bacterial communication", Chembiochem, 10, pp.205~216 (2009)
  83. Lesic, B, "Inhibitors of pathogen intercellular signals as selective anti- infective compounds", PLoS Pathog, 3, pp.1229~1239 (2007)
  84. Yeon, K. M, "Quorum Sensing: A New Biofouling Control Paradigm in a Membrane Bioreactor for Advanced Wastewater Treatment", ENVIRONMENTAL SCIENCE TECHNOLOGY, 43(2), pp.380~385 (2009), AMER CHEMICAL SOC
  85. Mae, A, "Transgenic plants producing the bacterial pheromone N-acyl-homoserine lactone exhibit enhanced resistance to the bacterial phytopathogen Erwinia carotovora", Mol. Plant Microbe. Interact, 14, pp.1035~1042 (2001)
  86. Yates, E. A, "-acylhomoserine lactones undergo lactonolysis in a pH, temperature and acyl chain length dependent manner during growth of Yersinia pseudotuberculosis and Pseudomonas aeruginosa", Infect. Immun, 70, pp.5635~5646 (2002)
  87. Byers, J. T, "Non-enzymatic turnover of an Erwinia carotovora quorum-sensing signaling molecule", J. Bacteriol, 184, pp.1163~1171 (2002)
  88. Hu, B, "An environment- sensitive synthetic microbial ecosystem", PLos One, 5, pp.e10619~ (2010)
  89. Bulter, T, "Design of artificial cell-cell communication using gene and metabolic networks", Proc. Natl. Acad. Sci. U.S.A, 101, pp.2299~2304 (2004)
  90. Garcia-Ojalvo, J, "Modeling a synthetic multicellular clock: repressilators coupled by quorum sensing", Proc. Natl. Acad. Sci. U.S.A, 101, pp.10955~10960 (2004)
  91. Ghim, C.-M, "Two-component genetic switch as a synthetic module with tunable stability", Phys. Rev. Lett, 103, pp.028101~ (2009)
  92. Ghim, C.-M, "Genetic noise control via protein oligomerization", BMC Syst. Biol, 2, pp.94~ (2008)
  93. Cheol-Min Ghim, "The art of reporter proteins in science: past, present and future applications", BMB reports, 43(7), pp.451~460 (2010), 생화학분자생물학회

관련 논문AI추천

Acyl Homoserine Lactone in Interspecies Bacterial SignalingBanerji Rajashri, Kanojiya Poonam, Saroj Sunil D.한국미생물·생명공학회 · 한국미생물·생명공학회지2022 · 제50권 제1호Quorum Sensing Regulation of Biofilm Formation by Periodontal Pathogens최봉규대한구강생물학회 · International Journal of Oral Biology2018 · 제43권 제4호박테리아의 Quorum Sensing 및 생물막 형성 억제를 위한 Quorum Quenching 연구 동향이정기한국미생물·생명공학회 · 한국미생물·생명공학회지2012 · 제40권 제2호세균의 적정밀도 인식을 통한 신호전달 및 신호전달 차단연구박순양, 이정기한국미생물·생명공학회 · 한국미생물·생명공학회지2004 · 제32권 제1호Synthetic Bacteria for Therapeutics나도균, 이향미, Phuong N. Lam VO한국미생물·생명공학회 · Journal of Microbiology and Biotechnology2019 · 제29권 제6호Bacterial Outer Membrane Vesicles as a Delivery System for Virulence Regulation윤현진한국미생물·생명공학회 · Journal of Microbiology and Biotechnology2016 · 제26권 제8호

이 간행물의 다른 논문 (10건)

Small RNA biology is systems biologyDaniel Jost, Erel Levine, Andrzej Nowojewskipp. 11-21Contribution of lysine-containing cationic domains to thermally-induced phase transition of elastin-like proteins and their sensitivity to different stimuliWon Bae Jeonpp. 22-27The microRNA expression profiles of mouse mesenchymal stem cell during chondrogenic differentiationShiwu Dong, Bo Yang, Hongfeng Guo, Yulan Zhangpp. 28-33A novel variant of t-PA resistant to plasminogen activator inhibitor-1; expression in CHO cells based on In Silico experimentsFarzaneh Barkhordari, Somayeh Enayati, Ahmad Adeli, Fereidoun Mahboudi, Mahdi Hemayatkar, Keivan Majidzadeh-A, Soroush Sardari, Fatemeh Davamipp. 34-39Inactive extracellular superoxide dismutase disrupts secretion and function of active extracellular superoxide dismutase김병학, Byeongwook Jeon, 윤종복, 김태윤, 김성섭, 이윤상pp. 40-45
원문 보기