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Crosstalk between integrin and receptor tyrosine kinase signaling in breast carcinoma progression

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This review explored the mechanism of breast carcinoma progression by focusing on integrins and receptor tyrosine kinases (or growth factor receptors). While the primary role of integrins was previously thought to be solely as mediators of adhesive interactions between cells and extracellular matrices, it is now believed that integrins also regulate signaling pathways that control cancer cell growth, survival, and invasion. A large body of evidence suggests that the cooperation between integrin and receptor tyrosine kinase signaling regulates certain signaling functions that are important for cancer progression. Recent developments on the crosstalk between integrins and receptor tyrosine kinases, and its implication in mammary tumor progression, are discussed.

Abstract

This review explored the mechanism of breast carcinoma progression by focusing on integrins and receptor tyrosine kinases (or growth factor receptors). While the primary role of integrins was previously thought to be solely as mediators of adhesive interactions between cells and extracellular matrices, it is now believed that integrins also regulate signaling pathways that control cancer cell growth, survival, and invasion. A large body of evidence suggests that the cooperation between integrin and receptor tyrosine kinase signaling regulates certain signaling functions that are important for cancer progression. Recent developments on the crosstalk between integrins and receptor tyrosine kinases, and its implication in mammary tumor progression, are discussed.

참고문헌 (71)

  1. Hanahan, D., "The hallmarks of cancer", Cell, 100, pp.57~70 (2000)
  2. Larsen, M., "The matrix reorganized: extracellular matrix remodeling and integrin signaling", Curr. Opin. Cell Biol., 18, pp.463~471 (2006)
  3. Giancotti, F. G., "Integrin signaling", Science, 285, pp.1028~1032 (1999)
  4. Perou, C. M., "Molecular portraits of human breast tumours", Nature, 406, pp.747~752 (2000)
  5. Nielsen, T. O., "Immunohistochemical and clinical characterization of the basal-like subtype of invasive breast carcinoma", Clin. Cancer Res., 10, pp.5367~5374 (2004)
  6. Byers, S., "Breast carcinoma: a collective disorder", Breast Cancer Res. Treat., 31, pp.203~215 (1994)
  7. Shaw, L. M., "Integrin function in breast carcinoma progression", J. Mammary. Gland. Biol. Neoplasia., 4, pp.367~376 (1999)
  8. Aumailley, M., "Altered synthesis of laminin 1 and absence of basement membrane component deposition in (beta)1 integrin-deficient embryoid bodies", J. Cell Sci., 113(2), pp.259~268 (2000)
  9. Plow, E. F., "Ligand binding to integrins", J. Biol. Chem., 275, pp.21785~21788 (2000)
  10. van der Flier, A., "Function and interactions of integrins", Cell Tissue. Res., 305, pp.285~298 (2001)
  11. Aplin, A. E., "Cell adhesion molecules, signal transduction and cell growth", Curr. Opin. Cell Biol., 11, pp.737~744 (1999)
  12. Luo, B. H., "Structural basis of integrin regulation and signaling", Annu. Rev. Immunol., 25, pp.619~647 (2007)
  13. Bryan, B. A., "What tangled webs they weave: Rho-GTPase control of angiogenesis", Cell Mol. Life Sci., 64, pp.2053~2065 (2007)
  14. Kanda, S., "Role of Src in angiopoietin 1-induced capillary morphogenesis of endothelial cells: effect of chronic hypoxia on Src inhibition by PP2", Cell Signal, 19, pp.472~480 (2007)
  15. Ridley, A., "Rho GTPases. Integrating integrin signaling", J. Cell Biol., 150, pp.F107~F109 (2000)
  16. Schwartz, M. A., "Signaling networks linking integrins and rho family GTPases", Trends Biochem. Sci., 25, pp.388~391 (2000)
  17. Bertotti, A., "Beta4 integrin activates a Shp2-Src signaling pathway that sustains HGF-induced anchorage-independent growth", J. Cell Biol., 175, pp.993~1003 (2006)
  18. Klemke, R. L., "CAS", Crk coupling serves as a "molecular switch" for induction of cell migration, 1998, pp.140, 961~972
  19. Collins, L. R., "Bifurcation of cell migratory and proliferative signaling by the adaptor protein Shc", J. Cell Biol., 147, pp.1561~1568 (1999)
  20. Mariotti, A., "EGF-R signaling through Fyn kinase disrupts the function of integrin alpha6beta4 at hemidesmosomes: role in epithelial cell migration and carcinoma invasion", J. Cell Biol., 155, pp.447~458 (2001)
  21. Moro, L., "Integrin-induced epidermal growth factor (EGF) receptor activation requires c-Src and p130Cas and leads to phosphorylation of specific EGF receptor tyrosines", J. Biol. Chem., 277, pp.9405~9414 (2002)
  22. Mahabeleshwar, G. H., "Mechanisms of integrin-vascular endothelial growth factor receptor cross-activation in angiogenesis", Circ. Res., 101, pp.570~580 (2007)
  23. Somanath, P. R., "Akt1 signaling regulates integrin activation, matrix recognition, and fibronectin assembly", J. Biol. Chem., 282, pp.22964~22976 (2007)
  24. Schneller, M., "Alphavbeta3 integrin associates with activated insulin and PDGF beta receptors and potentiates the biological activity of PDGF", EMBO J., 16, pp.5600~5607 (1997)
  25. Borges, E., "Platelet-derived growth factor receptor beta and vascular endothelial growth factor receptor 2 bind to the beta 3 integrin through its extracellular domain", J. Biol. Chem., 275, pp.39867~39873 (2000)
  26. Soldi, R., "Role of alphavbeta3 integrin in the activation of vascular endothelial growth factor receptor-2", EMBO J., 18, pp.882~892 (1999)
  27. Falcioni, R., "Alpha 6 beta 4 and alpha 6 beta 1 integrins associate with ErbB-2 in human carcinoma cell lines", Exp. Cell Res., 236, pp.76~85 (1997)
  28. Trusolino, L., "A signaling adapter function for alpha6beta4 integrin in the control of HGF-dependent invasive growth", Cell, 107, pp.643~654 (2001)
  29. Santoro, M. M., "The MSP receptor regulates alpha6beta4 and alpha3beta1 integrins via 14-3-3 proteins in keratinocyte migration", Dev. Cell, 5, pp.257~271 (2003)
  30. Lipscomb, E. A., "Mobilization and activation of a signaling competent alpha6beta4integrin underlies its contribution to carcinoma progression", Cancer Metastasis Rev., 24, pp.413~423 (2005)
  31. Maile, L. A., "The alphaVbeta3 integrin regulates insulin-like growth factor I (IGF-I) receptor phosphorylation by altering the rate of recruitment of the Src-homology 2-containing phosphotyrosine phosphatase-2 to the activated IGF-I receptor", Endocrinology, 143, pp.4259~4264 (2002)
  32. Baron, W., "The oligodendrocyte precursor mitogen PDGF stimulates proliferation by activation of alpha(v)beta3 integrins", EMBO J., 21, pp.1957~1966 (2002)
  33. Rabinovitz, I., "Protein kinase C-dependent mobilization of the alpha 6beta4 integrin from hemidesmosomes and its association with actin-rich cell protrusions drive the chemotactic migration of carcinoma cells", J. Cell Biol., 146, pp.1147~1160 (1999)
  34. Rabinovitz, I., "Protein kinase C-alpha phosphorylation of specific serines in the connecting segment of the beta 4 integrin regulates the dynamics of type II hemidesmosomes", Mol. Cell Biol., 24, pp.4351~4360 (2004)
  35. Germain, E. C., "Phosphorylation of a novel site on the {beta}4 integrin at the trailing edge of migrating cells promotes hemidesmosome disassembly", Mol. Biol. Cell, 20, pp.56~67 (2009)
  36. Trusolino, L., "Scatter-factor and semaphorin receptors: cell signalling for invasive growth", Nat. Rev. Cancer, 2, pp.289~300 (2002)
  37. Mercurio, A. M., "The metastatic odyssey: the integrin connection", Surg. Oncol. Clin. N. Am., 10, pp.313~328 (2001)
  38. Nguyen, B. P., "Deposition of laminin 5 in epidermal wounds regulates integrin signaling and adhesion", Curr. Opin. Cell Biol., 12, pp.554~562 (2000)
  39. Mercurio, A. M., "Autocrine signaling in carcinoma: VEGF and the alpha6beta4 integrin", Semin. Cancer Biol., 14, pp.115~122 (2004)
  40. Jun Chung, "Contributions of the a6 Integrins to Breast Carcinoma Survival and Progression", 분자와 세포, 17(2), pp.203~209 (2004), 한국분자세포생물학회
  41. Mercurio, A. M., "Towards a mechanistic understanding of tumor invasion--lessons from the alpha6beta 4 integrin", Semin. Cancer Biol., 11, pp.129~141 (2001)
  42. Chung, J., "Integrin (alpha 6 beta 4) regulation of eIF-4E activity and VEGF translation: a survival mechanism for carcinoma cells", J. Cell Biol., 158, pp.165~174 (2002)
  43. Mercurio, A. M., "The alpha 6 beta 4 integrin and epithelial cell migration", Curr. Opin. Cell Biol., 13, pp.541~545 (2001)
  44. Head, B. P., "Microtubules and actin microfilaments regulate lipid raft", caveolae localization of adenylyl cyclase signaling components, 2006, pp.281, 26391~26399
  45. de Laurentiis, A., "Lipid rafts and caveolae in signaling by growth factor receptors", Open Biochem. J., 1, pp.12~32 (2007)
  46. Guo, W., "Beta 4 integrin amplifies ErbB2 signaling to promote mammary tumorigenesis", Cell, 126, pp.489~502 (2006)
  47. Gambaletta, D., "Cooperative signaling between alpha(6)beta(4) integrin and ErbB-2 receptor is required to promote phosphatidylinositol 3-kinasedependent invasion", J. Biol. Chem., 275, pp.10604~10610 (2000)
  48. Folgiero, V., "The alpha6beta4 integrin can regulate ErbB-3 expression: implications for alpha6 beta4 signaling and function", Cancer Res., 67, pp.1645~1652 (2007)
  49. Gilcrease, M. Z., "Alpha6beta4 integrin crosslinking induces EGFR clustering and promotes EGF-mediated Rho activation in breast cancer", J. Exp. Clin. Cancer Res., 28, pp.67~ (2009)
  50. Chung, J., "The Met receptor and alpha 6 beta 4 integrin can function independently to promote carcinoma invasion", J. Biol. Chem., 279, pp.32287~32293 (2004)
  51. Meyer, T., "Expression of alphav integrins and vitronectin receptor identity in breast cancer cells", Br. J. Cancer, 77, pp.530~536 (1998)
  52. Wong, N. C., "Alphav integrins mediate adhesion and migration of breast carcinoma cell lines", Clin. Exp. Metastasis., 16, pp.50~61 (1998)
  53. Brooks, P. C., "Antiintegrin alpha v beta 3 blocks human breast cancer growth and angiogenesis in human skin", J. Clin. Invest., 96, pp.1815~1822 (1995)
  54. Gramoun, A., "Effects of Vitaxin, a novel therapeutic in trial for metastatic bone tumors, on osteoclast functions in vitro", J. Cell Biochem., 102, pp.341~352 (2007)
  55. Eliceiri, B. P., "Integrin and growth factor receptor crosstalk", Circ. Res., 89, pp.1104~1110 (2001)
  56. Tuck, A. B., "Osteopontin-induced, integrindependent migration of human mammary epithelial cells involves activation of the hepatocyte growth factor receptor (Met)", J. Cell Biochem., 78, pp.465~475 (2000)
  57. White, D. E., "Multifaceted roles of integrins in breast cancer metastasis", J. Mammary. Gland. Biol. Neoplasia., 12, pp.135~142 (2007)
  58. Colognato, H., "CNS integrins switch growth factor signalling to promote target-dependent survival", Nat. Cell Biol., 4, pp.833~841 (2002)
  59. Somanath, P. R., "Cooperation between integrin alphavbeta3 and VEGFR2 in angiogenesis", Angiogenesis, 12, pp.177~185 (2009)
  60. Phillips, D. R., "Integrin tyrosine phosphorylation in platelet signaling", Curr. Opin. Cell Biol., 13, pp.546~554 (2001)
  61. Mori, S., "Direct binding of integrin alphavbeta3 to FGF1 plays a role in FGF1 signaling", J. Biol. Chem., 283, pp.18066~18075 (2008)
  62. Danen, E. H., "Fibronectin, in tegrins, and growth control", J. Cell Physiol., 189, pp.1~13 (2001)
  63. Nista, A., "Functional role of alpha4beta1 and alpha5beta1 integrin fibronectin receptors expressed on adriamycin-resistant MCF-7 human mammary carcinoma cells", Int. J. Cancer, 72, pp.133~141 (1997)
  64. Morozevich, G., "Integrin alpha5beta1 controls invasion of human breast carcinoma cells by direct and indirect modulation of MMP-2 collagenase activity", Cell Cycle, 8, pp.2219~2225 (2009)
  65. Jia, Y., "Integrin fibronectin receptors in matrix metalloproteinase-1-dependent invasion by breast cancer and mammary epithelial cells", Cancer Res., 64, pp.8674~8681 (2004)
  66. Liu, Y., "Cleaved high-molecular-weight kininogen and its domain 5 inhibit migration and invasion of human prostate cancer cells through the epidermal growth factor receptor pathway", Oncogene, 28, pp.2756~2765 (2009)
  67. Cascone, I., "Stable interaction between alpha5beta1 integrin and Tie2 tyrosine kinase receptor regulates endothelial cell response to Ang-1", J. Cell Biol., 170, pp.993~1004 (2005)
  68. Zhang, X., "Extracellular matrix regulates endothelial functions through interaction of VEGFR-3 and integrin alpha5beta1", J. Cell Physiol., 202, pp.205~214 (2005)
  69. Lee, J. W., "The alpha5beta1 integrin selectively enhances epidermal growth factor signaling to the phosphatidylinositol-3-kinase", Akt pathway in intestinal epithelial cells, 2002, pp.1542, 23~31
  70. Rahman, S., "Novel hepatocyte growth factor (HGF) binding domains on fibronectin and vitronectin coordinate a distinct and amplified Met-integrin induced signalling pathway in endothelial cells", BMC. Cell Biol., 6, pp.8~ (2005)
  71. Bell, L. N., "A central role for hepatocyte growth factor in adipose tissue angiogenesis", Am. J. Physiol. Endocrinol. Metab., 294, pp.E336~E344 (2008)

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