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Bacterial Outer Membrane Vesicles as a Delivery System for Virulence Regulation

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초록

Outer membrane vesicles (OMVs) are spherical nanostructures that are ubiquitously shed from gram-negative bacteria both in vitro and in vivo. Recent findings revealed that OMVs, which contain diverse components derived from the parent bacterium, play an important role in communication with neighboring bacteria and the environment. Furthermore, nanoscale proteoliposomes decorated with pathogen-associated molecules attract considerable attention as a non-replicative carrier for vaccines and drug materials. This review introduces recent advances in OMV biogenesis and discusses the roles of OMVs in the context of bacterial communication and virulence regulation. It also describes the remarkable accomplishments in OMV engineering for diverse therapeutic applications.

Abstract

Outer membrane vesicles (OMVs) are spherical nanostructures that are ubiquitously shed from gram-negative bacteria both in vitro and in vivo. Recent findings revealed that OMVs, which contain diverse components derived from the parent bacterium, play an important role in communication with neighboring bacteria and the environment. Furthermore, nanoscale proteoliposomes decorated with pathogen-associated molecules attract considerable attention as a non-replicative carrier for vaccines and drug materials. This review introduces recent advances in OMV biogenesis and discusses the roles of OMVs in the context of bacterial communication and virulence regulation. It also describes the remarkable accomplishments in OMV engineering for diverse therapeutic applications.

참고문헌 (34)

  1. Alaniz RC, "Membrane vesicles are immunogenic facsimiles of Salmonella typhimurium that potently activate dendritic cells, prime B and T cell responses, and stimulate protective immunity in vivo", J. Immunol, 179, pp.7692~7701 (2007)
  2. Bai J, "Identification and characterization of outer membrane vesicle-associated proteins in Salmonella enterica serovar Typhimurium", Infect. Immun, 82, pp.4001~4010 (2014)
  3. Collins BS, "Gram-negative outer membrane vesicles in vaccine development", Discov. Med, 12, pp.7~15 (2011)
  4. Duperthuy M, "Role of the Vibrio cholerae matrix protein Bap1 in cross-resistance to antimicrobial peptides", PLoS Pathog, 9, pp.e1003620~ (2013)
  5. Evans AG, "Predatory activity of Myxococcus xanthus outer-membrane vesicles and properties of their hydrolase cargo", Microbiology, 158, pp.2742~2752 (2012)
  6. Fulsundar S, "Gene transfer potential of outer membrane vesicles of Acinetobacter baylyi and effects of stress on vesiculation", Appl. Environ. Microbiol, 80, pp.3469~3483 (2014)
  7. Galka F, "Proteomic characterization of the whole secretome of Legionella pneumophila and functional analysis of outer membrane vesicles", Infect. Immun, 76, pp.1825~1836 (2008)
  8. Imayoshi R, "NO production in RAW264 cells stimulated with Porphyromonas gingivalis extracellular vesicles", Oral Dis, 17, pp.83~89 (2011)
  9. Jose J, "The autodisplay story, from discovery to biotechnical and biomedical applications", Microbiol. Mol. Biol. Rev, 71, pp.600~619 (2007)
  10. Kesty NC, "Incorporation of heterologous outer membrane and periplasmic proteins into Escherichia coli outer membrane vesicles", J. Biol. Chem, 279, pp.2069~2076 (2004)
  11. Kesty NC, "Enterotoxigenic Escherichia coli vesicles target toxin delivery into mammalian cells", EMBO J, 23, pp.4538~4549 (2004)
  12. Kim JY, "Engineered bacterial outer membrane vesicles with enhanced functionality", J. Mol. Biol, 380, pp.51~66 (2008)
  13. Mashburn-Warren LM, "Special delivery:vesicle trafficking in prokaryotes", Mol. Microbiol, 61, pp.839~846 (2006)
  14. Prados-Rosales R, "Role for Mycobacterium tuberculosis membrane vesicles in iron acquisition", J. Bacteriol, 196, pp.1250~1256 (2014)
  15. Rakoff-Nahoum S, "An ecological network of polysaccharide utilization among human intestinal symbionts", Curr. Biol, 24, pp.40~49 (2014)
  16. Schaar V, "Moraxella catarrhalis outer membrane vesicles carry betalactamase and promote survival of Streptococcus pneumoniae and Haemophilus influenzae by inactivating amoxicillin", Antimicrob. Agents Chemother, 55, pp.3845~3853 (2011)
  17. Schaar V, "Group A streptococci are protected from amoxicillin-mediated killing by vesicles containing beta-lactamase derived from Haemophilus influenzae", J. Antimicrob. Chemother, 69, pp.117~120 (2014)
  18. Schertzer JW, "A bilayer-couple model of bacterial outer membrane vesicle biogenesis", MBio, 3(2) (2012)
  19. Schroeder J, "Recombinant outer membrane vesicles to augment antigen-specific live vaccine responses", Vaccine, 27, pp.6748~6754 (2009)
  20. Schwechheimer C, "Modulation of bacterial outer membrane vesicle production by envelope structure and content", BMC Microbiol, 14, pp.324~ (2014)
  21. Schwechheimer C, "NlpImediated modulation of outer membrane vesicle production through peptidoglycan dynamics in Escherichia coli", Microbiologyopen, 4, pp.375~389 (2015)
  22. Schwechheimer C, "Envelope control of outer membrane vesicle production in gramnegative bacteria", Biochemistry, 52, pp.3031~3040 (2013)
  23. Sharpe SW, "Elicitation of epithelial cell-derived immune effectors by outer membrane vesicles of nontypeable Haemophilus influenzae", Infect. Immun, 79, pp.4361~4369 (2011)
  24. Shen Y, "Outer membrane vesicles of a human commensal mediate immune regulation and disease protection", Cell Host Microbe, 12, pp.509~520 (2012)
  25. Soderblom T, "Effects of the Escherichia coli toxin cytolysin A on mucosal immunostimulation via epithelial Ca2+ signalling and Toll-like receptor 4", Cell Microbiol, 7, pp.779~788 (2005)
  26. Stentz R, "Cephalosporinases associated with outer membrane vesicles released by Bacteroides spp. protect gut pathogens and commensals against beta-lactam antibiotics", J. Antimicrob. Chemother, 70, pp.701~709 (2015)
  27. Tran AX, "Periplasmic cleavage and modification of the 1-phosphate group of Helicobacter pylori lipid A", J. Biol. Chem, 279, pp.55780~55791 (2004)
  28. van der Ley P, "Modification of lipid A biosynthesis in Neisseria meningitidis lpxL mutants: influence on lipopolysaccharide structure, toxicity, and adjuvant activity", Infect. Immun, 69, pp.5981~5990 (2001)
  29. Velimirov B, "Mobilizable bacterial DNA packaged into membrane vesicles induces serial transduction", Mob. Genet. Elements, 1, pp.80~81 (2011)
  30. Vidakovics ML, "B cell activation by outer membrane vesicles - a novel virulence mechanism", PLoS Pathog, 6, pp.e1000724~ (2010)
  31. Winter J, "Helicobacter pylori membrane vesicles stimulate innate proand anti-inflammatory responses and induce apoptosis in Jurkat T cells", Infect. Immun, 82, pp.1372~1381 (2014)
  32. Yaron S, "Vesiclemediated transfer of virulence genes from Escherichia coli O157:H7 to other enteric bacteria", Appl. Environ. Microbiol, 66, pp.4414~4420 (2000)
  33. Yoon H, "Discovery of Salmonella virulence factors translocated via outer membrane vesicles to murine macrophages", Infect. Immun, 79, pp.2182~2192 (2011)
  34. Zhao K, "Pseudomonas aeruginosa outer membrane vesicles modulate host immune responses by targeting the Toll-like receptor 4 signaling pathway", Infect. Immun, 81, pp.4509~4518 (2013)

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