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TM4SF5-mediated protein-protein networks and tumorigenic roles

이정원
생화학분자생물학회 (Korean Society Of Biochemistry And Molecular Biology)|2014.09|BMB Reports|제47권 제9호|pp. 483-487

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참고문헌

키워드

FibrosisMetastasisEGFRCytokine receptorsIntegrinsTetraspaninTM4SF5
주제분류화학

초록

Transmembrane 4 L six family member 5 (TM4SF5), as amembrane glycoprotein with 4 transmembrane domains, issimilar to the tetraspanins in terms of membrane topology andplays important roles in tumorigenesis and tumor metastasis. Especially, TM4SF5 appears to form a massive protein-proteincomplex consisting of diverse membrane proteins and/orreceptors in addition to cytosolic signaling molecules toregulate their signaling activities during the pathologicalprocesses. TM4SF5 is shown to interact with integrins α2, α5,and β1, EGFR, IL6R, CD151, focal adhesion kinase (FAK), andc-Src. This review focuses on the significance of theinteractions with regards to TM4SF5-positive tumorigenesisand metastasis.

Abstract

Transmembrane 4 L six family member 5 (TM4SF5), as amembrane glycoprotein with 4 transmembrane domains, issimilar to the tetraspanins in terms of membrane topology andplays important roles in tumorigenesis and tumor metastasis. Especially, TM4SF5 appears to form a massive protein-proteincomplex consisting of diverse membrane proteins and/orreceptors in addition to cytosolic signaling molecules toregulate their signaling activities during the pathologicalprocesses. TM4SF5 is shown to interact with integrins α2, α5,and β1, EGFR, IL6R, CD151, focal adhesion kinase (FAK), andc-Src. This review focuses on the significance of theinteractions with regards to TM4SF5-positive tumorigenesisand metastasis.

참고문헌 (28)

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