적층 제조형 방식의 3D 프린터로 제작한 뇌 팬텀의 유용성
Usefulness of Brain Phantom Made by Fused Filament Fabrication Type 3D Printer
2
조회
0
다운로드
2
인용
0
참고문헌
키워드
초록
The price of the Brain phantom (Hoffman 3D brain phantom) used in nuclear medicine is quite expensive, it is difficult to be purchased by a medical institution or an educational institution. Therefore, the purpose of present research is to produce a low-price 3D brain phantom and evaluate its usefulness by using a 3D printer capable of producing 3D structures. The New 3D brain phantom consisted of 36 slices 0.7 mm thick and 58 slices 1.5 mm thick. A 0.7 mm thick slice was placed between 1. 5 mm thick slices to produce a composite slice. ROI was set at the gray matter and white matter scanned with CT to measure and compare the HU, in order to verify the similarity between PLA which was used as the material for the New 3D brain phantom and acrylic which was used as the material for Hoffman 3D brain phantom. As a result of measuring the volume of each Phantom, the error rate was 3.2% and there was no difference in the signal intensity in five areas. However, there was a significant difference in the average values of HU which was measured at the gray and white matter to verify the similarity between PLA and acrylic. By reproducing the previous Hoffman 3D brain phantom with a 100 times less cost, I hope this research could contribute to be used as the fundamental data in the areas of 3D printer, nuclear medicine and molecular imaging and to increasing the distribution rate of 3D brain phantom.
Abstract
The price of the Brain phantom (Hoffman 3D brain phantom) used in nuclear medicine is quite expensive, it is difficult to be purchased by a medical institution or an educational institution. Therefore, the purpose of present research is to produce a low-price 3D brain phantom and evaluate its usefulness by using a 3D printer capable of producing 3D structures. The New 3D brain phantom consisted of 36 slices 0.7 mm thick and 58 slices 1.5 mm thick. A 0.7 mm thick slice was placed between 1. 5 mm thick slices to produce a composite slice. ROI was set at the gray matter and white matter scanned with CT to measure and compare the HU, in order to verify the similarity between PLA which was used as the material for the New 3D brain phantom and acrylic which was used as the material for Hoffman 3D brain phantom. As a result of measuring the volume of each Phantom, the error rate was 3.2% and there was no difference in the signal intensity in five areas. However, there was a significant difference in the average values of HU which was measured at the gray and white matter to verify the similarity between PLA and acrylic. By reproducing the previous Hoffman 3D brain phantom with a 100 times less cost, I hope this research could contribute to be used as the fundamental data in the areas of 3D printer, nuclear medicine and molecular imaging and to increasing the distribution rate of 3D brain phantom.
참고문헌 (17)
- Sweet WH, "The uses of nuclear disintegration in the diagnosis and treatment of brain tumor", New England Journal of Medicine, 245(23), pp.875~878 (1951)
- Hounsfield GN, "Computerized transverse axial scanning (tomography): Part 1. Description of system", British Journal of Radiology, 46(552), pp.1016~1022 (1973)
- 윤명성, "삼차원 프린팅 기술을 이용한 전산화단층영상 품질 측정용 팬텀 제작 및 비교 연구", 방사선기술과학, 41(6), pp.595~602 (2018), 대한방사선과학회[DOI]
- Cho ZH, "Circular ring transverse axial positron camera for 3-dimensional reconstruction of radionuclides distribution", IEEE Transactions on Nuclear Science, 23(1), pp.613~622 (1976)
- Hoffman EJ, "Design and performance characteristics of a whole-body positron transaxial tomograph", Journal of Nuclear Medicine, 17(6), pp.493~502 (1976)
- Cho JH, "Fusion images of molecular imaging era PET-MRI", Molecular and Cellular Biology News, 17(3), pp.43~51 (2005)
- 김정수, "The Study of Radiation Exposure Reduction by Developing Corpus Striatum Phantom", 방사선기술과학, 40(4), pp.595~603 (2017), 대한방사선과학회[DOI]
- Park SO, "Gamma ray detection processing in PET", CT scanner, 2006, pp.29(3), 125~132
- International Electrotechnical Commission, "EC Standard 61675-1: Radionuclide Imaging Devices—Characteristics and Test Conditions. Part 1. Positron Emission Tomographs", International Electrotechnical Commission, ~ (1998)
- Lee BI, "Quality assurance and performance evaluation of PET", CT, 2008, pp.42(2), 137~144
- Collins DL, "Design and construction of a realistic digital brain phantom", IEEE Transactions on Medical Imaging, 17(3), pp.463~468 (1998)
- Lim GC, "Nuclear medical imaging system", The Institute of Electronics and Information Engineers, 40(7), pp.29~42 (2013)
- 김인영, "FDG를 이용한 Brain PET에서 Glucose Level이 영상에 미치는 영향", 방사선기술과학, 40(2), pp.275~280 (2017), 대한방사선과학회[DOI]
- Ham SM, "Attenuation correction for human brain PET image using a CT template", Master, pp.2017
- Lee JR, "Performance measurements of positron emission tomography : An investigation using general electric AdvanceTM", The Korean Journal of Nuclear Medicine, 30(4), pp.548~559 (1996)
- Teuho J, "Quantitative bias in PET", MR from attenuation correction and reconstruction: A comparison with PET and PET, IEEE Nuclear Science Symposium and Medical Imaging Conference, pp.2013[DOI]
- Li HJ, "Optimization of PET activation studies based on the SNR measured in the 3-D Hoffman brain phantom", IEEE Transactions on Medical Imaging, 17(4), pp.596~605 (1998)