Propranolol, a β-adrenergic antagonist, attenuates the decrease in trabecular bone mass in high calorie diet fed growing mice
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We investigated the effects of high calorie and low caloriediets on skeletal integrity, and whether β-adrenergic blockade(BB) attenuates bone loss induced by dietary calorie alteration. Male 6-week-old C57BL/6 mice were assigned to either anad-lib fed control diet (CON), a high calorie diet (HIGH), or alow calorie diet (LOW) group. In each diet group, mice weretreated with either vehicle (VEH) or propranolol, a β-adrenergicantagonist. Over 12-weeks, β-blockade mitigated bodyweight and fat mass increases induced by the high calorie diet. Femoral trabecular bone mineral density and the expressionlevels of osteogenic marker genes in bone marrow cells werereduced in HIGHVEH and LOWVEH mice, and BB significantlyattenuated this decline only in HIGH mice. In summary,the magnitude of bone loss induced by low calorie diet wasgreater than that caused by high calorie diet in growing mice,and β-blockade mitigated high calorie diet-induced bone loss.
Abstract
We investigated the effects of high calorie and low caloriediets on skeletal integrity, and whether β-adrenergic blockade(BB) attenuates bone loss induced by dietary calorie alteration. Male 6-week-old C57BL/6 mice were assigned to either anad-lib fed control diet (CON), a high calorie diet (HIGH), or alow calorie diet (LOW) group. In each diet group, mice weretreated with either vehicle (VEH) or propranolol, a β-adrenergicantagonist. Over 12-weeks, β-blockade mitigated bodyweight and fat mass increases induced by the high calorie diet. Femoral trabecular bone mineral density and the expressionlevels of osteogenic marker genes in bone marrow cells werereduced in HIGHVEH and LOWVEH mice, and BB significantlyattenuated this decline only in HIGH mice. In summary,the magnitude of bone loss induced by low calorie diet wasgreater than that caused by high calorie diet in growing mice,and β-blockade mitigated high calorie diet-induced bone loss.
참고문헌 (20)
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