猪苓湯煎湯液이 家兎 및 개의 腎臟機能에 미치는 影響
Effects of Jeo Ryong-tang water Extract on Renal Function in Rabbit and Dog
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In order to investigate the Pharmacological action of Jeo Ryoung- Tang on renal function, this study was performed in rabbit and dog, making use of it’s water extract. Jeo Ryoung- Tang water extract (JRWE), when given into ear vein of rabbits, produced diuresis in a small dose, but antidiuresis in a large dose. Diuretic action of JRWE accompanied the increase of glomerular filtration rate (GFR), renal plasma flow (RPF) and amounts of Na+ in exdreated in urin, but fractional excretion of filtered Na+ was not changed. JRWE, when injected into proleg’s vein of dog, produced diuresis, At this time, changes of renal function were similar to that of diuresis in rabbit. JRWE, when infused into a renal artery of dog, exhibited the diuresis in both kidney. It is thought that JRWE, when given into vein of rabbit or dog, induces the diuresis, and the mechanism of it’s diuresis is the increase of renal plasma flow through secondary action by some endogenous humoural substance.
Abstract
In order to investigate the Pharmacological action of Jeo Ryoung- Tang on renal function, this study was performed in rabbit and dog, making use of it’s water extract. Jeo Ryoung- Tang water extract (JRWE), when given into ear vein of rabbits, produced diuresis in a small dose, but antidiuresis in a large dose. Diuretic action of JRWE accompanied the increase of glomerular filtration rate (GFR), renal plasma flow (RPF) and amounts of Na+ in exdreated in urin, but fractional excretion of filtered Na+ was not changed. JRWE, when injected into proleg’s vein of dog, produced diuresis, At this time, changes of renal function were similar to that of diuresis in rabbit. JRWE, when infused into a renal artery of dog, exhibited the diuresis in both kidney. It is thought that JRWE, when given into vein of rabbit or dog, induces the diuresis, and the mechanism of it’s diuresis is the increase of renal plasma flow through secondary action by some endogenous humoural substance.