본문 바로가기
KERD
논문KCI 등재

Wnt signaling in liver regeneration, disease, and cancer

2

조회

0

다운로드

0

인용

0

참고문헌

키워드

초록

The liver exhibits the highest recovery rate from acute injuries. However, in chronic liver disease, the long-term loss of hepatocytes often leads to adverse consequences such as fibrosis, cirrhosis, and liver cancer. The Wnt signaling plays a pivotal role in both liver regeneration and tumorigenesis. Therefore, manipulating the Wnt signaling has become an attractive approach to treating liver disease, including cancer. Nonetheless, given the crucial roles of Wnt signaling in physiological processes, blocking Wnt signaling can also cause several adverse effects. Recent studies have identified cancer-specific regulators of Wnt signaling, which would overcome the limitation of Wnt signaling target approaches. In this review, we discussed the role of Wnt signaling in liver regeneration, precancerous lesion, and liver cancer. Furthermore, we summarized the basic and clinical approaches of Wnt signaling blockade and proposed the therapeutic prospects of cancer-specific Wnt signaling blockade for liver cancer treatment.

Abstract

The liver exhibits the highest recovery rate from acute injuries. However, in chronic liver disease, the long-term loss of hepatocytes often leads to adverse consequences such as fibrosis, cirrhosis, and liver cancer. The Wnt signaling plays a pivotal role in both liver regeneration and tumorigenesis. Therefore, manipulating the Wnt signaling has become an attractive approach to treating liver disease, including cancer. Nonetheless, given the crucial roles of Wnt signaling in physiological processes, blocking Wnt signaling can also cause several adverse effects. Recent studies have identified cancer-specific regulators of Wnt signaling, which would overcome the limitation of Wnt signaling target approaches. In this review, we discussed the role of Wnt signaling in liver regeneration, precancerous lesion, and liver cancer. Furthermore, we summarized the basic and clinical approaches of Wnt signaling blockade and proposed the therapeutic prospects of cancer-specific Wnt signaling blockade for liver cancer treatment.

참고문헌 (176)

  1. Clemens MM, "Mechanisms and biomarkers of liver regeneration after drug-induced liver injury", Adv Pharmacol, 85, pp.241~262 (2019)
  2. Michalopoulos GK, "Hepatostat : liver regeneration and normal liver tissue maintenance", Hepatology, 65, pp.1384~1392 (2017)
  3. Ko S, "Liver progenitors and adult cell plasticity in hepatic injury and repair : knowns and unknowns", Annu Rev Pathol, 15, pp.23~50 (2020)
  4. Duncan AW, "The ploidy conveyor of mature hepatocytes as a source of genetic variation", Nature, 467, pp.707~710 (2010)
  5. Anti M, "DNA ploidy pattern in human chronic liver diseases and hepatic nodular lesions. Flow cytometric analysis on echoguided needle liver biopsy", Cancer, 73, pp.281~288 (1994)
  6. Duncan AW, "Frequent aneuploidy among normal human hepatocytes", Gastroenterology, 142, pp.25~28 (2012)
  7. Siegel RL, "Cancer statistics, 2022", CA Cancer J Clin, 72, pp.7~33 (2022)
  8. Llovet JM, "Hepatocellular carcinoma", Nat Rev Dis Primers, 2, pp.16018~ (2016)
  9. Tortelote GG, "Complexity of the Wnt", β‑catenin pathway : searching for an activation model, 2017, pp.40, 30~43
  10. Xia XH, "Facilitation of liver cancer SMCC7721cell aging by sirtuin 4 via inhibiting JAK2", STAT3 signal pathway, 2017, pp.21, 1248~1253
  11. Chen J, "Immunomodulatory TGF-βsignaling in hepatocellular carcinoma", Trends Mol Med, 25, pp.1010~1023 (2019)
  12. Czauderna C, "Contextdependent role of NF-κB signaling in primary liver cancerfrom tumor development to therapeutic implications", Cancers(Basel), 11, pp.1053~ (2019)
  13. Russell JO, "Wnt", β-catenin signaling in liver development, homeostasis, and pathobiology, 2018, pp.13, 351~378
  14. Cheng JH, "Wnt antagonism inhibits hepatic stellate cell activation and liver fibrosis", Am J Physiol Gastrointest Liver Physiol, 294, pp.G39~G49 (2008)
  15. Zeng G, "Wnt’er in liver : expression of Wnt and frizzled genes in mouse", Hepatology, 45, pp.195~204 (2007)
  16. Ma R, "Metabolic and non-metabolic liver zonation is established non-synchronously and requires sinusoidal Wnts", Elife, 9, pp.e46206~ (2020)
  17. Monga SP, "β-catenin signaling and roles in liver homeostasis, injury, and tumorigenesis", Gastroenterology, 148, pp.1294~1310 (2015)
  18. Nusse R, "Wnt", β-catenin signaling, disease, and emerging therapeutic modalities, 2017, pp.169, 985~999
  19. Clevers H, "Wnt", β-catenin signaling and disease, 2012, pp.149, 1192~1205
  20. Scheibner K, "Wnt signaling : implications in endoderm development and pancreas organogenesis", Curr Opin Cell Biol, 61, pp.48~55 (2019)
  21. Steinhart Z, "Wnt signaling in development and tissue homeostasis", Development, 145, pp.dev146589~ (2018)
  22. Hu S, "Wnt", -catenin signaling and liver regeneration : circuit, biology, and opportunities, 2021, pp.20, 189~199
  23. Zhan T, "Wnt signaling in cancer", Oncogene, 36, pp.1461~1473 (2017)
  24. Ahmed A. Raslan, "WNT Signaling in Lung Repair and Regeneration", Molecules and Cells, 43(9), pp.774~783 (2020), 한국분자세포생물학회[DOI]
  25. Girardi F, "Wnt signaling in skeletal muscle development and regeneration", Prog Mol Biol Transl Sci, 153, pp.157~179 (2018)
  26. Jackstadt R, "WNT and β-catenin in cancer : genes and therapy", Annu Rev Cancer Biol, 4, pp.177~196 (2020)
  27. Monga SP, "Changes in WNT", beta-catenin pathway during regulated growth in rat liver regeneration, 2001, pp.33, 1098~1109
  28. Stolz DB, "Growth factor signal transduction immediately after two-thirds partial hepatectomy in the rat", Cancer Res, 59, pp.3954~3960 (1999)
  29. Köhler C, "Expression of notch-1 and its ligand Jagged-1 in rat liver during liver regeneration", Hepatology, 39, pp.1056~1065 (2004)
  30. Higgins GM, "Experimental pathology of the liver. 1. Restoration of the liver of the white rat following partial surgical removal", Arch Pathol, 12, pp.186~202 (1931)
  31. Nikfarjam M, "A model of partial hepatectomy in mice", J Invest Surg, 17, pp.291~294 (2004)
  32. Sadler KC, "Liver growth in the embryo and during liver regeneration in zebrafish requires the cell cycle regulator, uhrf1", Proc Natl Acad Sci U S A, 104, pp.1570~1575 (2007)
  33. Curado S, "Nitroreductase-mediated cell", tissue ablation in zebrafish : a spatially and temporally controlled ablation method with applications in developmental and regeneration studies, 2008, pp.3, 948~954
  34. Teschke R, "Carbon tetrachloride(CCl4)levels and serum activities of liver enzymes following acute CCl4 intoxication", Toxicol Lett, 17, pp.175~180 (1983)
  35. Preisegger KH, "Atypical ductular proliferation and its inhibition by transforming growth factor beta1 in the 3, 5-diethoxycarbonyl-1, 4-dihydrocollidine mouse model for chronic alcoholic liver disease", Lab Invest, 79, pp.103~109 (1999)
  36. Oderberg IM, "Partial hepatectomy in adult zebrafish", J Vis Exp, (170) (2021)[DOI]
  37. North TE, "PGE2-regulated Wnt signaling and N-acetylcysteine are synergistically hepatoprotective in zebrafish acetaminophen injury", Proc Natl Acad Sci U S A, 107, pp.17315~17320 (2010)
  38. Sekine S, "Liver-specific loss of beta-catenin results in delayed hepatocyte proliferation after partial hepatectomy", Hepatology, 45, pp.361~368 (2007)
  39. Goessling W, "APC mutant zebrafish uncover a changing temporal requirement for wnt signaling in liver development", Dev Biol, 320, pp.161~174 (2008)
  40. Sun T, "AXIN2+ pericentral hepatocytes have limited contributions to liver homeostasis and regeneration", Cell Stem Cell, 26, pp.97~107 (2020)
  41. Huch M, "In vitro expansion of single Lgr5+ liver stem cells induced by Wnt-driven regeneration", Nature, 494, pp.247~250 (2013)
  42. Carmon KS, "LGR5 interacts and cointernalizes with Wnt receptors to modulate Wnt", β-catenin signaling, 2012, pp.32, 2054~2064
  43. Jho EH, "Wnt", beta-catenin, Mol Cell Biol, pp.2002, 22[DOI]
  44. Lustig B, "Negative feedback loop of Wnt signaling through upregulation of conductin", axin2 in colorectal and liver tumors, 2002, pp.22, 1184~1193
  45. Jung YS, "TMEM9 promotes intestinal tumorigenesis through vacuolar-ATPase-activated Wnt", β-catenin signalling, 2018, pp.20, 1421~1433
  46. Jung YS, "TMEM9-v-ATPase activates Wnt", β-catenin signaling via APC lysosomal degradation for liver regeneration and tumorigenesis, 2021, pp.73, 776~794
  47. Kudo Y, "PKCλ", ι loss induces autophagy, oxidative phosphorylation, and NRF2 to promote liver cancer progression, 2020, pp.38, 247~262
  48. Wang Z, "Oxidative stress and liver cancer : etiology and therapeutic targets", Oxid Med Cell Longev, 2016, pp.7891574~ (2016)
  49. Funato Y, "The thioredoxinrelated redox-regulating protein nucleoredoxin inhibits Wntbeta-catenin signalling through dishevelled", Nat Cell Biol, 8, pp.501~508 (2006)
  50. Zhou T, "The role of lipid peroxidation products and oxidative stress in activation of the canonical wingless-type MMTV integration site(WNT)pathway in a rat model of diabetic retinopathy", Diabetologia, 54, pp.459~468 (2011)
  51. Sun HC, "Positive serum hepatitis B e antigen is associated with higher risk of early recurrence and poorer survival in patients after curative resection of hepatitis B-related hepatocellular carcinoma", J Hepatol, 47, pp.684~690 (2007)
  52. Rein DB, "Forecasting the morbidity and mortality associated with prevalent cases of pre-cirrhotic chronic hepatitis C in the United States", Dig Liver Dis, 43, pp.66~72 (2011)
  53. Yang JD, "Cirrhosis is present in most patients with hepatitis B and hepatocellular carcinoma", Clin Gastroenterol Hepatol, 9, pp.64~70 (2011)
  54. Roudot-Thoraval F, "Epidemiology of hepatitis C virus infection", Clin Res Hepatol Gastroenterol, 45, pp.101596~ (2021)
  55. Mavilia MG, "HBV-HCV coinfection : viral interactions, management, and viral reactivation", J Clin Transl Hepatol, 6, pp.296~305 (2018)
  56. Levrero M, "Mechanisms of HBV-induced hepatocellular carcinoma", J Hepatol, 64(1 Suppl), pp.S84~S101 (2016)
  57. Arbuthnot P, "Hepatitis B virus and hepatocellular carcinoma", Int J Exp Pathol, 82, pp.77~100 (2001)
  58. Neuveut C, "Mechanisms of HBV-related hepatocarcinogenesis", J Hepatol, 52, pp.594~604 (2010)
  59. Tian X, "Role of hepatitis B surface antigen in the development of hepatocellular carcinoma : regulation of lymphoid enhancer-binding factor 1", J Exp Clin Cancer Res, 28, pp.58~ (2009)
  60. Javanmard D, "Investigation of CTNNB1 gene mutations and expression in hepatocellular carcinoma and cirrhosis in association with hepatitis B virus infection", Infect Agent Cancer, 15, pp.37~ (2020)
  61. Zucman-Rossi J, "Differential effects of inactivated Axin1 and activated beta-catenin mutations in human hepatocellular carcinomas", Oncogene, 26, pp.774~780 (2007)
  62. Galy O, "Mutations in TP53 and CTNNB1 in relation to hepatitis B and C infections in hepatocellular carcinomas from Thailand", Hepat Res Treat, 2011, pp.697162~ (2011)
  63. Hsieh A, "Hepatitis B viral X protein interacts with tumor suppressor adenomatous polyposis coli to activate Wnt", β-catenin signaling, 2011, pp.300, 162~172
  64. Feitelson MA, "Hepatitis B virus X antigen in the pathogenesis of chronic infections and the development of hepatocellular carcinoma", Am J Pathol, 150, pp.1141~1157 (1997)
  65. Lau CC, "Viralhuman chimeric transcript predisposes risk to liver cancer development and progression", Cancer Cell, 25, pp.335~349 (2014)
  66. Moradpour D, "Hepatitis C virus proteins : from structure to function", Curr Top Microbiol Immunol, 369, pp.113~142 (2013)
  67. Fukutomi T, "Hepatitis C virus core protein stimulates hepatocyte growth : correlation with upregulation of Wnt-1 expression", Hepatology, 41, pp.1096~1105 (2005)
  68. Liu J, "Enhancement of canonical Wnt", β-catenin signaling activity by HCV core protein promotes cell growth of hepatocellular carcinoma cells, 2011, pp.6, e27496~
  69. Umer M, "Promoter hypermethylation of Wnt pathway inhibitors in hepatitis C virus-induced multistep hepatocarcinogenesis", Virol J, 11, pp.117~ (2014)
  70. Quan H, "Hepatitis C virus core protein epigenetically silences SFRP1 and enhances HCC aggressiveness by inducing epithelial-mesenchymal transition", Oncogene, 33, pp.2826~2835 (2014)
  71. Ripoli M, "Hypermethylated levels of E-cadherin promoter in Huh-7 cells expressing the HCV core protein", Virus Res, 160, pp.74~81 (2011)
  72. Jung YS, "Deregulation of CRAD-controlled cytoskeleton initiates mucinous colorectal cancer via β-catenin", Nat Cell Biol, 20, pp.1303~1314 (2018)
  73. Liu Y, "WNT signaling pathway gene polymorphisms and risk of hepatic fibrosis and inflammation in HCV-infected patients", PLoS One, 8, pp.e84407~ (2013)
  74. Takahara Y, "Serial changes in expression of functionally clustered genes in progression of liver fibrosis in hepatitis C patients", World J Gastroenterol, 14, pp.2010~2022 (2008)
  75. Mercer KE, "Alcohol consumption, Wnt", β-catenin signaling, and hepatocarcinogenesis, 2015, pp.815, 185~195
  76. 김한상, "The p90rsk-mediated signaling of ethanol-induced cell proliferation in HepG2 cell line", The Korean Journal of Physiology & Pharmacology, 20(6), pp.595~603 (2016), 대한약리학회
  77. Wang F, "Activation of the NF-κB pathway as a mechanism of alcohol enhanced progression and metastasis of human hepatocellular carcinoma", Mol Cancer, 14, pp.10~ (2015)
  78. Yang CF, "NOX4", ROS mediate ethanol‑induced apoptosis via MAPK signal pathway in L‑02 cells, 2018, pp.41, 2306~2316
  79. Zhang C, "Inhibition of vascular endothelial growth factor signaling facilitates liver repair from acute ethanol-induced injury in zebrafish", Dis Model Mech, 9, pp.1383~1396 (2016)
  80. Mandrekar P, "An essential role for monocyte chemoattractant protein-1 in alcoholic liver injury : regulation of proinflammatory cytokines and hepatic steatosis in mice", Hepatology, 54, pp.2185~2197 (2011)
  81. Yuen MF, "Independent risk factors and predictive score for the development of hepatocellular carcinoma in chronic hepatitis B", J Hepatol, 50, pp.80~88 (2009)
  82. Wong VW, "Prevalence of non-alcoholic fatty liver disease and advanced fibrosis in Hong Kong Chinese : a population study using proton-magnetic resonance spectroscopy and transient elastography", Gut, 61, pp.409~415 (2012)
  83. Bhala N, "The natural history of nonalcoholic fatty liver disease with advanced fibrosis or cirrhosis : an international collaborative study", Hepatology, 54, pp.1208~1216 (2011)
  84. Geoffrey C. Farrell, "NASH is an Infl ammatory Disorder: Pathogenic, Prognostic and Therapeutic Implications", Gut and Liver, 6(2), pp.149~171 (2012), 거트앤리버 소화기연관학회협의회[DOI]
  85. Murphy SK, "Relationship between methylome and transcriptome in patients with nonalcoholic fatty liver disease", Gastroenterology, 145, pp.1076~1087 (2013)
  86. Chettouh H, "Hyperinsulinaemia and insulin signalling in the pathogenesis and the clinical course of hepatocellular carcinoma", Liver Int, 35, pp.2203~2217 (2015)
  87. Jonatan D, "Sox17 regulates insulin secretion in the normal and pathologic mouse β cell", PLoS One, 9, pp.e104675~ (2014)
  88. Jia Y, "SOX17 antagonizes WNT", β-catenin signaling pathway in hepatocellular carcinoma, 2010, pp.5, 743~749
  89. Ackers I, "Interrelationship of canonical and noncanonical Wnt signalling pathways in chronic metabolic diseases", Diab Vasc Dis Res, 15, pp.3~13 (2018)
  90. Wang S, "Nonalcoholic fatty liver disease induced by noncanonical Wnt and its rescue by Wnt3a", FASEB J, 29, pp.3436~3445 (2015)
  91. Kew MC, "Synergistic interaction between aflatoxin B1and hepatitis B virus in hepatocarcinogenesis", Liver Int, 23, pp.405~409 (2003)
  92. Devereux TR, "CTNNB1 mutations and beta-catenin protein accumulation in human hepatocellular carcinomas associated with high exposure to aflatoxin B1", Mol Carcinog, 31, pp.68~73 (2001)
  93. Yang JD, "A global view of hepatocellular carcinoma : trends, risk, prevention and management", Nat Rev Gastroenterol Hepatol, 16, pp.589~604 (2019)
  94. Bengochea A, "Common dysregulation of Wnt", frizzled receptor elements in human hepatocellular carcinoma, 2008, pp.99, 143~150
  95. Boyault S, "Transcriptome classification of HCC is related to gene alterations and to new therapeutic targets", Hepatology, 45, pp.42~52 (2007)
  96. Fodde R, "APC, signal transduction and genetic instability in colorectal cancer", Nat Rev Cancer, 1, pp.55~67 (2001)
  97. Khemlina G, "The biology of hepatocellular carcinoma : implications for genomic and immune therapies", Mol Cancer, 16, pp.149~ (2017)
  98. Satoh S, "AXIN1 mutations in hepatocellular carcinomas, and growth suppression in cancer cells by virus-mediated transfer of AXIN1", Nat Genet, 24, pp.245~250 (2000)
  99. Park JY, "Mutations of beta-catenin and AXIN I genes are a late event in human hepatocellular carcinogenesis", Liver Int, 25, pp.70~76 (2005)
  100. Zhu M, "Somatic mutations increase hepatic clonal fitness and regeneration in chronic liver disease", Cell, 177, pp.608~621 (2019)
  101. Marquardt JU, "Sequential transcriptome analysis of human liver cancer indicates late stage acquisition of malignant traits", J Hepatol, 60, pp.346~353 (2014)
  102. Rebouissou S, "Advances in molecular classification and precision oncology in hepatocellular carcinoma", J Hepatol, 72, pp.215~229 (2020)
  103. Abitbol S, "AXIN deficiency in human and mouse hepatocytes induces hepatocellular carcinoma in the absence of β-catenin activation", J Hepatol, 68, pp.1203~1213 (2018)
  104. Lazaridis KN, "Zakim and Boyer’s Hepatology", pp.1032~1044 (2012), Saunders
  105. Boulter L, "WNT signaling drives cholangiocarcinoma growth and can be pharmacologically inhibited", J Clin Invest, 125, pp.1269~1285 (2015)
  106. Chen W, "Characterizing the activation of the Wnt signaling pathway in hilar cholangiocarcinoma using a tissue microarray approach", Eur J Histochem, 60, pp.2536~ (2016)
  107. Banales JM, "Cholangiocarcinoma 2020 : the next horizon in mechanisms and management", Nat Rev Gastroenterol Hepatol, 17, pp.557~588 (2020)
  108. Vaquero J, "Epithelial-mesenchymal transition in cholangiocarcinoma : from clinical evidence to regulatory networks", J Hepatol, 66, pp.424~441 (2017)
  109. Nitta T, "Prognostic significance of epithelialmesenchymal transition-related markers in extrahepatic cholangiocarcinoma : comprehensive immunohistochemical study using a tissue microarray", Br J Cancer, 111, pp.1363~1372 (2014)
  110. Chaw SY, "Epithelial to mesenchymal transition(EMT)biomarkers--E-cadherin, beta-catenin, APC and vimentin--in oral squamous cell carcinogenesis and transformation", Oral Oncol, 48, pp.997~1006 (2012)
  111. Valenta T, "The many faces and functions of β-catenin", EMBO J, 31, pp.2714~2736 (2012)
  112. Zhang GF, "Wnt", β-catenin signaling as an emerging potential key pharmacological target in cholangiocarcinoma, 2020, pp.40, BSR20193353~
  113. Xue W, "Upregulation of TTYH3 promotes epithelial-to-mesenchymal transition through Wnt", β-catenin signaling and inhibits apoptosis in cholangiocarcinoma, 2021, pp.44, 1351~1361
  114. Carrillo-Reixach J, "Epigenetic footprint enables molecular risk stratification of hepatoblastoma with clinical implications", J Hepatol, 73, pp.328~341 (2020)
  115. Gupta K, "Relationship of β-catenin and postchemotherapy histopathologic changes with overall survival in patients with hepatoblastoma", J Pediatr Hematol Oncol, 34, pp.e320~e328 (2012)
  116. Crippa S, "Mutant CTNNB1 and histological heterogeneity define metabolic subtypes of hepatoblastoma", EMBO Mol Med, 9, pp.1589~1604 (2017)
  117. López-Terrada D, "Histologic subtypes of hepatoblastoma are characterized by differential canonical Wnt and notch pathway activation in DLK+ precursors", Hum Pathol, 40, pp.783~794 (2009)
  118. Taniguchi K, "Mutational spectrum of beta-catenin, AXIN1, and AXIN2 in hepatocellular carcinomas and hepatoblastomas", Oncogene, 21, pp.4863~4871 (2002)
  119. Shah K, "Porcupine inhibitors : novel and emerging anti-cancer therapeutics targeting the Wnt signaling pathway", Pharmacol Res, 167, pp.105532~ (2021)
  120. Liu J, "Targeting Wnt-driven cancer through the inhibition of porcupine by LGK974", Proc Natl Acad Sci U S A, 110, pp.20224~20229 (2013)
  121. Madan B, "Wnt addiction of genetically defined cancers reversed by PORCN inhibition", Oncogene, 35, pp.2197~2207 (2016)
  122. Proffitt KD, "Pharmacological inhibition of the Wnt acyltransferase PORCN prevents growth of WNT-driven mammary cancer", Cancer Res, 73, pp.502~507 (2013)
  123. Wang W, "Blocking Wnt secretion reduces growth of hepatocellular carcinoma cell lines mostly independent of β-catenin signaling", Neoplasia, 18, pp.711~723 (2016)
  124. Barrott JJ, "Deletion of mouse porcn blocks Wnt ligand secretion and reveals an ectodermal etiology of human focal dermal hypoplasia", Goltz syndrome, 2011, pp.108, 12752~12757
  125. Liu W, "Deletion of porcn in mice leads to multiple developmental defects and models human focal dermal hypoplasia(Goltz syndrome)", PLoS One, 7, pp.e32331~ (2012)
  126. Funck-Brentano T, "Porcupine inhibitors impair trabecular and cortical bone mass and strength in mice", J Endocrinol, 238, pp.13~23 (2018)
  127. He X, "LDL receptor-related proteins 5 and 6 in Wnt", beta-catenin signaling : arrows point the way, 2004, pp.131, 1663~1677
  128. Wei W, "Blockade of Wnt-1 signaling leads to anti-tumor effects in hepatocellular carcinoma cells", Mol Cancer, 8, pp.76~ (2009)
  129. Cruciat CM, "Secreted and transmembrane wnt inhibitors and activators", Cold Spring Harb Perspect Biol, 5, pp.a015081~ (2013)
  130. Niehrs C, "Function and biological roles of the Dickkopf family of Wnt modulators", Oncogene, 25, pp.7469~7481 (2006)
  131. Kawazoe M, "Glucocorticoid therapy suppresses Wnt signaling by reducing the ratio of serum Wnt3a to Wnt inhibitors, sFRP-1 and Wif-1", Clin Rheumatol, 40, pp.2947~2954 (2021)
  132. Hu J, "Blockade of Wnt signaling inhibits angiogenesis and tumor growth in hepatocellular carcinoma", Cancer Res, 69, pp.6951~6959 (2009)
  133. Glinka A, "Dickkopf-1 is a member of a new family of secreted proteins and functions in head induction", Nature, 391, pp.357~362 (1998)
  134. Caneparo L, "Dickkopf-1 regulates gastrulation movements by coordinated modulation of Wnt", beta catenin and Wnt, Genes Dev, pp.2007, 21[DOI]
  135. Cha SW, "Wnt5a and Wnt11 interact in a maternal Dkk1-regulated fashion to activate both canonical and non-canonical signaling in Xenopus axis formation", Development, 135, pp.3719~3729 (2008)
  136. Nambotin SB, "Pharmacological inhibition of frizzled-7 displays anti-tumor properties in hepatocellular carcinoma", J Hepatol, 54, pp.288~299 (2011)
  137. Jimeno A, "A first-in-human phase I study of the anticancer stem cell agent ipafricept(OMP-54F28), a decoy receptor for wnt ligands, in patients with advanced solid tumors", Clin Cancer Res, 23, pp.7490~7497 (2017)
  138. Moore KN, "A phase 1b dose escalation study of ipafricept(OMP54F28)in combination with paclitaxel and carboplatin in patients with recurrent platinumsensitive ovarian cancer", Gynecol Oncol, 154, pp.294~301 (2019)
  139. Hoey T, "Development of FZD8-Fc (OMP-54F28), a Wnt signaling antagonist that inhibits tumor growth and reduces tumor initiating cell frequency", AACR Annual Meeting (2013)
  140. Wei W, "Soluble frizzled-7 receptor inhibits Wnt signaling and sensitizes hepatocellular carcinoma cells towards doxorubicin", Mol Cancer, 10, pp.16~ (2011)
  141. Fischer MM, "WNT antagonists exhibit unique combinatorial antitumor activity with taxanes by potentiating mitotic cell death", Sci Adv, 3, pp.e1700090~ (2017)
  142. Gurney A, "Wnt pathway inhibition via the targeting of frizzled receptors results in decreased growth and tumorigenicity of human tumors", Proc Natl Acad Sci U S A, 109, pp.11717~11722 (2012)
  143. Davis SL, "A phase 1b dose escalation study of Wnt pathway inhibitor vantictumab in combination with nab-paclitaxel and gemcitabine in patients with previously untreated metastatic pancreatic cancer", Invest New Drugs, 38, pp.821~830 (2020)
  144. Smith DC, "First-in-human evaluation of the human monoclonal antibody vantictumab(OMP-18R5; antiFrizzled)targeting the WNT pathway in a phase I study for patients with advanced solid tumors", J Clin Oncol, 31(suppl), pp.2540a~ (2013)
  145. Gupta PB, "Identification of selective inhibitors of cancer stem cells by high-throughput screening", Cell, 138, pp.645~659 (2009)
  146. Huczynski A, "Salinomycin : a new cancer drug candidate", Chem Biol Drug Des, 79, pp.235~238 (2012)
  147. Lu D, "Salinomycin inhibits Wnt signaling and selectively induces apoptosis in chronic lymphocytic leukemia cells", Proc Natl Acad Sci U S A, 108, pp.13253~13257 (2011)
  148. Niwa AM, "Salinomycin induces cell cycle arrest and apoptosis and modulates hepatic cytochrome P450mRNA expression in HepG2", C3a cells, 2022, pp.32, 341~351
  149. Liu Q, "Salinomycin suppresses tumorigenicity of liver cancer stem cells and Wnt", beta-catenin signaling, 2021, pp.16, 630~637
  150. Huang SM, "Tankyrase inhibition stabilizes axin and antagonizes Wnt signalling", Nature, 461, pp.614~620 (2009)
  151. Clevers H, "Wnt", beta-catenin signaling in development and disease, 2006, pp.127, 469~480
  152. Rubinfeld B, "Binding of GSK3beta to the APC-beta-catenin complex and regulation of complex assembly", Science, 272, pp.1023~1026 (1996)
  153. Ma Y, "Dihydroartemisinin suppresses proliferation, migration, the Wnt", β-catenin pathway and EMT via TNKS in gastric cancer, 2021, pp.22, 688~
  154. Ma Z, "circ5615 functions as a ceRNA to promote colorectal cancer progression by upregulating TNKS", Cell Death Dis, 11, pp.356~ (2020)
  155. Ma L, "Tankyrase inhibitors attenuate WNT", β-catenin signaling and inhibit growth of hepatocellular carcinoma cells, 2015, pp.6, 25390~25401
  156. Wu X, "Tankyrase 1 inhibitior XAV939 increases chemosensitivity in colon cancer cell lines via inhibition of the Wnt signaling pathway", Int J Oncol, 48, pp.1333~1340 (2016)
  157. Huang J, "Tankyrases", β-catenin signaling pathway as an anti-proliferation and anti-metastatic target in hepatocarcinoma cell lines, 2020, pp.11, 432~440
  158. Ghany MG, "Diagnosis, management, and treatment of hepatitis C : an update", Hepatology, 49, pp.1335~1374 (2009)
  159. Lee D, "Safety and efficacy of adjuvant pegylated interferon therapy for metastatic tumor antigen 1-positive hepatocellular carcinoma", Cancer, 119, pp.2239~2246 (2013)
  160. Thompson MD, "Pegylated interferon alpha targets Wnt signaling by inducing nuclear export of β-catenin", J Hepatol, 54, pp.506~512 (2011)
  161. Deng J, "The CREB-binding protein inhibitor ICG-001 : a promising therapeutic strategy in sporadic meningioma with NF2 mutations", Neurooncol Adv, 2, pp.vdz055~ (2020)
  162. Takahashi-Yanaga F, "Targeting Wnt signaling : can we safely eradicate cancer stem cells?", Clin Cancer Res, 16, pp.3153~3162 (2010)
  163. Delgado ER, "Identification and characterization of a novel smallmolecule inhibitor of β-catenin signaling", Am J Pathol, 184, pp.2111~2122 (2014)
  164. Wei W, "Small molecule antagonists of Tcf4", beta-catenin complex inhibit the growth of HCC cells in vitro and in vivo, 2010, pp.126, 2426~2436
  165. Gedaly R, "Targeting the Wnt", β-catenin signaling pathway in liver cancer stem cells and hepatocellular carcinoma cell lines with FH535, 2014, pp.9, e99272~
  166. Handeli S, "A small-molecule inhibitor of Tcf", beta-catenin signaling down-regulates PPARgamma and PPARdelta activities, 2008, pp.7, 521~529
  167. Gwak J, "Small moleculebased promotion of PKCα-mediated β-catenin degradation suppresses the proliferation of CRT-positive cancer cells", PLoS One, 7, pp.e46697~ (2012)
  168. Chen X, "Wnt signaling: the good and the bad", Acta Biochim Biophys Sin(Shanghai), 40, pp.577~594 (2008)
  169. Chen D, "Wnt signaling in bone, kidney, intestine, and adipose tissue and interorgan interaction in aging", Ann N Y Acad Sci, 1442, pp.48~60 (2019)
  170. Behari J, "The Wnt", β-catenin signaling pathway in liver biology and disease, 2010, pp.4, 745~756
  171. Bowman EJ, "The bafilomycin", concanamycin binding site in subunit c of the v-ATPases from Neurospora crassa and Saccharomyces cerevisiae, 2004, pp.279, 33131~33138
  172. Huss M, "Concanamycin A, the specific inhibitor of v-ATPases, binds to the v(o)subunit c", J Biol Chem, 277, pp.40544~40548 (2002)
  173. Capurro M, "Glypican-3 binds to frizzled and plays a direct role in the stimulation of canonical Wnt signaling", J Cell Sci, 127(Pt 7), pp.1565~1575 (2014)
  174. Guo M, "Glypican-3 : a new target for diagnosis and treatment of hepatocellular carcinoma", J Cancer, 11, pp.2008~2021 (2020)
  175. Capurro MI, "Glypican-3 promotes the growth of hepatocellular carcinoma by stimulating canonical Wnt signaling", Cancer Res, 65, pp.6245~6254 (2005)
  176. Gao W, "Inactivation of Wnt signaling by a human antibody that recognizes the heparan sulfate chains of glypican-3 for liver cancer therapy", Hepatology, 60, pp.576~587 (2014)

이 간행물의 다른 논문 (46건)