The role of insulin/IGF-1 signaling in the longevity of model invertebrates, C. elegans and D. melanogaster

키워드

참고문헌 (207)

1. Lee Y, "Aging Mechanisms", pp.123~169 (2015), Springer Japan
2. Giannakou ME, "Role of insulin-like signalling in Drosophila lifespan", Trends Biochem Sci, 32, pp.180~188 (2007)
3. Fontana L, "Extending healthy life span--from yeast to humans", Science, 328, pp.321~326 (2010)
4. Kenyon CJ, "The genetics of ageing", Nature, 464, pp.504~512 (2010)
5. Morris JZ, "A phosphatidylinositol-3-OH kinase family member regulating longevity, diapause in Caenorhabditis elegans", Nature, 382, pp.536~539 (1996)
6. Kimura KD, "daf-2, an insulin receptor-like gene that regulates longevity, diapause in Caenorhabditis elegans", Science, 277, pp.942~946 (1997)
7. Friedman DB, "A mutation in the age-1 gene in Caenorhabditis elegans lengthens life, reduces hermaphrodite fertility", Genetics, 118, pp.75~86 (1988)
8. Kenyon C, "A C. elegans mutant that lives twice as long as wild type", Nature, 366, pp.461~464 (1993)
9. Klass MR, "A method for the isolation of longevity mutants in the nematode Caenorhabditis elegans, initial results", Mech Ageing Dev, 22, pp.279~286 (1983)
10. Wolkow CA, "Insulin receptor substrate, p55 orthologous adaptor proteins function in the Caenorhabditis elegans daf-2", insulin-like signaling pathway, 2002, pp.277, 49591~49597
11. phosphatidylinositol trisphosphate levels, alters F-actin distribution, impairs pinocytosis, "J Cell Sci", 1998, 283~294
12. Ogg S, "The C. elegans PTEN homolog, DAF-18, acts in the insulin receptor-like metabolic signaling pathway", Mol Cell, 2, pp.887~893 (1998)
13. Gil EB, "Regulation of the insulin-like developmental pathway of Caenorhabditis elegans by a homolog of the PTEN tumor suppressor gene", Proc Natl Acad Sci U S A, 96, pp.2925~2930 (1999)
14. Mihaylova VT, "The PTEN tumor suppressor homolog in Caenorhabditis elegans regulates longevity, dauer formation in an insulin receptor-like signaling pathway", Proc Natl Acad Sci U S A, 96, pp.7427~7432 (1999)
15. Rouault JP, "Regulation of dauer larva development in Caenorhabditis elegans by daf-18, a homologue of the tumour suppressor PTEN", Curr Biol, 9, pp.329~332 (1999)
16. Dorman JB, "The age-1, daf-2 genes function in a common pathway to control the lifespan of Caenorhabditis elegans", Genetics, 141, pp.1399~1406 (1995)
17. Larsen PL, "Genes that regulate both development, longevity in Caenorhabditis elegans", Genetics, 139, pp.1567~1583 (1995)
18. Gottlieb S, "daf-2, daf-16, daf-23: genetically interacting genes controlling Dauer formation in Caenorhabditis elegans", Genetics, 137, pp.107~120 (1994)
19. Solari F, "The human tumour suppressor PTEN regulates longevity, dauer formation in Caenorhabditis elegans", Oncogene, 24, pp.20~27 (2005)
20. Paradis S, "A PDK1 homolog is necessary, sufficient to transduce AGE-1 PI3 kinase signals that regulate diapause in Caenorhabditis elegans", Genes Dev, 13, pp.1438~1452 (1999)
21. Paradis S, "Caenorhabditis elegans Akt", PKB transduces insulin receptor-like signals from AGE-1 PI3 kinase to the DAF-16 transcription factor, 1998, pp.12, 2488~2498
22. Hertweck M, "C. elegans SGK-1 is the critical component in the Akt", PKB kinase complex to control stress response, life span, 2004, pp.6, 577~588
23. Chen AT, "Effects of Caenorhabditis elegans sgk-1 mutations on lifespan, stress resistance, , DAF-16", FoxO regulation, 2013, pp.12, 932~940
24. Xiao R, "A genetic program promotes C. elegans longevity at cold temperatures via a thermosensitive TRP channel", Cell, 152, pp.806~817 (2013)
25. Henderson ST, "daf-16 integrates developmental, environmental inputs to mediate aging in the nematode Caenorhabditis elegans", Curr Biol, 11, pp.1975~1980 (2001)
26. Lee RY, "Regulation of C. elegans DAF-16, its human ortholog FKHRL1 by the daf-2 insulin-like signaling pathway", Curr Biol, 11, pp.1950~1957 (2001)
27. Lin K, "Regulation of the Caenorhabditis elegans longevity protein DAF-16by insulin", IGF-1, germline signaling, 2001, pp.28, 139~145
28. Cahill CM, "Phosphatidylinositol 3-kinase signaling inhibits DAF-16 DNA binding, function via 14-3-3-dependent, 14-3-3-independent pathways", J Biol Chem, 276, pp.13402~13410 (2001)
29. Ogg S, "The Fork head transcription factor DAF-16 transduces insulin-like metabolic, longevity signals in C. elegans", Nature, 389, pp.994~999 (1997)
30. Lin K, "daf-16 : An HNF-3", forkhead family member that can function to double the life-span of Caenorhabditis elegans, 1997, pp.278, 1319~1322
31. Oh SW, "JNK regulates lifespan in Caenorhabditis elegans by modulating nuclear translocation of forkhead transcription factor", DAF-16, 2005, pp.102, 4494~4499
32. Curtis R, "Aging networks in Caenorhabditis elegans: AMP-activated protein kinase (aak-2) links multiple aging and metabolism pathways", Aging Cell, 5, pp.119~126 (2006)
33. Greer EL, "An AMPK-FOXO pathway mediates longevity induced by a novel method of dietary restriction in C. elegans", Curr Biol, 17, pp.1646~1656 (2007)
34. Apfeld J, "The AMP-activated protein kinase AAK-2links energy levels, insulin-like signals to lifespan in C. elegans", Genes Dev, 18, pp.3004~3009 (2004)
35. Lehtinen MK, "A conserved MST-FOXO signaling pathway mediates oxidative-stress responses, extends life span", Cell, 125, pp.987~1001 (2006)
36. Wolff S, "SMK-1, an essential regulator of DAF-16-mediated longevity", Cell, 124, pp.1039~1053 (2006)
37. Seo M, "RNA helicase HEL-1 promotes longevity by specifically activating DAF-16", FOXO transcription factor signaling in Caenorhabditis elegans, 2015, pp.112, E4246~E4255
38. Chiang WC, "C. elegans SIRT6", 7 homolog SIR-2. 4 promotes DAF-16 relocalization, function during stress, 2012, pp.8, e1002948~
39. Hu PJ, "Two membrane-associated tyrosine phosphatase homologs potentiate C. elegans AKT-1", PKB signaling, 2006, pp.2, e99~
40. Li J, "Caenorhabditis elegans HCF-1 functions in longevity maintenance as a DAF-16 regulator", PLoS Biol, 6, pp.e233~ (2008)
41. Alam H, "EAK-7controls development, life span by regulating nuclear DAF-16", FoxO activity, 2010, pp.12, 30~41
42. Berdichevsky A, "C. elegans SIR-2. 1 interacts with 14-3-3proteins to activate DAF-16, extend life span", Cell, 125, pp.1165~1177 (2006)
43. Li J, "The 14-3-3protein FTT-2 regulates DAF-16 in Caenorhabditis elegans", Dev Biol, 301, pp.82~91 (2007)
44. Wang Y, "C. elegans 14-3-3 proteins regulate life span, interact with SIR-2. 1, DAF-16", FOXO, 2006, pp.127, 741~747
45. Lee SS, "DAF-16 target genes that control C. elegans life-span, metabolism", Science, 300, pp.644~647 (2003)
46. Ookuma S, "Identification of a DAF-16 transcriptional target gene, scl-1, that regulates longevity, stress resistance in Caenorhabditis elegans", Curr Biol, 13, pp.427~431 (2003)
47. Murphy CT, "Genes that act downstream of DAF-16 to influence the lifespan of Caenorhabditis elegans", Nature, 424, pp.277~283 (2003)
48. McElwee J, "Transcriptional outputs of the Caenorhabditis elegans forkhead protein DAF-16", Aging Cell, 2, pp.111~121 (2003)
49. Golden TR, "Microarray analysis of gene expression with age in individual nematodes", Aging Cell, 3, pp.111~124 (2004)
50. Halaschek-Wiener J, "Analysis of long-lived C. elegans daf-2 mutants using serial analysis of gene expression", Genome Res, 15, pp.603~615 (2005)
51. Lee SJ, "Glucose shortens the life span of C. elegans by downregulating DAF-16", FOXO activity, aquaporin gene expression, 2009, pp.10, 379~391
52. Tullet JM, "Direct inhibition of the longevity-promoting factor SKN-1 by insulin-like signaling in C. elegans", Cell, 132, pp.1025~1038 (2008)
53. An JH, "SKN-1 links C. elegans mesendodermal specification to a conserved oxidative stress response", Genes Dev, 17, pp.1882~1893 (2003)
54. An JH, "Regulation of the Caenorhabditis elegans oxidative stress defense protein SKN-1 by glycogen synthase kinase-3", Proc Natl Acad Sci U S A, 102, pp.16275~16280 (2005)
55. Kahn NW, "Proteasomal dysfunction activates the transcription factor SKN-1, produces a selective oxidativestress response in Caenorhabditis elegans", Biochem J, 409, pp.205~213 (2008)
56. Oliveira RP, "Condition-adapted stress, longevity gene regulation by Caenorhabditis elegans SKN-1", Nrf, 2009, pp.8, 524~541
57. Wang J, "RNAi screening implicates a SKN-1-dependent transcriptional response in stress resistance, longevity deriving from translation inhibition", PLoS Genet, 6, pp.e1001048~ (2010)
58. Staab TA, "The conserved SKN-1", Nrf2stress response pathway regulates synaptic function in Caenorhabditis elegans, 2013, pp.9, e1003354~
59. Glover-Cutter KM, "Integration of the unfolded protein, oxidative stress responses through SKN-1", Nrf, 2013, pp.9, e1003701~
60. Choe KP, "The WD40repeat protein WDR-23 functions with the CUL4", DDB1ubiquitin ligase to regulate nuclear abundance, activity of SKN-1 in Caenorhabditis elegans, 2009, pp.29, 2704~2715
61. Park SK, "Oxidative stress, longevity in Caenorhabditis elegans as mediated by SKN-1", Aging Cell, 8, pp.258~269 (2009)
62. Pang S, "SKN-1, Nrf2 couples proline catabolism with lipid metabolism during nutrient deprivation", Nat Commun, 5, pp.5048~ (2014)
63. Kell A, "Activation of SKN-1 by novel kinases in Caenorhabditis elegans", Free Radic Biol Med, 43, pp.1560~1566 (2007)
64. Li X, "Specific SKN-1", Nrf stress responses to perturbations in translation elongation, proteasome activity, 2011, pp.7, e1002119~
65. Ewald CY, "Dauer-independent insulin", IGF-1-signalling implicates collagen remodelling in longevity, 2015, pp.519, 97~101
66. Hsu AL, "Regulation of aging, age-related disease by DAF-16, heat-shock factor", Science, 300, pp.1142~1145 (2003)
67. Morley JF, "Regulation of longevity in Caenorhabditis elegans by heat shock factor, molecular chaperones", Mol Biol Cell, 15, pp.657~664 (2004)
68. Cohen E, "Opposing activities protect against age-onset proteotoxicity", Science, 313, pp.1604~1610 (2006)
69. Chiang WC, "HSF-1 regulators DDL-1", 2 link insulin-like signaling to heat-shock responses, modulation of longevity, 2012, pp.148, 322~334
70. Seo K, "Heat shock factor 1 mediates the longevity conferred by inhibition of TOR, insulin", IGF-1 signaling pathways in C. elegans, 2013, pp.12, 1073~1081
71. Garigan D, "Genetic analysis of tissue aging in Caenorhabditis elegans: a role for heat-shock factor, bacterial proliferation", Genetics, 161, pp.1101~1112 (2002)
72. Douglas PM, "Heterotypic signals from neural HSF-1 separate thermotolerance from longevity", Cell Rep, 12, pp.1196~1204 (2015)
73. Baird NA, "HSF-1-mediated cytoskeletal integrity determines thermotolerance, life span", Science, 346, pp.360~363 (2014)
74. Amin J, "Key features of heat shock regulatory elements", Mol Cell Biol, 8, pp.3761~3769 (1988)
75. Kay RJ, "Efficient transcription of a Caenorhabditis elegans heat shock gene pair in mouse fibroblasts is dependent on multiple promoter elements which can function bidirectionally", Mol Cell Biol, 6, pp.3134~3143 (1986)
76. Russnak RH, "Locus encoding a family of small heat shock genes in Caenorhabditis elegans:two genes duplicated to form a 3.8-kilobase inverted repeat", Mol Cell Biol, 5, pp.1268~1278 (1985)
77. Yokoyama K, "Extended longevity of Caenorhabditis elegans by knocking in extra copies of hsp70F, a homolog of mot-2(mortalin)", mthsp70, FEBS Lett, pp.2002, 516[DOI]
78. Walker GA, "Lifespan extension in C. elegans by a molecular chaperone dependent upon insulin-like signals", Aging Cell, 2, pp.131~139 (2003)
79. Pierce SB, "Regulation of DAF-2 receptor signaling by human insulin, ins-1, a member of the unusually large, diverse C. elegans insulin gene family", Genes Dev, 15, pp.672~686 (2001)
80. Li W, "daf-28 encodes a C. elegans insulin superfamily member that is regulated by environmental cues, acts in the DAF-2 signaling pathway", Genes Dev, 17, pp.844~858 (2003)
81. Chen Z, "Two insulin-like peptides antagonistically regulate aversive olfactory learning in C. elegans", Neuron, 77, pp.572~585 (2013)
82. Cornils A, "Specific insulin-like peptides encode sensory information to regulate distinct developmental processes", Development, 138, pp.1183~1193 (2011)
83. Murphy CT, "Tissue entrainment by feedback regulation of insulin gene expression in the endoderm of Caenorhabditis elegans", Proc Natl Acad Sci U S A, 104, pp.19046~19050 (2007)
84. Kawli T, "Neuroendocrine signals modulate the innate immunity of Caenorhabditis elegans through insulin signaling", Nat Immunol, 9, pp.1415~1424 (2008)
85. Malone EA, "Genetic analysis of the roles of daf-28, age-1 in regulating Caenorhabditis elegans dauer formation", Genetics, 143, pp.1193~1205 (1996)
86. Malone EA, "A screen for nonconditional dauer-constitutive mutations in Caenorhabditis elegans", Genetics, 136, pp.879~886 (1994)
87. Fernandes de Abreu DA, "An insulin-to-insulin regulatory network orchestrates phenotypic specificity in development, physiology", PLoS Genet, 10, pp.e1004225~ (2014)
88. Ritter AD, "Complex expression dynamics, robustness in C. elegans insulin networks", Genome Res, 23, pp.954~965 (2013)
89. Hung WL, "A Caenorhabditis elegans developmental decision requires insulin signaling-mediated neuron-intestine communication", Development, 141, pp.1767~1779 (2014)
90. Chen Y, "Ins-4, daf-28 function redundantly to regulate C. elegans L1 arrest", Dev Biol, 394, pp.314~326 (2014)
91. Duret L, "New insulin-like proteins with atypical disulfide bond pattern characterized in Caenorhabditis elegans by comparative sequence analysis, homology modeling", Genome Res, 8, pp.348~353 (1998)
92. Michaelson D, "Insulin signaling promotes germline proliferation in C. elegans", Development, 137, pp.671~680 (2010)
93. Leinwand SG, "Neuropeptide signaling remodels chemosensory circuit composition in Caenorhabditis elegans", Nat Neurosci, 16, pp.1461~1467 (2013)
94. Ohta A, "Light, pheromone-sensing neurons regulates cold habituation through insulin signalling in Caenorhabditis elegans", Nat Commun, 5, pp.4412~ (2014)
95. Wolkow CA, "Regulation of C. elegans life-span by insulinlike signaling in the nervous system", Science, 290, pp.147~150 (2000)
96. Iser WB, "Insulin signaling in Caenorhabditis elegans regulates both endocrine-like, cell-autonomous outputs", Dev Biol, 303, pp.434~447 (2007)
97. Hu PJ, "Dauer. WormBook: the online review of C. elegans biology", pp.1~19 (2007)
98. Riddle DL, "C. elegans II" (1997), Cold Spring Harbor Laboratory Press
99. Libina N, "Tissue-specific activities of C. elegans DAF-16 in the regulation of lifespan", Cell, 115, pp.489~502 (2003)
100. Dillin A, "Timing requirements for insulin", IGF-1 signaling in C. elegans, 2002, pp.298, 830~834
101. Larsen PL, "Aging, resistance to oxidative damage in Caenorhabditis elegans", Proc Natl Acad Sci U S A, 90, pp.8905~8909 (1993)
102. Vanfleteren JR, "Oxidative stress, ageing in Caenorhabditis elegans", Biochem J, 292(Pt 2), pp.605~608 (1993)
103. Honda Y, "The daf-2 gene network for longevity regulates oxidative stress resistance, Mn-superoxide dismutase gene expression in Caenorhabditis elegans", FASEB J, 13, pp.1385~1393 (1999)
104. Gems D, "Two pleiotropic classes of daf-2 mutation affect larval arrest, adult behavior, reproduction, longevity in Caenorhabditis elegans", Genetics, 150, pp.129~155 (1998)
105. Lithgow GJ, "Thermotolerance, extended life-span conferred by single-gene mutations, induced by thermal stress", Proc Natl Acad Sci U S A, 92, pp.7540~7544 (1995)
106. McColl G, "Insulin-like signaling determines survival during stress via posttranscriptional mechanisms in C. elegans", Cell Metab, 12, pp.260~272 (2010)
107. Scott BA, "Regulation of hypoxic death in C. elegans by the insulin", IGF receptor homolog DAF-2, 2002, pp.296, 2388~2391
108. Mabon ME, "Divergent mechanisms controlling hypoxic sensitivity, lifespan by the DAF-2", insulin, PLoS One, pp.2009, 4[DOI]
109. Lamitina ST, "Transcriptional targets of DAF-16 insulin signaling pathway protect C. elegans from extreme hypertonic stress", Am J Physiol Cell Physiol, 288, pp.C467~C474 (2005)
110. Burkewitz K, "Hypertonic stress induces rapid, widespread protein damage in C. elegans", Am J Physiol Cell Physiol, 301, pp.566~576 (2011)
111. Murakami S, "A genetic pathway conferring life extension, resistance to UV stress in Caenorhabditis elegans", Genetics, 143, pp.1207~1218 (1996)
112. Barsyte D, "Longevity, heavy metal resistance in daf-2, age-1 long-lived mutants of Caenorhabditis elegans", FASEB J, 15, pp.627~634 (2001)
113. Morley JF, "The threshold for polyglutamine-expansion protein aggregation, cellular toxicity is dynamic, influenced by aging in Caenorhabditis elegans", Proc Natl Acad Sci U S A, 99, pp.10417~10422 (2002)
114. Henis-Korenblit S, "Insulin", IGF-1 signaling mutants reprogram ER stress response regulators to promote longevity, 2010, pp.107, 9730~9735
115. Essers MA, "Functional interaction between beta-catenin, FOXO in oxidative stress signaling", Science, 308, pp.1181~1184 (2005)
116. Mueller MM, "DAF-16", FOXO, EGL-27, Nat Cell Biol, pp.2014, 16[DOI]
117. Ermolaeva MA, "Insights from the worm: the C. elegans model for innate immunity", Semin Immunol, 26, pp.303~309 (2014)
118. Garsin DA, "Long-lived C. elegans daf-2 mutants are resistant to bacterial pathogens", Science, 300, pp.1921~ (2003)
119. Kerry S, "GATA transcription factor required for immunity to bacterial, fungal pathogens", PLoS One, 1, pp.e77~ (2006)
120. Singh V, "Heat-shock transcription factor(HSF)-1 pathway required for Caenorhabditis elegans immunity", Proc Natl Acad Sci U S A, 103, pp.13092~13097 (2006)
121. Papp D, "A role for SKN-1", Nrf in pathogen resistance, immunosenescence in Caenorhabditis elegans, 2012, pp.8, e1002673~
122. Evans EA, "The DAF-2 insulin-like signaling pathway independently regulates aging, immunity in C. elegans", Aging Cell, 7, pp.879~893 (2008)
123. Portal-Celhay C, "Control of intestinal bacterial proliferation in regulation of lifespan in Caenorhabditis elegans", BMC Micobiol, 12, pp.49~ (2012)
124. Evans EA, "Pseudomonas aeruginosa suppresses host immunity by activating the DAF-2 insulin-like signaling pathway in Caenorhabditis elegans", PLoS Pathog, 4, pp.e1000175~ (2008)
125. Link CD, "Expression of human β-amyloid peptide in transgenic Caenorhabditis elegans", Proc Natl Acad Sci U S A, 92, pp.9368~9372 (1995)
126. Fay DS, "In Vivo Aggregation of β‐Amyloid Peptide Variants", J Neurochem, 71, pp.1616~1625 (1998)
127. Link CD, "Gene expression analysis in a transgenic Caenorhabditis elegans Alzheimer’s disease model", Neurobiol Aging, 24, pp.397~413 (2003)
128. Faber PW, "Polyglutamine-mediated dysfunction, apoptotic death of a Caenorhabditis elegans sensory neuron", Proc Natl Acad Sci U S A, 96, pp.179~184 (1999)
129. Satyal SH, "Polyglutamine aggregates alter protein folding homeostasis in Caenorhabditis elegans", Proc Natl Acad Sci U S A, 97, pp.5750~5755 (2000)
130. Parker JA, "Expanded polyglutamines in Caenorhabditis elegans cause axonal abnormalities, severe dysfunction of PLM mechanosensory neurons without cell death", Proc Natl Acad Sci U S A, 98, pp.13318~13323 (2001)
131. Brignull HR, "Polyglutamine proteins at the pathogenic threshold display neuron-specific aggregation in a pan-neuronal Caenorhabditis elegans model", J Neurosci, 26, pp.7597~7606 (2006)
132. Mohri-Shiomi A, "Insulin signaling, the heat shock response modulate protein homeostasis in the Caenorhabditis elegans intestine during infection", J Biol Chem, 283, pp.194~201 (2008)
133. Lakso M, "Dopaminergic neuronal loss, motor deficits in Caenorhabditis elegans overexpressing human alpha-synuclein", J Neurochem, 86, pp.165~172 (2003)
134. Cao S, "Torsin-mediated protection from cellular stress in the dopaminergic neurons of Caenorhabditis elegans", J Neurosci, 25, pp.3801~3812 (2005)
135. Kuwahara T, "Familial Parkinson mutant α-synuclein causes dopamine neuron dysfunction in transgenic Caenorhabditis elegans", J Biol Chem, 281, pp.334~340 (2006)
136. Kuwahara T, "A systematic RNAi screen reveals involvement of endocytic pathway in neuronal dysfunction in α-synuclein transgenic C. elegans", Hum Mol Genet, 17, pp.2997~3009 (2008)
137. Hamamichi S, "Hypothesis-based RNAi screening identifies neuroprotective genes in a Parkinson's disease model", Proc Natl Acad Sci U S A, 105, pp.728~733 (2008)
138. Oeda T, "Oxidative stress causes abnormal accumulation of familial amyotrophic lateral sclerosis-related mutant SOD1 in transgenic Caenorhabditis elegans", Hum Mol Genet, 10, pp.2013~2023 (2001)
139. Gidalevitz T, "Destabilizing protein polymorphisms in the genetic background direct phenotypic expression of mutant SOD1 toxicity", PLoS Genet, 5, pp.e1000399~ (2009)
140. Wang J, "An ALS-linked mutant SOD1 produces a locomotor defect associated with aggregation, synaptic dysfunction when expressed in neurons of Caenorhabditis elegans", PLoS Genet, 5 (2009)
141. Li J, "Establishing a novel C. elegans model to investigate the role of autophagy in amyotrophic lateral sclerosis", Acta Pharmacol Sin, 34, pp.644~650 (2013)
142. Florez-McClure ML, "Decreased insulin-receptor signaling promotes the autophagic degradation of β-amyloid peptide in C. elegans", Autophagy, 3, pp.569~580 (2007)
143. David DC, "Widespread protein aggregation as an inherent part of aging in C. elegans", PLoS Biol, 8, pp.e1000450~ (2010)
144. Wang H, "Suppression of polyglutamine-induced toxicity in cell, animal models of Huntington's disease by ubiquilin", Hum Mol Genet, 15, pp.1025~1041 (2006)
145. Wang H, "Effects of overexpression of huntingtin proteins on mitochondrial integrity", Hum Mol Genet, 18, pp.737~752 (2009)
146. Steinkraus KA, "Dietary restriction suppresses proteotoxicity, enhances longevity by an hsf-1-dependent mechanism in Caenorhabditis elegans", Aging Cell, 7, pp.394~394 (2008)
147. Faber PW, "Glutamine", proline-rich PQE-1 proteins protect Caenorhabditis elegans neurons from huntingtin polyglutamine neurotoxicity, 2002, pp.99, 17131~17136
148. Parker JA, "Huntingtininteracting protein 1 influences worm, mouse presynaptic function, protects Caenorhabditis elegans neurons against mutant polyglutamine toxicity", J Neurosci, 27, pp.11056~11064 (2007)
149. Parker JA, "Resveratrol rescues mutant polyglutamine cytotoxicity in nematode, mammalian neurons", Nat Genet, 37, pp.349~350 (2005)
150. Bates EA, "Differential contributions of Caenorhabditis elegans histone deacetylases to huntingtin polyglutamine toxicity", J Neurosci, 26, pp.2830~2838 (2006)
151. Schapira AH, "Etiology, pathogenesis of Parkinson's disease", Mov Disord, 26, pp.1049~1055 (2011)
152. Knight AL, "The glycolytic enzyme, GPI, is a functionally conserved modifier of dopaminergic neurodegeneration in Parkinson's models", Cell Metab, 20 (2014)
153. Pasinelli P, "Molecular biology of amyotrophic lateral", insights from genetics. Nat Rev Neurosci, 7, pp.710~723 (2006)
154. Rosen DR, "Mutations in Cu", Zn superoxide dismutase gene are associated with familial amyotrophic lateral sclerosis, 1993, pp.362, 59~62
155. Cudkowicz M, "Epidemiology of mutations in superoxide dismutase in amyotrophic lateal sclerosis", Ann Neurol, 41 (1997)
156. Bohni R, "Autonomous control of cell, organ size by CHICO, a Drosophila homolog of vertebrate IRS1-4", Cell, 97, pp.865~875 (1999)
157. Verdu J, "Cell-autonomous regulation of cell, organ growth in Drosophila by Akt", PKB, 1999, pp.1, 500~506
158. Weinkove D, "Regulation of imaginal disc cell size, cell number, organ size by Drosophila class I(A)phosphoinositide 3-kinase, its adaptor", Curr Biol, 9, pp.1019~1029 (1999)
159. Leevers SJ, "The Drosophila phosphoinositide 3-kinase Dp110 promotes cell growth", EMBO J, 15, pp.6584~6594 (1996)
160. Junger MA, "The Drosophila forkhead transcription factor FOXO mediates the reduction in cell number associated with reduced insulin signaling", J Biol, 2, pp.20~ (2003)
161. Kramer JM, "Expression of Drosophila FOXO regulates growth, can phenocopy starvation", BMC Dev Biol, 3, pp.5~ (2003)
162. Puig O, "Control of cell number by Drosophila FOXO: downstream, feedback regulation of the insulin receptor pathway", Genes Dev, 17, pp.2006~2020 (2003)
163. Staveley BE, "Genetic analysis of protein kinase B(AKT)in Drosophila", Curr Biol, 8, pp.599~602 (1998)
164. Poltilove RM, "Characterization of Drosophila insulin receptor substrate", J Biol Chem, 275, pp.23346~23354 (2000)
165. Petruzzelli L, "Isolation of a Drosophila genomic sequence homologous to the kinase domain of the human insulin receptor, detection of the phosphorylated Drosophila receptor with an anti-peptide antibody", Proc Natl Acad Sci U S A, 83, pp.4710~4714 (1986)
166. Fernandez-Almonacid R, "Structure, ligand specificity of the Drosophila melanogaster insulin receptor", Mol Cell Biol, 7, pp.718~2727 (1987)
167. Fernandez R, "The Drosophila insulin receptor homolog:a gene essential for embryonic development encodes two receptor isoforms with different signaling potential", EMBO J, 14, pp.3373~3384 (1995)
168. Marin-Hincapie M, "The carboxyl terminal extension of the Drosophila insulin receptor homologue binds IRS-1, influences cell survival", J Biol Chem, 274, pp.24987~24994 (1999)
169. Franke TF, "The SH2-like Akt homology(AH)domain of c-akt is present in multiple copies in the genome of vertebrate, invertebrate eucaryotes. Cloning, characterization of the Drosophila melanogaster c-akt homolog Dakt1", Oncogene, 9, pp.141~148 (1994)
170. Cho KS, "Drosophila phosphoinositide-dependent kinase-1 regulates apoptosis, growth via the phosphoinositide 3-kinase-dependent signaling pathway", Proc Natl Acad Sci U S A, 98, pp.6144~6149 (2001)
171. Linassier C, "Molecular cloning, biochemical characterization of a Drosophila phosphatidylinositol-specific phosphoinositide 3-kinase", Biochem J, 321(Pt 3), pp.849~856 (1997)
172. Brogiolo W, "An evolutionarily conserved function of the Drosophila insulin receptor, insulin-like peptides in growth control", Curr Biol, 11, pp.213~221 (2001)
173. Gao X, "Drosophila PTEN regulates cell growth, proliferation through PI3K-dependent, -independent pathways", Dev Biol, 221, pp.404~418 (2000)
174. Goberdhan DC, "Drosophila tumor suppressor PTEN controls cell size, number by antagonizing the Chico", PI3-kinase signaling pathway, 1999, pp.13, 3244~3258
175. Huang H, "PTEN affects cell size, cell proliferation, apoptosis during Drosophila eye development", Development, 126, pp.5365~5372 (1999)
176. Bai H, "Activin signaling targeted by insulin", dFOXO regulates aging, muscle proteostasis in Drosophila, 2013, pp.9, e1003941~
177. Hwangbo DS, "Drosophila dFOXO controls lifespan, regulates insulin signalling in brain, fat body", Nature, 429, pp.562~566 (2004)
178. Gronke S, "Molecular evolution, functional characterization of Drosophila insulin-like peptides", PLoS Genet, 6, pp.e1000857~ (2010)
179. Broughton SJ, "Longer lifespan, altered metabolism, , stress resistance in Drosophila from ablation of cells making insulin-like ligands", Proc Natl Acad Sci U S A, 102, pp.3105~3110 (2005)
180. Tatar M, "A mutant Drosophila insulin receptor homolog that extends life-span, impairs neuroendocrine function", Science, 292, pp.107~110 (2001)
181. Clancy DJ, "Extension of life-span by loss of CHICO, a Drosophila insulin receptor substrate protein", Science, 292, pp.104~106 (2001)
182. Tu MP, "The demography of slow aging in male, female Drosophila mutant for the insulin-receptor substrate homologue chico", Aging Cell, 1, pp.75~80 (2002)
183. Nielsen MD, "14-3-3ε antagonizes FoxO to control growth, apoptosis, longevity in Drosophila", Aging Cell, 7, pp.688~699 (2008)
184. Demontis F, "FOXO", 4E-BP signaling in Drosophila muscles regulates organism-wide proteostasis during aging, 2010, pp.143, 813~825
185. Giannakou ME, "Long-lived Drosophila with overexpressed dFOXO in adult fat body", Science, 305, pp.361~ (2004)
186. Wessells RJ, "Insulin regulation of heart function in aging fruit flies", Nat Genet, 36, pp.1275~1281 (2004)
187. Ford D, "Alteration of Drosophila life span using conditional, tissue-specific expression of transgenes triggered by doxycyline or RU486", Mifepristone, 2007, pp.42, 483~497
188. Broeck JV, "Neuropeptides, their precursors in the fruitfly, Drosophila melanogaster", Peptides, 22, pp.241~254 (2001)
189. Colombani J, "Secreted peptide Dilp8 coordinates Drosophila tissue growth with developmental timing", Science, 336, pp.582~585 (2012)
190. Garelli A, "Imaginal discs secrete insulin-like peptide 8 to mediate plasticity of growth, maturation", Science, 336, pp.579~582 (2012)
191. Cao C, "Localization of an insulin-like peptide in brains of two flies", Cell Tissue Res, 304, pp.317~321 (2001)
192. Ikeya T, "Nutrient-dependent expression of insulin-like peptides from neuroendocrine cells in the CNS contributes to growth regulation in Drosophila", Curr Biol, 12, pp.1293~1300 (2002)
193. Rulifson EJ, "Ablation of insulin-producing neurons in flies: growth and diabetic phenotypes", Science, 296, pp.1118~1120 (2002)
194. Lee KS, "Drosophila short neuropeptide F signalling regulates growth by ERK-mediated insulin signalling", Nat Cell Biol, 10, pp.~468-475 (2008)
195. Grönke S, "IGFs: Local Repair, Survival Factors Throughout Life Span", pp.105~124 (2010), Springer
196. Nassel DR, "Insulin", IGF signaling, its regulation in Drosophila, 2015, pp.221, 255~266
197. Haselton A, "Partial ablation of adult Drosophila insulin-producing neurons modulates glucose homeostasis, extends life span without insulin resistance", Cell Cycle, 9, pp.3135~3143 (2010)
198. Jeong DE, "Regulation of lifespan by chemosensory, thermosensory systems:findings in invertebrates, their implications in mammalian aging", Front Genet, 3, pp.218~ (2012)
199. Wang MC, "JNK extends life span, limits growth by antagonizing cellular, organism-wide responses to insulin signaling", Cell, 121, pp.115~125 (2005)
200. Bauer JH, "Expression of dominant-negative Dmp53 in the adult fly brain inhibits insulin signaling", Proc Natl Acad Sci U S A, 104, pp.13355~13360 (2007)
201. Broughton S, "Reduction of DILP2 in Drosophila triages a metabolic phenotype from lifespan revealing redundancy, compensation among DILPs", PLoS One, 3, pp.e3721~ (2008)
202. Okamoto N, "A fat body-derived IGF-like peptide regulates postfeeding growth in Drosophila", Dev Cell, 17, pp.885~891 (2009)
203. Slaidina M, "A Drosophila insulin-like peptide promotes growth during nonfeeding states", Dev Cell, 17, pp.874~884 (2009)
204. Bai H, "Drosophila insulin‐like peptide‐6(dilp6)expression from fat body extends lifespan, represses secretion of Drosophila insulin‐like peptide‐2 from the brain", Aging cell, 11, pp.978~985 (2012)
205. Holzenberger M, "IGF-1receptor regulates lifespan, resistance to oxidative stress in mice", Nature, 421, pp.182~187 (2003)
206. Yuan R, "Aging in inbred strains of mice: study design, interim report on median lifespans, circulating IGF1 levels", Aging Cell, 8, pp.277~287 (2009)
207. Tazearslan C, "Discovery of functional gene variants associated with human longevity:opportunities, challenges", J Gerontol A Biol Sci Med Sci, 67, pp.376~383 (2012)

관련 논문AI추천