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Acyl Homoserine Lactone in Interspecies Bacterial Signaling

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Bacteria communicate with each other through an intricate communication mechanism known as quorum sensing (QS). QS regulates different behavioral aspects in bacteria, such as biofilm formation, sporulation, virulence gene expression, antibiotic production, and bioluminescence. Several different chemical signals and signal detection systems play vital roles in promoting highly efficient intra- and interspecies communication. Gram-negative bacteria coordinate gene regulation through the production of acyl homoserine lactones (AHLs). Gram-positive bacteria do not code for AHL production, while some gram-negative bacteria have an incomplete AHL-QS system. Despite this fact, these microbes can detect AHLs owing to the presence of LuxR solo receptors. Various studies have reported the role of AHLs in interspecies signaling. Moreover, as bacteria live in a polymicrobial community, the production of extracellular compounds to compete for resources is imperative. Thus, AHL-mediated signaling and inhibition are considered to affect virulence in bacteria. In the current review, we focus on the synthesis and regulation mechanisms of AHLs and highlight their role in interspecies bacterial signaling. Exploring interspecies bacterial signaling will further help us understand host-pathogen interactions, thereby contributing to the development of therapeutic strategies intended to target chronic polymicrobial infections.

Abstract

Bacteria communicate with each other through an intricate communication mechanism known as quorum sensing (QS). QS regulates different behavioral aspects in bacteria, such as biofilm formation, sporulation, virulence gene expression, antibiotic production, and bioluminescence. Several different chemical signals and signal detection systems play vital roles in promoting highly efficient intra- and interspecies communication. Gram-negative bacteria coordinate gene regulation through the production of acyl homoserine lactones (AHLs). Gram-positive bacteria do not code for AHL production, while some gram-negative bacteria have an incomplete AHL-QS system. Despite this fact, these microbes can detect AHLs owing to the presence of LuxR solo receptors. Various studies have reported the role of AHLs in interspecies signaling. Moreover, as bacteria live in a polymicrobial community, the production of extracellular compounds to compete for resources is imperative. Thus, AHL-mediated signaling and inhibition are considered to affect virulence in bacteria. In the current review, we focus on the synthesis and regulation mechanisms of AHLs and highlight their role in interspecies bacterial signaling. Exploring interspecies bacterial signaling will further help us understand host-pathogen interactions, thereby contributing to the development of therapeutic strategies intended to target chronic polymicrobial infections.

참고문헌 (102)

  1. Rutherford ST, "Bacterial quorum sensing : its role in virulence and possibilities for its control", Cold Spring Harb. Perspect. Med, 2, pp.a012427~ (2012)
  2. Waters CM, "Quorum sensing : cell-to-cell communication in bacteria", Annu. Rev. Cell Dev. Biol, 21, pp.319~346 (2005)
  3. Ryan RP, "Diffusible signals and interspecies communication in bacteria", Microbiology, 154, pp.1845~1858 (2008)
  4. Fajardo A, "Antibiotics as signals that trigger specific bacterial responses", Curr. Opin. Microbiol, 11, pp.161~167 (2008)
  5. Miller MB, "Quorum sensing in bacteria", Annu. Rev. Microbiol, 55, pp.165~199 (2001)
  6. Parsek MR, "Acyl homoserine-lactone quorum-sensing signal generation", Proc. Natl. Acad. Sci. USA, 96, pp.4360~4365 (1999)
  7. Eberl L, "N-acyl homoserinelactone-mediated gene regulation in gram-negative bacteria", Syst. Appl. Microbiol, 22, pp.493~506 (1999)
  8. Schauder S, "The languages of bacteria", Genes Dev, 15, pp.1468~1480 (2001)
  9. Ismail AS, "A host-produced autoinducer-2 mimic activates bacterial quorum sensing", Cell Host Microbe, 19, pp.470~480 (2016)
  10. Hughes DT, "Inter-kingdom signaling communication between bacteria and their hosts", Nat. Rev. Microbiol, 6, pp.111~120 (2008)
  11. Sircili MP, "Modulation of enteropathogenic Escherichia coli virulence by quorum sensing", Infect. Immun, 72, pp.2329~2337 (2004)
  12. Verstrepen KJ, "Origins of variation in the fungal cell surface", Nat. Rev. Microbiol, 2, pp.533~540 (2004)
  13. Lee J, "Indole is an inter-species biofilm signal mediated by SdiA", BMC Microbiol, 7, pp.42~ (2007)
  14. Kuczyńska-Wiśnik D, "Antibiotics promoting oxidative stress inhibit formation of Escherichia coli biofilm via indole signaling", Res. Microbiol, 161, pp.847~853 (2010)
  15. Lee JH, "Indole as an intercellular signal in microbial communities", FEMS Microbiol. Rev, 34, pp.426~444 (2010)
  16. Davies J., "What are antibiotics? Archaic functions for modern activities", Mol. Microbiol, 4, pp.1227~1232 (1990)
  17. Davies J., "Microbes have the last word : A drastic re-evaluation of antimicrobial treatment is needed to overcome the threat of antibiotic-resistant bacteria", EMBO Rep, 8, pp.616~621 (2007)
  18. Seshasayee AS, "Transcriptional regulatory networks in bacteria : from input signals to output responses", Curr. Opin. Microbiol, 9, pp.511~519 (2006)
  19. Yim G, "The truth about antibiotics", Int. J. Med. Microbiol, 296, pp.163~170 (2006)
  20. Yim G, "Antibiotics as signaling molecules", Philos. Trans. R. Soc. Lond., B, Biol. Sci, 362, pp.1195~1200 (2007)
  21. Eberhard A, "Structural identification of autoinducer of Photobacterium fischeri luciferase", Biochemistry, 20, pp.2444~2449 (1981)
  22. Pearson JP, "Structure of the autoinducer required for expression of Pseudomonas aeruginosa virulence genes", Proc. Natl. Acad. Sci. USA, 91, pp.197~201 (1994)
  23. Pearson JP, "A second N-acylhomoserine lactone signal produced by Pseudomonas aeruginosa", Proc. Natl. Acad. Sci. USA, 92, pp.1490~1494 (1995)
  24. Gray KM, "Cell-to-cell signaling in the symbiotic nitrogen-fixing bacterium Rhizobium leguminosarum : autoinduction of a stationary phase and rhizosphere-expressed genes", J. Bacteriol, 178, pp.372~376 (1996)
  25. Eberhard A, "Synthesis of the lux gene autoinducer in Vibrio fischeri is positively autoregulated", Arch. Microbiol, 155, pp.294~297 (1991)
  26. Gilson L, "AinS and a new family of autoinducer synthesis proteins", J. Bacteriol, 177, pp.6946~6951 (1995)
  27. Schaefer AL, "Generation of cell-to-cell signals in quorum sensing : acyl homoserine lactone synthase activity of a purified Vibrio fischeri LuxI protein", Proc. Natl. Acad. Sci. USA, 93, pp.9505~9509 (1996)
  28. Pearson JP, "Active efflux and diffusion are involved in transport of Pseudomonas aeruginosa cell-to-cell signals", J. Bacteriol, 181, pp.1203~1210 (1999)
  29. Evans K, "Influence of the MexAB-OprM multidrug efflux system on quorum sensing in Pseudomonas aeruginosa", J. Bacteriol, 180, pp.5443~5437 (1998)
  30. Alcalde-Rico M, "Multidrug efflux pumps at the crossroad between antibiotic resistance and bacterial virulence", Front. Microbiol, 7, pp.1483~ (2016)
  31. Hanzelka BL, "Acylhomoserine lactone synthase activity of the Vibrio fischeri AinS protein", J. Bacteriol, 181, pp.5766~5770 (1999)
  32. Parsek MR, "Acyl-homoserine lactone quorum sensing in gram-negative bacteria : a signaling mechanism involved in associations with higher organisms", Proc. Natl. Acad. Sci. USA, 97, pp.8789~8793 (2000)
  33. Mok KC, "Vibrio harveyi quorum sensing : a coincidence detector for two autoinducers controls gene expression", EMBO J, 22, pp.870~881 (2003)
  34. Henke JM, "Three parallel quorum-sensing systems regulate gene expression in Vibrio harveyi", J. Bacteriol, 186, pp.6902~6914 (2004)
  35. Cao JG, "Purification and structural identification of an autoinducer for the luminescence system of Vibrio harveyi", J. Biol. Chem, 264, pp.21670~21676 (1989)
  36. Surette MG, "Quorum sensing in Escherichia coli, Salmonella Typhimurium, and Vibrio harveyi : a new family of genes responsible for autoinducer production", Proc. Natl. Acad. Sci. USA, 96, pp.1639~1644 (1999)
  37. Chen X, "Structural identification of a bacterial quorumsensing signal containing boron", Nature, 415, pp.545~549 (2002)
  38. Bassler BL, "Multiple signaling systems controlling expression of luminescence in Vibrio harveyi : sequence and function of genes encoding a second sensory pathway", Mol. Microbiol, 13, pp.273~286 (1994)
  39. Freeman JA, "A genetic analysis of the function of LuxO, a two-component response regulator involved in quorum sensing in Vibrio harveyi", Mol. Microbiol, 31, pp.665~677 (1999)
  40. Freeman JA, "Sequence and function of LuxU : a Two-component phosphorelay protein that regulates quorum sensing in Vibrio harveyi", J. Bacteriol, 181, pp.899~906 (1999)
  41. Defoirdt T, "The impact of mutations in the quorum sensing systems of Aeromonas hydrophila, Vibrio anguillarum and Vibrio harveyi on their virulence towards gnotobiotically cultured Artemia franciscana", Environ. Microbiol, 7, pp.1239~1247 (2005)
  42. Silby MW, "Pseudomonas genomes : diverse and adaptable", FEMS Microbiol. Rev, 35, pp.652~680 (2011)
  43. Schuster M, "A network of networks : quorum-sensing gene regulation in Pseudomonas aeruginosa", Int. J. Med. Microbiol, 296, pp.73~81 (2006)
  44. Williams P, "Quorum sensing and environmental adaptation in Pseudomonas aeruginosa : a tale of regulatory networks and multifunctional signal molecules", Curr. Opin. Microbiol, 12, pp.182~191 (2009)
  45. Schuster M, "Identification, timing, and signal specificity of Pseudomonas aeruginosa quorum-controlled genes : a transcriptome analysis", J. Bacteriol, 185, pp.2066~2079 (2003)
  46. Wagner VE, "Microarray analysis of Pseudomonas aeruginosa quorumsensing regulons : effects of growth phase and environment", J. Bacteriol, 185, pp.2080~2095 (2003)
  47. Crump JA, "Intravascular catheter-associated infections", Eur. J. Clin. Microbiol. Infect. Dis, 19, pp.1~8 (2000)
  48. Wargo MJ, "Fungal-bacterial interactions : a mixed bag of mingling microbes", Curr. Opin. Microbiol, 9, pp.359~364 (2006)
  49. Duan K, "Modulation of Pseudomonas aeruginosa gene expression by host microflora through interspecies communication", Mol. Microbiol, 50, pp.1477~1491 (2003)
  50. Hogan DA, "A Pseudomonas aeruginosa quorum-sensing molecule influences Candida albicans morphology", Mol. Microbiol, 54, pp.1212~1223 (2004)
  51. Trejo-Hernández A, "Interspecies competition triggers virulence and mutability in Candida albicans–Pseudomonas aeruginosa mixed biofilms", ISME J, 8, pp.1974~1988 (2014)
  52. Roux D, "Candida albicans impairs macrophage function and facilitates Pseudomonas aeruginosa pneumonia in rat", Crit. Care Med, 37, pp.1062~1067 (2009)
  53. Cugini C, "Farnesol, a common sesquiterpene, inhibits PQS production in Pseudomonas aeruginosa", Mol. Microbiol, 65, pp.896~906 (2007)
  54. Tashiro Y, "Interspecies interaction between Pseudomonas aeruginosa and other microorganisms", Microbes Environ, 28, pp.13~24 (2013)
  55. Hoffman LR, "Selection for Staphylococcus aureus small-colony variants due to growth in the presence of Pseudomonas aeruginosa", Proc. Natl. Acad. Sci. USA, 103, pp.19890~19895 (2006)
  56. Fishbain J, "Treatment of Acinetobacter infections", Clin. Infect. Dis, 51, pp.79~84 (2010)
  57. Weinstein RA, "Overview of nosocomial infections caused by gram-negative bacilli", Clin. Infect. Dis, 41, pp.848~854 (2005)
  58. Nucleo E, "Growth in glucose-based medium and exposure to subinhibitory concentrations of imipenem induce biofilm formation in a multidrug-resistant clinical isolate of Acinetobacter baumannii", BMC Microbiol, 9, pp.270~ (2009)
  59. Tomaras AP, "Attachment to and biofilm formation on abiotic surfaces by Acinetobacter baumannii : involvement of a novel chaperone-usher pili assembly system", Microbiology, 149, pp.3473~3484 (2003)
  60. Dent LL, "Multidrug resistant Acinetobacter baumannii : a descriptive study in a city hospital", BMC Infect. Dis, 10, pp.196~ (2010)
  61. Bhargava N, "N-acyl homoserine lactone mediated interspecies interactions between A. baumannii and P. aeruginosa", Biofouling, 28, pp.813~822 (2012)
  62. Niu C, "Isolation and characterization of an autoinducer synthase from Acinetobacter baumannii", J. Bacteriol, 190, pp.3386~3392 (2008)
  63. Savka MA, "LasR receptor for detection of long-chain quorum-sensing signals : identification of N-acylhomoserine lactones encoded by the avsI locus of Agrobacterium vitis", Curr. Microbiol, 62, pp.101~110 (2011)
  64. Govan JR, "Microbial pathogenesis in cystic fibrosis : mucoid Pseudomonas aeruginosa and Burkholderia cepacia", Microbiol. Rev, 60, pp.539~574 (1996)
  65. Tümmler B, "Cystic fibrosis : an inherited susceptibility to bacterial respiratory infections", Mol. Med. Today, 5, pp.351~358 (1999)
  66. Saiman LI, "Pseudomonas cepacia adherence to respiratory epithelial cells is enhanced by Pseudomonas aeruginosa", Infect. Immun, 58, pp.2578~2584 (1990)
  67. Isles A, "Pseudomonas cepacia infection in cystic fibrosis : an emerging problem", J. Pediatr, 104, pp.206~210 (1984)
  68. Lewenza S, "Quorum sensing in Burkholderia cepacia : identification of the LuxRI homologs CepRI", J. Bacteriol, 181, pp.748~756 (1999)
  69. Gotschlich A, "Synthesis of multiple N-acylhomoserine lactones is wide-spread among the members of the Burkholderia cepacia complex", Syst. Appl. Microbiol, 24, pp.1~4 (2001)
  70. McKenney D, "Influence of Pseudomonas aeruginosa exoproducts on virulence factor production in Burkholderia cepacia : evidence of interspecies communication", J. Bacteriol, 177, pp.6989~6992 (1995)
  71. Riedel K, "N-acylhomoserine-lactone-mediated communication between Pseudomonas aeruginosa and Burkholderia cepacia in mixed biofilms", Microbiology, 147, pp.3249~3262 (2001)
  72. Carapetis JR, "The global burden of group A streptococcal diseases", Lancet Infect. Dis, 5, pp.685~694 (2005)
  73. Jimenez JC, "Quorum sensing in group A Streptococcus", Front. Cell. Infect. Microbiol, 4, pp.127~ (2014)
  74. Saroj SD, "Inhibitory role of acyl homoserine lactones in hemolytic activity and viability of Streptococcus pyogenes M6 S165", Sci. Rep, 7, pp.44902~ (2017)
  75. Saroj SD, "Lactobacilli interfere with Streptococcus pyogenes hemolytic activity and adherence to host epithelial cells", Front. Microbiol, 7, pp.1176~ (2016)
  76. Banerji R, "Interspecies signalling affects virulence related morphological characteristics of Streptococcus pyogenes M3", FEMS Microbiol. Lett, 368, pp.fnab079~ (2021)
  77. Rajashri Banerji, "Exposure to Acyl Homoserine Lactone Enhances Survival of Streptococcus pyogenes in Murine Macrophages", Microbial Ecology, 84(4), pp.1256~1263 (2021), Springer Science and Business Media LLC[DOI]
  78. Subramoni S, "LuxR-family ‘solos’ : bachelor sensors", regulators of signaling molecules, 2009, pp.155, 1377~1385
  79. Case RJ, "AHL-driven quorumsensing circuits : their frequency and function among the proteobacteria", ISME J, 2, pp.345~349 (2008)
  80. Fuqua C, "Listening in on bacteria : acylhomoserine lactone signaling", Nat. Rev. Mol. Cell Biol, 3, pp.685~695 (2002)
  81. Lintz MJ, "Crystal structure of QscR, a Pseudomonas aeruginosa quorum sensing signal receptor", Proc. Natl. Acad. Sci. USA, 108, pp.15763~15768 (2011)
  82. Ahmer BM, "Cell-to-cell signaling in Escherichia coli and Salmonella enterica", Mol. Microbiol, 52, pp.933~945 (2004)
  83. Chugani SA, "QscR, a modulator of quorum-sensing signal synthesis and virulence in Pseudomonas aeruginosa", Proc. Natl. Acad. Sci. USA, 98, pp.2752~2757 (2001)
  84. Janssens JC, "Synthesis of N-acyl homoserine lactone analogues reveals strong activators of SdiA, the Salmonella enterica serovar Typhimurium LuxR homologue", Appl. Environ. Microbiol, 73, pp.535~544 (2007)
  85. Michael B, "SdiA of Salmonella enterica is a LuxR homolog that detects mixed microbial communities", J. Bacteriol, 183, pp.5733~5742 (2001)
  86. Yao Y, "Structure of the Escherichia coli quorum sensing protein SdiA : activation of the folding switch by acyl homoserine lactones", J. Mol. Biol, 355, pp.262~273 (2006)
  87. Rahmati S, "Control of the AcrAB multidrug efflux pump by quorum-sensing regulator SdiA", Mol. Microbiol, 43, pp.677~685 (2002)
  88. Chan KG, "Inhibiting N-acyl-homoserine lactone synthesis and quenching Pseudomonas quinolone quorum sensing to attenuate virulence", Front. Microbiol, 6, pp.1173~ (2015)
  89. Hoang TT, "Characterization of Pseudomonas aeruginosa enoyl-acyl carrier protein reductase(FabI) : a target for the antimicrobial triclosan and its role in acylated homoserine lactone synthesis", J. Bacteriol, 181, pp.5489~5497 (1999)
  90. Singh V, "Femtomolar transition state analogue inhibitors of 5'-methylthioadenosine", S-adenosylhomocysteine nucleosidase from Escherichia coli, 2005, pp.280, 18265~18273
  91. Singh V, "Structure and inhibition of a quorum sensing target from Streptococcus pneumoniae", Biochemistry, 45, pp.12929~12941 (2006)
  92. Taga ME, "Chemical communication among bacteria", Proc. Natl. Acad. Sci. USA, 100(suppl 2), pp.14549~14554 (2003)
  93. Eberl L, "Involvement of N-acyl-l-homoserine lactone autoinducers in controlling the multicellular behaviour of Serratia liquefaciens", Mol. Microbiol, 20, pp.127~136 (1996)
  94. Lindum PW, "N-Acyl-L-homoserine lactone autoinducers control production of an extracellular lipopeptide biosurfactant required for swarming motility of Serratia liquefaciens MG1", J. Bacteriol, 180, pp.6384~6388 (1998)
  95. Manefield M, "Evidence that halogenated furanones from Delisea pulchra inhibit acylated homoserine lactone(AHL)-mediated gene expression by displacing the AHL signal from its receptor protein", Microbiology, 145, pp.283~291 (1999)
  96. Borchardt SA, "Reaction of acylated homoserine lactone bacterial signaling molecules with oxidized halogen antimicrobials", Appl. Environ. Microbiol, 67, pp.3174~3179 (2001)
  97. Lee SJ, "Genes encoding the N-acyl homoserine lactone-degrading enzyme are widespread in many subspecies of Bacillus thuringiensis", Appl. Environ. Microbiol, 68, pp.3919~3924 (2002)
  98. Givskov M, "Two separate regulatory systems participate in control of swarming motility of Serratia liquefaciens MG1", J. Bacteriol, 180, pp.742~745 (1998)
  99. Eberl L, "Surface motility of Serratia liquefaciens MG1", J. Bacteriol, 181, pp.1703~1712 (1999)
  100. Bernheimer AW, "Lysosomal disruption by bacterial toxins", J. Bacteriol, 87, pp.1100~1104 (1964)
  101. Keiser H, "STUDIES ON LYSOSOMES: IV. Solubilization of enzymes during mitochondrial swelling and disruption of lysosomes by streptolysin S and other hemolytic agents", J. Cell Biol, 22, pp.101~113 (1964)
  102. Lowery CA, "Interspecies and interkingdom communication mediated by bacterial quorum sensing", Chem. Soc. Rev, 37, pp.1337~1346 (2008)

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