Radiation-Induced IL(interleukin)-6 in Mice with Algin-Oligosaccharide Treatment
0
조회
0
다운로드
0
인용
0
참고문헌
키워드
초록
To examine the radioprotective effect of algin-oligosaccharide(AOS), radiation-induced IL(interleukin)-6 in mice treated with 3 Gy whole body irradiation once were examined. In the measurement of irradiation-induced IL-6, in comparison with the irradiation control group, in both small intestine and liver tissues of the group treated with algin-oligosaccharide for 7 days prior to irradiation, was suppressed IL-6 synthesis(p<0.001). It is considered that the protection against radiation hazard by antioxydative reaction of algin-oligosaccharide results in down control of IL-6 value in experimental groups treated with algin-oligosaccharide. In conclusion, through our study, the fact that algin-oligosaccharide has irradiation protection effects was elucidated, and simultaneously, the possibility of the use of a natural product without chemical toxicity as an irradiation protection agent was confirmed.
Abstract
To examine the radioprotective effect of algin-oligosaccharide(AOS), radiation-induced IL(interleukin)-6 in mice treated with 3 Gy whole body irradiation once were examined. In the measurement of irradiation-induced IL-6, in comparison with the irradiation control group, in both small intestine and liver tissues of the group treated with algin-oligosaccharide for 7 days prior to irradiation, was suppressed IL-6 synthesis(p<0.001). It is considered that the protection against radiation hazard by antioxydative reaction of algin-oligosaccharide results in down control of IL-6 value in experimental groups treated with algin-oligosaccharide. In conclusion, through our study, the fact that algin-oligosaccharide has irradiation protection effects was elucidated, and simultaneously, the possibility of the use of a natural product without chemical toxicity as an irradiation protection agent was confirmed.
참고문헌 (13)
- Seong-Kwan Choi, "Radioprotective Effect of Algin-oligosaccharide through Measuring Caspase-3 and Caspase-9 in Mice", 방사선방어학회지, 32(4), pp.134~139 (2007), 대한방사선방어학회
- 장우영, "알긴산올리고당 처치 마우스에서 방사선 유도 산화질소의 변화", 한국콘텐츠학회 논문지, 9(7), pp.211~217 (2009), 한국콘텐츠학회
- S.H. Kim, "Radioprotective effect of red ginseng in irradiated mice with high and low dose of radiation", Korean J. Ginseng Sci, 22(1), pp.67~ (1998)
- V.K. Singh, "Radioprotection by N-palmitoylated nonapeptide of human interleukin-1β", Peptides, 26, pp.413~418 (2005)
- P. Fedorocko, "Radioprotection of haemopoietic stem cells by a single injection of bacterial lysate - IRS-19 administered to mice before or after irradiation", International Journal of Immunopharmacology, 22, pp.989~999 (2000)
- G.H.W. Wong, "Protective roles of cytokines against radiation: induction of mitochondrial MnSOD", Biochemeca et Biophysica Acta, 1271, pp.205~209 (1995)
- V.K. Singh, "Role of cytokines and growth factors in radioprotection", Experimental and Molecular Pathology, 78, pp.156~169 (2005)
- 배영훈, "토끼의 관절병증에 미치는 알긴산올리고당의 치료효관", 대한수의학회지, 42(2), pp.4~162 (2002), 대한수의학회
- H. Seki, "Differential protective action of cytokines on radiation- induced apoptosis of peripheral lymphocyte subpopulations", Cellular Immunology, 163, pp.30~36 (1995)
- F. Legue, "IL-6 a key cytokine in vitro and in vivo response of sertoli cells to external gamma irradiation", CYTOKINE, 16(6), pp.232~238 (2001)
- D. Frasca, "Modulation of X-ray-induced damage recog‐nition and repair in ageing human peripheral blood mononuclear cells by an interleukin- 6-type cytokine", Mechanisms of Ageing and Development, 121, pp.5~19 (2000)
- A.V. Der Meeren, "Differential regulation by IL-4 and IL-10 of radiation-induced IL-6 and IL-8 production and ICAM-1 expression by human endothelial cells", CYTOKINE, 11(11), pp.831~838 (1999)
- H.J. Ross, "High and low dose rate irradiation have opposing effects on cytokine gene expression in human glioblastoma cell lines", European journal of cancer, 33(1), pp.144~152 (1997)