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Synthetic Bacteria for Therapeutics

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초록

Synthetic biology builds programmed biological systems for a wide range of purposes such as improving human health, remedying the environment, and boosting the production of valuable chemical substances. In recent years, the rapid development of synthetic biology has enabled synthetic bacterium-based diagnoses and therapeutics superior to traditional methodologies by engaging bacterial sensing of and response to environmental signals inherent in these complex biological systems. Biosynthetic systems have opened a new avenue of disease diagnosis and treatment. In this review, we introduce designed synthetic bacterial systems acting as living therapeutics in the diagnosis and treatment of several diseases. We also discuss the safety and robustness of genetically modified synthetic bacteria inside the human body.

Abstract

Synthetic biology builds programmed biological systems for a wide range of purposes such as improving human health, remedying the environment, and boosting the production of valuable chemical substances. In recent years, the rapid development of synthetic biology has enabled synthetic bacterium-based diagnoses and therapeutics superior to traditional methodologies by engaging bacterial sensing of and response to environmental signals inherent in these complex biological systems. Biosynthetic systems have opened a new avenue of disease diagnosis and treatment. In this review, we introduce designed synthetic bacterial systems acting as living therapeutics in the diagnosis and treatment of several diseases. We also discuss the safety and robustness of genetically modified synthetic bacteria inside the human body.

참고문헌 (65)

  1. Cameron DE, "A brief history of synthetic biology", Nat Rev. Microbiol, 12, pp.381~390 (2014)
  2. Chubukov V, "Synthetic and systems biology for microbial production of commodity chemicals", NPJ Syst. Biol. Appl, 2, pp.16009~ (2016)
  3. Paddon CJ, "Semi-synthetic artemisinin : a model for the use of synthetic biology in pharmaceutical development", Nat. Rev. Microbiol, 12, pp.355~367 (2014)
  4. Lee SK, "Metabolic engineering of microorganisms for biofuels production : from bugs to synthetic biology to fuels", Curr. Opin. Biotechnol, 19, pp.556~563 (2008)
  5. 김송이, "Current Status of Microbial Phenylethanoid Biosynthesis", Journal of Microbiology and Biotechnology, 28(8), pp.1225~1232 (2018), 한국미생물·생명공학회
  6. Fangyu Cheng, "Biosynthesis of Chondroitin in Engineered Corynebacterium glutamicum", Journal of Microbiology and Biotechnology, 29(3), pp.392~400 (2019), 한국미생물·생명공학회[DOI]
  7. Ruder WC, "Synthetic biology moving into the clinic", Science, 333, pp.1248~1252 (2011)
  8. Folcher M, "Synthetic biology advancing clinical applications", Curr. Opin. Chem. Biol, 16, pp.345~354 (2012)
  9. Chen YY, "From DNA to targeted therapeutics : bringing synthetic biology to the clinic", Sci. Transl. Med, 3(106), pp.106~ (2011)[DOI]
  10. Pedrolli DB, "Engineering microbial living therapeutics : the synthetic biology toolbox", Trends Biotechnol, 37, pp.100~115 (2019)
  11. Mays ZJ, "Synthetic biology in probiotic lactic acid bacteria : at the frontier of living therapeutics", Curr. Opin. Biotechnol, 53, pp.224~231 (2018)
  12. Jain A, "Microbial synthetic biology for human therapeutics", Syst. Synth. Biol, 6, pp.9~22 (2012)
  13. Riglar DT, "Engineering bacteria for diagnostic and therapeutic applications", Nat. Rev. Microbiol, 16, pp.214~225 (2018)
  14. Vandenbroucke K, "Orally administered L, lactis secreting an anti-TNF nanobody demonstrate efficacy in chronic colitis", Mucosal Immunol, 3, pp.49~56 (2010)
  15. Chien T, "Advances in bacterial cancer therapies using synthetic biology", Curr. Opin. Syst. Biol, 5, pp.1~8 (2017)
  16. Chen Z, "Recent development on synthetic biological devices treating bladder cancer", Synth. Syst. Biotechnol, 1, pp.216~220 (2016)
  17. Chakravarti D, "Synthetic biology in cellbased cancer immunotherapy", Trends Biotechnol, 33, pp.449~461 (2015)
  18. Bhattarai SR, "Engineered phage-based therapeutic materials inhibit Chlamydia trachomatis intracellular infection", Biomaterials, 33, pp.5166~5174 (2012)
  19. Din MO, "Synchronized cycles of bacterial lysis for in vivo delivery", Nature, 536, pp.81~85 (2016)
  20. Isabella VM, "Development of a synthetic live bacterial therapeutic for the human metabolic disease phenylketonuria", Nat. Biotechnol, 36, pp.857~864 (2018)
  21. Wegmann U, "Use of genetically modified bacteria for drug delivery in humans: Revisiting the safety aspect", Sci. Rep, 7, pp.2294~ (2017)
  22. Slomovic S, "Synthetic biology devices for in vitro and in vivo diagnostics", Proc. Natl. Acad. Sci. USA, 112, pp.14429~14435 (2015)
  23. Courbet A, "Bringing next-generation diagnostics to the clinic through synthetic biology", EMBO Mol. Med, 8, pp.987~991 (2016)
  24. Kotula JW, "Programmable bacteria detect and record an environmental signal in the mammalian gut", Proc. Natl. Acad. Sci. USA, 111, pp.4838~4843 (2014)
  25. Daeffler KN, "Engineering bacterial thiosulfate and tetrathionate sensors for detecting gut inflammation", Mol. Syst. Biol, 13, pp.923~ (2017)
  26. Winter SE, "Gut inflammation provides a respiratory electron acceptor for Salmonella", Nature, 467, pp.426~429 (2010)
  27. Jackson MR, "Human sulfide : quinone oxidoreductase catalyzes the first step in hydrogen sulfide metabolism and produces a sulfane sulfur metabolite", Biochemistry, 51, pp.6804~6815 (2012)
  28. Hensel M, "The genetic basis of tetrathionate respiration in Salmonella typhimurium", Mol. Microbiol, 32, pp.275~287 (1999)
  29. Heinzinger NK, "Sequence analysis of the phs operon in Salmonella typhimurium and the contribution of thiosulfate reduction to anaerobic energy metabolism", J. Bacteriol, 177, pp.2813~2820 (1995)
  30. Chassaing B, "Dextran sulfate sodium (DSS)-induced colitis in mice", Curr. Protoc. Immunol, 104, pp.Unit 15.25~ (2014)
  31. Danino T, "Programmable probiotics for detection of cancer in urine", Sci. Transl. Med, 7(289), pp.289ra84~ (2015)
  32. Liang Q, "Fecal bacteria act as novel biomarkers for noninvasive diagnosis of colorectal cancer", Clin. Cancer Res, 23, pp.2061~2070 (2017)
  33. Brader P, "Escherichia coli Nissle 1917 facilitates tumor detection by positron emission tomography and optical imaging", Clin. Cancer Res, 14, pp.2295~2302 (2008)
  34. Stritzker J, "Tumor-specific colonization, tissue distribution, and gene induction by probiotic Escherichia coli Nissle 1917in live mice", Int. J. Med. Microbiol, 297, pp.151~162 (2007)
  35. Gerdes K, "The Parb(Hok Sok)Locus of plasmid-R1-a general-purpose plasmid stabilization system", Bio-Technol, 6, pp.1402~1405 (1988)
  36. Derman AI, "Phylogenetic analysis identifies many uncharacterized actin-like proteins(Alps)in bacteria : regulated polymerization, dynamic instability and treadmilling in Alp7A", Mol. Microbiol, 73, pp.534~552 (2009)
  37. Claesen J, "Synthetic microbes as drug delivery systems", ACS Synth. Biol, 4, pp.358~364 (2015)
  38. Hamady ZZ, "Xylan-regulated delivery of human keratinocyte growth factor-2 to the inflamed colon by the human anaerobic commensal bacterium Bacteroides ovatus", Gut, 59, pp.461~469 (2010)
  39. Duchmann R, "Tolerance exists towards resident intestinal flora but is broken in active inflammatory bowel disease(IBD)", Clin. Exp. Immunol, 102, pp.448~455 (1995)
  40. Cook DP, "Lactococcus lactis as a versatile vehicle for tolerogenic immunotherapy", Front. Immunol, 8, pp.1961~ (2017)
  41. Housley RM, "Keratinocyte growth factor induces proliferation of hepatocytes and epithelial cells throughout the rat gastrointestinal tract", J. Clin. Invest, 94, pp.1764~1777 (1994)
  42. Abil Z, "Synthetic biology for therapeutic applications", Mol. Pharm, 12, pp.322~331 (2015)
  43. Ozdemir T, "Synthetic biology and engineered live biotherapeutics : toward increasing system complexity", Cell Syst, 7, pp.5~16 (2018)
  44. Panida Sittipo, "Intestinal microbiota and the immune system in metabolic diseases", The Journal of Microbiology, 56(3), pp.154~162 (2018), 한국미생물학회[DOI]
  45. Duan F, "Engineered bacterial communication prevents Vibrio cholerae virulence in an infant mouse model", Proc Natl. Acad. Sci. USA, 107, pp.11260~11264 (2010)
  46. Lenz DH, "The small RNA chaperone Hfq and multiple small RNAs control quorum sensing in Vibrio harveyi and Vibrio cholerae", Cell, 118, pp.69~82 (2004)
  47. Hwang IY, "Engineered probiotic Escherichia coli can eliminate and prevent Pseudomonas aeruginosa gut infection in animal models", Nat. Commun, 8, pp.15028~ (2017)
  48. Saeidi N, "Engineering microbes to sense and eradicate Pseudomonas aeruginosa, a human pathogen", Mol. Syst. Biol, 7, pp.521~ (2011)
  49. Nerup J, "Mechanisms of pancreatic beta-cell destruction in type I diabetes", Diabetes Care, 11(Suppl 1), pp.16~23 (1988)
  50. Robert S, "Oral delivery of glutamic acid decarboxylase(GAD)-65 and IL10 by Lactococcus lactis reverses diabetes in recent-onset NOD mice", Diabetes, 63, pp.2876~2887 (2014)
  51. Tisch R, "Immune response to glutamic acid decarboxylase correlates with insulitis in non-obese diabetic mice", Nature, 366, pp.72~75 (1993)
  52. Dosoky NS, "Dietary fatty acids control the species of N-Acylphosphatidylethanolamines synthesized by therapeutically modified bacteria in the intestinal tract", ACS Infect. Dis, 4, pp.3~13 (2018)
  53. Chen Z, "Incorporation of therapeutically modified bacteria into gut microbiota inhibits obesity", J. Clin. Invest, 124, pp.3391~3406 (2014)
  54. Gillum MP, "N-acylphosphatidylethanolamine, a gutderived circulating factor induced by fat ingestion, inhibits food intake", Cell, 135, pp.813~824 (2008)
  55. Pinero-Lambea C, "Programming controlled adhesion of E, coli to target surfaces, cells, and tumors with synthetic adhesins", ACS Synth. Biol, 4, pp.463~473 (2015)
  56. Park SH, "RGD Peptide cell-surface display enhances the targeting and therapeutic efficacy of attenuated salmonella-mediated cancer therapy", Theranostics, 6, pp.1672~1682 (2016)
  57. Kramer MG, "Bacterial therapy of cancer : promises, limitations, and insights for future directions", Front. Microbiol, 9, pp.16~ (2018)
  58. Hiroshima Y, "Efficacy of Salmonella typhimurium A1-R versus chemotherapy on a pancreatic cancer patientderived orthotopic xenograft(PDOX)", J. Cell Biochem, 115, pp.1254~1261 (2014)
  59. Yamamoto M, "Efficacy of tumor-targeting Salmonella A1-R on a melanoma patient-derived orthotopic xenograft(PDOX)nude mouse model", PLoS One, 11, pp.e0160882~ (2016)
  60. Bull MJ, "The domestication of the probiotic bacterium Lactobacillus acidophilus", Sci. Rep, 4, pp.7202~ (2014)
  61. Dou J, "Synthetic biology and the gut microbiome", Biotechnol. J, 13, pp.e1700159~ (2018)
  62. Park W, "Gut microbiomes and their metabolites shape human and animal health", J. Microbiol, 56, pp.151~153 (2018)
  63. Probiotics in human health and disease: from nutribiotics to pharmabiotics, "The Journal of Microbiology", 2018, 773~782, pp.한국미생물학회, 10.1007[DOI]
  64. Wright O, "Building-in biosafety for synthetic biology", Microbiology, 159, pp.1221~1235 (2013)
  65. Wang F, "Synthetic biology : Recent progress, biosafety and biosecurity concerns, and possible solutions", J. Biosafety Biosecurity, 1, pp.22~30 (2019)

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