Secreted decoy of insulin receptor is required for blood-brain and blood-retina barrier integrity in Drosophila
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Glial cells play important roles during neurogenesis and inmaintaining complex functions of the nervous system. Here,we report the characterization of a gene, Sdr, which contains aputative insulin-like growth factor receptor domain and is requiredto maintain critical nervous system functions in Drosophila. Sdr is expressed in glial cells during embryonic and larval stagesof development, but its role in adult flies is poorly understood. As insulin signaling is important throughout the lifespan inhuman, we investigated the Sdr’s role in adult flies. Our resultsdemonstrate that Sdr is expressed on surface glial cells thatsurround the nervous system. Mutation of Sdr did not affect developmentbut caused defects in locomotion and lifespan. Sdrmutants also showed increasingly severe defects in the bloodbrain-and blood-retina-barriers as they aged. Therefore, wesuggest a novel role of Sdr in maintaining the integrity of theblood-brain- and blood-retina-barriers in adult flies.
Abstract
Glial cells play important roles during neurogenesis and inmaintaining complex functions of the nervous system. Here,we report the characterization of a gene, Sdr, which contains aputative insulin-like growth factor receptor domain and is requiredto maintain critical nervous system functions in Drosophila. Sdr is expressed in glial cells during embryonic and larval stagesof development, but its role in adult flies is poorly understood. As insulin signaling is important throughout the lifespan inhuman, we investigated the Sdr’s role in adult flies. Our resultsdemonstrate that Sdr is expressed on surface glial cells thatsurround the nervous system. Mutation of Sdr did not affect developmentbut caused defects in locomotion and lifespan. Sdrmutants also showed increasingly severe defects in the bloodbrain-and blood-retina-barriers as they aged. Therefore, wesuggest a novel role of Sdr in maintaining the integrity of theblood-brain- and blood-retina-barriers in adult flies.
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