Role of Wnt signaling in fracture healing

키워드

참고문헌 (70)

1. Nüsslein-Volhard, C., "Mutations affecting segment number and polarity in Drosophila", Nature, 287, pp.795~801 (1980)
2. Rijsewijk, F., "The Drosophila homology of the mouse mammary oncogene int-1 is identical to the segment polarity gene wingless", Cell, 50, pp.649~657 (1987)
3. Nusse, R., "Three decades of Wnts: a personal perspective on how a scientific field developed", EMBO J, 31, pp.2670~2684 (2012)
4. Regard, J. B., "Wnt signaling in bone development and disease: making stronger bone with Wnts", Cold Spring Harb. Perspect. Biol, 4, pp.a007997~ (2012)
5. Chen, Y., "Wnt pathway, an essential role in bone regeneration", J. Cell. Biochem, 106, pp.353~362 (2009)
6. Bruder, S. P., "Mesenchymal stem cells in bone development, bone repair, and skeletal regenaration therapy", J. Cell. Biochem, 56, pp.283~294 (1994)
7. Silkstone, D., "β-Catenin in the race to fracture repair: in it to Wnt", Nat. Clin. Pract. Rheumatol, 4, pp.413~419 (2008)
8. Einhorn, T. A., "The Wnt signaling pathway as a potential target for therapies to enhance bone repair", Sci. Transl. Med, 2, pp.42~36 (2010)
9. Tzioupis, C., "Prevalence of long-bone non-unions", Injury, 38, pp.S3~S9 (2007)
10. Hak, D. J., "Delayed union and nonunions: Epidemiology, clinical issues, and financial aspects", Injury, 45, pp.S3~S7 (2014)
11. Bhanot, P., "A new member of the frizzled family from Drosophila functions as a Wingless receptor", Nature, 382, pp.225~230 (1996)
12. He, X., "LDL receptor-related proteins 5 and 6 in Wnt", β-catenin signaling: arrows point the way, 2004, pp.131, 1663~1677
13. Eastman, Q., "Regulation of LEF-1", TCF transcription factors by Wnt and other signals, 1999, pp.11, 233~240
14. Slusarski, D. C., "Interaction of Wnt and a Frizzled homologue triggers G-protein-linked phosphatidylinositol signalling", Nature, 390, pp.410~413 (1997)
15. Nusse, R., "WNT targets: repression and activation", Trends Genet, 15, pp.1~3 (1999)
16. De, A., "Wnt", Ca2+ signaling pathway: a brief overview, 2011, pp.43, 745~756
17. Kühl, M., "The WNT", calcium pathway: biochemical mediators, tools and future requirements, 2004, pp.9, 967~974
18. Nakamura, R. E. I., "Analysis of Dickkopf3 interactions with Wnt signaling receptors", Growth Factors, 28, pp.232~242 (2010)
19. Hoeppner, L. H., "Wnt signaling as a therapeutic target for bone diseases", Expert Opin. Ther. Targets, 13, pp.485~496 (2009)
20. Patthy, L., "The WIF module", Trends Biochem. Sci, 25, pp.12~13 (2000)
21. Einhorn, T. A., "The cell and molecular biology of fracture healing", Clin. Orthop. Relat. Res, 355, pp.S7~S21 (1998)
22. Marsell, R., "The biology of fracture healing", Injury, 42, pp.551~555 (2011)
23. Schindeler, A., "Bone remodeling during fracture repair: The cellular picture", Semin. Cell Dev. Biol, 19, pp.459~466 (2008)
24. Phillips, A. M., "Overview of the fracture healing cascade", Injury, 36, pp.S5~S7 (2005)
25. Chen, Y., "Beta-catenin signaling plays a disparate role in different phases of fracture repair: implications for therapy to improve bone healing", PLoS Med, 4, pp.e249~ (2007)
26. Hadjiargyrou, M., "Transcriptional profiling of bone regeneration Insight into the molecular complexity of wound repair", J. Biol. Chem, 277, pp.30177~30182 (2002)
27. Zhong, N., "Wnt signaling activation during bone regeneration and the role of Dishevelled in chondrocyte proliferation and differentiation", Bone, 39, pp.5~16 (2006)
28. Leucht, P., "Beta-catenin- dependent Wnt signaling in mandibular bone regeneration", J. Bone Joint. Surg, 90, pp.3~8 (2008)
29. Macsai, C. E., "Microarray expression analysis of genes and pathways involved in growth plate cartilage injury responses and bony repair", Bone, 50, pp.1081~1091 (2012)
30. Kakar, S., "Enhanced chondrogenesis and Wnt signaling in PTH-treated fractures", J. Bone Miner. Res, 22, pp.1903~1912 (2007)
31. Kim, J. B., "Bone regeneration is regulated by wnt signaling", J. Bone Miner. Res, 22, pp.1913~1923 (2007)
32. Bollerslev, J., "LRP5 gene polymorphisms predict bone mass and incident fractures in elderly Australian women", Bone, 36, pp.599~606 (2005)
33. van Meurs, J. B. J., "Common genetic variation of the low-density lipoprotein receptor-related protein 5 and 6 genes determines fracture risk in elderly white men", J. Bone Miner. Res, 21, pp.141~150 (2006)
34. Komatsu, D. E., "Modulation of Wnt signaling influences fracture repair", J. Orthop. Res, 28, pp.928~936 (2010)
35. Phiel, C. J., "Molecular targets of lithium action", Annu. Rev. Pharmacol. Toxicol, 41, pp.789~813 (2001)
36. Lauing, K. L., "Exogenous activation of Wnt", β-Catenin signaling attenuates binge alcohol-induced deficient bone fracture healing, 2014, pp.9, 399~408
37. Vestergaard, P., "Reduced relative risk of fractures among users of lithium", Calcif. Tissue Int, 77, pp.1~8 (2005)
38. Sisask, G., "Rats treated with AZD2858, a GSK3 inhibitor, heal fractures rapidly without endochondral bone formation", Bone, 54, pp.126~132 (2013)
39. Kawano, Y., "Secreted antagonists of the Wnt signalling pathway", J. Cell Sci, 116, pp.2627~2634 (2003)
40. Bodine, P. V. N., "The Wnt antagonist secreted frizzled-related protein-1 is a negative regulator of trabecular bone formation in adult mice", Mol. Endocrinol, 18, pp.1222~1237 (2004)
41. Gaur, T., "Secreted frizzled related protein 1 is a target to improve fracture healing", J. Cell. Physiol, 220, pp.174~181 (2009)
42. Semenov, M., "Sost is a ligand for lrp5", lrp6 and a wnt signaling inhibitor, 2005, pp.280, 26770~26775
43. Li, X, "Targeted deletion of the sclerostin gene in mice results in increased bone formation and bone strength", J. Bone Miner. Res, 23, pp.860~869 (2008)
44. McGee-Lawrence, M. E., "Sclerostin deficient mice rapidly heal bone defects by activating β-catenin and increasing intramembranous ossification", Biochem. Biophys. Res. Commun, 441, pp.886~890 (2013)
45. Li, C., "Increased callus mass and enhanced strength during fracture healing in mice lacking the sclerostin gene", Bone, 49, pp.1178~1185 (2011)
46. Sarahrudi, K., "Strongly enhanced levels of sclerostin during human fracture healing", J. Orthop. Res, 30, pp.1549~1555 (2012)
47. Ominsky, M. S., "Inhibition of sclerostin by monoclonal antibody enhances bone healing and improves bone density and strength of nonfractured bones", J. Bone Miner. Res, 26, pp.1012~1021 (2011)
48. Virk, M. S., "Systemic administration of sclerostin antibody enhances bone repair in a critical- sized femoral defect in a rat model", J. Bone Joint. Surg, 95, pp.694~701 (2013)
49. Gamie, Z., "Sclerostin monoclonal antibodies on bone metabolism and fracture healing", Exper. Opin. Inv. Drug, 21, pp.1523~1534 (2012)
50. Jawad, M. U., "Effects of sclerostin antibody on healing of a non-critical size femoral bone defect", J. Orthop. Res, 31, pp.155~163 (2013)
51. Suen, P. K., "Sclerostin monoclonal antibody enhanced bone fracture healing in an open osteotomy model in rats", J. Orthop. Res, 32, pp.997~1005 (2014)
52. Agholme, F., "Sclerostin antibody treatment enhances metaphyseal bone healing in rats", J. Bone Miner. Res, 25, pp.2412~2418 (2010)
53. Alaee, F., "Evaluation of the effects of systemic treatment with a sclerostin neutralizing antibody on bone repair in a rat femoral defect model", J. Orthop. Res, 32, pp.197~203 (2014)
54. Glinka, A., "Dickkopf-1 is a member of a new family of secreted proteins and functions in head induction", Nature, 391, pp.357~362 (1998)
55. Morvan, F., "Deletion of a single allele of the Dkk1 gene leads to an increase in bone formation and bone mass", J. Bone Miner. Res, 21, pp.934~945 (2006)
56. Li, X, "Dickkopf-1 regulates bone formation in young growing rodents and upon traumatic injury", J. Bone Miner. Res, 26, pp.2610~2621 (2011)
57. Loiselle, A. E., "Inhibition of GSK-3β rescues the impairments in bone formation and mechanical properties associated with fracture healing in osteoblast selective connexin 43 deficient mice", PloS one, 8, pp.e81399~ (2013)
58. Loiselle, A. E., "Osteoblast and osteocyte-specific loss of Connexin43 results in delayed bone formation and healing during murine fracture healing", J. Orthop. Res, 31, pp.147~154 (2013)
59. Aspenberg, P., "Annotation: Parathyroid hormone and fracture healing", Acta. Orthop, 84, pp.4~6 (2013)
60. Bodine, P. V. N., "Bone anabolic effects of parathyroid hormone are blunted by deletion of the Wnt antagonist secreted frizzled-related protein-1", J. Cell. Physiol, 210, pp.352~357 (2007)
61. Ronga, M., "Clinical applications of growth factors in bone injuries: experience with BMPs", Injury, 44, pp.S34~S39 (2013)
62. Bostrom, M. P., "Immunolocalization and expression of bone morphogenetic proteins 2 and 4 in fracture healing", J. Orthop. Res, 13, pp.357~367 (1995)
63. Fourman, M. S., "Recombinant human BMP-2 increases the incidence and rate of healing in complex ankle arthrodesis", Clin. Orthop. Relat. Res, 472, pp.732~739 (2014)
64. Lissenberg-Thunnissen, S. N., "Use and efficacy of bone morphogenetic proteins in fracture healing", Int. Orthop, 35, pp.1271~1280 (2011)
65. Mbalaviele, G., "β−Catenin and BMP-2 synergize to promote osteoblast differentiation and new bone formation", J. Cell. Biochem, 94, pp.403~418 (2005)
66. Chen, Y., "β-catenin signaling pathway is crucial for bone morphogenetic protein 2 to induce new bone formation", J. Biol. Chem, 282, pp.526~533 (2007)
67. Fischer, L., "Wnt signaling during BMP-2 stimulation of mesenchymal chondrogenesis", J. Cell. Biochem, 84, pp.816~831 (2002)
68. Lowik, C., "Wnt signaling is involved in the inhibitory action of sclerostin on BMP-stimulated bone formation", J. Musculoskelet. Neuronal. Interact, 6, pp.357~ (2006)
69. van Bezooijen, R. L., "Wnt but Not BMP signaling is involved in the inhibitory action of sclerostin on BMP-stimulated bone formation", J. Bone Miner. Res, 22, pp.19~28 (2007)
70. Yu, Y. Y., "Effects of bone morphogenetic proteins on tgf-beta, wnt and bmp pathways during tibial fracture repair", FASEB J, 25, pp.680~ (2011)

관련 논문AI추천