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광원에 따른 수종의 치면열구전색제로부터 용리되는모노머에 관한 연구

A study of monomer release from pit and fissure sealants according tovarious light sources

박호원|서현우
대한소아치과학회 (The Korean Academy Of Pediatric Dentistry)|2005.06|대한소아치과학회지 (Journal of the Korean academy of pediatric dentistry)|제32권 제2호|pp. 284-292

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참고문헌

키워드

HPLCLEDHalogenPlasma arc치면열구전색제Pit and fissure sealant할로겐모노머Monomer플라즈마 아크고성능 액체크로마토그래피
주제분류치의학

초록

본 연구에서는 치과용 복합레진의 중합률에 영향을 미치는 다양한 광원인 할로겐, 플라즈마, LED를 사용하여 임상에서 사용하는 여러 치면열구전색제들을 중합 시, 이로부터 용리되는 미반응 모노머들을 확인하고 정량화하고자 하였다. 5가지의 광중합형 치면열구전색제를 각각의 광원에 따라 중합한 시편을 제작하여 3차 증류수에 넣은 후 바로 용리시킨 액을 0시간으로 하고 37℃ 항온수조에서 10분, 1시간, 12시간, 24시간 보관한 후 각각의 용리액을 고성능 액체 크로마토그래피를 이용하여 미반응 모노머의 정성 및 정량 분석을 시행하였고, 다음과 같은 결과를 얻었다.1. 표준 모노머들의 분리시간은 BPA 2.3분, TEGDMA 3.2분, UDMA 5.6분, Bis-GMA 6.5분, Bis-DMA 10.4분 이었다.2. 모든 치면열구전색제에서 TEGDMA를 제외한 어떠한 모노머들도 용리되지 않았다.3. 저장 12시간까지 대부분의 TEGDMA가 용리되었으며, 이후부터는 그 양이 현저히 줄어드는 양상을 보였다.4. 최소권장중합 시간인 할로겐 20초, 플라즈마 3초, LED 10초 중합 시 TEGDMA의 용리량은 할로겐, LED, 플라즈마 순으로 적었다. 5. 모든 중합기에서 Pit & Fissure SealantTM의 용리량이 가장 적었으며, 할로겐 중합시 Helioseal?? F가, 플라즈마 아크 중합 시 ConciseTM가, LED 중합 시 Teethmate?? F-1이 가장 많은 용리량을 보였다.

Abstract

The aim of this study was to identify and quantify the major or detectable monomers released from any of five commercially-available, light-cured pit and fissure sealants with three different light sources : conventional halogen light curing unit, plasma arc light curing unit and LED curing unit. After curing, specimens were immediately immersed in distilled water for different time intervals. The time related release of monomers were analyzed by high performance liquid chromatography(HPLC). Identification and quantitative analysis of monomers were performed by the comparison of the elution time and the absorption peak height of the eluates with those of the authentic sample. The result of this study can be summarized as follows. 1. Standard solution peaks with retention times of 2.3, 3.2, 5.6, 6.5, 10.4 minutes were identified as BPA, TEGDMA, UDMA, Bis-GMA, Bis-DMA, respectively. 2. None of the chromatograms of the tested sealants displayed peaks with the same retention time as that of the standard solution, except for TEGDMA. 3. The highest release rate of TEGDMA was observed during the 12hr period for all samples and declined thereafter. 4. The elution of TEGDMA from curing with Halogen curing unit for 20 second and LED for 10 second was less than that resulting from curing with Plasma arc for 3 second. 5. TEGDMA was detected at much lower levels in eluates from the Pit & Fissure Sealant™ than other sealants. The elution of TEGDMA from the Helioseal F cured with Halogen light curing unit, the Concise™ cured with Plasma arc curing unit and the Teethmate F-1 cured with LED curing unit were higher than other sealants.

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