Maintenance of cellular tetrahydrobiopterin homeostasis
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Tetrahydrobiopterin (BH4) is a multifunctional cofactor of aromatic amino acid hydroxylases and nitric oxide synthase (NOS) as well as an intracellular antioxidant in animals. Through regulation of NOS activity BH4 plays a pivotal role not only in a variety of normal cellular functions but also in the pathogenesis of cardiovascular and neurodegenerative diseases,which develop under oxidative stress conditions. It appears that a balanced interplay between BH4 and NOS is crucial for cellular fate. If cellular BH4 homeostasis maintained by BH4 synthesis and regeneration fails to cope with increased oxidative stress, NOS is uncoupled to generate superoxide rather than NO and, in turn, exacerbates impaired BH4 homeostasis,thereby leading to cell death. The fundamental biochemical events involved in the BH4-NOS interplay are essentially the same, as revealed in mammalian endothelial, cardiac,and neuronal cells. This review summarizes information on the cellular BH4 homeostasis in mammals, focusing on its regulation under normal and oxidative stress conditions.
Abstract
Tetrahydrobiopterin (BH4) is a multifunctional cofactor of aromatic amino acid hydroxylases and nitric oxide synthase (NOS) as well as an intracellular antioxidant in animals. Through regulation of NOS activity BH4 plays a pivotal role not only in a variety of normal cellular functions but also in the pathogenesis of cardiovascular and neurodegenerative diseases,which develop under oxidative stress conditions. It appears that a balanced interplay between BH4 and NOS is crucial for cellular fate. If cellular BH4 homeostasis maintained by BH4 synthesis and regeneration fails to cope with increased oxidative stress, NOS is uncoupled to generate superoxide rather than NO and, in turn, exacerbates impaired BH4 homeostasis,thereby leading to cell death. The fundamental biochemical events involved in the BH4-NOS interplay are essentially the same, as revealed in mammalian endothelial, cardiac,and neuronal cells. This review summarizes information on the cellular BH4 homeostasis in mammals, focusing on its regulation under normal and oxidative stress conditions.
참고문헌 (89)
- Thöny, B., "Tetrahydrobiopterin biosynthesis, regeneration and functions", Biochem. J., 347, pp.1~16 (2000)
- Kim, H. L., "Tetrahydropteridine deficiency impairs mitochondrial function in Dictyostelium discoideum Ax2", FEBS Letters, 581, pp.5430~5434 (2007)
- En-Young Cha, "Functional Characterization of the Gene Encoding UDP-glucose: Tetrahydrobiopterin a-Glucosyltransferase in Synechococcus sp. PCC 7942", The Journal of Microbiology, 43(2), pp.191~195 (2005), 한국미생물학회
- Longo, N., "Disorders of biopterin metabolism", J. Inherit. Metab. Dis., 32, pp.333~342 (2009)
- Tegeder, I., "GTP cyclohydrolase and tetrahydrobiopterin regulate pain sensitivity and persistence", Nat. Med., 12, pp.1269~1277 (2006)
- Schnetz-Boutaud, N. C., "Examination of tetrahydrobiopterin pathway genes in autism", Genes. Brain and Behavior, 8, pp.753~757 (2009)
- Richardson, M. A., "Analysis of plasma biopterin levels in psychiatric disorders suggests a common BH4 deficit in schizophrenia and schizoaffective disorder", Neurochem. Res., 32, pp.107~113 (2006)
- Foxton, R. H., "Tetrahydrobiopterin availability in Parkinson's and Alzheimer's disease; potential pathogenic mechanisms", Neurochem. Res., 32, pp.751~756 (2007)
- Vásquez-Vivar, J., "Tetrahydrobiopterin, superoxide and vascular dysfunction", Free Radic. Biol. Med., 15, pp.1108~1119 (2009)
- Fleming, I., "Molecular mechanisms underlying the activation of eNOS", Pflugers Arch., 459, pp.793~806 (2010)
- Leeming, R. J., "Relationship between plasma and red cell biopterins in acute and chronic hyperphenylalaninaemia", J. Inherit. Metab. Dis., 13, pp.883~887 (1990)
- tetrahydrobiopterin and its developmental change in mice, "J. Pharmacol. Exp. Ther.", 1993, 971~978
- Katusic, Z. S., "Vascular endothelial dysfunction: does tetrahydrobiopterin play a role?", Am. J. Physiol. Heart Circ. Physiol., 281, pp.981~986 (2001)
- Silberman, G. A., "Uncoupled cardiac nitric oxide synthase mediates diastolic dysfunction", Circulation, 121, pp.519~528 (2010)
- Shang, T., "1-Methyl-4-phenylpyridiniuminduced apoptosis in cerebellar granule neurons is mediated by transferrin receptor iron-dependent depletion of tetrahydrobiopterin and neuronal nitric-oxide synthasederived superoxide", J. Biol. Chem., 279, pp.19099~19112 (2004)
- Shang, T., "Sepiapterin attenuates 1-methyl-4-phenylpyridinium-induced apoptosis in neuroblastoma cells transfected with neuronal NOS: role of tetrahydrobiopterin, nitric oxide and proteasome activation", Free Radic. Biol. Med., 15, pp.1059~1074 (2005)
- Auerbach, G., "The 1.25 Å crystal structure of sepiapterin reductase reveals its binding mode to pterins and brain neurotransmitters", EMBO J., 16, pp.7219~7230 (1997)
- Milstien, S., "The biosynthesis of tetrahydrobiopterin in rat brain. Purification and characterization of 6-pyruvoyl tetrahydropterin (2'-oxo) reductase", J. Biol. Chem., 264, pp.8066~8073 (1989)
- Park, Y. S., "Human carbonyl and aldose reductase: new catalytic functions in tetrahydrobiopterin biosynthesis", Biochem. Biophys. Res. Commun., 175, pp.738~744 (1991)
- Hirakawa, H., "Expression analysis of the aldo-keto reductases involved in the novel biosynthetic pathway of tetrahydrobiopterin in human and mouse tissues", J. Biochem., 146, pp.51~60 (2009)
- Bonafé, L., "Mutations in the sepiapterin reductase gene cause a novel tetrahydrobiopterin-dependent monoamine-neurotransmitter deficiency without hyperphenylalaninemia", Am. J. Hum. Genet., 69, pp.269~277 (2001)
- Zorzi, G., "Detection of sepiapterin in CSF of patients with sepiapterin reductase deficiency", Mol. Genet. Metab., 75, pp.174~177 (2002)
- Yang, S., "A murine model for human sepiapterin-reductase deficiency", Am. J. Hum. Genet., 78, pp.575~587 (2006)
- Craine, J. E., "The isolation and characterization of dihydropteridine reductase from sheep liver", J. Biol. Chem., 247, pp.6082~6091 (1972)
- Hevel, J. M., "Can the DCoHalpha isozyme compensate in patients with4a-hydroxy-tetrahydrobiopterin dehydratase", DCoH deficiency?, 2006, pp.88, 38~46
- Harada, T., "Feedback Regulation Mechanisms for the control of GTP Cyclohydrolase I Activity", Science, 260, pp.1507~1510 (1993)
- Yoneyama, T., "Decameric GTP cyclohydrolase I forms complexes with two pentameric GTP cyclohydrolase I feedback regulatory proteins in the presence of phenylalanine or of a combination of tetrahydrobiopterin and GTP", J. Biol. Chem., 273, pp.20102~20108 (1998)
- Maita, N., "Crystal structure of the stimulatory complex of GTP cyclohydrolase I and its feedback regulatory protein GFRP", Proc. Natl. Acad. Sci. U.S.A., 통권 : 99, pp.1212~1217 (2002)
- Milstien, S., "Purification and cloning of the GTP cyclohydrolase I feedback regulatory protein, GFRP", J. Biol. Chem., 271, pp.19743~19751 (1996)
- Gesierich, A., "Role of human GTP cyclohydrolase I and its regulatory protein in tetrahydrobiopterin metabolism", Basic Res. Cardiol., 98, pp.69~75 (2003)
- Widder, J. D., "Regulation of tetrahydrobiopterin biosynthesis by shear stress", Circ. Res., 101, pp.830~838 (2007)
- Duncan, J. S., "Too much of a good thing: the role of protein kinase CK2 in tumorigenesis and prospects for therapeutic inhibition of CK2", Biochimica et Biophysica Acta., 1784, pp.33~47 (2008)
- Li, L., "GTP cyclohydrolase I phosphorylation and interaction with GTP cyclohydrolase feedback regulatory protein provide novel regulation of endothelial tetrahydrobiopterin and nitric oxide", Circ. Res., 106, pp.328~336 (2010)
- Kanaya, S., "Intraplatelet tetrahydrobiopterin plays an important role in regulating canine coronary arterial thrombosis by modulating intraplatelet nitric oxide and superoxide generation", Circulation, 104, pp.2478~2484 (2001)
- Lapize, C., "Protein kinase C phosphorylates and activates GTP cyclohydrolase I in rat renal mesangial cells", Biochem. Biophys. Res. Commun., 251, pp.802~805 (1998)
- Hesslinger, C., "Phosphorylation of GTP cyclohydrolase I and modulation of Its activity in rodent mast cells. GTP cyclohydrolase I hyperphosphorylation is coupled to high affinity IgE receptor signaling and involves protein kinase C", J. Biol. Chem., 273, pp.21616~21622 (1998)
- Gilchrist, M., "Tetrahydrobiopterin, a critical factor in the production and role of nitric oxide in mast cells", J. Biol. Chem., 278, pp.50607~50614 (2003)
- Du, J., "Identification and functional characterization of phosphorylation sites on GTP cyclohydrolase I", Arterioscler Thromb. Vasc. Biol., 29, pp.2161~2168 (2009)
- Elzaouk, L., "Nuclear localization of tetrahydrobiopterin biosynthetic enzymes", Biochim. Biophys. Acta., 1670, pp.56~68 (2004)
- Chavan, B., "GTP cyclohydrolase feedback regulatory protein controls cofactor 6-tetrahydrobiopterin synthesis in the cytosol and in the nucleus of epidermal keratinocytes and melanocytes", J. Invest. Dermatol., 126, pp.2481~2489 (2006)
- Xu, J., "Proteasome-dependent degradation of guanosine 5'-triphosphate cyclohydrolase I causes tetrahydrobiopterin deficiency in diabetes mellitus", Circulation, 116, pp.944~953 (2007)
- Wang, S., "In vivo activation of AMP-activated protein kinase attenuates diabetes-enhanced degradation of GTP cyclohydrolase I", Diabetes, 58, pp.1893~1901 (2009)
- Chiarini, A., "Proteomic analysis of GTP cyclohydrolase 1 multiprotein complexes in cultured normal adult human astrocytes under both basal and cytokine-activated conditions", Proteomics, 9, pp.1850~1860 (2009)
- Peterson, T. E, "Guanosine triphosphate cyclohydrolase I expression and enzymatic activity are present in caveolae of endothelial cells", Hypertension, 53, pp.189~195 (2009)
- Goligorsky, M. S., "Relationships between caveolae and eNOS: everything in proximity and the proximity of everything", Am. J. Physiol. Renal. Physiol., 283, pp.1~10 (2002)
- Shi, W., "Regulation of tetrahydrobiopterin synthesis and bioavailability in endothelial cells", Cell Biochem. Biophys., 41, pp.415~434 (2004)
- Moens, A. L., "Therapeutic potential of tetrahydrobiopterin for treating vascular and cardiac disease", J. Cardiovasc. Pharmacol., 50, pp.238~246 (2007)
- Kalivendi, S., "Changes in tetrahydrobiopterin levels in endothelial cells and adult cardiomyocytes induced by LPS and hydrogen peroxide?A role for GFRP?", Free Radic. Biol. Med., 38, pp.481~491 (2005)
- Werner, E. R., "Bacterial lipopolysaccharide down-regulates expression of GTP cyclohydrolase I feedback regulatory protein", J. Biol. Chem., 227, pp.10129~10133 (2002)
- Xie, L., "GTP cyclohydrolase I inhibition by the prototypic inhibitor 2,4-diamino-6-hydroxypyrimidine. Mechanisms and unanticipated role of GTP cyclohydrolase I feedback regulatory protein", J. Biol. Chem., 273, pp.21091~21098 (1998)
- Ionova, I. A., "Deficient BH4 production via de novo and salvage pathways regulates NO responses to cytokines in adult cardiac myocytes", Am. J. Physiol. Heart Circ. Physiol., 295, pp.2178~2187 (2008)
- Tatham, A. L., "GTP cyclohydrolase I expression, protein and activity determine intracellular tetrahydrobiopterin levels, independent of GTP cyclohydrolase feedback regulatory protein expression", J. Biol. Chem., 284, pp.13660~13668 (2009)
- Linscheid, P., "Regulation of 6-pyruvoyltetrahydropterin synthase activity and messenger RNA abundance in human vascular endothelial cells", Circulation, 98, pp.1703~1706 (1998)
- Franscini, N., "Critical role of interleukin-1beta for transcriptional regulation of endothelial 6-pyruvoyltetrahydropterin synthase", Arterioscler. Thromb. Vasc. Biol., 23, pp.50~53 (2003)
- Niederwieser, A., "Prenatal diagnosis of "dihydrobiopterin synthetase" deficiency, a variant form of phenylketonuria", Eur. J. Pediatr., 145, pp.176~178 (1986)
- Katoh, S., "Sepiapterin reductase exhibits a NADPH-dependent dicarbonyl reductase activity", Biochem. Biophys. Res. Commun., 118, pp.859~866 (1984)
- Ponzone, A., "Dihydropteridine reductase deficiency in man: from biology to treatment", Med. Res. Rev., 24, pp.127~150 (2004)
- Wei, C. C., "Catalytic reduction of a tetrahydrobiopterin radical within nitric-oxide synthase", J. Biol. Chem., 25, pp.11734~11742 (2008)
- Woodward, J. J., "Pterin-centered radical as a mechanistic probe of the second step of nitric oxide synthase", J. Am. Chem. Soc., 14, pp.5105~5113 (2010)
- Milstien, S., "Oxidation of tetrahydrobiopterin by peroxynitrite: implications for vascular endothelial function", Biochem. Biophys. Res. Commun., 263, pp.681~684 (1999)
- Rafferty, S. P., "Stoichiometric arginine binding in the oxygenase domain of inducible nitric oxide synthase requires a single molecule of tetrahydrobiopterin per dimer", Biochem. Biophys. Res. Commun., 257, pp.344~347 (1999)
- Wever, R. M., "Atherosclerosis and the two faces of endothelial nitric oxide synthase", Circulation, 97, pp.108~112 (1998)
- Vásquez-Vivar, J., "Superoxide generation by endothelial nitric oxide synthase: the influence of cofactors", Proc. Natl. Acad. Sci. U.S.A., 통권 : 95, pp.9220~9225 (1998)
- Crabtree, M. J., "Ratio of 5,6,7,8-tetrahydrobiopterin to 7,8-dihydrobiopterin in endothelial cells determines glucose-elicited changes in NO vs. superoxide production by eNOS", Am. J. Physiol. Heart Circ. Physiol., 294, pp.1530~1540 (2008)
- Vásquez-Vivar, J., "Reaction of tetrahydrobiopterin with superoxide: EPR-kinetic analysis and characterization of the pteridine radical", Free Radic. Biol. Med., 31, pp.975~985 (2001)
- Sun, J., "Dose dependent effects of reactive oxygen and nitrogen species on the function of neuronal nitric oxide synthase", Arch. Biochem. Biophys., 471, pp.126~133 (2008)
- Sun, J., "Reactive oxygen and nitrogen species regulate inducible nitric oxide synthase function shifting the balance of nitric oxide and superoxide production", Arch. Biochem. Biophys., 494, pp.130~137 (2010)
- Grobe, A. C., "Increased oxidative stress in lambs with increased pulmonary blood flow and pulmonary hypertension: role of NADPH oxidase and endothelial NO synthase", Am. J. Physiol. Lung Cell Mol. Physiol., 290, pp.1069~1077 (2006)
- Chrissobolis, S., "Trends in molecular medicine. The role of oxidative stress and NADPH oxidase in cerebrovascular disease", Trends Mol. Med., 14, pp.495~502 (2008)
- Padmaja, S., "The reaction of nitric oxide with organic peroxyl radicals", Biochem. Biophys. Res. Commun., 195, pp.539~544 (1993)
- Davis, M. D., "The auto-oxidation of tetrahydrobiopterin", Eur. J. Biochem., 173, pp.345~351 (1988)
- Laursen, J. B., "Endothelial regulation of vasomotion in apoEdeficient mice: implications for interactions between peroxynitrite and tetrahydrobiopterin", Circulation, 103, pp.1282~1288 (2001)
- Shimizu, S., "Possible involvement of hydroxyl radical on the stimulation of tetrahydrobiopterin synthesis by hydrogen peroxide and peroxynitrite in vascular endothelial cells", Int. J. Biochem. Cell Biol., 37, pp.864~875 (2005)
- Brewer, G. J., "Iron and copper toxicity in diseases of aging, particularly atherosclerosis and Alzheimer's disease", Exp. Biol. Med., 232, pp.323~335 (2007)
- Shimizu, S., "Hydrogen peroxide stimulates tetrahydrobiopterin synthesis through the induction of GTP-cyclohydrolase I and increases nitric oxide synthase activity in vascular endothelial cells", Free Radic. Biol. Med., 34, pp.1343~1352 (2003)
- Shimizu, S., "Hydrogen peroxide stimulates tetrahydrobiopterin synthesis through activation of the Jak2 tyrosine kinase pathway in vascular endothelial cells", Int. J. Biochem. Cell Biol., 40, pp.755~765 (2008)
- Chen, W., "Peroxynitrite induces destruction of the tetrahydrobiopterin and heme in endothelial nitric oxide synthase: transition from reversible to irreversible enzyme inhibition", Biochemistry, 49, pp.3129~3137 (2010)
- Förstermann, U., "Janus-faced role of endothelial NO synthase in vascular disease: uncoupling of oxygen reduction from NO synthesis and its pharmacological reversal", Biol. Chem., 387, pp.1521~1533 (2006)
- Chalupsky, K., "Endothelial dihydrofolate reductase: critical for nitric oxide bioavailability and role in angiotensin II uncoupling of endothelial nitric oxide synthase", Proc. Natl. Acad. Sci. U.S.A., 통권 : 102, pp.9056~9061 (2005)
- Crabtree, M. J., "Critical role for tetrahydrobiopterin recycling by dihydrofolate reductase in regulation of endothelial nitric-oxide synthase coupling: relative importance of the de novo biopterin synthesis versus salvage pathways", J. Biol. Chem., 284, pp.28128~28136 (2009)
- Lee, C. K., "Diminished expression of dihydropteridine reductase is a potent biomarker for hypertensive vessels", Proteomics, 9, pp.4851~4858 (2009)
- Hasse, S., "Perturbed 6-tetrahydrobiopterin recycling via decreased dihydropteridine reductase in vitiligo: more evidence for H2O2 stress", J. Invest. Dermatol., 122, pp.307~313 (2004)
- Shinozaki, K., "Coronary endothelial dysfunction in the insulin-resistant state is linked to abnormal pteridine metabolism and vascular oxidative stress", J. Am. Coll. Cardiol., 38, pp.1821~1828 (2001)
- Waring, P., "The time-dependent inactivation of human brain dihydropteridine reductase by the oxidation products of L-dopa", Eur. J. Biochem., 3, pp.305~310 (1986)
- Khoo, J. P., "Pivotal role for endothelial tetrahydrobiopterin in pulmonary hypertension", Circulation, 111, pp.2126~2133 (2005)
- Nandi, M., "Pulmonary hypertension in a GTP-cyclohydrolase 1-deficient mouse", Circulation, 111, pp.2086~2090 (2005)
- Shang, T., "Sepiapterin attenuates 1-methyl-4-phenylpyridinium-induced apoptosis in neuroblastoma cells transfected with neuronal NOS: role of tetrahydrobiopterin, nitric oxide and proteasome activation", Free Radic. Biol. Med., 39, pp.1059~1074 (2005)
- Cardaci, S., "p38MAPK", p53 signaling axis mediates neuronal apoptosis in response to tetrahydrobiopterin-induced oxidative stress and glucose uptake inhibition: implication for neurodegeneration, 2010, ~
- Casadei, B., "The emerging role of neuronal nitric oxide synthase in the regulation of myocardial function", Exp. Physiol., 91, pp.943~955 (2006)
