ADAM and ADAMTS family proteins and their role in the colorectal cancer etiopathogenesis
2
조회
0
다운로드
3
인용
0
참고문헌
키워드
초록
The ADAM and ADAMTS families, also called adamalysins belong to an important group of extracellular matrix proteins. The ADAMs family belong to both the transmembrane and secreted proteins, while ADAMTS family only contains secreted forms. Adamalysins play an important role in the cell phenotype regulation via their activities in signaling pathways,cell adhesion and migration. The human proteome contains 21 ADAM, and 19 ADAMTS proteins, which are involved in extracellular matrix remodeling, shedding of various substrates such as: adhesion ligands, growth factors, their receptors and diverse cytokines. Recent studies provide evidence that adamalysins play a crucial role in colorectal cancer (CRC)etiopathogenesis. It seems possible that adamalysins might be used as CRC prediction markers or potential pharmaceutical targets.
Abstract
The ADAM and ADAMTS families, also called adamalysins belong to an important group of extracellular matrix proteins. The ADAMs family belong to both the transmembrane and secreted proteins, while ADAMTS family only contains secreted forms. Adamalysins play an important role in the cell phenotype regulation via their activities in signaling pathways,cell adhesion and migration. The human proteome contains 21 ADAM, and 19 ADAMTS proteins, which are involved in extracellular matrix remodeling, shedding of various substrates such as: adhesion ligands, growth factors, their receptors and diverse cytokines. Recent studies provide evidence that adamalysins play a crucial role in colorectal cancer (CRC)etiopathogenesis. It seems possible that adamalysins might be used as CRC prediction markers or potential pharmaceutical targets.
참고문헌 (115)
- Hanahan, D, "Hallmarks of cancer: the next generation", Cell, 144, pp.646~674 (2011)
- Sasiadek, M. M., "Genetic theory of cancer", Pol. Przegl. Chir, 81, pp.478~485 (2009)
- Stocker, W., "The metzincins-topological and sequential relations between the astacins, adamalysins, serralysins, and matrixins (collagenases) define a superfamily of zinc-peptidases", Protein Sci, 4, pp.823~840 (1995)
- Kim, Y. H., "Epigenomic analysis of aberrantly methylated genes in colorectal cancer identifies genes commonly affected by epigenetic alterations", Ann. Surg. Oncol, 18, pp.2338~2347 (2011)
- Ugalde, A. P., "Metalloproteases and the degradome", Methods. Mol. Biol, 622, pp.3~29 (2010)
- Kessenbrock, K., "Matrix metalloproteinases: regulators of the tumor microenvironment", Cell, 141, pp.52~67 (2010)
- Tallant, C., "Matrix metalloproteinases: Fold and function of their catalytic domains", Biochim. Biophys. Acta-Mol. Basis Dis, 1803, pp.20~28 (2010)
- Gross, J., "Collagenolytic activity in amphibian tissues: a tissue culture assay", Proc. Natl. Acad. Sci. U.S.A, 48, pp.1014~1022 (1962)
- Kuno, K., "Molecular cloning of a gene encoding a new type of metalloproteinase-disintegrin family protein with thrombospondin motifs as an inflammation associated gene", J. Biol. Chem, 272, pp.556~562 (1997)
- Kaushal, G. P., "The new kids on the block: ADAMTSs, potentially multifunctional metalloproteinases of the ADAM family", J. Clin. Invest, 105, pp.1335~1337 (2000)
- Wagstaff, L., "The roles of ADAMTS metalloproteinases in tumorigenesis and metastasis", Front Biosci, 16, pp.1861~1872 (2011)
- van Goor, H., "Adamalysins in biology and disease", J. Pathol, 219, pp.277~286 (2009)
- Rocks, N., "Emerging roles of ADAM and ADAMTS metalloproteinases in cancer", Biochimie, 90, pp.369~379 (2008)
- Edwards, D. R., "The ADAM metalloproteinases", Mol. Aspects. Med, 29, pp.258~289 (2008)
- Brocker, C. N., "Evolutionary divergence and functions of the ADAM and ADAMTS gene families", Hum. Genomics, 4, pp.43~55 (2009)
- Stanton, H., "Proteoglycan degradation by the ADAMTS family of proteinases", Biochim. Biophys. Acta-Mol. Basis. Dis, 1812, pp.1616~1629 (2011)
- Kang, T. B., "Intracellular activation of human adamalysin 19", disintegrin and metalloproteinase 19 by furin occurs via one of the two consecutive recognition sites, 2002, pp.277, 25583~25591
- Van Wart, H. E., "The cysteine switch: a principle of regulation of metalloproteinase activity with potential applicability to the entire matrix metalloproteinase gene family", Proc. Natl. Acad. Sci. U.S.A, 87, pp.5578~5582 (1990)
- Tortorella, M. D., "ADAMTS-4 (aggrecanase-1): N-Terminal activation mechanisms", Arch. Biochem. Biophys, 444, pp.34~44 (2005)
- Hall, T., "Autoactivation of human ADAM8: a novel preprocessing step is required for catalytic activity", Biosci. Rep, 29, pp.217~228 (2009)
- Milla, M. E., "Specific sequence elements are required for the expression of functional tumor necrosis factor-alpha-converting enzyme (TACE)", J. Biol. Chem, 274, pp.30563~30570 (1999)
- Bridges, L. C., "ADAM disintegrin-like domain recognition by the lymphocyte integrins alpha4beta1 and alpha4beta7", Biochem. J, 387, pp.101~108 (2005)
- Gomis-Ruth, F. X., "Refined 2.0 A X-ray crystal structure of the snake venom zinc-endopeptidase adamalysin II. Primary and tertiary structure determination, refinement, molecular structure and comparison with astacin, collagenase and thermolysin", J. Mol. Biol, 239, pp.513~544 (1994)
- Arribas, J., "ADAMs, cell migration and cancer", Cancer Metastasis Rev, 25, pp.57~68 (2006)
- Iba, K., "The cysteine-rich domain of human ADAM 12 supports cell adhesion through syndecans and triggers signaling events that lead to beta 1 integrin- dependent cell spreading", J. Cell Biol, 149, pp.1143~1155 (2000)
- Gaultier, A., "ADAM13 disintegrin and cysteine-rich domains bind to the second heparin-binding domain of fibronectin", J. Biol. Chem, 277, pp.23336~23344 (2002)
- Lorenzen, I., "Multimerisation of A disintegrin and metalloprotease protein-17 (ADAM17) is mediated by its EGF-like domain", Biochem. Biophys. Res. Commun, 415, pp.330~336 (2011)
- Kang, Q., "Metalloprotease- disintegrin ADAM 12 binds to the SH3 domain of Src and activates Src tyrosine kinase in C2C12 cells", Biochem. J, 352(Pt 3), pp.883~892 (2000)
- Poghosyan, Z., "Phosphorylationdependent interactions between ADAM15 cytoplasmic domain and Src family protein-tyrosine kinases", J. Biol. Chem, 277, pp.4999~5007 (2002)
- Killock, D. J., "The cytoplasmic domains of TNFalpha-converting enzyme (TACE", ADAM17) and L-selectin are regulated differently by p38 MAPK and PKC to promote ectodomain shedding, 2010, pp.428, 293~304
- Jones, G. C, "ADAMTS proteinases: a multi-domain, multi-functional family with roles in extracellular matrix turnover and arthritis", Arthritis. Res. Ther, 7, pp.160~169 (2005)
- Kuno, K., "ADAMTS-1 protein anchors at the extracellular matrix through the thrombospondin type I motifs and its spacing region", J. Biol. Chem, 273, pp.13912~13917 (1998)
- Guo, N. -H., "Thrombospondin 1 and type I repeat peptides of thrombospondin 1 specifically induce apoptosis of endothelial cells", Cancer Res, 57, pp.1735~1742 (2012)
- de Groot, R., "Essential role of the disintegrin-like domain in ADAMTS13 function", Blood, 113, pp.5609~5616 (2009)
- Somerville, R. P., "Characterization of ADAMTS-9 and ADAMTS-20 as a distinct ADAMTS subfamily related to Caenorhabditis elegans GON-1", J. Biol. Chem, 278, pp.9503~9513 (2003)
- Porter, S., "The ADAMTS metalloproteinases", Biochem. J, 386, pp.15~27 (2005)
- Nardi, J. B., "Expression of lacunin, a large multidomain extracellular matrix protein, accompanies morphogenesis of epithelial monolayers in Manduca sexta", Insect. Biochem. Mol. Biol, 29, pp.883~897 (1999)
- Somerville, R. P., "ADAMTS7B, the full-length product of the ADAMTS7 gene, is a chondroitin sulfate proteoglycan containing a mucin domain", J. Biol. Chem, 279, pp.35159~35175 (2004)
- Zheng, X., "Structure of von Willebrand factor-cleaving protease (ADAMTS13), a metalloprotease involved in thrombotic thrombocytopenic purpura", J. Biol. Chem, 276, pp.41059~41063 (2001)
- Bork, P., "The CUB domain. A widespread module in developmentally regulated proteins", J. Mol. Biol, 231, pp.539~545 (1993)
- Vazquez, F., "METH-1, a human ortholog of ADAMTS-1, and METH-2 are members of a new family of proteins with angio- inhibitory activity", J. Biol. Chem, 274, pp.23349~23357 (1999)
- Cal, S., "Cloning, expression analysis, and structural characterization of seven novel human ADAMTSs, a family of metalloproteinases with disintegrin and thrombospondin-1 domains", Gene, 283, pp.49~62 (2002)
- Primakoff, P, "The ADAM gene family - surface proteins with adhesion and protease activity", Trends Genet, 16, pp.83~87 (2000)
- Han, C., "Comprehensive analysis of reproductive ADAMs: relationship of ADAM4 and ADAM6 with an ADAM complex required for fertilization in mice", Biol. Reprod, 80, pp.1001~1008 (2009)
- Kim, T., "Expression and relationship of male reproductive ADAMS in mouse", Biol. Reprod, 74, pp.744~750 (2006)
- Grzmil, P., "Human cyritestin genes (CYRN1 and CYRN2) are non-functional", Biochem. J, 357, pp.551~556 (2001)
- Kim, E., "Mouse sperm lacking ADAM1b", ADAM2 fertilin can fuse with the egg plasma membrane and effect fertilization, 2006, pp.281, 5634~5639
- 김지영, "Implication of ADAM-8, -9, -10, -12, -15, -17, and ADAMTS-1 in Implantational Remodeling of a Mouse Uterus", Yonsei Medical Journal, 47(4), pp.558~567 (2006), 연세대학교의과대학
- Zhou, H. M., "Essential role for ADAM19 in cardiovascular morphogenesis", Mol. Cell. Biol, 24, pp.96~104 (2004)
- McKie, N., "Cloning of a novel membrane-linked metalloproteinase from human myeloma cells", Biochem. J, 318(Pt 2), pp.459~462 (1996)
- Roghani, M., "Metalloprotease-disintegrin MDC9: Intracellular maturation and catalytic activity", J. Biol. Chem, 274, pp.3531~3540 (1999)
- Hotoda, N., "A secreted form of human ADAM9 has an alpha- secretase activity for APP", Biochem. Biophys. Res. Commun, 293, pp.800~805 (2002)
- Peduto, L., "Critical function for ADAM9 in mouse prostate cancer", Cancer Res, 65, pp.9312~9319 (2005)
- Schwettmann, L., "Cloning and Expression in Pichia pastoris of Metalloprotease Domain of ADAM 9 Catalytically Active against Fibronectin", Protein Expr. Purif, 21, pp.65~70 (2001)
- Wolfsberg, T. G., "ADAM, a novel family of membrane proteins containing A Disintegrin And Metalloprotease domain: multipotential functions in cell-cell and cell-matrix interactions", J. Cell Biol, 131, pp.275~278 (1995)
- Sahin, U., "Distinct roles for ADAM10 and ADAM17 in ectodomain shedding of six EGFR ligands", J. Cell Biol, 164, pp.769~779 (2004)
- Allinson, T. M., "ADAMs family members as amyloid precursor protein alpha-secretases", J. Neurosci. Res, 74, pp.342~352 (2003)
- Chen, C. D., "Insulin stimulates the cleavage and release of the extracellular domain of Klotho by ADAM10 and ADAM 17", Proc. Natl. Acad. Sci. U.S.A, 104, pp.19796~19801 (2007)
- Bland, C. E., "Notch-induced proteolysis and nuclear localization of the delta ligand", J. Biol. Chem, 278, pp.13607~13610 (2003)
- Hartmann, D., "The disintegrin", metalloprotease ADAM 10 is essential for Notch signalling but not for alpha-secretase activity in fibroblasts, 2002, pp.11, 2615~2624
- Gilpin, B. J., "A novel, secreted form of human ADAM 12 (meltrin alpha) provokes myogenesis in vivo", J. Biol. Chem, 273, pp.157~166 (1998)
- Roy, R., "ADAM 12 cleaves extracellular matrix proteins and correlates with cancer status and stage", J. Biol. Chem, 279, pp.51323~51330 (2004)
- Yagami-Hiromasa, T., "A metalloprotease-disintegrin participating in myoblast fusion", Nature, 377, pp.652~656 (1995)
- Kurisaki, T., "Phenotypic analysis of Meltrin alpha (ADAM12)- deficient mice: Involvement of Meltrin alpha in adipogenesis and myogenesis", Mol. Cell Biol, 23, pp.55~61 (2003)
- Moghadaszadeh, B., "Compensation for dystrophin-deficiency: ADAM12 overexpression in skeletal muscle results in increased alpha 7 integrin, utrophin and associated glycoproteins", Hum. Mol. Genet, 12, pp.2467~2479 (2003)
- Black, R. A., "A metalloproteinase disintegrin that releases tumour-necrosis factor-alpha from cells", Nature, 385, pp.729~733 (1997)
- Saftig, P., "ADAM10 A major membrane protein ectodomain sheddase involved in regulated intramembrane proteolysis; in The Adam Family of Proteases", pp.85~121 (2005), Springer
- Peschon, J. J., "An essential role for ectodomain shedding in mammalian development", Science, 282, pp.1281~1284 (1998)
- Wang, Y., "Regulation of mature ADAM17 by redox agents for L-selectin shedding", J. Immunol, 182, pp.2449~2457 (2009)
- Sagane, K., "Metalloproteinase-like, disintegrin-like, cysteine-rich proteins MDC2 and MDC3: novel human cellular disintegrins highly expressed in the brain", Biochem. J, 334(Pt 1), pp.93~98 (1998)
- Sagane, K., "Cloning and chromosomal mapping of mouse ADAM11, ADAM22 and ADAM23", Gene, 236, pp.79~86 (1999)
- Mitchell, K. J., "Functional analysis of secreted and transmembrane proteins critical to mouse development", Nature Genetics, 28, pp.241~249 (2001)
- Brocker, C. N., "Evolutionary divergence and functions of the ADAM and ADAMTS gene families", Hum. Genomics, 4, pp.43~55 (2009)
- Xu, R., "Molecular cloning and mapping of a novel ADAM gene (ADAM29) to human chromosome 4", Genomics, 62, pp.537~539 (1999)
- Cerretti, D. P., "Isolation of two novel metalloproteinase- disintegrin (ADAM) cDNAs that show testis-specific gene expression", Biochem. Biophys. Res. Commun, 263, pp.810~815 (1999)
- Oppezzo, P., "The LPL", ADAM29 expression ratio is a novel prognosis indicator in chronic lymphocytic leukemia, 2005, pp.106, 650~657
- Wei, X., "Analysis of the disintegrin-metalloproteinases family reveals ADAM29 and ADAM7 are often mutated in melanoma", Hum. Mutat, 32, pp.E2148~E2175 (2011)
- Kuno, K., "Molecular cloning of a gene encoding a new type of metalloproteinase-disintegrin family protein with thrombospondin motifs as an inflammation associated gene", J. Biol. Chem, 272, pp.556~562 (1997)
- Rodriguez-Manzaneque, J. C., "ADAMTS1 cleaves aggrecan at multiple sites and is differentially inhibited by metalloproteinase inhibitors", Biochem. Biophys. Res. Commun, 293, pp.501~508 (2002)
- Luque, A., "ADAMTS1", METH1 inhibits endothelial cell proliferation by direct binding and sequestration of VEGF165, 2003, pp.278, 23656~23665
- Lee, N. V., "ADAMTS1 mediates the release of antiangiogenic polypeptides from TSP1 and 2", EMBO J, 25, pp.5270~5283 (2006)
- Ricciardelli, C., "The ADAMTS1 protease gene is required for mammary tumor growth and metastasis", Am. J. Pathol, 179, pp.3075~3085 (2011)
- Lu, X., "ADAMTS1 and MMP1 proteolytically engage EGF-like ligands in an osteolytic signaling cascade for bone metastasis", Genes Dev, 23, pp.1882~1894 (2009)
- Blelloch, R., "The gon-1 gene is required for gonadal morphogenesis in Caenorhabditis elegans.", Dev. Biol, 216, pp.382~393 (1999)
- Jungers, K. A., "Adamts9 is widely expressed during mouse embryo development", Gene Expr. Patterns, 5, pp.609~617 (2005)
- Lo, P. H., "Identification of a tumor suppressive critical region mapping to 3p14.2 in esophageal squamous cell carcinoma and studies of a candidate tumor suppressor gene, ADAMTS9", Oncogene, 26, pp.148~157 (2007)
- Liu, C. J., "ADAMTS-12 associates with and degrades cartilage oligomeric matrix protein", J. Biol. Chem, 281, pp.15800~15808 (2006)
- Moncada-Pazos, A., "The ADAMTS12 metalloprotease gene is epigenetically silenced in tumor cells and transcriptionally activated in the stroma during progression of colon cancer", J. Cell Sci, 122, pp.2906~2913 (2009)
- El Hour, M., "Higher sensitivity of Adamts12-deficient mice to tumor growth and angiogenesis", Oncogene, 29, pp.3025~3032 (2010)
- Cross, N. A., "The expression and regulation of ADAMTS-1, -4, -5, -9, and -15, and TIMP-3 by TGFbeta1 in prostate cells: relevance to the accumulation of versican", Prostate, 63, pp.269~275 (2005)
- Porter, S., "ADAMTS8 and ADAMTS15 expression predicts survival in human breast carcinoma", Int. J. Cancer, 118, pp.1241~1247 (2006)
- Zeng, W., "Glycosaminoglycanbinding properties and aggrecanase activities of truncated ADAMTSs: comparative analyses with ADAMTS-5, -9, -16 and -18", Biochim. Biophys. Acta, 1760, pp.517~524 (2006)
- Li, Z., "High-resolution melting analysis of ADAMTS18 methylation levels in gastric, colorectal and pancreatic cancers", Med. Oncol, 27, pp.998~1004 (2010)
- Li, Z., "C-terminal ADAMTS-18 fragment induces oxidative platelet fragmentation, dissolves platelet aggregates, and protects against carotid artery occlusion and cerebral stroke", Blood, 113, pp.6051~6060 (2009)
- Leufkens, A. M., "Educational level and risk of colorectal cancer in EPIC with specific reference to tumor location", Int. J. Cancer, 130, pp.622~630 (2012)
- Parkin, D. M., "Global cancer statistics, 2002", CA. Cancer J. Clin, 55, pp.74~108 (2002)
- Gonzalez, C. A., "Diet and cancer prevention: Contributions from the European Prospective Investigation into Cancer and Nutrition (EPIC) study", Eur. J. Cancer, 46, pp.2555~2562 (2010)
- Mazzocca, A., "Secreted form of ADAM9 promotes carcinoma invasion through tumor- stromal interactions", Cancer Res, 65, pp.4728~4738 (2005)
- Hirao, T., "Overexpression of ADAM9 enhances growth factor-mediated recycling of E-cadherin in human colon cancer cell line HT29 cells", Exp. Cell Res, 312, pp.331~339 (2006)
- Knosel, T, "Immunoprofiles of 11 biomarkers using tissue microarrays identify prognostic subgroups in colorectal cancer", Neoplasia, 7, pp.741~747 (2005)
- Le Naour, F., "Profiling of the tetraspanin web of human colon cancer cells", Mol. Cell Proteomics, 5, pp.845~857 (2006)
- Gavert, N., "Expression of L1-CAM and ADAM10 in human colon cancer cells induces metastasis", Cancer Res, 67, pp.7703~7712 (2007)
- Wang, Y. Y., "ADAM 10 is Associated With Gastric Cancer Progression and Prognosis of Patients", J. Surg. Oncol, 103, pp.116~123 (2011)
- Lin, H. M., "Genome wide expression profiling identifies genes associated with colorectal liver metastasis", Oncol. Rep, 17, pp.1541~1549 (2007)
- Kyula, J. N., "Chemotherapy-Induced Activation of ADAM-17: A Novel Mechanism of Drug Resistance in Colorectal Cancer", Clin. Cancer Res, 16, pp.3378~3389 (2010)
- Van Schaeybroeck, S, "Oncogenic Kras promotes chemotherapy- induced growth factor shedding via ADAM17", Cancer Res, 71, pp.1071~1080 (2011)
- Choi, J.-S., "Promoter hypermethylation of the ADAM23 gene in colorectal cancer cell lines and cancer tissues", Int. J. Cancer, 124, pp.1258~1262 (2009)
- Wang, H., "MicroRNA-342 inhibits colorectal cancer cell proliferation and invasion by directly targeting DNA methyltransferase 1", Carcinogenesis, 32, pp.1033~1042 (2011)
- Sjoblom, T, "The consensus coding sequences of human breast and colorectal cancers", Science, 314, pp.268~274 (2006)
- Ashktorab, H., "Distinct genetic alterations in colorectal cancer", PLoS One, 5, pp.e8879~ (2010)
- Ahlquist, T., "Gene methylation profiles of normal mucosa, and benign and malignant colorectal tumors identify early onset markers", Mol. Cancer, 7, pp.94~ (2008)
- Lind, G. E., "ADAMTS1, CRABP1, and NR3C1 identified as epigenetically deregulated genes in colorectal tumorigenesis", Cell. Oncol, 28, pp.259~272 (2006)
- Zhang, C., "High-resolution melting analysis of ADAMTS9 methylation levels in gastric, colorectal, and pancreatic cancers", Cancer Genet. Cytogenet, 196, pp.38~44 (2010)
- Wang, D., "Expression of ADAMTS12 in colorectal cancer-associated stroma prevents cancer development and is a good prognostic indicator of colorectal cancer", Dig. Dis. Sci, 56, pp.3281~3287 (2011)
- Viloria, C. G, "Genetic inactivation of ADAMTS15 metalloprotease in human colorectal cancer", Cancer Res, 69, pp.4926~4934 (2009)
